摘要:
A ruthenium catalyzed method to synthesize cyclic sulfate compounds from the corresponding cyclic sulfites, and the cyclic sulfate reaction products obtained by this method. These cyclic sulfates further react with selected nucleophiles to give various substituted products. The method is an efficient means for the synthesis of chiral building blocks from tartaric acid enantiomers in high yields using an overall two-stage, one-pot reaction procedure. The chiral compounds can be transformed by nucleophilic reactions into chiral building blocks useful for the synthesis of natural biologically active products, such as antibiotics and pheromones.
摘要:
In accordance with various embodiments, a set of features are described for enabling an application server platform for telecom based applications. A system for providing an application server for telecom-based applications can include an application server that includes a session initiation protocol (SIP) adapter. The SIP adapter can use a connection oriented protocol and provides interactions with application code in an actor of said application server by means of asynchronized SIP protocol events. The SIP adapter can also provide stateless node mapping to a stateful server node hosting a specific session for the actor.
摘要:
The present invention relates to a sheet enabling to form dynamic three-dimensional images and a device for preparing thereof. The sheet comprises a base layer (1), a transparent protective layer (2), a reflective layer (3), and pixel points (4) that can form images. The transparent protective layer (2) is disposed at one side of the base layer (1), the pixel points (4) are embedded in the transparent protective layer (2). The pixel points (4) consist of microlenses (401) tightly closed together. The reflective layer (3) is disposed downbently at a lower part of the microlenses (401), wherein picture-text is recorded in the reflective layer (3). There is an altitude difference H between horizontal positions of two adjacent pixel points (4). Microlenses (401) in any one of pixel point have the same curvature radius, and curvature radius of microlenses (401) in two adjacent pixel points (4) have a difference of 1 to 70 μm.
摘要:
The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting 17-ammonium hydroquinone ansamycin analog.
摘要:
The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting 17-ammonium hydroquinone ansamycin analog.
摘要:
The present invention relates to a sheet enabling to form dynamic three-dimensional images and a device for preparing thereof. The sheet comprises a base layer (1), a transparent protective layer (2), a reflective layer (3), and pixel points (4) that can form images. The transparent protective layer (2) is disposed at one side of the base layer (1), the pixel points (4) are embedded in the transparent protective layer (2). The pixel points (4) consist of microlenses (401) tightly closed together. The reflective layer (3) is disposed downbently at a lower part of the microlenses (401), wherein picture-text is recorded in the reflective layer (3). There is an altitude difference H between horizontal positions of two adjacent pixel points (4). Microlenses (401) in any one of pixel point have the same curvature radius, and curvature radius of microlenses (401) in two adjacent pixel points (4) have a difference of 1 to 70 μm.
摘要:
The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting 17-ammonium hydroquinone ansamycin analog.
摘要:
This invention relates to compositions, and related methods, of synthetic nanocarriers that comprise immunomodulatory agents and antigens that are differentially released from the synthetic nanocarriers.
摘要:
The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting 17-ammonium hydroquinone ansamycin analog.
摘要:
The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting 17-ammonium hydroquinone ansamycin analog.