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    METHOD FOR EFFECTIVE SEARCH FOR TARGET MOLECULE
    31.
    发明申请
    METHOD FOR EFFECTIVE SEARCH FOR TARGET MOLECULE 审中-公开
    有效搜索目标分子的方法

    公开(公告)号：US20090042318A1

    公开(公告)日：2009-02-12

    申请号：US11814986

    申请日：2006-01-26

    Applicant: Akito Tanaka ,  Akira Yamazaki ,  Masayuki Haramura

    Inventor： Akito Tanaka ,  Akira Yamazaki ,  Masayuki Haramura

    IPC: G01N33/545

    CPC classification number: G01N33/54393 ,  B01J20/3227 ,  B01J20/3248 ,  B01J20/3253 ,  B01J20/3255 ,  B01J20/3285 ,  G01N33/54306

    Abstract: The present invention provides a solid phase carrier capable of adsorbing a highly hydrophobic target molecule, for example, a membrane associated protein, and a solid phase carrier optimized not only for a highly hydrophobic target molecule, but also for an optionally chosen target molecule. More specifically, the present invention provides a solid phase carrier having a ligand and a capping agent immobilized thereon, with the hydrophobic property of the surface thereof adjusted to enable the binding of the target molecule to the ligand, or to increase the amount of target molecule bound to the ligand; various methods using the solid phase carrier (for example, method of concentrating, isolating, or purifying a target molecule, a method of selectively adsorbing a particular target molecule to the solid phase carrier, or a method of analyzing the interaction between ligand and target molecule therefor); a production method for the solid phase carrier; and an improvement method for a solid phase carrier having a ligand and a capping agent immobilized thereon and the like.

    Abstract translation: 本发明提供了能够吸附高度疏水的靶分子例如膜相关蛋白的固相载体，以及不仅对于高度疏水的靶分子而且优选任选地选择的靶分子优化的固相载体。 更具体地说，本发明提供一种具有固定在其上的配体和封端剂的固相载体，其表面的疏水性被调节以使靶分子与配体结合，或增加靶分子的量 与配体结合; 使用固相载体的各种方法（例如，浓缩，分离或纯化靶分子的方法，将特定靶分子选择性吸附到固相载体上的方法或分析配体与靶分子之间的相互作用的方法 为此） 一种固相载体的制备方法; 以及其上固定有配体和封端剂等的固相载体的改进方法。

    Coated polydivinbenzene beads
    34.
    发明申请
    Coated polydivinbenzene beads 有权
    涂层聚丹宁苯珠

    公开(公告)号：US20080255269A1

    公开(公告)日：2008-10-16

    申请号：US12080269

    申请日：2008-04-01

    Applicant: Howard C. Jordi ,  Qiding Mi

    Inventor： Howard C. Jordi ,  Qiding Mi

    IPC: C08F12/36 ,  C08K7/00

    CPC classification number: B01J20/265 ,  B01D15/34 ,  B01J20/28004 ,  B01J20/28033 ,  B01J20/28097 ,  B01J20/286 ,  B01J20/321 ,  B01J20/3253 ,  B01J2220/54 ,  B01J2220/58 ,  C08F8/10 ,  C08F8/22 ,  C08F8/32 ,  C08J9/40 ,  C08F112/36

    Abstract: The present invention provides novel, polymeric supports, methods of making, and methods of using the supports, that have a fluorinated, amidated surface. The supports include polymeric microbeads, thin layers or membranes, plates, monoliths and the like. The supports are useful as packing materials for normal phase, reverse phase, and size exclusion chromatography, and provide high speed separation of analytes with excellent resolution. The fluorinated, amidated surface may include a composition comprising a plurality of repeating units, for example, having the following structure:

    Abstract translation: 本发明提供具有氟化的酰胺化表面的新颖的聚合物载体，制备方法和使用载体的方法。 载体包括聚合物微珠，薄层或膜，板，整料等。 该载体可用作正相，反相和尺寸排阻层析的包装材料，并且以优异的分辨率提供分析物的高速分离。 氟化的酰胺化表面可以包括包含多个重复单元的组合物，例如具有以下结构：

    Use of a granulate for the removal of liquid, gaseous and/or dissolved constituents from a process stream
    38.
    发明授权
    Use of a granulate for the removal of liquid, gaseous and/or dissolved constituents from a process stream 有权
    使用颗粒从工艺流中除去液体，气体和/或溶解成分

    公开(公告)号：US07258796B2

    公开(公告)日：2007-08-21

    申请号：US10344544

    申请日：2001-08-15

    Applicant: Richard Hendrikus Gerrit Brinkhuis ,  Elwin Schomaker ,  Johannes Bos

    Inventor： Richard Hendrikus Gerrit Brinkhuis ,  Elwin Schomaker ,  Johannes Bos

    IPC: B01D15/00 ,  C02F1/28

    CPC classification number: B01J20/28097 ,  B01J20/26 ,  B01J20/321 ,  B01J20/3248 ,  B01J20/3253 ,  B01J20/3293

    Abstract: The invention pertains to the use of a granulate for the removal of liquid, gaseous and/or dissolved organic constituents from a process stream, said granulate consisting of dimensionally stable, porous synthetic particles with an extracting agent having a boiling point higher than 350° C. at 1 bar immobilized therein, characterized in that the granulate is obtainable by suspension polymerization of a monovinyl compound in the presence of a polyvinyl compound, with at least 50% wt. % of the monomer units having an aromatic structure and with the solvent for the monomers acting both as a non-solvent for the copolymer and as an extracting agent.

    Abstract translation: 本发明涉及使用颗粒从工艺流中除去液体，气体和/或溶解的有机成分，所述颗粒由具有沸点高于350℃的萃取剂的尺寸稳定的多孔合成颗粒组成 固定在其中的1巴，其特征在于，所述颗粒可通过聚乙烯基化合物存在下的单乙烯基化合物的悬浮聚合获得，至少50重量％。 ％的具有芳族结构的单体单元和用作单体的溶剂用作共聚物的非溶剂和作为萃取剂。

    Method for selectively binding a substrate to sorbents by way of at least bivalent bonds
    40.
    发明申请
    Method for selectively binding a substrate to sorbents by way of at least bivalent bonds 审中-公开
    通过至少二价键选择性地将底物与吸附剂结合的方法

    公开(公告)号：US20060292569A1

    公开(公告)日：2006-12-28

    申请号：US10550756

    申请日：2004-03-24

    Applicant: Klaus Gottschall

    Inventor： Klaus Gottschall

    IPC: C40B30/06 ,  C40B40/04

    CPC classification number: B01J20/3253 ,  B01J20/3242 ,  B01J20/3248 ,  B01J20/3251 ,  B01J20/3255 ,  B01J20/3285 ,  G01N33/543

    Abstract: A method for the manufacture of at least one sorbent having at least two different groups, which are capable of binding, for the selective binding of a substrate, characterized in that it comprises the steps (i) to (ii): (i) determining at least two groups capable of binding a sorbent from a synthetic or natural first substrate, (ii) respectivly applying at least two different groups capable of binding a second synthetic or natural substrate to one respective carrier, thereby forming at least one sorbent, whereby the groups are the same groups of step (i) or are groups that are complementary thereto, and the second substrate of step (ii) is the same or different from the first substrate according to step (i), and whereby the groups are determined such that the contributions of the Gibbs energies of the individual groups to the non-covalent bond with the second substrate yield a negative value of the Gibbs energy ΔG, such that a binding strengthening occurs that results in an improved separation selectivity with respect to at least one substance to be separated off.

    Abstract translation: 一种用于制造具有至少两个能够结合底物的选择性结合的至少两个不同基团的吸附剂的方法，其特征在于其包括步骤（i）至（ii）：（i）确定 至少两个能够从合成或天然的第一底物粘合吸附剂的基团，（ii）相对于至少两个能够将第二合成或天然底物结合到一个相应载体上的不同基团，从而形成至少一种吸附剂，由此， 基团是步骤（i）的相同组或与其互补的基团，并且步骤（ii）的第二底物与根据步骤（i）的第一底物相同或不同，并且由此确定这些基团 单个组的吉布斯能量对与第二底物的非共价键的贡献产生吉布斯能量DeltaG的负值，使得发生结合强化，导致改进 相对于待分离的至少一种物质的分离选择性。

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