PROCESS FOR PRODUCING CELLULOSE DERIVATIVES OF HIGH BULK DENSITY, GOOD FLOWABILITY AND/OR DISPERSIBILITY IN COLD WATER AS WELL AS LOW SOLUTION COLOR
    33.
    发明申请
    PROCESS FOR PRODUCING CELLULOSE DERIVATIVES OF HIGH BULK DENSITY, GOOD FLOWABILITY AND/OR DISPERSIBILITY IN COLD WATER AS WELL AS LOW SOLUTION COLOR 有权
    用于生产高密度密度的纤维素衍生物的方法,冷水中良好的流动性和/或分散性,以及作为低溶液颜色

    公开(公告)号:US20150239992A1

    公开(公告)日:2015-08-27

    申请号:US14422253

    申请日:2013-09-23

    IPC分类号: C08B11/193 A61K47/38 A61K9/48

    摘要: A particulate cellulose derivative is obtained in a process of grinding and drying a moist cellulose derivative which comprises the steps of A) providing a cellulose derivative having a moisture content of from 60 to 95 percent, based on the total weight of the moist cellulose derivative; B) grinding and partially drying the moist cellulose derivative in a gas-swept impact mill; C) contacting the ground and partially dried cellulose derivative with an additional amount of a drying gas outside the gas-swept impact mill; and D) subjecting the cellulose derivative to partial depolymerization after having contacted the cellulose derivative with a drying gas in step C). The obtained particulate cellulose derivative has a high untapped bulk density, a good flowability and a low color intensity.

    摘要翻译: 在研磨和干燥湿纤维素衍生物的方法中获得颗粒状纤维素衍生物,其包括以下步骤:A)提供基于湿纤维素衍生物的总重量的水分含量为60至95%的纤维素衍生物; B)在气体扫掠冲击式研磨机中研磨和部分干燥湿纤维素衍生物; C)将接地和部分干燥的纤维素衍生物与气体扫掠冲击式磨机外部的附加量的干燥气体接触; 和D)在步骤C)中使纤维素衍生物与干燥气体接触后使纤维素衍生物部分解聚。 所获得的颗粒状纤维素衍生物具有高的未开发堆积密度,良好的流动性和低的颜色强度。

    Pliable medical device and method of use
    34.
    发明授权
    Pliable medical device and method of use 有权
    柔韧的医疗器械及使用方法

    公开(公告)号:US09101694B2

    公开(公告)日:2015-08-11

    申请号:US12086557

    申请日:2006-12-15

    摘要: A firm but pliable medical device for use as a bone graft substitute or bone graft extender retains its shape without the requirement of a containment device, such as a syringe. Because the device is solid, it is easy to locate or position in-vivo and, in the moist environment of the body, it will hold its shape well, for an extended time. Because the lyophilized pliable medical device is porous, it adsorbs blood and other beneficial cells containing body fluids, such as bone marrow, contributing to its superior bone repair efficacy in comparison to an analogous putty that has not been lyophilized. In addition these lyophilized pliable medical devices are easier to terminally steam sterilize than the analogous putty because there is no moisture present to boil and “blow-out” of the containment device (syringe). The glycerin that is present in the formulation lends pliability but has a low vapor pressure.

    摘要翻译: 用作骨移植物替代物或骨移植物延长剂的牢固但柔韧的医疗装置保持其形状,而不需要诸如注射器的容纳装置。 因为该装置是固体,所以很容易在体内定位或定位,并且在身体的潮湿环境中,其将保持良好的形状,长时间。 因为冻干的柔韧的医疗装置是多孔的,因此与没有被冻干的类似的腻子相比,它吸收含有体液如骨髓的血液和其它有益细胞,有助于其优异的骨修复功效。 此外,这些冻干的柔韧的医疗设备比类似的油灰更容易终止蒸汽消毒,因为不存在水分以便将容器(注射器)煮沸和“吹出”。 存在于制剂中的甘油具有柔韧性但具有低蒸气压。

    CURED-FILM FORMATION COMPOSITION, ORIENTATION MATERIAL, AND RETARDATION MATERIAL
    35.
    发明申请
    CURED-FILM FORMATION COMPOSITION, ORIENTATION MATERIAL, AND RETARDATION MATERIAL 有权
    固化膜形成组成,定向材料和延展材料

    公开(公告)号:US20150191572A1

    公开(公告)日:2015-07-09

    申请号:US14414309

    申请日:2013-07-11

    摘要: A cured-film formation composition for forming a cured film having photoreaction efficiency and solvent resistance, and high adhesiveness alignment uniformity, and an orientation material for photo-alignment, and a retardation material formed by use of the orientation material. A cured-film formation composition includes (A) a compound having a photo-aligning group and one substituent selected from a hydroxy group, a carboxy group, and an amino group; (B) a hydrophilic polymer having one or more substituents selected from a hydroxy group, a carboxy group, and an amino group; and (C) a polymer obtained by polymerizing a monomer including an N-hydroxymethyl compound or an N-alkoxymethyl (meth)acrylamide compound, and optionally further a cross-linking catalyst as a component (D). By use of the composition, a cured-film is formed and an orientation material is formed by utilizing photo-alignment technique. A retardation material is obtained by applying a polymerizable liquid crystal on the orientation material and curing it.

    摘要翻译: 用于形成具有光反应效率和耐溶剂性,高粘合性取向均匀性的固化膜的固化膜形成组合物,以及用于光取向的取向材料以及使用取向材料形成的延迟材料。 固化膜形成组合物包含(A)具有光取代基和选自羟基,羧基和氨基的一个取代基的化合物; (B)具有一个或多个选自羟基,羧基和氨基的取代基的亲水性聚合物; 和(C)通过使包含N-羟甲基化合物或N-烷氧基甲基(甲基)丙烯酰胺化合物的单体聚合得到的聚合物,以及任选地作为(D)成分的交联催化剂。 通过使用该组合物,形成固化膜,利用光取向技术形成取向材料。 通过在取向材料上涂布聚合性液晶并使其固化来获得延迟材料。

    Hydrogel and biomedical applications thereof
    37.
    发明授权
    Hydrogel and biomedical applications thereof 有权
    水凝胶及其生物医学应用

    公开(公告)号:US09050392B2

    公开(公告)日:2015-06-09

    申请号:US12515059

    申请日:2007-11-16

    摘要: The invention relates to a method for preparing a cross-linked sterile and homogeneous hydrogel for injection, characterized in that it comprises the following steps: (a) preparing an aqueous solution containing a polymer derived from cellulose and at least one water-soluble polymer, the total polymer content ranging from 0.5 and 5 wt %, preferably from 1 to 4 wt % and more preferably from 1.5 to 3 wt %; (b) optionally adding sold particles; (c) pouring the resulting liquid mixture with the optional solid particles into a vessel and closing dais vessel using a water-tight and gas-tight system; and (d) exposing said vessel containing the liquid and the optional solid particles to a radiation dose of between 5 and 50 kGy, preferably between 20 and 30 kGy, and more preferably of about 25 kGy. The invention also relates to a hydrogel obtained according to the above method and to the use thereof in medical applications.

    摘要翻译: 本发明涉及一种制备用于注射的交联无菌均匀水凝胶的方法,其特征在于包括以下步骤:(a)制备含有衍生自纤维素和至少一种水溶性聚合物的聚合物的水溶液, 总聚合物含量为0.5至5重量%,优选1至4重量%,更优选1.5至3重量%; (b)任选地加入销售的颗粒; (c)将所得液体混合物与任选的固体颗粒倒入容器中,并使用防水和气密系统关闭dais容器; 和(d)将含有液体和任选的固体颗粒的所述容器暴露于5至50kGy之间,优选20至30kGy,更优选约25kGy的辐射剂量。 本发明还涉及根据上述方法获得的水凝胶及其在医疗应用中的用途。

    Water-soluble polysaccharide ethers and their use
    38.
    发明授权
    Water-soluble polysaccharide ethers and their use 有权
    水溶性多糖醚及其用途

    公开(公告)号:US09045565B2

    公开(公告)日:2015-06-02

    申请号:US13390733

    申请日:2010-08-17

    摘要: The invention relates to modified polysaccharide ethers having a weight-averaged molecular weight of 40,000 to 500,000 g/mole, zero shear viscosity of more than 10 Pa·s, and pseudo-plasticity of more than 20. These modified polysaccharide ethers are obtainable by reacting cellulose-based polysaccharide ether(s) with at least one mesogenic modification agent or modified polysaccharide ethers, obtainable by reacting polysaccharide ether(s) selected from hydroxypropylmethyl cellulose (HPMC), hydroxyethylmethyl cellulose (HEMC), methyl cellulose, and cellulose ethers with methyl and/or ethyl and/or propyl groups and mixtures thereof, with at least one mesogenic modification agent. These substances can be used to produce gel-like to stable aqueous preparations having viscoelastic flow properties, which are suited for use in the human body, particularly within the scope of ophthalmologic procedures.

    摘要翻译: 本发明涉及重均分子量为40,000至500,000g / mol,零剪切粘度大于10Pa·s,假塑性大于20的改性多糖醚。这些改性多糖醚可通过使 通过使选自羟丙基甲基纤维素(HPMC),羟乙基甲基纤维素(HEMC),甲基纤维素和纤维素醚的多糖醚与甲基的纤维素醚反应获得的具有至少一种介晶改性剂或改性多糖醚的纤维素基多糖醚 和/或乙基和/或丙基及其混合物与至少一种介晶改性剂。 这些物质可以用于制备具有粘弹性流动性的稳定的水性制剂,其适用于人体,特别是在眼科手术范围内。

    COMPOSITION COMPRISING AN ORGANIC DILUENT AND A CELLULOSE ETHER
    39.
    发明申请
    COMPOSITION COMPRISING AN ORGANIC DILUENT AND A CELLULOSE ETHER 有权
    包含有机稀释剂和纤维素醚的组合物

    公开(公告)号:US20150065548A1

    公开(公告)日:2015-03-05

    申请号:US14390049

    申请日:2013-04-08

    摘要: A liquid composition comprises an organic diluent and at least one cellulose ether having anhydroglucose units joined by 1-4 linkages and having methyl groups, hydroxyalkyl groups, and optionally alkyl groups being different from methyl as substituents such that hydroxyl groups of anhydroglucose units are substituted with methyl groups such that s23/s26 is 0.29 or less, wherein s23 is the molar fraction of anhydroglucose units wherein only the two hydroxyl groups in the 2- and 3-positions of the anhydroglucose unit are substituted with a methyl group and wherein s26 is the molar fraction of anhydroglucose units wherein only the two hydroxyl groups in the 2- and 6-positions of the anhydroglucose unit are substituted with a methyl group. The liquid composition can be used for preparing a solid dispersion of an active ingredient in a cellulose ether.

    摘要翻译: 液体组合物包含有机稀释剂和至少一种具有通过1-4键连接并具有甲基,羟基烷基和任选的不同于甲基作为取代基的烷基的脱水葡萄糖单元的纤维素醚,使得脱水葡萄糖单元的羟基被 甲基,使得s23 / s26为0.29以下,其中s23是脱水葡萄糖单元的摩尔分数,其中脱水葡萄糖单元的2-和3-位上的两个羟基仅被甲基取代,其中s26是 脱水葡萄糖单元的摩尔分数,其中只有脱水葡萄糖单元的2-和6-位上的两个羟基被甲基取代。 液体组合物可用于制备活性成分在纤维素醚中的固体分散体。

    Liquid embolic material including carboxymethyl chitosan crosslinked with carboxymethyl cellulose
    40.
    发明授权
    Liquid embolic material including carboxymethyl chitosan crosslinked with carboxymethyl cellulose 有权
    液体栓塞材料包括与羧甲基纤维素交联的羧甲基壳聚糖

    公开(公告)号:US08936795B2

    公开(公告)日:2015-01-20

    申请号:US13720135

    申请日:2012-12-19

    摘要: A liquid embolic material may include a mixture of a first solution comprising between about 1.2% and about 2.5% weight per volume (w/v) carboxymethyl chitosan (CCN) in a first solvent and a second solution comprising between about 1.2% and about 2.5% w/v oxidized carboxymethyl cellulose (OCMC) in a second solvent. The liquid embolic material may be used to embolize a targeted embolization location by mixing the first solution and the second solution to form a liquid embolic material (or hydrogel precursor material), introducing the hydrogel precursor material to a targeted embolization location within a body of a patient, and allowing the CCN and the OCMC to react to form the hydrogel material and embolize the targeted embolization location.

    摘要翻译: 液体栓塞材料可以包括在第一溶剂中包含约1.2%至约2.5%重量/体积(w / v)羧甲基壳聚糖(CCN)的第一溶液和包含约1.2%至约2.5%的第二溶液的混合物 %w / v氧化的羧甲基纤维素(OCMC)在第二溶剂中。 液体栓塞材料可以用于通过混合第一溶液和第二溶液来栓塞目标栓塞位置以形成液体栓塞材料(或水凝胶前体材料),将水凝胶前体材料引入到体内的目标栓塞位置 患者,并允许CCN和OCMC反应形成水凝胶材料并栓塞目标栓塞位置。