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143 条记录 (耗时 0.032 秒)

    DIFFERENTIATION OF STEM CELLS WITH NANOPARTICLES
    35.
    发明申请
    DIFFERENTIATION OF STEM CELLS WITH NANOPARTICLES 审中-公开
    具有纳米颗粒的干细胞分化

    公开(公告)号：US20150080770A1

    公开(公告)日：2015-03-19

    申请号：US14554433

    申请日：2014-11-26

    申请人： The Research Foundation for The State University of New York

    发明人： Balaji SITHARAMAN ,  Jon LONGTIN

    IPC分类号： A61N7/00

    CPC分类号： A61N7/00 ,  B82Y5/00 ,  C12N5/0654 ,  C12N2529/00 ,  C12N2533/10

    摘要： This invention relates to stimulation of stem cells and other progenitors of differentiated cells using nanoparticles and electromagnetic stimulation. The invention provides a method for differentiating mesenchymal stem cells (MSCs) towards osteoblasts and other connective tissue. The invention provides osteoinductive materials useful for bone regeneration and reconstruction in treatment of bone trauma and bone related diseases, and to correct birth defects. The invention also provides for reduced adipogenesis.

    摘要翻译： 本发明涉及使用纳米颗粒和电磁刺激刺激分化细胞的干细胞和其他祖细胞。 本发明提供了一种将间充质干细胞（MSC）分化成成骨细胞和其他结缔组织的方法。 本发明提供用于治疗骨创伤和骨相关疾病的骨再生和重建以及矫正出生缺陷的骨诱导材料。 本发明还提供减少脂肪形成。

    SYSTEMS AND METHODS FOR MAGNETIC GUIDANCE AND PATTERNING OF MATERIALS
    37.
    发明申请
    SYSTEMS AND METHODS FOR MAGNETIC GUIDANCE AND PATTERNING OF MATERIALS 有权
    用于磁性指导和材料图案的系统和方法

    公开(公告)号：US20140322784A1

    公开(公告)日：2014-10-30

    申请号：US14331377

    申请日：2014-07-15

    申请人： William Marsh Rice University

    发明人： Glauco R. SOUZA ,  Renata Pasqualini ,  Wadih ARAP ,  Thomas Charles KILLIAN ,  Robert M. RAPHAEL ,  Daniel Joshua STARK

    IPC分类号： C12N13/00 ,  C12N5/00

    CPC分类号： C12N13/00 ,  B82Y5/00 ,  C12M35/06 ,  C12N5/0062 ,  C12N2529/00 ,  C12N2533/10

    摘要： Systems and methods generally useful in medicine, cellular biology, nanotechnology, and cell culturing are discussed. In particular, at least in some embodiments, systems and methods for magnetic guidance and patterning of cells and materials are discussed. Some specific applications of these systems and methods may include levitated culturing of cells away from a surface, making and manipulating patterns of levitated cells, and patterning culturing of cells on a surface. Specifically, a method of culturing cells is presented. The method may comprise providing a plurality of cells, providing a magnetic field, and levitating at least some of the plurality of cells in the magnetic field, wherein the plurality of cells comprise magnetic nanoparticles. The method may also comprise maintaining the levitation for a time sufficient to permit cell growth to form an assembly.

    摘要翻译： 讨论了一般在医学，细胞生物学，纳米技术和细胞培养中有用的系统和方法。 特别地，至少在一些实施例中，讨论了用于细胞和材料的磁性引导和图案化的系统和方法。 这些系统和方法的一些具体应用可以包括将细胞悬浮培养离开表面，制备和操纵悬浮细胞的图案，以及对表面上的细胞进行图案化培养。 具体地说，提出培养细胞的方法。 该方法可以包括提供多个单元，提供磁场，以及悬浮在磁场中的多个单元中的至少一些单元，其中多个单元包括磁性纳米颗粒。 该方法还可以包括将悬浮液维持足以允许细胞生长形成组件的时间。

    Systems and methods for magnetic guidance and patterning of materials
    38.
    发明授权
    Systems and methods for magnetic guidance and patterning of materials 有权
    用于磁性引导和材料图案化的系统和方法

    公开(公告)号：US08815231B2

    公开(公告)日：2014-08-26

    申请号：US13070873

    申请日：2011-03-24

    申请人： Glauco R. Souza ,  Renata Pasqualini ,  Wadih Arap ,  Thomas Charles Killian ,  Robert M. Raphael ,  Daniel Joshua Stark

    发明人： Glauco R. Souza ,  Renata Pasqualini ,  Wadih Arap ,  Thomas Charles Killian ,  Robert M. Raphael ,  Daniel Joshua Stark

    IPC分类号： C12N5/00

    CPC分类号： C12N13/00 ,  B82Y5/00 ,  C12M35/06 ,  C12N5/0062 ,  C12N2529/00 ,  C12N2533/10

    摘要： Systems and methods generally useful in medicine, cellular biology, nanotechnology, and cell culturing are discussed. In particular, at least in some embodiments, systems and methods for magnetic guidance and patterning of cells and materials are discussed. Some specific applications of these systems and methods may include levitated culturing of cells away from a surface, making and manipulating patterns of levitated cells, and patterning culturing of cells on a surface. Specifically, a method of culturing cells is presented. The method may comprise providing a plurality of cells, providing a magnetic field, and levitating at least some of the plurality of cells in the magnetic field, wherein the plurality of cells comprise magnetic nanoparticles. The method may also comprise maintaining the levitation for a time sufficient to permit cell growth to form an assembly.

    摘要翻译： 讨论了一般在医学，细胞生物学，纳米技术和细胞培养中有用的系统和方法。 特别地，至少在一些实施例中，讨论了用于细胞和材料的磁性引导和图案化的系统和方法。 这些系统和方法的一些具体应用可以包括将细胞悬浮培养离开表面，制备和操纵悬浮细胞的图案，以及对表面上的细胞进行图案化培养。 具体地说，提出培养细胞的方法。 该方法可以包括提供多个单元，提供磁场，以及悬浮在磁场中的多个单元中的至少一些单元，其中多个单元包括磁性纳米颗粒。 该方法还可以包括将悬浮液维持足以允许细胞生长形成组件的时间。

    METHOD FOR IN-VITRO TREATMENT OF DIFFERENTIATED OR UNDIFFERENTIATED CELLS BY APPLICATION ELECTROMAGNETIC FIELDS
    39.
    发明申请
    METHOD FOR IN-VITRO TREATMENT OF DIFFERENTIATED OR UNDIFFERENTIATED CELLS BY APPLICATION ELECTROMAGNETIC FIELDS 审中-公开
    通过应用电磁场对不同或不同的细胞进行体内治疗的方法

    公开(公告)号：US20140212943A1

    公开(公告)日：2014-07-31

    申请号：US14238499

    申请日：2012-08-10

    申请人： Salvatore Rinaldi ,  Vania Fontani

    发明人： Salvatore Rinaldi ,  Vania Fontani

    IPC分类号： C12N13/00

    CPC分类号： C12N13/00 ,  C12N5/0696 ,  C12N2529/00 ,  F04C2270/041

    摘要： A process is described for the treatment of stem cells or differentiated cells by application of radiofrequency electro-magnetic fields, by means of an electromagnetic field generator (10), comprising a power supply (11), at least one antenna (12) adapted to radiate a scattered electromagnetic field (13) of a power less than 100 mW, a modulator (14) associated with said generator (10) and adapted to modulate the emission thereof, and at least one convector electrode (15), adapted to be direct the radiofrequency currents induced by said electromagnetic field (13), and applied in proximity of said stem or differentiated cells.

    摘要翻译： 描述了通过施加射频电磁场通过电磁场发生器（10）处理干细胞或分化细胞的方法，该电磁场发生器（10）包括电源（11），至少一个天线（12），适于 辐射功率小于100mW的散射电磁场（13），与所述发生器（10）相关联并适于调制其发射的调制器（14），以及至少一个对流电极（15），其适于直接 由所述电磁场（13）感应并施加在所述茎或分化细胞附近的射频电流。