公开(公告)号：US5468643A

公开(公告)日：1995-11-21

申请号：US104522

申请日：1993-08-10

Applicant: Syang Y. Su ,  Gerald K. Shiu

Inventor： Syang Y. Su ,  Gerald K. Shiu

IPC: G01N30/02 ,  G01N30/14 ,  G01N30/16 ,  G01N30/20 ,  G01N30/24 ,  G01N30/34

CPC classification number: G01N30/16 ,  G01N2030/027 ,  G01N2030/201 ,  G01N2030/202 ,  G01N2030/347 ,  G01N30/14 ,  G01N30/24 ,  Y10T436/25375

Abstract: A valving arrangement and a method are provided by which a biological sample is mixed with a reactant, such as a solvent or a precipitating agent, as it is injected through a multi-position injection valve. A multi-position switching valve is connected to the injection valve, and one or more filters attached to the switching valve remove precipitates of predetermined size from the reacted sample. The sample the flows to conventional analytical columns for liquid chromatography analysis of analytes of interest. Proteins and/or peptides are thus quickly and efficiently removed from the sample as precipitates collected in the filters. The injection valve and the switching valve are then placed in respective cooperating positions to flow a carrier fluid through the injection valve and the switching valve directly to the analysis columns, while a back-flow of a suitable surfactant is pumped through the filters to purge them of collected precipitates. This quickly purges the system and puts it in condition for a repeat of the procedure. The apparatus and method may be used both when samples are provided manually under the direct control of an operator and when an autoinjector or autosampler of known type is employed for repeated sampling.

Abstract translation: 提供了一种阀装置和方法，通过该方法将生物样品与通过多位置注射阀注射的反应物（例如溶剂或沉淀剂）混合。 多位置切换阀连接到喷射阀，并且连接到切换阀的一个或多个过滤器从反应的样品中去除预定尺寸的沉淀物。 样品流向常规分析柱，用于目标分析物的液相色谱分析。 因此，当沉淀物收集在过滤器中时，蛋白质和/或肽因此被快速有效地从样品中除去。 然后将注射阀和切换阀放置在相应的配合位置，以使载体流体通过注射阀和切换阀直接流到分析柱，同时将合适的表面活性剂的反流泵送通过过滤器以将其清除 的收集沉淀物。 这很快清除了系统，并将其置于重复该过程的条件。 当在操作者的直接控制下手动提供样品并且当使用已知类型的自动注射器或自动进样器用于重复取样时，可以使用该装置和方法。

公开(公告)号：US5205845A

公开(公告)日：1993-04-27

申请号：US817306

申请日：1992-01-06

Applicant: Richard D. Sacks ,  Anita J. Peters

Inventor： Richard D. Sacks ,  Anita J. Peters

IPC: G01N1/00 ,  G01N1/22 ,  G01N1/26 ,  G01N1/28 ,  G01N1/40 ,  G01N30/12 ,  G01N30/20 ,  G01N30/24 ,  G01N30/30 ,  G01N30/38 ,  G01N30/40 ,  G01N30/46 ,  G01N30/62 ,  G01N30/86

CPC classification number: G01N30/20 ,  G01N1/26 ,  G01N30/12 ,  G01N30/40 ,  G01N1/2214 ,  G01N1/40 ,  G01N2030/121 ,  G01N2030/122 ,  G01N2030/201 ,  G01N2030/202 ,  G01N2030/204 ,  G01N2030/3046 ,  G01N2030/383 ,  G01N2030/385 ,  G01N2030/402 ,  G01N2030/405 ,  G01N2030/407 ,  G01N2030/623 ,  G01N2030/628 ,  G01N30/24 ,  G01N30/466 ,  G01N30/8651 ,  G01N35/1097

Abstract: Several embodiments of gas chromatography systems are disclosed incorporating mechanical sample injection valves. The injection valves incorporate a delivery tube having an outlet which is swept past the inlet of a separation column to provide a short duration inlet plug into the separation column. Carrier gas and sample gas flow is managed through the valve to prevent inadvertent injection after an injection is desired and to assure that the sample is not contaminated by past sample flow. Embodiments of injections valve are described for providing inputs into several gas chromatography columns. In addition, a gas chromatography system is described in which multiple columns are used which are time multiplexed with a single detector to produce a complex combined chromatogram from the plural columns. By appropriate selection of column characteristics and injection sequence, the resulting chromatogram can provide an overlay of chromatograms which provide good resolution of all the constituents of the mixture of interest within a short analysis time.

Abstract translation: 公开了气相色谱系统的几个实施例，其结合机械样品注射阀。 注射阀包括具有出口的输送管，该出口被扫过经过分离塔的入口以向分离柱提供短持续时间的入口塞。 载气和样品气体流量通过阀门进行管理，以防止在需要注射后意外注入，并确保样品不会被过去的样品流污染。 描述了注射阀的实施例，用于向几个气相色谱柱提供输入。 此外，描述了气相色谱系统，其中使用与单个检测器时间复用的多个色谱柱以从多个色谱柱产生复合组合色谱图。 通过适当选择色谱柱特性和注射顺序，得到的色谱图可以提供色谱图的重叠，可以在短时间内提供所有感兴趣的混合物成分的良好分辨率。

公开(公告)号：US4444066A

公开(公告)日：1984-04-24

申请号：US278771

申请日：1981-06-29

Applicant: David G. Ogle ,  John T. Taylor

Inventor： David G. Ogle ,  John T. Taylor

IPC: G01N30/20 ,  G01N1/10

CPC classification number: G01N30/20 ,  G01N2030/201 ,  G01N2030/202

Abstract: A high pressure valve for control of the injection of a sample into an analyzer system such as an amino acid analyzer with liquid column chromatography. The valve is designed in such a manner that no rinse solution that is used to cleanse the system after the injection of a particular sample will enter the liquid column. The valve operates in two positions and requires a minimum of movement between the two positions. In one position the valve allows for the injection of the sample into the liquid column. In the second position the valve allows for the entry of only a buffer solution into the liquid column and blocks the entry of any rinse solution that may flow through the system for cleansing after the injection of the sample. No residual rinse solution is allowed to remain within the valve prior to injection of either a sample or a buffer material into the liquid column.

Abstract translation: 用于控制将样品注入分析仪系统（例如使用液相色谱法的氨基酸分析仪）的高压阀。 该阀被设计成使得在注射特定样品之后不用于清洁系统的冲洗溶液将进入液柱。 阀在两个位置操作，并且在两个位置之间需要最小的运动。 在一个位置，阀允许将样品注入液柱。 在第二位置，阀允许仅将缓冲溶液进入液柱并阻止任何可能流过系统的冲洗溶液的进入，以便在注射样品之后进行清洁。 在将样品或缓冲材料注入液体柱之前，不允许残留的冲洗溶液留在阀内。

公开(公告)号：US3592064A

公开(公告)日：1971-07-13

申请号：US3592064D

申请日：1969-02-18

Applicant: BRYGGERIINDUSTRIENS FORSKNINGS

Inventor： GETHER JORGEN JOHAN

IPC: G01N30/12 ,  G01N30/20 ,  G01N30/30 ,  G01N1/28

CPC classification number: G01N30/12 ,  G01N2030/122 ,  G01N2030/123 ,  G01N2030/126 ,  G01N2030/201 ,  G01N2030/202 ,  G01N2030/3046 ,  G01N2030/3061

Abstract: An apparatus and a method for transferring a sample to be analyzed into the column of a gas chromatograph by rapid heating of the sample to evaporate it whereby transfer is effected. It further relates to a precolumn system for carrying out the method, in particular a tube in which the sample is frozen out and then heated, a restrictor providing a pressure drop in the system, a gas-operated valve, and a selection unit comprising two discs of which one is turnable, both having channels therethrough.

公开(公告)号：US20240241086A1

公开(公告)日：2024-07-18

申请号：US18562216

申请日：2022-05-17

Applicant: Agilent Technologies, Inc.

Inventor： Thomas Ortmann ,  Dominik Ruf

IPC: G01N30/22 ,  G01N30/20

CPC classification number: G01N30/22 ,  G01N2030/201 ,  G01N2030/202 ,  G01N2030/204 ,  G01N2030/207

Abstract: A switching unit is configured for selectively fluidically coupling a sampling volume, a sampling drive, a mobile phase drive, and a separating device. In a sample load configuration, the switching unit is configured for fluidically coupling the sampling volume and the sampling drive, for moving the fluidic sample into the sampling volume. In a decouple configuration, the switching unit is configured for fluidically coupling the sampling volume between the sampling drive and the separating device, while the mobile phase drive is fluidically decoupled from the separating device. In a sample introduction configuration, the switching unit is configured for fluidically coupling the mobile phase drive, the sampling volume, and the separating device for introducing at least an amount of the fluidic sample stored in the sampling volume into the mobile phase for fluid separation by the separating device.

公开(公告)号：US12038418B2

公开(公告)日：2024-07-16

申请号：US16933663

申请日：2020-07-20

Applicant: Baker Hughes Oilfield Operations LLC

Inventor： Salar Azizi ,  Nicklas Ritzmann

IPC: G01N30/00 ,  E21B49/08 ,  G01N30/06 ,  G01N30/40 ,  G01N30/02 ,  G01N30/20

CPC classification number: G01N30/40 ,  E21B49/088 ,  G01N30/06 ,  G01N2030/025 ,  G01N2030/062 ,  G01N2030/201 ,  G01N2030/402

Abstract: One or more embodiments of the present disclosure include a gas-analysis system. The gas-analysis system may include a first valve, a gas-measurement device, and a second valve. The first valve may be between a sample-gas line and a sample-gas outlet. The first valve may be configured to either allow or prevent gas movement between the sample-gas line and the sample-gas outlet. The gas-measurement device operatively coupled to a testing-gas line. The second valve may be between the sample-gas line, a flushing-gas inlet, and the testing-gas line. The second valve may be configured to allow gas movement from one of the sample-gas line or the flushing-gas inlet to the testing-gas line.

公开(公告)号：US20190120799A1

公开(公告)日：2019-04-25

申请号：US16084456

申请日：2017-03-17

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： Sylvain G. CORMIER

IPC: G01N30/20 ,  F16K11/085 ,  G01N30/06 ,  G01N30/22

CPC classification number: G01N30/20 ,  F16K11/085 ,  G01N30/06 ,  G01N30/22 ,  G01N2030/201 ,  G01N2030/202 ,  G01N2030/207

Abstract: A rotary injection valve used in chromatography includes a stator having a stator sealing surface and a sample load channel disposed inside the stator body below the stator sealing surface. The valve can have a reduced number of ports thereby allowing faster integration of the valve into a chromatographic system. Flow restriction is reduced compared to valves that use an external sample loop for a similar volume of sample. The lack of stator ports for the sample load channel eliminates the potential for carryover created by external valve couplings. Another advantage is the reduction of surface wear achieved by locating the sample load channel below the stator sealing surface.

公开(公告)号：US20190113484A1

公开(公告)日：2019-04-18

申请号：US16212914

申请日：2018-12-07

Applicant: DIONEX SOFTRON GMBH

Inventor： Hermann HOCHGRAEBER

IPC: G01N30/20 ,  G01N35/10 ,  G01N30/32

CPC classification number: G01N30/20 ,  G01N30/24 ,  G01N30/32 ,  G01N35/1097 ,  G01N2030/027 ,  G01N2030/201 ,  G01N2030/207

Abstract: A sample injection method for liquid chromatography is performed with an injection valve having a waste port, two sample loop ports, and two high-pressure ports. One high-pressure port can be connected to a pump and the other high-pressure port can be connected to a chromatography column. A sample loop is connected to one of the sample loop ports on one end and to a pump volume of a sample conveying device on the other end. A section of the sample loop can be separated to facilitate receiving a sample fluid in the sample loop. A control unit controls the injection valve and the sample conveying device. The sample injector allows a sample to be loaded into the sample loop and then pressurized to an operating pressure prior to injecting the sample into the chromatography column. The sample loop may also be isolated from the operating pressure for facilitating depressurization of the loop.

公开(公告)号：US20180328899A1

公开(公告)日：2018-11-15

申请号：US16035000

申请日：2018-07-13

Applicant: Waters Technologies Corporation

Inventor： Theodore A. Dourdeville

IPC: G01N30/60 ,  B23K20/24 ,  B23K20/02 ,  B23K20/233 ,  G01N30/20 ,  B23K103/14 ,  B23K101/14

CPC classification number: G01N30/606 ,  B23K20/023 ,  B23K20/233 ,  B23K20/24 ,  B23K2101/14 ,  B23K2103/14 ,  G01N30/20 ,  G01N30/6095 ,  G01N2030/201 ,  G01N2030/202

Abstract: An HPLC apparatus includes a heat exchanger formed from diffusion-bonded first and second titanium substrates. At least two conduits for counterflow are defined between the first and second substrates.

公开(公告)号：US20180128792A1

公开(公告)日：2018-05-10

申请号：US15809239

申请日：2017-11-10

Applicant: DIONEX SOFTRON GMBH

Inventor： Thomas WACHINGER ,  Christoph HOLLNAGEL

IPC: G01N30/60 ,  G01N30/14

CPC classification number: G01N30/6034 ,  G01N30/14 ,  G01N30/20 ,  G01N30/24 ,  G01N2030/027 ,  G01N2030/201 ,  G01N2030/202 ,  G01N2030/385

Abstract: A liquid chromatography system includes a separation column, a trap column, and a first switching valve. The first switching valve is adapted to assume a first switching position for bringing a sample into the trap column in a first flow direction. The switching valve is also adapted to assume a second switching position for fluidly connecting the trap column with the separation column and providing a flow from the trap column to the separation column in a second flow direction. The second flow direction is opposite to the first flow direction. The first switching valve is adapted to assume a third switching position for fluidly connecting the trap column, with the separation column and providing a flow from the trap column to the separation column in the first flow direction.