公开(公告)号：US20220314202A1

公开(公告)日：2022-10-06

申请号：US17640175

申请日：2020-09-03

申请人： EVONIK OPERATIONS GMBH

发明人： Arne REINSDORF ,  Dorit WOLF ,  Renat KADYROV ,  Sarah CHAMSKI

IPC分类号： B01J21/18 ,  B01J23/75 ,  B01J35/00 ,  B01J35/02 ,  B01J37/04 ,  B01J37/08 ,  B01J37/32 ,  B01J37/00 ,  B01J23/889 ,  C07C67/303 ,  C07C29/145 ,  C07C209/48 ,  C07C209/52 ,  C07C209/26

摘要： The present invention relates to catalytically active material, comprising grains of non-graphitizing carbon with cobalt nanoparticles dispersed therein, wherein dp, the average diameter of cobalt nanoparticles in the non-graphitizing carbon grains, is in the range of 1 nm to 20 nm, D, the average distance between cobalt nanoparticles in the non-graphitizing carbon grains, is in the range of 2 nm to 150 nm, and ω, the combined total mass fraction of metal in the non-graphitizing carbon grains, is in the range of 30 wt % to 70 wt % of the total mass of the non-graphitizing carbon grains, and wherein dp, D and ω conform to the following relation: 4.5 dp/ω>D≥0.25 dp/ω. The present invention, further, relates to a process for the manufacture of material according to the invention, as well as its use as a catalyst.

公开(公告)号：US20220251024A1

公开(公告)日：2022-08-11

申请号：US17629617

申请日：2020-03-25

申请人： CHENGDU SHIBEIKANG BIOMEDICAL TECHNOLOGY CO., LTD.

发明人： Guodong CEN ,  Maoting YANG ,  Shaojun TAN

IPC分类号： C07C213/02 ,  C07C209/52 ,  C07C249/02

摘要： A dibromobenzyl derivative with a structure shown as formula I, a stereoisomer or a pharmaceutically acceptable salt thereof and a preparation method and an application of the dibromobenzyl derivative are provided. The dibromobenzyl derivative or the stereoisomer thereof is superior in in-vivo pharmacokinetic stability and drug efficacy, and capable of being used for preparing respiratory drugs, in particular the apophlegmatic drugs.

公开(公告)号：US20210371382A1

公开(公告)日：2021-12-02

申请号：US16766556

申请日：2019-02-18

申请人： FIRMENICH SA

发明人： Lionel SAUDAN

IPC分类号： C07D213/53 ,  C07C209/52 ,  C07C211/27 ,  C07C217/58 ,  C07D231/38 ,  C07D333/20 ,  C07D409/12 ,  B01J31/18 ,  B01J31/24

摘要： Described herein are catalytic hydrogenation and the use of ruthenium complexes having a bidentate diphosphine ligand or two monodentate phosphine ligands, two carboxylate ligands, and optionally a diamine ligand in hydrogenation processes for the reduction of imines into the corresponding amines.

公开(公告)号：US11180440B2

公开(公告)日：2021-11-23

申请号：US16954774

申请日：2018-11-30

申请人： Zhejiang Nhu Company Ltd. ,  Zhejiang University ,  Shandong Nhu Amino Acid Co., Ltd. ,  Shandong Nhu Fine Chemical Science and Technology Company Ltd.

发明人： Zhirong Chen ,  Jianyong Mao ,  Baishan Hu ,  Guanbing Li ,  Haoran Li ,  Yu Wang ,  Yingkuo Yang ,  Qing Liu ,  Jiyu Tang ,  Weiyong Chen

IPC分类号： C07C209/52 ,  B01J23/78 ,  B01J35/04 ,  C07C209/48

摘要： The present disclosure relates to a method for preparing isophorone diamine by means of a hydrogenation reduction of isophorone nitrile imine. The hydrogenation reduction is continuously carried out in a multi-stage bubble column reactor loaded with a supported alkaline cobalt-based catalyst, wherein isophorone nitrile imine is successively in countercurrent contact with hydrogen in each stage of the reactor to carry out a hydrogenation reduction reaction, so as to obtain the isophorone diamine. The preparation method solves the problem of back-mixing, and further improves the conversion rate and the cis/trans ratio of the product.

公开(公告)号：US10167252B2

公开(公告)日：2019-01-01

申请号：US15618301

申请日：2017-06-09

申请人： Eastman Chemical Company

发明人： Matthew Allen Boone ,  Donald L. Fields, Jr. ,  Frederick Ignatz-Hoover

IPC分类号： C07C251/20 ,  C09K15/18 ,  C07C249/02 ,  C07C209/52 ,  B60C1/00 ,  C07C211/54 ,  C08K5/18 ,  C10L1/222 ,  C10L1/223 ,  C10M133/12

摘要： Antidegradant compounds are disclosed, and methods of making them, that are represented by the formula I: wherein each X is independently selected from the group consisting of ethyl, methyl, or hydrogen. Also disclosed are diimine intermediates corresponding to formula III: wherein each X is independently selected from the group consisting of ethyl, methyl, or hydrogen. These intermediates themselves exhibit antidegradant activity.

公开(公告)号：US09744528B2

公开(公告)日：2017-08-29

申请号：US14775159

申请日：2014-03-11

申请人： Rutgers, The State University Of New Jersey

发明人： Xumu Zhang

IPC分类号： C07C201/12 ,  B01J31/24 ,  C07D307/38 ,  C07F17/02 ,  C07C209/52 ,  C07C213/02 ,  C07B53/00 ,  C07F17/00

CPC分类号： B01J31/2409 ,  B01J31/2414 ,  B01J2231/643 ,  B01J2231/645 ,  B01J2531/0205 ,  B01J2531/0263 ,  B01J2531/16 ,  B01J2531/17 ,  B01J2531/18 ,  B01J2531/26 ,  B01J2531/821 ,  B01J2531/822 ,  B01J2531/824 ,  B01J2531/827 ,  B01J2531/84 ,  B01J2531/842 ,  B01J2540/22 ,  B01J2540/225 ,  B01J2540/66 ,  B01J2540/68 ,  C07B53/00 ,  C07C201/12 ,  C07C209/52 ,  C07C213/02 ,  C07D307/38 ,  C07F17/00 ,  C07F17/02 ,  C07C205/04 ,  C07C205/09 ,  C07C205/32 ,  C07C211/30 ,  C07C211/29 ,  C07C211/27 ,  C07C217/58

摘要： A ligand having the structure or its enantiomer; (I) wherein: each one of Ra, Rb, Rc and Rd is selected from alkyl, cycloalkyl, and aryl; the bridge group is selected from CH2NH; *CH(CH3)NH(C*,R); and the organocatalyst is an organic molecule catalyst covalently bound to the bridge group. Also, a catalyst having the structure or its enantiomer: (II) wherein: each one of Ra, Rb, Rc and Rd is selected from alkyl, cycloalkyl, and aryl; the bridge group is selected from CH2NH; *CH(CH3)NH(C*,R); and *CH(CH3)NH(C*,S); the organocatalyst is an organic molecule catalyst covalently bound to the bridge group; and M is selected from the group consisting of Rh, Pd, Cu, Ru, Ir, Ag, Au, Zn, Ni, Co, and Fe.

公开(公告)号：US09708261B2

公开(公告)日：2017-07-18

申请号：US15186415

申请日：2016-06-17

申请人： Neurovance, Inc.

发明人： Anthony Alexander McKinney ,  Franklin Bymaster ,  Walter Piskorski ,  Fred J. Fleitz ,  Yonglai Yang ,  David A. Engers ,  Valeriya Smolenskaya ,  Venkat Kusukuntla

IPC分类号： C07C209/52 ,  C07C211/17 ,  C07C255/46 ,  C07D209/52

CPC分类号： C07D209/52 ,  C07C211/17

摘要： The present invention relates to crystalline forms of (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane hydrochloride and compositions comprising the same and methods of making and using the same.

公开(公告)号：US09468919B2

公开(公告)日：2016-10-18

申请号：US14940643

申请日：2015-11-13

申请人： Takasago International Corporation

发明人： Taichiro Touge ,  Hideki Nara ,  Tomohiko Hakamada

IPC分类号： C07F15/00 ,  C07C303/40 ,  C07C311/20 ,  C07C311/07 ,  C07C311/08 ,  C07C29/145 ,  B01J31/18 ,  C07C29/143 ,  C07C209/52 ,  C07C253/30 ,  C07D307/42 ,  C07D311/22 ,  C07F19/00 ,  B01J31/22

CPC分类号： B01J31/1805 ,  B01J31/2295 ,  B01J2231/326 ,  B01J2231/643 ,  B01J2231/646 ,  B01J2531/0208 ,  B01J2531/821 ,  B01J2540/32 ,  C07C29/143 ,  C07C209/52 ,  C07C253/30 ,  C07D307/42 ,  C07D311/22 ,  C07F15/0046 ,  C07F19/00 ,  H01L2924/0002 ,  H01L2924/00

摘要： Provided is a catalyst for asymmetric reduction, which can be produced by a convenient and safe production method, has a strong catalytic activity, and has excellent stereoselectivity. The present invention relates to a ruthenium complex represented by the following formula (1): wherein R1 represents an alkyl group or the like; Y represents a hydrogen atom; X represents a halogen atom or the like; j and k each represent 0 or 1; R2 and R3 each represent an alkyl group or the like; R11 to R19 each represent a hydrogen atom, an alkyl group or the like; Z represents oxygen or sulfur; n1 represents 1 or 2; and n2 represents an integer from 1 to 3, a method for producing the ruthenium complex, a catalyst for asymmetric reduction formed from the ruthenium complex, and methods for selectively producing an optically active alcohol and an optically active amine using the catalyst for asymmetric reduction.

公开(公告)号：US09434666B2

公开(公告)日：2016-09-06

申请号：US13587717

申请日：2012-08-16

申请人： Kalyan V. Vasudevan ,  Guoqi Zhang ,  Susan K. Hanson

发明人： Kalyan V. Vasudevan ,  Guoqi Zhang ,  Susan K. Hanson

IPC分类号： C07C29/145 ,  C07C67/303 ,  C07C51/36 ,  C07C41/18 ,  C07C41/01 ,  C07C41/20 ,  C07C45/62 ,  C07C209/52 ,  C07C5/03 ,  C07C5/05 ,  C07C231/24 ,  C07F15/04 ,  C07F15/06 ,  C07F5/04 ,  C07D211/46 ,  C07C29/17 ,  C07C17/354 ,  C07C29/141 ,  C07C41/26 ,  C07D211/02 ,  B01J31/18

CPC分类号： B01J31/2295 ,  B01J31/189 ,  B01J31/2476 ,  B01J2231/643 ,  B01J2231/645 ,  B01J2231/646 ,  B01J2531/0244 ,  B01J2531/845 ,  B01J2531/847 ,  C07C5/03 ,  C07C5/05 ,  C07C17/354 ,  C07C29/141 ,  C07C29/145 ,  C07C29/172 ,  C07C29/175 ,  C07C41/01 ,  C07C41/18 ,  C07C41/20 ,  C07C41/26 ,  C07C45/62 ,  C07C51/36 ,  C07C67/303 ,  C07C209/52 ,  C07C209/70 ,  C07C2531/14 ,  C07C2531/22 ,  C07C2531/28 ,  C07C2601/14 ,  C07C2601/16 ,  C07C2601/18 ,  C07C2602/08 ,  C07C2602/42 ,  C07C2603/12 ,  C07C2603/18 ,  C07D211/02 ,  C07D211/46 ,  C07F5/04 ,  C07F15/04 ,  C07F15/045 ,  C07F15/06 ,  C07F15/065 ,  Y02P20/52 ,  C07C43/23 ,  C07C33/20 ,  C07C33/22 ,  C07C33/24 ,  C07C35/38 ,  C07C69/24 ,  C07C53/126 ,  C07C31/125 ,  C07C33/46 ,  C07C43/04 ,  C07C35/32 ,  C07C43/205 ,  C07C49/403 ,  C07C211/27 ,  C07C211/48 ,  C07C25/13 ,  C07C15/073 ,  C07C15/02 ,  C07C15/085 ,  C07C11/02 ,  C07C13/26 ,  C07C13/64 ,  C07C13/20

摘要： Complexes of cobalt and nickel with tridentate ligand PNHPR are effective for hydrogenation of unsaturated compounds. Cobalt complex [(PNHPCy)Co(CH2SiMe3)]BArF4 (PNHPCy=bis[2-(dicyclohexylphosphino)ethyl]amine, BArF4=B(3,5-(CF3)2C6H3)4)) was prepared and used with hydrogen for hydrogenation of alkenes, aldehydes, ketones, and imines under mild conditions (25-60° C., 1-4 atm H2). Nickel complex [(PNHPCy)Ni(H)]BPh4 was used for hydrogenation of styrene and 1-octene under mild conditions. (PNPCy)Ni(H) was used for hydrogenating alkenes.

摘要翻译： 钴和镍与三齿配体PNHPR的配合物对于不饱和化合物的氢化是有效的。 钴配合物[（PNHPCy）Co（CH2SiMe3）] BArF4（PNHPCy =双[2-（二环己基膦基）乙基]胺，BArF 4 = B（3,5-（CF 3）2 C 6 H 3）4） 的烯烃，醛，酮和亚胺在温和条件下（25-60℃，1-4atm H 2）。 镍络合物[（PNHPCy）Ni（H）] BPh4用于在温和条件下苯乙烯和1-辛烯的氢化。 （PNPCy）Ni（H）用于氢化烯烃。

公开(公告)号：US20150315133A1

公开(公告)日：2015-11-05

申请号：US14648533

申请日：2012-12-07

申请人： WANHUA CHEMICAL GROUP CO., LTD. ,  WANHUA CHEMICAL (NINGBO) CO., LTD.

发明人： Changsheng Chen ,  Jinke Jiang ,  Zhongying Chen ,  Jiaoying Cui ,  Jing Wang ,  Fuguo Li ,  Chengge Lv ,  Wenjuan Zhao ,  Yuan Li ,  Weiqi Hua

IPC分类号： C07C253/30 ,  C07C209/52

CPC分类号： C07C253/30 ,  C07C209/48 ,  C07C209/52 ,  C07C2101/14 ,  C07C2601/14 ,  C07C255/46 ,  C07C211/36

摘要： The present invention provides a method for preparing 3-aminomethyl-3,5,5-trimethyl cyclohexylamine. The method comprises: a) reacting 3-cyano-3,5,5-trimethyl cyclohexanone with excess primary amine as well as removing the water generated from the reaction, so that IPN is substantially converted into imine compounds; b) in the presence of an ammonolysis catalyst, mixing the product of step a) with liquid ammonia, making the imine compound perform ammonolysis reaction to generate 3-cyano-3,5,5-trimethyl cyclohexylimine and the primary amine; and c) in the presence of hydrogen and a hydrogenation catalyst, hydrogenating 3-cyano-3,5,5-trimethyl cyclohexylimine obtained in step b) to obtain 3-aminomethyl-3,5,5-trimethyl cyclohexylamine. The method of the present invention avoids the generation of 3,5,5-trimethyl cyclohexanol and 3-aminomethyl-3,5,5-trimethyl cyclohexanol as the major by-products in the prior art, thereby improving the yield of 3-aminomethyl-3,5,5-trimethyl cyclohexylamine.

摘要翻译： 本发明提供3-氨基甲基-3,5,5-三甲基环己胺的制备方法。 该方法包括：a）使3-氰基-3,5,5-三甲基环己酮与过量的伯胺反应，并除去反应产生的水，使得IPN基本上转化为亚胺化合物; b）在氨解催化剂存在下，将步骤a）的产物与液氨混合，使亚胺化合物进行氨解反应，得到3-氰基-3,5,5-三甲基环己基亚胺和伯胺; 和c）在氢气和氢化催化剂的存在下，氢化步骤b）中获得的3-氰基-3,5,5-三甲基环己基亚胺，得到3-氨基甲基-3,5,5-三甲基环己胺。 本发明的方法避免了现有技术中主要副产物3,5,5-三甲基环己醇和3-氨基甲基-3,5,5-三甲基环己醇的产生，从而提高了3-氨基甲基 -3,5,5-三甲基环己胺。