公开(公告)号：US5451688A

公开(公告)日：1995-09-19

申请号：US174661

申请日：1993-12-28

申请人： Hiroshi Kogen ,  Sadao Ishihara ,  Teiichiro Koga ,  Eiichi Kitazawa ,  Nobufusa Serizawa ,  Kiyoshi Hamano

发明人： Hiroshi Kogen ,  Sadao Ishihara ,  Teiichiro Koga ,  Eiichi Kitazawa ,  Nobufusa Serizawa ,  Kiyoshi Hamano

IPC分类号： A61K31/22 ,  A61K31/35 ,  A61K31/365 ,  A61K31/366 ,  A61P3/06 ,  C07C69/03 ,  C07C69/24 ,  C07C69/33 ,  C07C69/67 ,  C07C69/675 ,  C07C69/732 ,  C07C69/734 ,  C07D309/30 ,  C12N9/02 ,  C12P7/62 ,  C12P17/06 ,  C12R1/01 ,  C12R1/465 ,  C12R1/785 ,  C07C69/74

CPC分类号： C07C69/33 ,  C07C69/675 ,  C07C69/732 ,  C07D309/30 ,  C12N9/0093 ,  C12P17/06 ,  C12P7/62 ,  Y02P20/55

摘要： Compounds of formula (I): ##STR1## [wherein R.sup.1 represents a group of formula (II) or (III): ##STR2## R.sup.2 is alkyl, alkenyl or alkynyl; R.sup.3 and R.sup.4 are each hydrogen, alkyl, alkenyl or alkynyl; R.sup.5 is hydrogen or a carboxy-protecting group; R.sup.a is hydrogen or a group of formula and --OR.sup.6 ; R.sup.6, R.sup.6a and R.sup.6b are each hydrogen, a hydroxy-protecting group, alkyl, alkanesulfonyl, halogenated alkanesulfonyl or arylsulfonyl] and their salts and esters have the ability to inhibit the synthesis of cholesterol, and can thus be used for the treatment and prophylaxis of hypercholesterolemia and of various cardiac disorders.

摘要翻译： 式（I）化合物：其中R 1表示式（II）或（III）的基团：烯基或炔基; R3和R4各自为氢，烷基，烯基或炔基; R5是氢或羧基保护基; R a是氢或式-OR 6基团; R6，R6a和R6b各自为氢，羟基保护基，烷基，烷基磺酰基，卤代烷磺酰基或芳基磺酰基），其盐和酯具有抑制胆固醇合成的能力，因此可用于治疗和预防 高胆固醇血症和各种心脏疾病。

公开(公告)号：US5332860A

公开(公告)日：1994-07-26

申请号：US85331

申请日：1993-06-29

申请人： Douglas R. Moore ,  Warren A. Kaplan ,  Ricky L. Tabor ,  Alan K. Schrock

发明人： Douglas R. Moore ,  Warren A. Kaplan ,  Ricky L. Tabor ,  Alan K. Schrock

IPC分类号： B01J31/02 ,  C07B61/00 ,  C07C69/03 ,  C07C69/80 ,  C07C69/82 ,  C07C213/04 ,  C07C217/30 ,  C08G18/48 ,  C08G63/78 ,  C08G65/28 ,  C07C69/76

CPC分类号： C07C69/80 ,  C07C69/82 ,  C08G2101/00

摘要： Polyurethane foams having improved retention of insulative properties can be prepared using one or more of two novel polyols. One of the polyols is a polyether prepared by reacting a monoepoxide with a compound having the general formula: ##STR1## wherein X is H, Li, Na, K; A is N, S or O; L is a covalent bond or a connecting group having from 1 to 10 carbons; M is any group capable of reacting with an ethylene oxide molecule in the presence of a basic catalyst; and J is an integer from 2 to 8. The other polyol is prepared by (1) admixing ethylene carbonate and one or more hydroxyl functional compounds under reaction conditions sufficient to react the ethylene carbonate and the hydroxyl functional compounds to produce a polyol precursor, and (2) admixing the polyol precursor with diethylene glycol and an anhydride, a dicarboxylic acid, a tricarboxylic acid or mixtures thereof, optionally in the presence of a catalyst.

摘要翻译： 具有改善的绝缘性能保持性的聚氨酯泡沫可以使用两种新型多元醇中的一种或多种制备。 多元醇之一是通过单环氧化物与具有以下通式的化合物反应制备的聚醚：其中X为H，Li，Na，K; A是N，S或O; L是共价键或具有1至10个碳的连接基团; M是能够在碱性催化剂存在下与环氧乙烷分子反应的任何基团; 并且J为2至8的整数。另外的多元醇通过（1）在足以使碳酸亚乙酯和羟基官能化合物反应以产生多元醇前体的反应条件下混合碳酸亚乙酯和一种或多种羟基官能化合物来制备，以及 （2）任选地在催化剂存在下，将多元醇前体与二甘醇和酸酐，二羧酸，三羧酸或其混合物混合。

公开(公告)号：US5177104A

公开(公告)日：1993-01-05

申请号：US503576

申请日：1990-04-03

申请人： Ravi K. Varma ,  Sam T. Chao ,  Eric M. Gordon

发明人： Ravi K. Varma ,  Sam T. Chao ,  Eric M. Gordon

IPC分类号： A61K31/22 ,  A61K31/365 ,  A61P3/06 ,  A61P9/10 ,  A61P43/00 ,  C07C69/013 ,  C07C69/03 ,  C07C69/675 ,  C07C69/732 ,  C07D309/30

CPC分类号： C07D309/30 ,  C07C69/732 ,  Y10S514/824

摘要： Compounds of the formula ##STR1## and pharmaceutically acceptable salts thereof have been found to possess activity as cell-selective HMG-CoA reductase inhibitors, thus making them useful as antihypercholesterolemic agents. In the above formula, ##STR2## R.sup.1 is hydrogen, alkyl, cycloalkyl, aryl or arylalkyl; and R.sup.2 is hydrogen, alkyl, ammonium, or alkali metal.

公开(公告)号：US5021451A

公开(公告)日：1991-06-04

申请号：US270983

申请日：1988-11-14

申请人： John A. McLane ,  Milan R. Uskokovic

发明人： John A. McLane ,  Milan R. Uskokovic

IPC分类号： A61K31/22 ,  A61K31/365 ,  A61P17/00 ,  A61P43/00 ,  C07C69/03 ,  C07D309/30

CPC分类号： A61K31/365 ,  A61K31/22 ,  Y10S514/863

摘要： A method of treating hyperproliferative skin diseases, such as psoriasis, using a compound of formula ##STR1## wherein R.sub.1 is hydrogen when R.sub.2 is hydroxy, and R.sub.1 is methyl when R.sub.2 is hydrogen; and A is alkyl; cycloalkyl; alkenyl; alkyl substituted with trifluoromethyl; phenyl; halophenyl; phenyl-C.sub.1-3 alkyl; phenyl-C.sub.1-3 alkyl substituted on the phenyl with 1 to 3 substituents selected from the group consisting of halo, C.sub.1-3 alkyl, and C.sub.1-3 alkoxy; orA is ##STR2## wherein R.sub.3 is hydrogen or ##STR3## R.sub.4 is hydrogen or methyl, and n is 1 to 5, or the corresponding hydroxy acid of formula ##STR4## or a pharmaceutically acceptable salt of said acid, an alkyl ester of said acid, an acetylamino-substituted-C.sub.1-4 alkyl ester of said acid, a phenyl-dimethylamino ester of said acid or a .alpha.-monoglyceride of said acid.

摘要翻译： 一种治疗过度增生性皮肤病的方法，例如银屑病，其中当R 2为羟基时，其中R 1为氢，R 2为氢时R 1为甲基; A是烷基; 环烷基 烯基; 被三氟甲基取代的烷基; 苯基; 卤代苯基; 苯基-C 1-3烷基; 在苯基上被1至3个选自卤素，C 1-3烷基和C 1-3烷氧基的取代基取代的苯基-C 1-3烷基; 或A是其中R 3是氢或者R 4是氢或甲基，n是1至5，或相应的式II的羟基酸或所述酸的药学上可接受的盐，烷基酯 的所述酸，所述酸的乙酰氨基取代的C 1-4烷基酯，所述酸的苯基二甲基氨基酯或所述酸的α-单酸甘油酯。

公开(公告)号：US4956124A

公开(公告)日：1990-09-11

申请号：US193304

申请日：1988-05-11

申请人： Horst Eierdanz ,  Paul Schulz ,  Wolfgang von Rybinski ,  Rita Koester

发明人： Horst Eierdanz ,  Paul Schulz ,  Wolfgang von Rybinski ,  Rita Koester

IPC分类号： C07C69/757 ,  B03D1/00 ,  B03D1/008 ,  C07C51/31 ,  C07C62/14 ,  C07C67/475 ,  C07C69/03

CPC分类号： C07C62/14 ,  B03D1/008 ,  B03D2201/02 ,  B03D2203/04

摘要： Bicyclic decanedioic acids corresponding to the following general formula ##STR1## in which R represents a C.sub.1 -C.sub.22 alkyl radical, a C.sub.2 -C.sub.34 alkylcarbonyl radical, or a residue of a polyalkoxylated C.sub.2 -C.sub.22 fatty alcohol, represent a new class of dicarboxylic acids which are useful as flotation aids in the flotation of non-sulfidic ores.

摘要翻译： 对应于以下通式（I）的双环癸二酸，其中R表示C1-C22烷基，C2-C34烷基羰基或聚烷氧基化C2-C22脂肪醇的残基，表示新的类别 可用作非硫化矿石浮选中浮选助剂的二羧酸。

公开(公告)号：US4927975A

公开(公告)日：1990-05-22

申请号：US223636

申请日：1988-07-25

申请人： Marie-Madeleine Bouton ,  Jean Jacques ,  Andre Pierdet

发明人： Marie-Madeleine Bouton ,  Jean Jacques ,  Andre Pierdet

IPC分类号： C07C69/013 ,  A61K8/00 ,  A61K8/11 ,  A61K8/35 ,  A61K8/37 ,  A61K8/49 ,  A61K31/045 ,  A61K31/12 ,  A61K31/215 ,  A61K31/22 ,  A61K31/44 ,  A61K31/4406 ,  A61K31/455 ,  A61P17/00 ,  A61P43/00 ,  A61Q5/00 ,  C07C45/00 ,  C07C45/61 ,  C07C45/67 ,  C07C49/513 ,  C07C49/517 ,  C07C49/737 ,  C07C49/753 ,  C07C67/00 ,  C07C69/03 ,  C07C69/08 ,  C07C313/00 ,  C07C323/13 ,  C07D213/79 ,  C07D213/80 ,  C07D317/70 ,  C07D317/72 ,  C07C49/403 ,  C07C49/497 ,  C07C49/603

CPC分类号： C07D213/80 ,  C07C49/513 ,  C07D317/70 ,  C07D317/72 ,  C07C2103/16

摘要： Novel antiandrogenic compositions comprising an antiandrogenically effective amount of at least one compound of the formula ##STR1## wherein R is alkyl of 1 to 4 carbon atoms, R.sub.1 is alkyl of 1 to 2 carbon atoms, R.sub.2 is selected from the group consisting of hydrogen, alkyl of 1 to 8 carbon atoms optionally interrupted with a heteroatom, alkenyl and alkynyl of 2 to 8 carbon atoms optionally interrupted with a heteroatom, formyl and acyl of an organic carboxylic acid of 2 to 18 carbon atoms, R.sub.3 is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms and alkenyl and alkynyl of 2 to 4 carbon atoms, R.sub.4 is selected from the group consisting of hydrogen and alkyl of 1 to 4 carbon atoms, the dotted lines indicate optional presence of a double bond between the 4(5) and 5a(6) carbons and the wavy line indicates that R.sub.4 may be in the .alpha.- or .beta.-position and a non-toxic, pharmaceutical carrier or excipient and a method of treating hyperandrogenic conditions in warm-blooded animals.

公开(公告)号：US4918236A

公开(公告)日：1990-04-17

申请号：US871989

申请日：1986-06-09

申请人： Christopher G. Knudsen ,  William J. Michaely

发明人： Christopher G. Knudsen ,  William J. Michaely

IPC分类号： A01N35/06 ,  A01N37/02 ,  A01N37/10 ,  A01N37/34 ,  A01N37/42 ,  A01N37/44 ,  A01N37/46 ,  A01N37/48 ,  A01N41/04 ,  A01N47/02 ,  C07C45/00 ,  C07C45/68 ,  C07C49/225 ,  C07C49/753 ,  C07C49/84 ,  C07C67/00 ,  C07C69/03 ,  C07C69/76 ,  C07C201/00 ,  C07C205/45 ,  C07C231/00 ,  C07C233/33 ,  C07C233/43 ,  C07C253/00 ,  C07C255/56 ,  C07C301/00 ,  C07C309/63 ,  C07C311/15 ,  C07C311/16 ,  C07C313/00 ,  C07C317/14 ,  C07C317/24 ,  C07C317/36 ,  C07C317/40 ,  C07C317/44 ,  C07C317/46 ,  C07C317/48 ,  C07C317/50 ,  C07C323/22 ,  C07C323/62 ,  C07C323/65 ,  C07C323/67

CPC分类号： C07C205/45 ,  A01N35/06 ,  A01N37/02 ,  A01N37/10 ,  A01N41/04 ,  C07C309/00 ,  C07C45/68 ,  C07C49/84

摘要： A compound of the formula ##STR1## wherein R is halogen, C.sub.1 -C.sub.2 alkyl, C.sub.1 -C.sub.2 alkoxy, nitro; cyano; C.sub.1 -C.sub.2 haloalkyl, or R.sup.a SO.sub.m -wherein m is 0 or 2 and R.sup.a is C.sub.1 -C.sub.2 alkyl; R.sup.1 is hydrogen or C.sub.1 -C.sub.2 alkyl; R.sup.2 is hydrogen or C.sub.1 -C.sub.4 alkyl; or R.sup.1 and R.sup.2 together are alkylene having 2 to 5 carbon atoms; R.sup.3 is hydrogen or C.sub.1 -C.sub.4 alkyl; R.sup.4 is hydrogen or C.sub.1 -C.sub.4 alkyl; or R.sup.3 and R.sup.4 together are oxo; R.sup.5 is hydrogen or C.sub.1 -C.sub.4 alkyl; R.sup.6 is hydrogen or C.sub.1 -C.sub.4 alkyl; or R.sup.5 and R.sup.6 together are alkylene having 2 to 5 carbon atoms; R.sup.7 and R.sup.8 independently are (1) hydrogen; (2) halogen; (3) C.sub.1 -C.sub.4 alkyl; (4) C.sub.1 - C.sub.4 alkoxy; (5) trifluoromethoxy; (6) cyano; (7) nitro; (8) C.sub.1 -C.sub.4 haloalkyl; (9) R.sup.b SO.sub.n -wherein n is the integer 0, 1 or 2; and R.sup.b is (a) C.sub.1 -C.sub.4 alkyl; (b) C.sub.1 -C.sub.4 alkyl substituted with halogen or cyano; (c) phenyl; or (d) benzyl; (10) -NR.sup.c R.sup.d wherein R.sup.c and R.sup.d independently are hydrogen or C.sub.1 -C.sub.4 alkyl; (11) R.sup.e C(O)- wherein R.sup.e is C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 alkoxy; (12) SO.sub.2 NR.sup.c R.sup.d wherein R.sup.c and R.sup.d are as defined; or (13) -N(R.sup.c)C(O)R.sup.d wherein R.sup.c and R.sup.d are as defined; and R.sup.9 is (a) C.sub.1 -C.sub.6 alkyl; (b) C.sub.4 -C.sub.6 cycloalkyl; (c) substituted C.sub.1 -C.sub.6 alkyl; (d) phenyl-SO.sub.2 -; (e) substituted phenyl-SO.sub.2 -; (f) C.sub.1 -C.sub.6 -alkyl-SO.sub.2 -, optionally substituted; (g) C.sub.1 -C.sub.6 alkyl-C(O)-, optionally substituted; (h) phenyl-C(O)-, optionally substituted; (i) benzyl; or (h) C.sub.3 -C.sub.6 alkenyl.

摘要翻译： 其中R是卤素，C 1 -C 2烷基，C 1 -C 2烷氧基，硝基; 氰基; C1-C2卤代烷基或RaSOm-，其中m为0或2，Ra为C1-C2烷基; R1是氢或C1-C2烷基; R2是氢或C1-C4烷基; 或R 1和R 2一起是具有2至5个碳原子的亚烷基; R3是氢或C1-C4烷基; R4是氢或C1-C4烷基; 或R3和R4一起是氧代; R5是氢或C1-C4烷基; R6是氢或C1-C4烷基; 或R 5和R 6一起是具有2至5个碳原子的亚烷基; R7和R8独立地是（1）氢; （2）卤素; （3）C 1 -C 4烷基; （4）C 1 -C 4烷氧基; （5）三氟甲氧基; （6）氰基; （7）硝基; （8）C 1 -C 4卤代烷基; （9）RbSOn-其中n是整数0,1或2; 并且R b是（a）C 1 -C 4烷基; （b）被卤素或氰基取代的C 1 -C 4烷基; （c）苯基; 或（d）苄基; （10）-NRcRd其中Rc和Rd独立地是氢或C1-C4烷基; （11）ReC（O） - 其中Re为C1-C4烷基或C1-C4烷氧基; （12）SO2NRcRd其中Rc和Rd如所定义; 或（13）-N（R c）C（O）R d，其中R c和R d如所定义; 并且R 9为（a）C 1 -C 6烷基; （b）C 4 -C 6环烷基; （c）取代的C 1 -C 6烷基; （d）苯基-SO 2 - ; （e）取代的苯基-SO 2 - ; （f）任选取代的C 1 -C 6烷基-SO 2 - ; （g）任选取代的C 1 -C 6烷基-C（O） - （h）苯基-C（O） - ，任选取代的; （i）苄基; 或（h）C 3 -C 6烯基。

公开(公告)号：US4879407A

公开(公告)日：1989-11-07

申请号：US109052

申请日：1987-10-16

申请人： Louis Amiet

发明人： Louis Amiet

IPC分类号： C07C69/63 ,  B01D3/34 ,  C07C67/08 ,  C07C67/58 ,  C07C69/00 ,  C07C69/03

CPC分类号： C07C67/08 ,  Y10S203/06

摘要： A process for the preparation of ethyl trifluoroacetate, in which:in a first stage, trifluoroacetic acid is brought into contact with a slight excess of ethanol in the presence of concentrated sulfuric acid and a solvent, the solvent having a boiling point higher than that of trifluoroacetic acid and specific gravity relative to water less than 1 and which solvent does not form an azeotrope with ethyl trifluoroacetate, and then carrying out a phase separation and removing the sulfuric layer, followed, if required, by an additional stage in which concentrated sulfuric acid is added to complete the esterification;in a second stage, an additional quantity of sulfuric acid and trifluoroacetic acid is introduced and a phase separation is then carried out to remove the sulfuric layer; andin a third stage, the mixture obtained in the second stage is distilled to recover ethyl trifluoroacetate.

摘要翻译： 一种制备三氟乙酸乙酯的方法，其中：在浓硫酸和溶剂的存在下，在第一阶段使三氟乙酸与略过量的乙醇接触，所述溶剂的沸点高于 三氟乙酸和相对于水的比重小于1，哪种溶剂不与三氟乙酸乙酯形成共沸物，然后进行相分离和除去硫酸层，然后如果需要，再加入浓硫酸 加完成酯化; 在第二阶段中，引入额外量的硫酸和三氟乙酸，然后进行相分离以除去硫酸层; 并且在第三阶段中，将在第二阶段中获得的混合物蒸馏以回收三氟乙酸乙酯。

公开(公告)号：US4724097A

公开(公告)日：1988-02-09

申请号：US865314

申请日：1986-05-21

申请人： Michael Romer ,  Rudolf Fidenschink ,  Joachim Krause ,  Bernhard Scheuble ,  Georg Weber

发明人： Michael Romer ,  Rudolf Fidenschink ,  Joachim Krause ,  Bernhard Scheuble ,  Georg Weber

IPC分类号： C07C43/18 ,  C07C1/00 ,  C07C13/28 ,  C07C17/00 ,  C07C17/093 ,  C07C23/18 ,  C07C25/02 ,  C07C25/18 ,  C07C41/00 ,  C07C43/03 ,  C07C43/168 ,  C07C43/184 ,  C07C43/20 ,  C07C43/21 ,  C07C43/225 ,  C07C43/30 ,  C07C67/00 ,  C07C69/03 ,  C07C69/035 ,  C07C69/157 ,  C07C69/753 ,  C07C69/76 ,  C07C253/00 ,  C07C255/45 ,  C07C255/46 ,  C07C255/50 ,  C07C255/51 ,  C09K19/00 ,  C09K19/30 ,  C09K19/42 ,  G02F1/13 ,  C07C121/64

CPC分类号： C07C255/00 ,  C07C13/28 ,  C07C25/18 ,  C07C43/168 ,  C07C43/21 ,  C07C43/30 ,  C09K19/3028

摘要： New bicyclohexylethanes of formula IR1--Cy--Cy--CH2CH2--A--(Cy)n--R2 (I)wherein R1 is alkyl; R2 is alkyl, in which one or two non-adjacent CH.sub.2 groups can be replaced by 0 atoms, or is F, Cl, Br, CN, --COOalkyl or --O--CO--alkyl; or one of the radicals R.sup.1 and R.sup.2 can also be H; A is Cy, or 1,4-phenylene which is unsubstituted or substituted by one or two F and/or Cl atoms and/or CH.sub.3 groups or by a CN group; Cy is 1,4-cyclohexylene and n is 0 or 1; the alkyl groups in each case containing 1-10 C atoms, with the proviso that n is 1 if A is Cy and R2 is CN, can be used as constituents of dielectrics for electrooptical display elements.

摘要翻译： 式I的新的双环己基乙烷R1-Cy-Cy-CH2CH2-A-（Cy）n-R2（Ⅰ）其中R1是烷基; R2是烷基，其中一个或两个不相邻的CH 2基团可以被0个原子取代，或者是F，Cl，Br，CN，-COO烷基或-O-CO-烷基; 或者R 1和R 2中的一个也可以是H; A是未取代或被一个或两个F和/或Cl原子和/或CH 3基团或CN基团取代的Cy或1,4-亚苯基; Cy是1,4-亚环己基，n是0或1; 每种情况下的烷基含有1-10个C原子，条件是如果A是Cy，R2是CN，n是1，可以用作电光显示元件的电介质的组分。

公开(公告)号：US4659372A

公开(公告)日：1987-04-21

申请号：US555538

申请日：1983-11-28

申请人： Thomas N. Wheeler

发明人： Thomas N. Wheeler

IPC分类号： A01N35/06 ,  A01N37/02 ,  A01N37/06 ,  A01N37/08 ,  A01N37/10 ,  A01N37/22 ,  A01N37/24 ,  A01N37/34 ,  A01N37/40 ,  A01N37/48 ,  A01N39/04 ,  A01N41/10 ,  A01N53/00 ,  C07C45/45 ,  C07C45/63 ,  C07C45/65 ,  C07C49/657 ,  C07C49/665 ,  C07C49/697 ,  C07C49/753 ,  C07C59/84 ,  C07C69/03 ,  A01N37/36 ,  C07C69/66

CPC分类号： C07C205/45 ,  A01N35/06 ,  A01N37/02 ,  A01N37/06 ,  A01N37/08 ,  A01N37/10 ,  A01N37/22 ,  A01N37/24 ,  A01N37/34 ,  A01N39/04 ,  A01N41/10 ,  A01N53/00 ,  C07C255/00 ,  C07C45/455 ,  C07C45/63 ,  C07C45/65 ,  C07C49/657 ,  C07C49/665 ,  C07C49/697 ,  C07C49/753 ,  C07C59/84

摘要： 2-Aryl-1,3-cyclohexanedione enol ester compounds exhibit outstanding miticidal, mite ovicidal and herbicidal activity.

摘要翻译： 2-芳基-1,3-环己二烯烯醇酯化合物具有突出的杀螨，杀螨和除草活性。