公开(公告)号：US20160139045A1

公开(公告)日：2016-05-19

申请号：US14993819

申请日：2016-01-12

Applicant: Zyomed Corp.

Inventor： Sandeep Gulati ,  Timothy L. Ruchti ,  William Van Antwerp ,  John L. Smith

IPC: G01N21/47 ,  A61B5/024 ,  G01N21/359

CPC classification number: A61B5/14532 ,  A61B5/0075 ,  A61B5/024 ,  A61B5/02416 ,  A61B5/02433 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1495 ,  A61B5/7203 ,  A61B5/7235 ,  A61B5/7253 ,  A61B5/7264 ,  A61B5/7267 ,  A61B2560/0223 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/4795 ,  G01N21/49 ,  G01N33/4833 ,  G01N33/49 ,  G01N2201/0612 ,  G01N2201/062 ,  G01N2201/067 ,  G01N2201/12 ,  G01N2201/129

Abstract: In a noninvasive system for detection/measurement of glucose and other analytes in a medium such as tissue, spectra from the medium are deconstructed into features. Conditioned features, which contain frequency components specific to glucose or the other analytes, are derived from one or more features by modulating a carrier kernel with the feature. The conditioned features are computationally collided with one or more Zyotons that are co-dependent with the conditioned features. One or more collisions amplify a property of the analyte e.g., energy absorbed by glucose in tissue from radiation directed to the skin. A gradient of several values of the amplified property, each value corresponding to a particular radiation pattern according to a spectroscopic tomographic sequence, is used to select a suitable projector curve, with which a representative amplified value is projected to an accurate estimate of the concentration of glucose or the other analytes, without needing personalized calibration.

Abstract translation: 在用于在诸如组织的培养基中检测/测量葡萄糖和其它分析物的非侵入性系统中，来自培养基的光谱被解构为特征。 包含特定于葡萄糖或其他分析物的频率分量的条件特征通过调制具有该特征的载体核心从一个或多个特征导出。 条件特征与一个或多个与条件特征相关的Zyotons计算相撞。 一个或多个碰撞放大分析物的性质，例如组织中由葡萄糖吸收的能量，辐射被引导到皮肤。 使用放大性能的几个值的梯度，每个值对应于根据光谱断层扫描序列的特定辐射图，其值被选择合适的投影仪曲线，其中代表性的放大值被预测为准确地估计浓度 葡萄糖或其他分析物，不需要个性化校准。

公开(公告)号：US20160084767A1

公开(公告)日：2016-03-24

申请号：US14954365

申请日：2015-11-30

Applicant: PD-LD, Inc.

Inventor： Boris Leonidovich Volodin ,  Vladimir Sinisa Ban

IPC: G01N21/65

CPC classification number: G01J3/0256 ,  G01J3/00 ,  G01J3/10 ,  G01J3/1895 ,  G01J3/44 ,  G01J3/4412 ,  G01J2003/104 ,  G01N21/65 ,  G01N21/658 ,  G01N2021/1793 ,  G01N2201/0221 ,  G01N2201/129 ,  G01N2201/1296 ,  G02B6/29319 ,  H01S5/005 ,  H01S5/32 ,  H01S5/4012 ,  H01S5/4087

Abstract: Apparatus for performing Raman spectroscopy may include a first laser source having a first emission wavelength and a second laser source having a second emission wavelength. A separation between the first and second emission wavelengths may correspond to a width of a Raman band of a substance of interest. A switch may provide switching between the first and second laser sources. An ensemble of laser emitters may be provided. A Bragg grating element may receive laser light from the ensemble. An optical system may direct light from the Bragg grating element into an optical fiber. A combined beam through the optical fiber may contain light from each of the emitters.

Abstract translation: 用于执行拉曼光谱的装置可以包括具有第一发射波长的第一激光源和具有第二发射波长的第二激光源。 第一和第二发射波长之间的间隔可以对应于感兴趣物质的拉曼带的宽度。 开关可以提供第一和第二激光源之间的切换。 可以提供激光发射器的组合。 布拉格光栅元件可以接收来自集合体的激光。 光学系统可以将来自布拉格光栅元件的光引导到光纤中。 通过光纤的组合光束可以包含来自每个发射器的光。

公开(公告)号：US09291610B2

公开(公告)日：2016-03-22

申请号：US13887563

申请日：2013-05-06

Applicant: Serguei Zelepouga ,  John M. Pratapas ,  Alexei V. Saveliev ,  Vilas V. Jangale

Inventor： Serguei Zelepouga ,  John M. Pratapas ,  Alexei V. Saveliev ,  Vilas V. Jangale

IPC: G01N33/22 ,  G01N21/3504 ,  G01N21/85 ,  G01N21/359 ,  G01N21/05

CPC classification number: G01N33/225 ,  G01N21/05 ,  G01N21/3504 ,  G01N21/359 ,  G01N21/85 ,  G01N2021/8578 ,  G01N2201/129

Abstract: An exemplary embodiment can be an apparatus for real-time, in situ measurement of gas compositions and heating values. The apparatus includes a near infrared sensor for measuring concentrations of hydrocarbons and carbon dioxide, a mid infrared sensor for measuring concentrations of carbon monoxide and a semiconductor based sensor for measuring concentrations of hydrogen gas. A data processor having a computer program for reducing the effects of cross-sensitivities of the sensors to components other than target components of the sensors is also included. Also provided are corresponding or associated methods for real-time, in situ determination of a composition and heating value of a fuel gas.

Abstract translation: 示例性实施例可以是用于实时，原位测量气体组成和加热值的装置。 该装置包括用于测量碳氢化合物和二氧化碳浓度的近红外传感器，用于测量一氧化碳浓度的中红外传感器和用于测量氢气浓度的基于半导体的传感器。 还包括具有计算机程序的数据处理器，该计算机程序用于将传感器的交叉敏感度对传感器的目标部件以外的部件的影响降低。 还提供了用于实时，原位测定燃料气体的组成和发热值的相应或相关联的方法。

公开(公告)号：US20150335248A1

公开(公告)日：2015-11-26

申请号：US14412053

申请日：2013-07-02

Applicant: National University of Singapore

Inventor： Zhiwei HUANG ,  Khek Yu HO ,  Mads Sylvest BERGHOLT ,  Wei ZHENG ,  Khay Guan YEOH ,  ShiyamlaB DURAIPANDIAN

IPC: A61B5/00 ,  G01N21/65 ,  A61B1/00

CPC classification number: A61B5/0075 ,  A61B1/00165 ,  A61B5/0084 ,  A61B2560/0233 ,  G01J2003/4424 ,  G01N21/274 ,  G01N21/65 ,  G01N2021/656 ,  G01N2201/08 ,  G01N2201/12753 ,  G01N2201/129

Abstract: A method of achieving instrument independent measurements for quantitative analysis of fiber-optic Raman spectroscope system, the system comprising a laser source, a spectroscope and a fiber optic probe to transmit light from the laser source to a target and return scattered light to the spectroscope, the method comprising transmitting light from the laser source to a standard target having a known spectrum, recording a calibration spectrum of the scattered light from the standard target, comparing the known spectrum and the calibration system and generating a probe and/or probe-system transfer function, and storing the transfer function. Further provided is a method of performing real-time diagnostic Raman spectroscopy optionally in combination with the other disclosed methods.

Abstract translation: 一种实现用于光纤拉曼光谱系统的定量分析的仪器独立测量的方法，该系统包括激光源，分光镜和光纤探针，以将来自激光源的光透射到目标物并将散射光返回到分光器， 所述方法包括将来自激光源的光传输到具有已知光谱的标准靶，记录来自标准靶的散射光的校准光谱，比较已知光谱和校准系统并产生探针和/或探针系统转移 功能，并存储传输功能。 进一步提供了可选地与其他公开的方法组合执行实时诊断拉曼光谱的方法。

公开(公告)号：US09170154B2

公开(公告)日：2015-10-27

申请号：US12295631

申请日：2007-06-26

Applicant: Michael L. Myrick ,  Ryan J. Priore ,  Robert P. Freese ,  John C. Blackburn

Inventor： Michael L. Myrick ,  Ryan J. Priore ,  Robert P. Freese ,  John C. Blackburn

IPC: G06N5/00 ,  G06F1/00 ,  G01J3/28 ,  G01J3/02 ,  G01J3/10 ,  G01J3/12

CPC classification number: G01J3/28 ,  G01J3/02 ,  G01J3/0291 ,  G01J3/10 ,  G01J2003/1213 ,  G01J2003/2866 ,  G01N2201/129

Abstract: A method of classifying information in an optical analysis system includes obtaining calibration data defining a plurality of data points, each data point representing values for two or more detectors when sampling a material used to construct a multivariate optical element. Based on the calibration data, one or more validation models can be developed to indicate one or more ranges of expected results. Validation data comprising the models can be used to compare data points representing values for two or more detectors when performing a measurement of a material to determine if the data points fall within an expected range. Classification data can be generated based on the comparison and, in some embodiments, one or more indicators, such as a confidence level in a measurement, can be provided.

Abstract translation: 在光学分析系统中对信息进行分类的方法包括：获取定义多个数据点的校准数据，当对用于构造多变量光学元件的材料进行采样时，每个数据点表示两个或更多个检测器的值。 基于校准数据，可以开发一个或多个验证模型来指示预期结果的一个或多个范围。 包括模型的验证数据可以用于比较在进行材料测量时确定两个或多个检测器的值的数据点，以确定数据点是否落在预期范围内。 可以基于比较来生成分类数据，并且在一些实施例中，可以提供一个或多个指标，例如测量中的置信水平。

公开(公告)号：US20150285736A1

公开(公告)日：2015-10-08

申请号：US14680574

申请日：2015-04-07

Applicant: Endress + Hauser Conducta Gesellschaft für Mess- und Regeltechnik mbH + Co. KG

Inventor： Edin Andelic ,  Ralf Bernhard ,  Michael Littmann

IPC: G01N21/31 ,  G01N21/63 ,  G01N33/00 ,  G01N21/78

CPC classification number: G01N21/31 ,  G01N21/274 ,  G01N21/314 ,  G01N21/63 ,  G01N21/78 ,  G01N21/783 ,  G01N33/0036 ,  G01N2201/062 ,  G01N2201/129 ,  Y10T436/16 ,  Y10T436/173076 ,  Y10T436/173845

Abstract: A method and analyzer for determining a measured value of a measured variable of process automation technology in a liquid or gaseous medium by means of an optical sensor, which has at least one emitter for sending light of at least two wavelengths, and a receiver associated with the emitter for receiving of received light, comprising the steps as follows: taking a sample of the medium; mixing the sample with one or more reagents; supplying the emitter with an exciter signal for producing the sent light, wherein the sent light by interaction with, especially by absorption by, the mixed sample is converted into received light as a function of the measured variable; producing a receiver signal by means of the receiver from the converted, received light; and determining the measured value based on the receiver signal and a calibration function. The method is characterized in that, in determining the measured value, aging of the reagents is taken into consideration, especially the calibration function includes a term which takes aging of the reagents into consideration.

Abstract translation: 一种用于通过具有至少一个用于发送至少两个波长的光的发射器的光学传感器来确定液体或气体介质中的过程自动化技术的测量变量的测量值的方法和分析器，以及与至少两个波长的发射器相关联的接收器 用于接收光的发射器，包括以下步骤：取介质的样品; 将样品与一种或多种试剂混合; 向发射器提供用于产生发射光的激发器信号，其中通过与混合样品的相互作用特别是通过吸收的发射光作为测量变量的函数被转换成接收光; 通过接收机从转换的接收光产生接收机信号; 以及基于接收机信号和校准功能确定测量值。 该方法的特征在于，在确定测量值时考虑试剂的老化，特别是校准功能包括考虑试剂老化的术语。

公开(公告)号：US20150226720A1

公开(公告)日：2015-08-13

申请号：US14427488

申请日：2013-08-30

Applicant: INCORPORATED ADMINISTRATIVE AGENCY NATIONAL AGRICULTURE AND FOOD RESEARCH ORGANIZATION

Inventor： Hiroyuki Abe ,  Masahiro Amari

IPC: G01N33/08 ,  G01N21/59 ,  G01N21/55 ,  G01N21/359

CPC classification number: G01N33/08 ,  G01N21/359 ,  G01N21/55 ,  G01N21/59 ,  G01N33/085 ,  G01N2201/129

Abstract: This invention provides a means for measuring a cholesterol content of a chicken egg by a non-destructive means. This invention relates to a method for measuring a cholesterol content of a chicken egg comprising: a step of light irradiation of irradiating the chicken egg with light in the visible to near-infrared wavelength range; a step of light detection of detecting light radiated from the chicken egg caused by that the light irradiated in the step of light irradiation is transmitted through the chicken egg or reflected inside the chicken egg; a step of spectrum acquisition of acquiring a near-infrared spectrum of the light detected in the step of light detection; and a step of cholesterol content determination of determining a cholesterol content of the chicken egg on the basis of the near-infrared spectrum acquired in the step of spectrum acquisition.

Abstract translation: 本发明提供了一种以非破坏性方式测定鸡蛋胆固醇含量的方法。 本发明涉及一种测定鸡蛋胆固醇含量的方法，其特征在于，包括以下步骤：用可见光到近红外波长范围的光照射鸡蛋; 由光照射步骤中照射的光传播通过鸡蛋或鸡蛋内部反射而检测从鸡蛋发出的光的光检测步骤; 获取在光检测步骤中检测到的光的近红外光谱的光谱采集步骤; 以及基于在光谱获取步骤中获取的近红外光谱来确定鸡蛋的胆固醇含量的胆固醇含量测定步骤。

公开(公告)号：US20150185157A1

公开(公告)日：2015-07-02

申请号：US14578666

申请日：2014-12-22

Applicant: HORIBA, Ltd.

Inventor： Yusuke MIZUNO ,  Takuji OIDA ,  Misato ARAKAWA

IPC: G01N21/76 ,  G01N33/00

CPC classification number: G01N21/766 ,  G01N33/0026 ,  G01N2201/129

Abstract: A gas analyzing apparatus includes a gas analyzing unit, a luminescence inducing component generating unit, and a measurement signal calculating unit. The gas analyzing unit receives a sample gas containing a component gas and/or a standard gas and the luminescence inducing gas. The gas analyzing unit is configured to output a detection signal based on an intensity of a reaction light generated by the interaction between the component gas and the luminescence inducing component. The luminescence inducing component generating unit generates the luminescence inducing gas by electric discharge generated repeatedly at specified intervals. The measurement signal calculating unit calculates a first measurement signal based on a first detection signal, based on the reaction light generated when the sample gas and the luminescence inducing gas are introduced, and a second detection signal, based on the reaction light generated when the standard gas and the luminescence inducing gas are introduced.

Abstract translation: 气体分析装置包括气体分析单元，发光感应组件生成单元和测量信号计算单元。 气体分析单元接收含有成分气体和/或标准气体和发光诱导气体的样品气体。 气体分析单元被配置为基于由组分气体和发光诱导组件之间的相互作用产生的反应光的强度来输出检测信号。 发光诱导分量产生单元通过以规定的间隔重复产生的放电产生发光诱导气体。 测量信号计算单元基于当引入样品气体和发光诱导气体时产生的反应光，基于第一检测信号计算第一测量信号，并且基于当标准 引入气体和发光诱导气体。

公开(公告)号：US20150160121A1

公开(公告)日：2015-06-11

申请号：US14561982

申请日：2014-12-05

Applicant: Trent Daniel Ridder ,  Benjamin Ver Steeg

Inventor： Trent Daniel Ridder ,  Benjamin Ver Steeg

IPC: G01N21/25 ,  A61B5/00

CPC classification number: A61B5/4845 ,  A61B5/082 ,  G01J3/28 ,  G01J3/45 ,  G01N21/274 ,  G01N21/359 ,  G01N2021/3595 ,  G01N2201/129

Abstract: Methods of producing a plurality of spectroscopic measurement devices, comprising producing a calibration model that includes the expected range of measurement variation across the plurality of devices; producing the devices; installing the calibration model on each device. Most standard methods focus on ways to reduce the number of replicate samples that are required to be taken on a given instrument or class of instruments. The present methods can reduce that number to zero by anticipating the expected range of instrument variation in manufacturing in the field. This can be important when measuring live biological samples as it is impractical to maintain standard humans, cells, etc. This is in contrast to measurements on dry agricultural products where a standard, sealed dry sample can be maintained for months/years when required.

Abstract translation: 一种制造多个光谱测量装置的方法，包括产生一个校准模型，该校准模型包括跨越多个装置的测量变化的期望范围; 生产设备; 在每个设备上安装校准模型。 大多数标准方法着重于减少在给定仪器或仪器类上需要采集的重复样品数量的方法。 目前的方法可以通过预期现场制造中的仪器变化的预期范围来将该数量减少到零。 这在测量活体生物样品时是非常重要的，因为维持标准人类，细胞等是不切实际的。这与干农业产品的测量形成对照，其中标准的密封干燥样品可以在需要时保持数月/数年。

公开(公告)号：US09040605B2

公开(公告)日：2015-05-26

申请号：US13991832

申请日：2011-12-21

Applicant: Kishori Deshpande ,  Serena K. Stephenson ,  Ravindra S. Dixit

Inventor： Kishori Deshpande ,  Serena K. Stephenson ,  Ravindra S. Dixit

IPC: C08J3/00 ,  C08F210/14 ,  G01N21/65 ,  C08F10/02 ,  C08F210/16 ,  G01N21/84

CPC classification number: C08F210/14 ,  C08F10/02 ,  C08F210/16 ,  C08F2400/02 ,  G01N21/65 ,  G01N2021/8416 ,  G01N2201/129 ,  C08F2/00 ,  C08F2/14 ,  C08F2500/08

Abstract: The invention provides a process for monitoring and/or adjusting a dispersion polymerization of an olefin-based polymer, the process comprising monitoring the concentration of the carbon-carbon unsaturations in the dispersion using Raman Spectroscopy. The invention also provides a process for polymerizing an olefin-based polymer, the process comprising polymerizing one or more monomer types, in the presence of at least one catalyst and at least one solvent, to form the polymer as a dispersed phase in the solvent; and monitoring the concentration of the carbon-carbon unsaturations in the dispersion using Raman Spectroscopy.

Abstract translation: 本发明提供了一种用于监测和/或调节烯烃基聚合物的分散聚合的方法，该方法包括使用拉曼光谱法监测分散体中的碳 - 碳不饱和度的浓度。 本发明还提供了一种聚合基于烯烃的聚合物的方法，该方法包括在至少一种催化剂和至少一种溶剂的存在下使一种或多种单体类型聚合，以形成分散相在聚合物中的溶剂; 并使用拉曼光谱法监测分散体中碳 - 碳不饱和度的浓度。