公开(公告)号：US20230400469A1

公开(公告)日：2023-12-14

申请号：US17787804

申请日：2020-12-21

Applicant: Essenlix Corporation

Inventor： Stephen Y. CHOU ,  Susan Y. SUN ,  Shengjian CAI ,  Wei DING

IPC: G01N33/58 ,  G01N21/64 ,  G01N1/30

CPC classification number: G01N33/582 ,  G01N21/6428 ,  G01N2800/26 ,  G01N2001/302 ,  G01N2021/6439 ,  G01N1/30

Abstract: The present invention is to provide methods and devices that monitoring health and diagnosing a disease by directly measuring the biomarkers inside a cell (intra-cellular detection) rapidly and easily.

公开(公告)号：US20230358648A1

公开(公告)日：2023-11-09

申请号：US18142008

申请日：2023-05-01

Applicant: Essenlix Corporation

Inventor： Stephen Y. CHOU ,  Wei DING ,  Ji Qi

IPC: G01N1/28 ,  G01N1/31 ,  G01N33/49 ,  G02B17/00 ,  G06V10/143 ,  G06V20/69

CPC classification number: G01N1/2813 ,  G01N1/312 ,  G01N33/492 ,  G02B17/006 ,  G06V10/143 ,  G06V20/695 ,  G01N33/49 ,  G01N2015/0073

Abstract: Disclosed are devices and methods for analyzing an analyte, such as white blood cells in liquid samples.

公开(公告)号：US11712177B2

公开(公告)日：2023-08-01

申请号：US17016298

申请日：2020-09-09

Applicant: Essenlix Corporation

Inventor： Stephen Y. Chou ,  Wei Ding ,  Yufan Zhang ,  Ji Qi

IPC: A61B5/097 ,  A61B5/00 ,  G01N1/22 ,  G01N1/30 ,  G01N1/31 ,  G01N33/543 ,  G01N33/497 ,  G16H10/40 ,  G16H40/67 ,  A61B5/083 ,  B01L3/00 ,  G01N21/01 ,  G01N21/27 ,  G01N21/64 ,  G01N21/78 ,  G06Q40/08 ,  G01N21/17

CPC classification number: A61B5/097 ,  A61B5/0022 ,  A61B5/0833 ,  A61B5/0836 ,  B01L3/508 ,  G01N1/22 ,  G01N1/30 ,  G01N1/31 ,  G01N21/01 ,  G01N21/272 ,  G01N21/645 ,  G01N21/78 ,  G01N33/497 ,  G01N33/54306 ,  G01N33/54386 ,  G16H10/40 ,  G16H40/67 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0851 ,  B01L2300/123 ,  B01L2300/168 ,  B01L2400/0406 ,  G01N21/17 ,  G01N2001/2244 ,  G01N2001/302 ,  G01N2021/1776 ,  G01N2033/4975 ,  G06Q40/08

Abstract: Among other thing, the present invention provides solution to the problem, particularly, the present invention certain surfaces and certain sample holder to improve the sensitivity, speed, and easy-to-use of an optical signal based assays, such as colorimetric assays or fluorescence assays.

公开(公告)号：US11709162B2

公开(公告)日：2023-07-25

申请号：US17268567

申请日：2019-08-16

Applicant: Essenlix Corporation

Inventor： Stephen Y. Chou ,  Wei Ding ,  Ji Li

IPC: G01N33/543 ,  G01N15/02

CPC classification number: G01N33/54313 ,  G01N15/0227 ,  G01N33/54373 ,  G01N2015/025

Abstract: Disclosed are devices and methods for performing biological and chemical assays, such as immunoassays and nucleic acid assays, more particularly a homogeneous assay that does not use a wash step by using the aggregation and de-aggregation processes of microparticles or nanoparticles.

公开(公告)号：US20230077906A1

公开(公告)日：2023-03-16

申请号：US17980400

申请日：2022-11-03

Applicant: Essenlix Corporation

Inventor： Stephen Y. Chou ,  Wei Ding ,  Yufan Zhang ,  Ji Qi

IPC: A61B5/097 ,  A61B5/083 ,  A61B5/00 ,  G01N1/22 ,  G01N1/30 ,  G01N1/31 ,  G01N33/543 ,  G01N33/497 ,  G16H10/40 ,  G16H40/67 ,  B01L3/00 ,  G01N21/01 ,  G01N21/27 ,  G01N21/64 ,  G01N21/78

Abstract: The present invention relates to provide, among other things, the methods, devices, and systems that can simply and quickly collecting and analyzing a tiny amount of vapor condensates (e.g. exhaled breath condensate (EBC)).

公开(公告)号：US20220404342A1

公开(公告)日：2022-12-22

申请号：US17775580

申请日：2020-11-09

Applicant: Essenlix Corporation

Inventor： Wei DING ,  Stephen Y. CHOU ,  Wu CHOU ,  Ji WANG ,  Chen JI

IPC: G01N33/52 ,  G01N21/25 ,  G01N21/27 ,  G01N21/78

Abstract: Disclosed is a device including a substrate having a plurality of detection areas to receive at least a portion of a sample having an analyte or suspected of having an analyte and at least one reference marker adjacent to at least one of the detection areas, wherein each of the detection areas detects a specific analyte and the at least one reference marker defines a scale mark, a shape mark, a color mark, or a combination thereof. Also disclosed is an imaging system and method for using the device and imaging system.

公开(公告)号：US11463608B2

公开(公告)日：2022-10-04

申请号：US17179319

申请日：2021-02-18

Applicant: Essenlix Corporation

Inventor： Stephen Y. Chou ,  Wei Ding ,  Yufan Zhang ,  Ji Qi ,  Jun Tian ,  Wei Dong

IPC: H04N5/225 ,  G01N21/84

Abstract: The present disclosure relates to devices, apparatus and methods of improving the accuracy of an image-based assay. One aspect of the present invention is to sandwich a sample between two plates and add reference marks in the sample areas of the plates, with at least one of the geometric and/optical properties of the reference marks being predetermined and known, and taking images of the sample with the reference marks, and applying a machine learning model in the analysis of the image-based assay.

公开(公告)号：US20220299422A1

公开(公告)日：2022-09-22

申请号：US17565115

申请日：2021-12-29

Applicant: Essenlix Corporation

Inventor： Stephen Y. CHOU ,  Wei DING ,  Wu CHOU ,  Jun TIAN ,  Yuecheng ZHANG ,  Mingquan WU ,  Xing LI

IPC: G01N15/14 ,  G06N20/00 ,  G01N1/28 ,  G06N3/08 ,  G06T1/00

Abstract: The present invention is related to correct the errors in instruments, operation, and others using intelligent monitoring structures and machine learning, and others.

公开(公告)号：US20220291093A1

公开(公告)日：2022-09-15

申请号：US17752823

申请日：2022-05-24

Applicant: Essenlix Corporation

Inventor： Stephen Y. CHOU ,  Wei DING

IPC: G01N1/28 ,  G01N33/49 ,  G01N21/64 ,  G01N1/30 ,  G01N15/14 ,  G01N21/69 ,  G01N21/76 ,  G01N33/543 ,  B01L3/00 ,  G01N33/487 ,  G01N35/00

Abstract: The present invention is related to the field of bio/chemical sampling, sensing, assays and applications. Particularly, the present invention is related to how to make the sampling/sensing/assay become simple to use, fast to results, highly sensitive, easy to use, using tiny sample volume (e.g. 0.5 uL or less), operated by a person without any professionals, reading by mobile-phone, or low cost, or a combination of them.

公开(公告)号：US20220260549A1

公开(公告)日：2022-08-18

申请号：US17736064

申请日：2022-05-03

Applicant: Essenlix Corporation

Inventor： Stephen Y. CHOU ,  Wei DING

IPC: G01N33/487 ,  A61B5/145 ,  G01N33/49 ,  G01N33/53 ,  G01N33/58 ,  G01N33/66

Abstract: Disclosed is a method for correlating a biomarker in a non-blood bodily fluid with the same biomarker in the blood of an individual, including: measuring, in a first period in time, the biomarker in non-blood bodily fluid and measuring the same biomarker in the blood of the same individual to establish an R ratio of [NBBF1]/[BB1], where [NBBF1] is the biomarker concentration in non-blood bodily fluid in the first period in time, and [BB1] is the biomarker concentration in the blood in the first period in time; storing the ratio in a memory; measuring, in a second period in time, the biomarker in non-blood bodily fluid to determine [NBBF2], where [NBBF2] is the biomarker concentration in the non-blood bodily fluid in the second period in time; and correlating the measured [NBBF2] with the R ratio to generate a correlated [BB2] biomarker concentration in the blood of the individual in the second period in time. Also disclosed is a device, apparatus, and method for correlating the glucose concentration in a non-blood bodily fluid such as saliva with the glucose in the blood of an individual.