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公开(公告)号：US11274320B2
公开(公告)日：2022-03-15
申请号：US17078872
申请日：2020-10-23
发明人： Kim Cecelia Anderson , Elena Brevnova , Dylan Alexander Carlin , Brian Carvalho , Nicholas Flores , Katrina Forrest , Massimo Merighi , Gabriel Rodriguez , Emily E. Wrenbeck
摘要： Aspects of the disclosure relate to biosynthesis of cannabinoids and cannabinoid precursors in recombinant cells and in vitro.
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公开(公告)号：US20210269835A1
公开(公告)日：2021-09-02
申请号：US17197710
申请日：2021-03-10
摘要： Nucleic acids and cells comprising a methyltransferase gene and/or a reductase gene are disclosed. These nucleic acids and cells may be used to produce branched (methyl)lipids, such as 10-methylstearate.
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公开(公告)号：US20210071209A1
公开(公告)日：2021-03-11
申请号：US17078872
申请日：2020-10-23
发明人： Kim Cecelia Anderson , Elena Brevnova , Dylan Alexander Carlin , Brian Carvalho , Nicholas Flores , Katrina Forrest , Matthew McMahon , Massimo Merighi , Gabriel Rodriguez , Emily E. Wrenbeck
摘要： Aspects of the disclosure relate to biosynthesis of cannabinoids and cannabinoid precursors in recombinant cells and in vitro.
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公开(公告)号：US20190264184A1
公开(公告)日：2019-08-29
申请号：US16345595
申请日：2017-10-27
发明人： Daniel C. GRAY , Enhu LI , Brian R. BOWMAN , Gregory L. VERDINE , Keith ROBISON , Marc CHEVRETTE , Dan UDWARY , Pam Shouping WANG , Anna LI , Jay P. MORGENSTERN
IPC分类号： C12N9/10 , C12N15/76 , C12P17/18 , A61P17/06 , A61P25/00 , C12N15/52 , C12N1/20 , C12R1/485 , C12R1/55
摘要： The present disclosure provides proteins, nucleic acids, vectors, and host molecules useful for the production of compounds of interest, and methods for their use.
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公开(公告)号：US10119975B2
公开(公告)日：2018-11-06
申请号：US15363243
申请日：2016-11-29
摘要： Systems, methods, libraries, kits, and computer software tools are provided for designing and producing engineered cells. Such engineered cells can be used for cell state quantification, such as genome, transcriptome and/or proteome quantification. In one aspect, an engineered cell having a plurality of artificially designed oligonucleotides introduced into the genome of the cell is provided. The oligonucleotides are each located in proximity of a gene of interest encoding a protein of interest, and are different from one another. The oligonucleotides can each encode a unique peptide tag for each protein of interest, wherein each peptide tag has a unique quantitatively measurable value such as mass-to-charge ratio which can be quantified by a mass spectrometer. The engineered cell is capable of expressing a plurality of proteins of interest each fused to its corresponding unique peptide tag, wherein each peptide tag is capable of being released therefrom.
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公开(公告)号：US20180216120A1
公开(公告)日：2018-08-02
申请号：US15937619
申请日：2018-03-27
发明人： Reshma P. Shetty , Curt R. Fischer
摘要： The present disclosure identifies pathways, mechanisms, systems and methods to confer production of carbon-based products of interest, such as sugars, alcohols, chemicals, amino acids, polymers, fatty acids and their derivatives, hydrocarbons, isoprenoids, and intermediates thereof, in engineered and/or evolved methylotrophs such that these organisms efficiently convert C1 compounds, such as formate, formic acid, formaldehyde or methanol, to organic carbon-based products of interest, and in particular the use of organisms for the commercial production of various carbon-based products of interest.
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公开(公告)号：US09902980B2
公开(公告)日：2018-02-27
申请号：US14354354
申请日：2012-10-30
CPC分类号： C12P7/40 , C12N9/0006 , C12N9/0051 , C12N15/52 , C12N15/70 , C12P5/00 , C12P7/00 , C12P7/16 , C12Y101/05006 , C12Y108/05004 , Y02E50/10
摘要： The present disclosure identifies pathways, mechanisms, systems and methods to confer chemoautotrophic production of carbon-based products of interest, such as sugars, alcohols, chemicals, amino acids, polymers, fatty acids and their derivatives, hydrocarbons, isoprenoids, and intermediates thereof, in organisms such that these organisms efficiently convert inorganic carbon to organic carbon-based products of interest using inorganic energy, such as formate, and in particular the use of organisms for the commercial production of various carbon-based products of interest.
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公开(公告)号：US20170240886A1
公开(公告)日：2017-08-24
申请号：US15440293
申请日：2017-02-23
发明人： Andrew V. Oleinikov
IPC分类号： C12N15/10
CPC分类号： C12N15/1068 , B01J19/0046 , B01J2219/00378 , B01J2219/00385 , B01J2219/00432 , B01J2219/00454 , B01J2219/005 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/00626 , B01J2219/00639 , B01J2219/00641 , B01J2219/00659 , B01J2219/00675 , B01J2219/00677 , B01J2219/00689 , B01J2219/00713 , B01J2219/00722 , B82Y30/00 , C12Q1/6837 , C40B40/06 , C40B50/14 , C40B80/00
摘要： There is disclosed a process for in vitro synthesis and assembly of long, gene-length polynucleotides based upon assembly of multiple shorter oligonucleotides synthesized in situ on a microarray platform. Specifically, there is disclosed a process for in situ synthesis of oligonucleotide fragments on a solid phase microarray platform and subsequent, “on device” assembly of larger polynucleotides composed of a plurality of shorter oligonucleotide fragments.
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公开(公告)号：US12091435B2
公开(公告)日：2024-09-17
申请号：US17045090
申请日：2019-04-03
IPC分类号： C12N9/22 , C07K14/005 , C07K14/015 , C07K14/47 , C12N7/00 , C12N15/11 , C12N15/86 , A61K38/00
CPC分类号： C07K14/015 , C07K14/005 , C07K14/4707 , C12N7/00 , C12N9/22 , C12N15/11 , C12N15/86 , A61K38/00 , C12N2750/14122 , C12N2750/14143
摘要： The present disclosure provides AAV capsid proteins comprising a modification in the amino acid sequence and virus vectors comprising the modified AAV capsid protein. The disclosure also provides methods of administering the virus vectors and virus capsids of the disclosure to a cell or to a subject in vivo.
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公开(公告)号：US12060390B2
公开(公告)日：2024-08-13
申请号：US18372823
申请日：2023-09-26
IPC分类号： C07K14/005 , C07K14/015 , C07K14/47 , C12N7/00 , C12N9/22 , C12N15/11 , C12N15/86 , A61K38/00
CPC分类号： C07K14/015 , C07K14/005 , C07K14/4707 , C12N7/00 , C12N9/22 , C12N15/11 , C12N15/86 , A61K38/00 , C12N2750/14122 , C12N2750/14143
摘要： The present disclosure provides AAV capsid proteins comprising a modification in the amino acid sequence and virus vectors comprising the modified AAV capsid protein. The disclosure also provides methods of administering the virus vectors and virus capsids of the disclosure to a cell or to a subject in vivo.
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