公开(公告)号：US20180326040A1

公开(公告)日：2018-11-15

申请号：US15776016

申请日：2016-11-16

Applicant: Kansas State University Research Foundation

Inventor： Ben Hause ,  Emily Collin

IPC: A61K39/145 ,  C07K14/005

CPC classification number: A61K39/145 ,  A61K39/12 ,  A61K2039/5256 ,  C07K14/005 ,  C12N7/00 ,  C12N2760/16022 ,  C12N2760/16034 ,  C12N2760/16121 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2760/16322

Abstract: Attenuated live or replication-deficient chimeric swine influenza virus vaccine, and a platform to develop a multitude of other vaccines in swine and other species. The chimeric influenza virus A comprises a backbone of viral genomic segments derived from influenza A, and expresses a heterologous surface protein (influenza D hemagglutinin esterase fusion protein), and optionally at least one other heterologous protein, such as an antigenic component of a target pathogen.

公开(公告)号：US20180237795A1

公开(公告)日：2018-08-23

申请号：US15957639

申请日：2018-04-19

Applicant: Kansas State University Research Foundation

Inventor： Harold N. Trick ,  Allan Fritz ,  Shyamal Talukder

IPC: C12N15/82 ,  C12N9/10

Abstract: Genetically-modified plants having increased tolerance to heat stress are described. Methods of producing such genetically-modified plants are also disclosed. The genetically-modified plants comprise exogenous nucleic acid encoding a thermostable protein having starch synthase activity. Genetically-modified plants have increased yield when grown under elevated conditions as compared to control plants.

公开(公告)号：US10050475B2

公开(公告)日：2018-08-14

申请号：US14891166

申请日：2014-05-19

Applicant: Kansas State University Research Foundation

Inventor： Saeed M. Khan ,  Nathan Maresch ,  Justin Kuntz

IPC: H01F38/00 ,  H02J50/12 ,  H02J7/02 ,  H02J50/90 ,  H02J50/40 ,  H01Q1/32 ,  H01Q11/08 ,  H01Q1/36 ,  H04B5/00 ,  H02J5/00 ,  H02J17/00

Abstract: A wireless power transfer system including a transmitting antenna with a first conductive helix wound about a first helical axis, and a first ground plane positioned adjacent to and angled orthogonally with the first helical axis. The wireless power transfer system additionally includes a receiving antenna with a second conductive helix wound about a second helical axis, and a second ground plane positioned adjacent to and angled orthogonally with the second helical axis. Furthermore, the wireless power transfer system further includes a conductive material connecting the first ground plane to the second ground plane.

公开(公告)号：US10010598B2

公开(公告)日：2018-07-03

申请号：US15824694

申请日：2017-11-28

Applicant: KANSAS STATE UNIVERSITY RESEARCH FOUNDATION

Inventor： Sanjeev Narayanan ,  Amit Kumar ,  Tiruvoor Nagaraja ,  Muckatira Chengappa

IPC: A61K39/39 ,  A61K39/114 ,  C07K14/195

CPC classification number: A61K39/114 ,  A61K39/39 ,  C07K14/195

Abstract: The present invention relates to protecting against, treating, and detecting Fusobacteria infections. Compositions and methods derived from nucleic acid and protein sequences of a 40 kDa Adhesin protein are provided to protect against, treat, and detect Fusobacteria infections in a subject. In one aspect, vaccines capable of inducing an immune response to a 40 kDa Adhesin protein are used to protect against Fusobacteria infection. Also, nucleic acid molecules, proteins, immunogens, antibodies, and antisense molecules derived from the sequences of the 40 kDa Adhesin protein may be used to protect against, treat, and detect Fusobacteria infections in a subject.

公开(公告)号：US09884102B2

公开(公告)日：2018-02-06

申请号：US15052594

申请日：2016-02-24

Applicant: KANSAS STATE UNIVERSITY RESEARCH FOUNDATION

Inventor： Sanjeev Narayanan ,  Amit Kumar ,  Tiruvoor Nagaraja ,  Muckatira Chengappa

IPC: C07K14/195 ,  A61K39/114 ,  A61K39/39

CPC classification number: A61K39/114 ,  A61K39/39 ,  C07K14/195

Abstract: The present invention relates to protecting against, treating, and detecting Fusobacteria infections. Compositions and methods derived from nucleic acid and protein sequences of a 40 kDa Adhesin protein are provided to protect against, treat, and detect Fusobacteria infections in a subject. In one aspect, vaccines capable of inducing an immune response to a 40 kDa Adhesin protein are used to protect against Fusobacteria infection. Also, nucleic acid molecules, proteins, immunogens, antibodies, and antisense molecules derived from the sequences of the 40 kDa Adhesin protein may be used to protect against, treat, and detect Fusobacteria infections in a subject.

公开(公告)号：US20180010170A1

公开(公告)日：2018-01-11

申请号：US15543712

申请日：2016-01-15

Applicant: Kansas State University Research Foundation

Inventor： Jianfa Bai ,  Xuming Liu ,  Gary Anderson

IPC: C12Q1/68

CPC classification number: C12Q1/689 ,  C12Q2537/143

Abstract: The present invention is concerned with PCR-based detection methods and kits for the identification, differentiation, and quantification of different bacterial strains (e.g., Gram-negative bacterial strains), and also association of two or more PCR-positive genes to a single genome. The methods generally comprise carrying out PCR reactions using at least a first PCR primer set and/or probe for at least one target nucleic acid; and a second PCR primer set and/or probe for at least a second target nucleic acid. Positive PCR reaction products are then detected to determine test samples containing positive PCR reaction products for both the first and second target nucleic acids. This information can be used to calculate the gene association rate to determine whether the sample contains, for example, Shiga toxin-producing E. coli of the O-type serogroup.

公开(公告)号：US20170354167A1

公开(公告)日：2017-12-14

申请号：US15527529

申请日：2015-11-19

Applicant: Kansas State University Research Foundation

Inventor： Cassandra K. Jones ,  Roger A. Cochrane ,  Jason C. Woodworth ,  Steven S. Dritz

IPC: A23K30/00 ,  A23K50/42 ,  A23K20/22 ,  A23K50/30 ,  A23K20/158

Abstract: Methods of preventing or decreasing PEDv and/or Salmonella bacteria in animal feed, feed ingredients, and pet food are provided. The methods utilize generally safe chemical mitigants, such as medium chain fatty acids, essential oils, and sodium bisulfate. The chemical mitigants are introduced to the feed or feed ingredients at inclusion rates selected so as to prevent or decrease PEDv and/or Salmonella bacteria in the animal feed, feed ingredients, or pet food. The methods are particularly suitable for use in post-processing treatment of animal feed, feed ingredients, or pet food that will be transported and stored for multiple days or weeks.

公开(公告)号：US20170188602A1

公开(公告)日：2017-07-06

申请号：US15322541

申请日：2015-07-02

Applicant: Kansas State University Research Foundation

Inventor： Sarah L. Mathe ,  Greg Aldrich

IPC: A23K20/163 ,  A23K50/00 ,  A23K40/20

CPC classification number: A23K20/163 ,  A23K40/20 ,  A23K40/25 ,  A23K50/00

Abstract: A process of forming a gelatin-based animal treat is provided. The process comprises forming a composition comprising a gelatin component, a carbohydrate material, and an aqueous liquid. The compositions comprising the animal treat general have less than about 1% by weight of acidulants and a pH from about 5.5 to about 8.0. Once the composition is introduced into a product mold, it is allowed to cool and harden into the gelatin-based treat product. Thus, the animal treats are cold-setting and do not require additional heating, cooking, or baking to form the final product. Optionally, the animal treat can be used as a carrier to deliver a pharmaceutical or nutraceutical compound to the animal through ingestion.

公开(公告)号：US20170144935A1

公开(公告)日：2017-05-25

申请号：US15323885

申请日：2015-07-08

Applicant: Kansas State University Research Foundation

Inventor： Gurpreet Singh ,  Lamuel David

IPC: C04B35/571 ,  C04B35/589 ,  H01M10/0525 ,  H01M4/136 ,  H01M4/58 ,  H01M4/66 ,  C04B35/583 ,  C08J3/24

CPC classification number: C04B35/571 ,  C01B21/0648 ,  C01P2002/70 ,  C01P2002/72 ,  C01P2002/82 ,  C01P2004/03 ,  C01P2004/04 ,  C01P2004/20 ,  C04B35/5603 ,  C04B35/583 ,  C04B35/589 ,  C04B2235/386 ,  C04B2235/483 ,  C08J3/20 ,  C08J3/24 ,  C08J3/247 ,  C08J2383/04 ,  C08J2383/16 ,  C09D1/00 ,  H01M4/136 ,  H01M4/58 ,  H01M4/66 ,  H01M4/661 ,  H01M10/052 ,  H01M10/0525 ,  H01M2004/027 ,  H01M2220/20

Abstract: Polymer-derived ceramic composites are described herein. The composites are formed using hexagonal boron nitride nanosheet-functionalized silicon-based ceramic precursor polymers. The composites a matrix of a polymer-derived ceramic and hexagonal boron nitride nanosheets embedded therein. Silicon-derived ceramic precursors such as polysilazane and/or polysiloxane are used to create improved SiCN and/or SiOC ceramic composites.

公开(公告)号：US09474759B2

公开(公告)日：2016-10-25

申请号：US14347756

申请日：2012-09-27

Applicant: Kansas State University Research Foundation ,  The Ohio State University ,  Wichita State University

Inventor： Kyeong-Ok Chang ,  Yunjeong Kim ,  William C. Groutas ,  Duy Hua ,  Linda J. Saif

IPC: A61K38/06 ,  A61K31/5377 ,  A61K31/4015 ,  A61K31/422 ,  A61K31/427 ,  A61K45/06 ,  C07D207/27

CPC classification number: A61K31/5377 ,  A61K31/4015 ,  A61K31/422 ,  A61K31/427 ,  A61K38/06 ,  A61K45/06 ,  C07D207/27 ,  C12N2770/16011 ,  C12N2770/20011 ,  C12N2770/32111 ,  C12N2770/32311 ,  C12N2770/32411 ,  C12N2770/32611 ,  Y02A50/463

Abstract: Antiviral protease inhibitors, including peptidyl aldehydes, peptidyl α-ketoamides, peptidyl bisulfate salts, and peptidyl heterocycles, are disclosed, along with related antiviral compounds, and methods of using the same to treat or prevent viral infection and disease. The compounds possess broad-spectrum activity against viruses that belong to the picornavirus-like supercluster, which include important human and animal pathogens including noroviruses, enteroviruses, poliovirus, foot-and-mouth disease virus, hepatitis A virus, human rhinovirus (cause of common cold), human coronavirus (another cause of common cold), transmissible gastroenteritis virus, murine hepatitis virus, feline infectious peritonitis virus, and severe acute respiratory syndrome coronavirus.

Abstract translation: 公开了抗病毒蛋白酶抑制剂，包括肽基醛，肽基α-酮酰胺，硫酸氢酯盐和肽基杂环，以及相关的抗病毒化合物，以及使用它们来治疗或预防病毒感染和疾病的方法。 该化合物对属于小核糖核酸病毒超级群集的病毒具有广谱活性，其包括重要的人和动物病原体，包括诺维病毒，肠道病毒，脊髓灰质炎病毒，口蹄疫病毒，甲型肝炎病毒，人类鼻病毒（常见病因 感冒），人类冠状病毒（普通感冒的另一原因），传染性胃肠炎病毒，鼠肝炎病毒，猫感染性腹膜炎病毒和严重急性呼吸综合征冠状病毒。