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公开(公告)号：US09243085B2
公开(公告)日：2016-01-26
申请号：US13762941
申请日：2013-02-08
Applicant: LIFE TECHNOLOGIES CORPORATION , LIFE TECHNOLOGIES AS
Inventor： Geir Fonnum , Grete Modahl , Nini Kjus , Astrid Evenroed Molteberg , Diem Tran , Jo Aaserud , M. Talha Gokmen , Steven Menchen , Carl Fuller , Luisa Andruzzi , Wolfgang Hinz
IPC: C08F2/16 , C08F230/08 , C08F8/34 , C08F6/24 , C07F7/18 , C08F130/08 , C08F2/20 , C08F2/26 , C08F220/58 , C08F222/38 , C08F8/32 , C12Q1/68
CPC classification number: C08F130/08 , C07F7/1804 , C07F7/188 , C08F2/20 , C08F2/26 , C08F6/24 , C08F8/12 , C08F8/32 , C08F8/34 , C08F220/58 , C08F222/385 , C08F230/08 , C08F2800/20 , C08J9/20 , C08J2343/04 , C12P19/34 , C12Q1/686 , C12Q1/6874 , G01N27/4145 , Y10T428/2982 , C08F257/02 , C08F2222/1013 , C08F212/36 , C08F220/60 , C12Q2563/149 , C12Q2563/159 , C12Q2565/543
Abstract: A method of forming a particle includes, in a disperse phase within an aqueous suspension, polymerizing a plurality of mer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups. The method further includes converting the polymeric particle to a hydrophilic particle.
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公开(公告)号：US09187691B2
公开(公告)日：2015-11-17
申请号：US14190054
申请日：2014-02-25
Applicant: LIFE TECHNOLOGIES AS
Inventor： Ellen Weng , Geir Fonnum , Grete Modahl , Astrid Molteberg , Torkel Stene
IPC: G01N33/553 , G01N33/544 , C09K11/06 , B82Y25/00 , B82Y40/00 , G01N33/543 , H01F1/01 , H01F41/00 , C09K11/02 , H01F1/00 , H01F1/26 , C08F220/18
CPC classification number: C09K11/06 , B82Y25/00 , B82Y40/00 , C08F220/18 , C09K11/025 , G01N33/5434 , H01F1/0018 , H01F1/01 , H01F1/26 , H01F41/00 , Y10T428/2991 , Y10T428/2998
Abstract: A coated magnetic particle comprising an optionally porous magnetic polymer particle of a matrix polymer, said polymer particle having on a surface and/or in the pores thereof superparamagnetic crystals, said coated particle having a coat formed of a coating polymer, wherein said coated magnetic particle is essentially non-autofluorescent.
Abstract translation: 一种涂覆的磁性颗粒，其包含基质聚合物的任选多孔磁性聚合物颗粒，所述聚合物颗粒在表面上和/或其孔中具有超顺磁性晶体，所述涂覆颗粒具有由涂覆聚合物形成的涂层，其中所述涂覆的磁性颗粒 本质上是非自发荧光。
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公开(公告)号：US09156925B2
公开(公告)日：2015-10-13
申请号：US14082419
申请日：2013-11-18
Applicant: LIFE TECHNOLOGIES CORPORATION , LIFE TECHNOLOGIES AS
Inventor： Geir Fonnum , Grete I. Modahl , Nini H. Kjus , Astrid E. Molteberg , Diem Tran , Jo Aaserud , Talha M. Gokmen , Steven M. Menchen , Carl Fuller , Luisa Andruzzi , Wolfgang Hinz
IPC: C08F6/24 , C08F8/34 , C08F2/20 , C08F2/26 , C07F7/18 , C08F130/08 , C08F220/58 , C08F230/08 , C08F222/38 , C08F8/32 , C12Q1/68
CPC classification number: C08F130/08 , C07F7/1804 , C07F7/188 , C08F2/20 , C08F2/26 , C08F6/24 , C08F8/12 , C08F8/32 , C08F8/34 , C08F220/58 , C08F222/385 , C08F230/08 , C08F2800/20 , C08J9/20 , C08J2343/04 , C12P19/34 , C12Q1/686 , C12Q1/6874 , G01N27/4145 , Y10T428/2982 , C08F257/02 , C08F2222/1013 , C08F212/36 , C08F220/60 , C12Q2563/149 , C12Q2563/159 , C12Q2565/543
Abstract: A method of forming a particle includes, in a disperse phase within an aqueous suspension, polymerizing a plurality of mer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups. The method further includes converting the polymeric particle to a hydrophilic particle.
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公开(公告)号：US09062079B2
公开(公告)日：2015-06-23
申请号：US13762489
申请日：2013-02-08
Applicant: LIFE TECHNOLOGIES CORPORATION , LIFE TECHNOLOGIES AS
Inventor： Nini Kjus , Geir Fonnum , Bruce Branchaud , Lai-Qiang Ying , Steven Menchen , Dmitriy Gremyachinskiy , Hee Chol Kang
IPC: C07F7/18 , C07F7/10 , C08F222/38 , C08F220/58 , C08F236/20 , C08K3/20
CPC classification number: C08F230/08 , C07F7/10 , C07F7/1804 , C08F220/58 , C08F222/385 , C08F236/20 , C08K3/20
Abstract: A silyl protected diacrylamide compound is described. A method of forming such a compound includes mixing a silylation reagent with a hydroxylated diamine compound under first reactive conditions to form a product in a first solution, separating the product from the first solution, and mixing the product with acryloyl chloride under second reactive conditions in a second solution to form a silyl protected diacrylamide compound.
Abstract translation: 描述了甲硅烷基保护的二丙烯酰胺化合物。 形成这种化合物的方法包括在第一反应条件下将甲硅烷基化试剂与羟基化二胺化合物混合以在第一溶液中形成产物，将产物与第一溶液分离，并在第二反应条件下将产物与丙烯酰氯混合 形成甲硅烷基保护的二丙烯酰胺化合物的第二溶液。
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公开(公告)号：US20150090664A1
公开(公告)日：2015-04-02
申请号：US14400671
申请日：2013-05-08
Applicant: Life Technologies AS
Inventor： Lars Nokleby , Berit Reed , Tine Hildisch , Axl Neurauter
IPC: B03C1/14
CPC classification number: B03C1/14 , B01L9/06 , B03C1/0332 , B03C1/0335 , B03C1/288 , B03C2201/18 , B03C2201/26 , G01N35/0098
Abstract: This invention relates to a sample holder for isolating magnetically labelled particles from a non-magnetic medium in a plurality of samples. The holder comprises a magnetic base for applying a magnetic force to the magnetically labelled particles and a body which is mountable on the base and demountable therefrom. The body comprises an array of sample holding portions and a magnetisable member which is magnetically urged towards the magnetic base when the body is seated on the base, whereby the body is urged to remain seated on the base. The invention also relates to use of the sample holder to separate magnetic particles from a non-magnetic medium and methods of performing such a separation.
Abstract translation: 本发明涉及用于从多个样品中的非磁性介质中分离磁性标记的颗粒的样品保持器。 保持器包括用于向磁性标记的颗粒施加磁力的磁性基座和可安装在基座上并可由其拆卸的主体。 身体包括一组样本保持部分和一个可磁化部件，当身体坐在基座上时，可磁化部件被磁力推向磁性基座，由此推动身体保持坐在基部上。 本发明还涉及样品保持器从非磁性介质中分离磁性颗粒的使用以及进行这种分离的方法。
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Patent Agency Ranking
公开(公告)号：US20140231697A1
公开(公告)日：2014-08-21
申请号：US14228158
申请日：2014-03-27
Applicant: LIFE TECHNOLOGIES AS
Inventor： Ellen WENG , Geir FONNUM , Grete MODAHL , Astrid MOLTEBERG , Erling FINNE , Torkel STENE
CPC classification number: C09K11/06 , B82Y25/00 , B82Y40/00 , C08F220/18 , C09K11/025 , G01N33/5434 , H01F1/0018 , H01F1/01 , H01F1/26 , H01F41/00 , Y10T428/2991 , Y10T428/2998
Abstract: A coated magnetic particle comprising an optionally porous magnetic polymer particle of a matrix polymer, said polymer particle having on a surface and/or in the pores thereof superparamagnetic crystals, said coated particle having a coat formed of a coating polymer, wherein said coated magnetic particle is essentially non-autofluorescent.
Abstract translation: 一种涂覆的磁性颗粒，其包含基质聚合物的任选多孔磁性聚合物颗粒，所述聚合物颗粒在表面上和/或其孔中具有超顺磁性晶体，所述涂覆颗粒具有由涂覆聚合物形成的涂层，其中所述涂覆的磁性颗粒 本质上是非自发荧光。
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公开(公告)号：US20140073738A1
公开(公告)日：2014-03-13
申请号：US14082336
申请日：2013-11-18
Applicant: LIFE TECHNOLOGIES AS , LIFE TECHNOLOGIES CORPORATION
Inventor： Geir FONNUM , Grete I. MODAHL , Nini H. KJUS , Astrid E. MOLTEBERG , Diem TRAN , Jo AASERUD , Talha M. GOKMEN , Steven M. MENCHEN , Carl FULLER , Luisa ANDRUZZI , Wolfgang HINZ
IPC: C08F130/08 , C08F8/32
CPC classification number: C08F130/08 , C07F7/1804 , C07F7/188 , C08F2/20 , C08F2/26 , C08F6/24 , C08F8/12 , C08F8/32 , C08F8/34 , C08F220/58 , C08F222/385 , C08F230/08 , C08F2800/20 , C08J9/20 , C08J2343/04 , C12P19/34 , C12Q1/686 , C12Q1/6874 , G01N27/4145 , Y10T428/2982 , C08F257/02 , C08F2222/1013 , C08F212/36 , C08F220/60 , C12Q2563/149 , C12Q2563/159 , C12Q2565/543
Abstract: A method of forming a particle includes, in a disperse phase within an aqueous suspension, polymerizing a plurality of mer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups. The method further includes converting the polymeric particle to a hydrophilic particle.
Abstract translation: 形成颗粒的方法包括在水性悬浮液中的分散相中聚合具有疏水保护基团的亲水性单体的多个聚合单元，从而形成包含多个疏水保护基团的聚合物颗粒。 该方法还包括将聚合物颗粒转化为亲水性颗粒。
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公开(公告)号：US20230322996A1
公开(公告)日：2023-10-12
申请号：US18053066
申请日：2022-11-07
Applicant: LIFE TECHNOLOGIES AS
Inventor： Huey Wen OOI , Pontus LUNDBERG , Maxi-Lu BOESCHEN , Hilde ALMAASBAK , Tuva Holt HERENG , Tor Espen STAV-NORAAS , Ole LANDSVERK , Geir FONNUM
IPC: C08F283/04
CPC classification number: C08F283/04
Abstract: The invention relates to polymer-interaction molecule (e.g., antibodies) conjugates and uses of such conjugates for delivery of interaction molecules to cells. The invention also relates uses polymer-interaction molecule (e.g., antibodies) conjugates for eliciting cellular responses (e.g., induction of cell proliferation).
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公开(公告)号：US20230295605A1
公开(公告)日：2023-09-21
申请号：US18069171
申请日：2022-12-20
Applicant: LIFE TECHNOLOGIES AS
Inventor： Laure JOBERT
IPC: C12N15/10
CPC classification number: C12N15/1013
Abstract: This invention relates to methods and compositions for coupling nucleic acid to a functionalized surface or support. In particular, the present invention provides an improved process for coupling aminated nucleic acid to a support functionalized with carboxylic acid groups, wherein the coupling reaction is conducted in the presence of an organic solvent. The invention further relates to compositions and kits for performing the coupling reaction and uses of nucleic acid-loaded supports for various applications.
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公开(公告)号：US11130833B2
公开(公告)日：2021-09-28
申请号：US17066326
申请日：2020-10-08
Applicant: Life Technologies AS
Inventor： Geir Fonnum , Nils Pontus Lundberg , Muhammed Talha Gokmen , Synne Larsen , Wilhelm Glomm , Heidi Johnsen , Ruth Schmid , Lars Kilaas
IPC: C08F265/10 , C08F120/54 , C08F265/06
Abstract: This invention relates to monodisperse cross-linked hydrogel polymer particles comprising a polymer formed from (a) a hydrophilic vinylic monomer; and (b) a crosslinker comprising at least two vinyl groups. The invention also relates to monodisperse seed particles with a Z-average diameter of from 100 nm to 1500 nm that comprise a plurality of non-crosslinked oligomers of poly N,N-dimethylacrylamide. Also provided are methods of forming the monodisperse cross-linked hydrogel polymer particles and monodisperse seed particles.
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