公开(公告)号：US09921166B2

公开(公告)日：2018-03-20

申请号：US14478197

申请日：2014-09-05

Applicant: Meso Scale Technologies, LLC

Inventor： Eli N. Glezer ,  Jonathan K. Leland ,  Mark A. Billadeau ,  Joseph M. Leginus ,  Bandele Jeffrey-Coker ,  Jeff D. Debad ,  Koustubh A. Phalnikar ,  Sriram Jambunathan

IPC: G01N21/76 ,  B01L3/00 ,  B01L9/00 ,  C12Q1/00 ,  G01N33/543 ,  G01N27/30 ,  B01J19/00 ,  B33Y80/00 ,  C40B40/10

CPC classification number: G01N21/76 ,  B01J19/0046 ,  B01J2219/00653 ,  B01J2219/00725 ,  B01J2219/0074 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/5029 ,  B01L9/527 ,  B01L2200/0684 ,  B01L2200/10 ,  B01L2300/0645 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/0887 ,  B01L2400/049 ,  B01L2400/0688 ,  B33Y80/00 ,  C12Q1/001 ,  C40B40/10 ,  G01N27/30 ,  G01N33/5438 ,  G01N2458/30 ,  Y10T436/25 ,  Y10T436/25375 ,  Y10T436/255

Abstract: Assay modules, preferably assay cartridges, are described as are reader apparatuses which may be used to control aspects of module operation. The modules preferably comprise a detection chamber with integrated electrodes that may be used for carrying out electrode induced luminescence measurements. Methods are described for immobilizing assay reagents in a controlled fashion on these electrodes and other surfaces. Assay modules and cartridges are also described that have a detection chamber, preferably having integrated electrodes, and other fluidic components which may include sample chambers, waste chambers, conduits, vents, bubble traps, reagent chambers, dry reagent pill zones and the like. In certain preferred embodiments, these modules are adapted to receive and analyze a sample collected on an applicator stick.

公开(公告)号：US20180074082A1

公开(公告)日：2018-03-15

申请号：US15564581

申请日：2016-04-06

Applicant: Eli N. GLEZER ,  Carl EDENS ,  Bandele JEFFREY-COKER ,  Sandor KOVACS ,  Christopher FRYE ,  Meso Scale Technologies, LLC.

Inventor： Eli N. Glezer ,  Carl Edens ,  Bandele Jeffery-Coker ,  Sandor Kovacs ,  Christopher Frye

IPC: G01N35/00 ,  B01F11/00 ,  G01N35/10 ,  G01N33/543 ,  B06B1/16

Abstract: The present invention relates to a system for performing assays on a solid phase to measure the level of analyte in a sample. Such a system may perform immunoassays using electrochemiluminescence (ECL) including a counterbalanced orbital shaking apparatus for assay consumables.

公开(公告)号：USD812836S1

公开(公告)日：2018-03-13

申请号：US29571985

申请日：2016-07-22

Applicant: Meso Scale Technologies, LLC.

Designer： Jacob N. Wohlstadter ,  Rodger Darin Osborne ,  Jennifer Parker ,  Aaron Leimkuehler ,  Manish Kochar ,  Peter Bosco ,  Michael Wade

公开(公告)号：US20180045720A1

公开(公告)日：2018-02-15

申请号：US15601297

申请日：2017-05-22

Applicant: Meso Scale Technologies, LLC.

Inventor： John Joern ,  Joseph Manimala ,  Keith McClary ,  Pankaj Oberoi ,  Gisbert Spieles ,  David Stewart ,  James Wilbur

IPC: G01N33/543 ,  G01N33/58 ,  G01N33/68 ,  G01N33/53

CPC classification number: G01N33/54306 ,  G01N33/53 ,  G01N33/58 ,  G01N33/68 ,  G01N33/6863 ,  G01N2800/60

Abstract: Described herein are kits and components thereof used for a multiplexed analysis of a set of cytokines.

公开(公告)号：US09878323B2

公开(公告)日：2018-01-30

申请号：US13662553

申请日：2012-10-29

Applicant: MESO SCALE TECHNOLOGIES, LLC

Inventor： Eli N. Glezer ,  Bandele Jeffrey-Coker ,  Jeffery D. Debad ,  Sudeep M. Kumar ,  George B. Sigal ,  Gisbert Spieles ,  Michael Tsionsky ,  Michael Warnock

IPC: C12Q1/00 ,  B01L3/00 ,  G01N33/543

CPC classification number: B01L3/5025 ,  B01L3/5085 ,  B01L2200/12 ,  B01L2200/16 ,  B01L2300/0636 ,  B01L2300/0645 ,  B01L2300/0829 ,  B01L2300/0851 ,  B01L2300/0858 ,  B01L2300/105 ,  G01N33/54366 ,  G01N33/54393 ,  Y10S436/809

Abstract: We describe assay modules (e.g., assay plates, cartridges, multi-well assay plates, reaction vessels, etc.), processes for their preparation, and method of their use for conducting assays. Reagents may be present in free form or supported on solid phases including the surfaces of compartments (e.g., chambers, channels, flow cells, wells, etc.) in the assay modules or the surface of colloids, beads, or other particulate supports. In particular, dry reagents can be incorporated into the compartments of these assay modules and reconstituted prior to their use in accordance with the assay methods. A desiccant material may be used to maintain and stabilize these reagents in a dry state.

公开(公告)号：USD799716S1

公开(公告)日：2017-10-10

申请号：US29558606

申请日：2016-03-18

Applicant: Meso Scale Technologies, LLC.

Designer： Eric Jones ,  Stanley Todd Smith ,  Jennifer Parker ,  Manish Kochar

公开(公告)号：US09773062B2

公开(公告)日：2017-09-26

申请号：US15178964

申请日：2016-06-10

Applicant: Meso Scale Technologies, LLC.

Inventor： Xinri Cong ,  Jerome Jackson ,  Carl Stevens ,  Michael Vock ,  Jacob N. Wohlstadter

IPC: G06F17/30 ,  G06F19/00 ,  G06Q10/10 ,  G07C9/00 ,  G01N35/00 ,  G01N35/04 ,  G01N35/10 ,  G06Q10/06 ,  G06Q30/02 ,  G06F19/28

CPC classification number: G06F17/30864 ,  G01N35/00871 ,  G01N35/0099 ,  G01N35/04 ,  G01N35/1002 ,  G01N2035/00881 ,  G01N2035/0425 ,  G01N2035/0475 ,  G06F17/30289 ,  G06F19/00 ,  G06F19/28 ,  G06Q10/06 ,  G06Q10/10 ,  G06Q30/0201 ,  G06Q30/0625 ,  G07C9/00103 ,  G16H10/40

Abstract: The present invention relates to methods, devices and systems for associating consumable data with an assay consumable used in a biological assay. Provided are assay systems and associated consumables, wherein the assay system adjusts one or more steps of an assay protocol based on consumable data specific for that consumable. Various types of consumable data are described, as well as methods of using such information in the conduct of an assay by an assay system.

公开(公告)号：US20170242012A1

公开(公告)日：2017-08-24

申请号：US15488743

申请日：2017-04-17

Applicant: Meso Scale Technologies, LLC.

Inventor： Simone Barbero ,  Eli N. Glezer ,  Anu Mathew

IPC: G01N33/574 ,  A61K31/5377

CPC classification number: G01N33/57415 ,  A61K31/5377 ,  C12Q1/42 ,  C12Q1/485 ,  G01N2333/912 ,  G01N2333/916 ,  G01N2800/52

Abstract: The present invention relates to methods of diagnosing breast cancer in a patient, as well as methods of monitoring the progression of breast cancer and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.

公开(公告)号：US20170199212A1

公开(公告)日：2017-07-13

申请号：US15468734

申请日：2017-03-24

Applicant: Meso Scale Technologies, LLC.

Inventor： Craig P. Lovell ,  Thomas Lucas Hampton, III

IPC: G01N35/00 ,  B01L3/00 ,  G01N35/02 ,  G05B15/02

CPC classification number: G01N35/00871 ,  B01L3/5085 ,  B01L3/545 ,  B01L9/50 ,  B01L2300/021 ,  G01N35/00584 ,  G01N35/028 ,  G01N2035/00831 ,  G01N2035/0491 ,  G05B15/02 ,  Y10T436/11

Abstract: A flexible instrument control and data storage/management system and method for representing and processing assay plates having one or more predefined plate locations is disclosed. The system utilizes a graph data structure, layer objects and data objects. The layer objects map the graph data structure to the data objects. The graph data structure can comprise one node for each of the one or more predefined plate locations, wherein the nodes can be hierarchically defined according to a predefined plate location hierarchy. Each node can be given a unique node identifier, a node type and a node association that implements the predefined plate location hierarchy. The layer objects can include an index that maps the node identifiers to the data objects.

公开(公告)号：US20170168070A1

公开(公告)日：2017-06-15

申请号：US15388358

申请日：2016-12-22

Applicant: Meso Scale Technologies, LLC. ,  Crescendo Bioscience ,  Oklahoma Medical Research Foundation

Inventor： Pankaj Oberoi ,  Steven C. Hoffmann ,  Guy L. Cavet ,  Yijing Shen ,  Nicholas Knowlton ,  Michael Centola

IPC: G01N33/68 ,  G06F19/24

CPC classification number: G01N33/6893 ,  C12Q1/6883 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N33/53 ,  G01N33/564 ,  G01N2333/4709 ,  G01N2333/4737 ,  G01N2333/475 ,  G01N2333/485 ,  G01N2333/5412 ,  G01N2333/70503 ,  G01N2333/70578 ,  G01N2333/72 ,  G01N2333/96494 ,  G01N2800/102 ,  G01N2800/60 ,  G16B40/00

Abstract: Biomarkers useful for diagnosing and assessing inflammatory disease are provided, along with kits for measuring their expression. The invention also provides predictive models, based on the biomarkers, as well as computer systems, and software embodiments of the models for scoring and optionally classifying samples. The biomarkers include at least two biomarkers selected from the DAIMRK group and the score is a disease activity index (DAI).