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    METHODS OF USING AN ARRAY OF POOLED PROBES IN GENETIC ANALYSIS
    42.
    发明申请
    METHODS OF USING AN ARRAY OF POOLED PROBES IN GENETIC ANALYSIS 有权
    在遗传分析中使用沉积探针阵列的方法

    公开(公告)号：US20110009289A1

    公开(公告)日：2011-01-13

    申请号：US12858237

    申请日：2010-08-17

    Applicant: ERIK GENTALEN ,  MARK CHEE

    Inventor： ERIK GENTALEN ,  MARK CHEE

    IPC: C40B30/04 ,  C40B40/06

    CPC classification number: C12Q1/6837 ,  C12Q1/6827 ,  C12Q1/6874 ,  C12Q2565/543 ,  C12Q2565/513

    Abstract: The invention provides arrays of polynucleotide probes having at least one pooled position. A typical array comprises a support having at least three discrete regions. A first region bears a pool of polynucleotide probes comprising first and second probes. A second region bears the first probe without the second probe and a third region bears the second probe without the first probe. A target nucleic acid having segments complementary to both the first and second probes shows stronger normalized binding to the first region than to the aggregate of binding to the second and third regions due to cooperative binding of pooled probes in the first region. The invention provides methods of using such arrays for e.g., linkage analysis, sequence analysis, and expression monitoring.

    Abstract translation: 本发明提供具有至少一个合并位置的多核苷酸探针阵列。 典型的阵列包括具有至少三个离散区域的支撑件。 第一区域具有包含第一和第二探针的多核苷酸探针池。 第二区域承载第一探针而没有第二探针，第三区域承载第二探针而没有第一探针。 具有与第一和第二探针两者互补的区段的靶核酸由于在第一区域中的合并探针的协同结合而显示比第一区域更强的标准化结合，而不是与第二和第三区域结合的聚集体。 本发明提供了使用这种阵列进行例如连锁分析，序列分析和表达监测的方法。

    METHODS OF USING AN ARRAY OF POOLED PROBES IN GENETIC ANALYSIS
    44.
    发明申请
    METHODS OF USING AN ARRAY OF POOLED PROBES IN GENETIC ANALYSIS 审中-公开
    在遗传分析中使用沉积探针阵列的方法

    公开(公告)号：US20100041569A1

    公开(公告)日：2010-02-18

    申请号：US11876920

    申请日：2007-10-23

    Applicant: Erik Gentalen ,  Mark Chee

    Inventor： Erik Gentalen ,  Mark Chee

    IPC: C40B40/06

    CPC classification number: C12Q1/6837 ,  C12Q1/6827 ,  C12Q1/6874 ,  C12Q2565/543 ,  C12Q2565/513

    Abstract: The invention provides arrays of polynucleotide probes having at least one pooled position. A typical array comprises a support having at least three discrete regions. A first region bears a pool of polynucleotide probes comprising first and second probes. A second region bears the first probe without the second probe and a third region bears the second probe without the first probe. A target nucleic acid having segments complementary to both the first and second probes shows stronger normalized binding to the first region than to the aggregate of binding to the second and third regions due to cooperative binding of pooled probes in the first region. The invention provide methods of using such arrays for e.g., linkage analysis, sequence analysis, and expression monitoring.

    Abstract translation: 本发明提供具有至少一个合并位置的多核苷酸探针阵列。 典型的阵列包括具有至少三个离散区域的支撑件。 第一区域具有包含第一和第二探针的多核苷酸探针池。 第二区域承载第一探针而没有第二探针，第三区域承载第二探针而没有第一探针。 具有与第一和第二探针两者互补的区段的靶核酸由于在第一区域中的合并探针的协同结合而显示比第一区域更强的标准化结合，而不是与第二和第三区域结合的聚集体。 本发明提供了使用这种阵列进行例如连锁分析，序列分析和表达监测的方法。

    Methods for mixing fluid in a rotating container
    48.
    发明授权
    Methods for mixing fluid in a rotating container 有权
    将流体混合在旋转容器中的方法

    公开(公告)号：US07125161B2

    公开(公告)日：2006-10-24

    申请号：US10727877

    申请日：2003-12-03

    Applicant: James L. Winkler ,  Mark Chee ,  David Lockhart

    Inventor： James L. Winkler ,  Mark Chee ,  David Lockhart

    IPC: B01F11/00

    CPC classification number: B01J19/28 ,  B01F9/0021 ,  B01J2219/00488 ,  B01J2219/00529 ,  B01J2219/00596 ,  B01J2219/00608 ,  B01J2219/00659 ,  B01J2219/00722 ,  C40B40/06 ,  C40B60/14 ,  Y10S435/809

    Abstract: The invention provides exemplary devices, systems and methods for mixing of fluids, such as biological fluids. One exemplary device comprises is particularly adapted for holding at least one cartridge having a chamber containing a biological fluid, with the chamber having a generally planar face. The device comprises a rotatable body having a rotational axis. The rotatable body includes at least one mounting element which is adapted to mount the rotatable body such that the face of the chamber is generally perpendicular to the rotational axis.

    Abstract translation: 本发明提供了用于混合流体例如生物流体的示例性装置，系统和方法。 一个示例性装置包括特别适用于保持具有包含生物流体的腔室的至少一个筒，该腔室具有大致平坦的面。 该装置包括具有旋转轴线的可转动体。 可旋转主体包括至少一个安装元件，该安装元件适于安装可旋转主体，使得腔室的表面大致垂直于旋转轴线。

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