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66 条记录 (耗时 0.036 秒)

    PTPN11 (SHP-2) mutations and cancer
    41.
    发明申请
    PTPN11 (SHP-2) mutations and cancer 有权
    PTPN11（SHP-2）突变和癌症

    公开(公告)号：US20040121384A1

    公开(公告)日：2004-06-24

    申请号：US10703210

    申请日：2003-11-05

    申请人： Mount Sinai School of Medicine of New York University ,  Universitaetsklinikum Freiburg

    发明人： Bruce D. Gelb ,  Marco Tartaglia ,  Charlotte Niemeyer

    IPC分类号： C12Q001/68

    CPC分类号： C07K14/705 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/16

    摘要： Diagnostic and therapeutic applications for certain types of cancer and precancerous conditions, including those deriving from hematologic cells, are described. Of particular interest are those cancers and precancerous conditions associated with increased signaling in the RAS-MAP kinase pathway. The diagnostic and therapeutic applications described herein are based on certain mutations in the protein tyrosine phosphatase gene PTPN11 and its expression product, PTPN11, promoting a gain-of-function in PTPN11 activity. Also described are nucleotide sequences, amino acid sequences, probes, and primers related to PTPN11 and PTPN11 variants, and cells expressing such variants.

    摘要翻译： 描述了某些类型的癌症和癌前病症的诊断和治疗应用，包括来自血液细胞的那些。 特别感兴趣的是与RAS-MAP激酶途径中增加的信号传导相关的那些癌症和癌前病症。 本文描述的诊断和治疗应用基于蛋白酪氨酸磷酸酶基因PTPN11及其表达产物PTPN11中某些突变，其促进PTPN11活性中的功能增益。 还描述了与PTPN11和PTPN11变体相关的核苷酸序列，氨基酸序列，探针和引物，以及表达这些变体的细胞。

    Noonan syndrome gene
    43.
    发明申请
    Noonan syndrome gene 有权
    Noonan综合征基因

    公开(公告)号：US20030125289A1

    公开(公告)日：2003-07-03

    申请号：US10262552

    申请日：2002-10-01

    申请人： Mount Sinai School of Medicine of New York University

    发明人： Bruce D. Gelb ,  Marco Tartaglia

    IPC分类号： A61K048/00 ,  A61K038/17 ,  C12Q001/68 ,  G01N033/53 ,  G01N033/567

    CPC分类号： C12N9/16 ,  A61K38/00 ,  A61K2039/505 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/172

    摘要： Diagnostic and therapeutic applications for Noonan Syndrome are described. The diagnostic and therapeutic applications are based on certain mutations in the protein tyrosine phosphatase gene PTPN11 and its expression product, PTPN11, as well as mutations in other components in a PTPN11 signal transduction pathway promoting an increased signaling flux. Also described are nucleotide sequences, amino acid sequences, probes, and primers related to PTPN11 and PTPN11 variants, and cells expressing such variants.

    摘要翻译： 描述了Noonan综合征的诊断和治疗应用。 诊断和治疗应用基于蛋白酪氨酸磷酸酶基因PTPN11及其表达产物PTPN11中的某些突变，以及PTPN11信号转导途径中其他成分的突变，促进增加的信号通量。 还描述了与PTPN11和PTPN11变体相关的核苷酸序列，氨基酸序列，探针和引物，以及表达这些变体的细胞。

    Methods for viral oncoapoptosis in cancer therapy
    44.
    发明申请
    Methods for viral oncoapoptosis in cancer therapy 审中-公开
    癌症治疗中病毒性癌细胞凋亡的方法

    公开(公告)号：US20020187126A1

    公开(公告)日：2002-12-12

    申请号：US10118655

    申请日：2002-04-08

    申请人： Mount Sinai School of Medicine

    发明人： John A. Blaho ,  Martine Aubert

    IPC分类号： C12N015/869 ,  A61K048/00

    CPC分类号： C12N7/00 ,  A61K48/005 ,  C07K14/005 ,  C12N2710/16622 ,  C12N2710/16662

    摘要： The present invention provides an effective approach to inducing apoptosis of cancer cells, for anti-cancer therapy, using modified herpes viruses (HSV). The modification, deletion of an immediate early gene, results in a replication defective HSV (rdHSV). As a result of deletion of the immediate early gene, specifically ICP27 or ICP4, or both, the modified HSV is unable to complete its replication cycle while inducing apoptosis of the infected tumor cell. A particular advantage of this approach is that induction of apoptosis is specific for tumor cells, but not for normal cells. Moreover, the modified HSV can be engineered to contain a cancer therapeutic gene, i.e., it can act as a cancer therapeutic gene therapy vector, although it has potent anti-tumor activity on its own.

    摘要翻译： 本发明提供使用修饰的疱疹病毒（HSV）来诱导癌细胞凋亡，用于抗癌治疗的有效方法。 立即早期基因的修饰，缺失导致复制缺陷型HSV（rdHSV）。 由于立即早期基因，特别是ICP27或ICP4或两者的缺失，修饰的HSV不能完成其复制循环，同时诱导感染的肿瘤细胞的凋亡。 这种方法的一个特别的优点是细胞凋亡的诱导对肿瘤细胞是特异性的，而不是对于正常细胞。 此外，修饰的HSV可以被设计成含有癌症治疗基因，即它可以作为癌症治疗基因治疗载体，尽管它本身具有有效的抗肿瘤活性。

    Inhibition of ATF2 activity to treat cancer
    45.
    发明申请
    Inhibition of ATF2 activity to treat cancer 失效
    抑制ATF2活性治疗癌症

    公开(公告)号：US20020169121A1

    公开(公告)日：2002-11-14

    申请号：US10076905

    申请日：2002-02-14

    申请人： Mount Sinai School of Medicine

    发明人： Ze?apos;ev Ronai

    IPC分类号： A61K038/17

    CPC分类号： C07K14/4705 ,  A61K38/00

    摘要： The present invention relates to novel therapies for cancer and, in particular, to therapies that are particularly suited to tumor cells resistant to other types of therapies such as radiation, chemotherapy, or combinations of both approaches. The invention provides methods for identifying and implementing strategies to inhibit a transcription factor which, in combination with other factors, renders the cells resistant and inhibits apopotosis of the cells. The invention provides an inhibitory ATF2 N-terminal fragment, specifically a fragment corresponding to amino acid residues 50-100 of ATF2 (termed peptide II). The invention provides methods for inhibiting tumor cell growth with such peptides.

    摘要翻译： 本发明涉及用于癌症的新疗法，特别涉及特别适用于对其它类型疗法如辐射，化疗或两种方法的组合有抗性的肿瘤细胞的治疗。 本发明提供了用于鉴定和实施抑制转录因子的策略的方法，所述策略与其他因素结合使细胞具有抗性并抑制细胞的凋亡。 本发明提供抑制性ATF2 N-末端片段，特别是对应于ATF2的氨基酸残基50-100（称为肽II）的片段。 本发明提供了用这种肽抑制肿瘤细胞生长的方法。

    POOLED ADAPTER STRATEGY FOR REDUCING BIAS IN SMALL RNA CHARACTERIZATION
    47.
    发明申请
    POOLED ADAPTER STRATEGY FOR REDUCING BIAS IN SMALL RNA CHARACTERIZATION 审中-公开

    公开(公告)号：US20200172972A1

    公开(公告)日：2020-06-04

    申请号：US16784848

    申请日：2020-02-07

    申请人： Mount Sinai School of Medicine

    发明人： Ravi Sachidanandam ,  Anitha Jayaprakash ,  Brian Brown

    IPC分类号： C12Q1/6876 ,  C12Q1/6855

    摘要： Modified nucleic acid adapters are provided that collectively provide a mixture of nucleotides at the 3′ end of 5′ adapters and at the 5′ end of 3′ adapters such that at least one adapter in each set has any given nucleotide at position 1, i.e., the nucleotide position available for ligation to a small RNA, and has any given nucleotide at position 2 adjacent to position 1 for use in overcoming bias during nucleic acid manipulation, such as small RNA characterization and/or profiling by, e.g., deep sequencing, along with methods for use of the modified adapters in small RNA characterization. The modified adapters have at least two mixed nucleotides at the adapter terminus to be ligated to a nucleic acid such as a small RNA.

    Method For Increasing The Activity Of Lysosomal Enzymes
    50.
    发明申请
    Method For Increasing The Activity Of Lysosomal Enzymes 有权
    增加溶酶体活性的方法

    公开(公告)号：US20140051725A1

    公开(公告)日：2014-02-20

    申请号：US13867914

    申请日：2013-04-22

    申请人： Mount Sinai School of Medicine of New York University

    发明人： Jian-Qiang Fan ,  Satoshi Ishii ,  Naoki Asano

    IPC分类号： A61K31/445

    CPC分类号： A61K31/445 ,  A61K31/70 ,  A61K31/7008 ,  C07D451/06 ,  C12N9/2465

    摘要： Method for enhancing in a mammalian cell the activity of an enzyme associated with Gaucher Disease by administering a competitive inhibitor of glucocerebrosidase in an amount effective to enhance the activity of the enzyme. Preferred compounds for use in the method are imino sugars and related compounds. In particular, C8-12-alkyl derivatives of N-alkyl-deoxynojirimycin, isofagomine compounds, and calystegine compounds are effective to enhance glucocerebrosidase activity.

    摘要翻译： 通过以有效增加酶的活性的量施用葡糖脑苷脂酶的竞争性抑制剂，在哺乳动物细胞中增强与戈谢病相关的酶的活性的方法。 用于该方法的优选化合物是亚氨基糖和相关化合物。 特别地，N-烷基脱氧野尻霉素的C8-12-烷基衍生物，异佛胺化合物和钙半胱氨酸化合物对增强葡糖脑苷脂酶活性是有效的。