公开(公告)号：US12016959B2

公开(公告)日：2024-06-25

申请号：US17163871

申请日：2021-02-01

Applicant: OSAKA UNIVERSITY ,  NATIONAL INSTITUTE FOR MATERIALS SCIENCE ,  NIPPON ZOKI PHARMACEUTICAL CO., LTD.

Inventor： Hiroyuki Tanaka ,  Kiyoshi Okada ,  Hideki Yoshikawa ,  Koji Suzuki ,  Mitsuhiro Ebara

IPC: A61K9/70 ,  A61K31/714 ,  A61K35/36 ,  A61K38/18 ,  A61K45/00 ,  A61K47/32 ,  A61K47/34 ,  A61K47/36 ,  A61P25/02

CPC classification number: A61K9/7007 ,  A61K9/70 ,  A61K31/714 ,  A61K35/36 ,  A61K38/18 ,  A61K38/185 ,  A61K45/00 ,  A61K47/32 ,  A61K47/34 ,  A61K47/36 ,  A61P25/02

Abstract: A sustained release sheet that includes a drug for treating nerve injury, wherein the sheet is applied to a nerve injury site, can maintain a high concentration of the drug over a long period, and promotes nerve regeneration without stimulating the nerves, even when the sheet is implanted in the periphery of the nerve injury site. Also provided is a production method for the sheet. This sustained drug release sheet for treating nerve injury is a sheet including a non-woven fabric that is formed from nanofibers each containing a drug such as vitamin B12 and a biocompatible polymer such as a biodegradable aliphatic polyester, and is implanted in the periphery of the nerve injury site to promote nerve regeneration.

公开(公告)号：US20240197753A1

公开(公告)日：2024-06-20

申请号：US18283585

申请日：2022-03-25

Applicant: OSAKA UNIVERSITY ,  CUORIPS INC.

Inventor： Yoshiki SAWA ,  Shigeru MIYAGAWA ,  Yoshiki SAKAI ,  Yasuhiro YANAGI

IPC: A61K31/559 ,  A61K9/06 ,  A61K9/16 ,  A61K9/70 ,  A61K47/42 ,  A61P9/04

CPC classification number: A61K31/559 ,  A61K9/06 ,  A61K9/1647 ,  A61K9/7007 ,  A61K47/42 ,  A61P9/04

Abstract: An object is to provide a pharmaceutical composition that improves cardiac function when administered during coronary artery bypass surgery for ischemic cardiomyopathy. A pharmaceutical composition for improving cardiac function comprising: (A) a release formulation comprising at least poly(lactic-co-glycolic acid) (PLGA) and a prostaglandin 12 receptor agonist, the PLGA having an average molecular weight of 10000 to 30000; and (B) a release formulation comprising at least poly(lactic-co-glycolic acid) (PLGA) and a prostaglandin 12 receptor agonist, the PLGA having an average molecular weight of 40000 to 60000.

公开(公告)号：US12013365B2

公开(公告)日：2024-06-18

申请号：US17258662

申请日：2019-07-18

Applicant: OSAKA UNIVERSITY

Inventor： Kohji Nishida ,  Noriyasu Hashida ,  Masateru Taniguchi ,  Makusu Tsutsui

IPC: G01N27/327 ,  G01N27/447 ,  G01N33/487 ,  G01N33/569

CPC classification number: G01N27/3278 ,  G01N27/447 ,  G01N33/48721 ,  G01N33/56983

Abstract: Provided are a virus measuring method, a virus measuring device, a virus determining program, a stress determining method, and a stress determining device. A virus measuring method includes a contact step of bringing a liquid specimen containing a body fluid of a subject and an electrolytic solution into contact with each other via a through-hole portion formed in a separating wall, a current measuring step of applying a voltage to the liquid specimen and the electrolytic solution with respect to the through-hole portion and obtaining a waveform of an ionic current flowing through the through-hole portion, and a virus determining step of determining the kind of a virus contained in the body fluid on the basis of the waveform. In the virus determining step, the kind of the virus is determined by comparing the waveform with waveform information that corresponds to a known virus and is obtained beforehand.

公开(公告)号：US11986901B2

公开(公告)日：2024-05-21

申请号：US17291557

申请日：2020-03-06

Applicant: NGK SPARK PLUG CO., LTD. ,  OSAKA UNIVERSITY

Inventor： Hidetoshi Fujii ,  Yoshiaki Morisada ,  Yusuke Katsu ,  Hiroki Takeuchi

IPC: B23K20/00 ,  B23K20/12 ,  B23K103/04

CPC classification number: B23K20/1255 ,  B23K2103/04

Abstract: A friction stir welding tool (1) has a shoulder portion (2) and a probe portion (6) provided on a bottom surface of the shoulder portion (2). The probe portion (6) has a length of 5.5 mm or more. In the friction stir welding tool (1), a ceramic material whose main phase is silicon nitride or sialon is used as a base material.

公开(公告)号：US20240162452A1

公开(公告)日：2024-05-16

申请号：US18548359

申请日：2022-03-14

Applicant: OSAKA UNIVERSITY

Inventor： Yu Katayama ,  Ryutaro Ono ,  Asuka Morinaga ,  Tomoya Higo ,  Shunsaku Uchiyama

IPC: H01M4/90 ,  C25B1/21

CPC classification number: H01M4/9016 ,  C25B1/21

Abstract: It is an object of the present invention to provide a catalyst having high catalytic activity for oxygen reduction reaction, hydrogen evolution reaction, and the like, particularly a catalyst employing platinum group particles having a small particle diameter. A layered manganese oxide comprising platinum group metal particles between layers. A method for producing a layered manganese oxide comprising platinum group metal particles between layers, or platinum group metal particles, the method comprising introducing a platinum group complex between layers of a layered manganese oxide and reducing the introduced platinum group complex by electrolysis, wherein a potential applied to the platinum group complex is changed in a positive direction and a negative direction.

公开(公告)号：US20240157467A1

公开(公告)日：2024-05-16

申请号：US18284426

申请日：2022-03-18

Applicant: OSAKA UNIVERSITY

Inventor： Hidetoshi FUJII ,  Yoshiaki MORISADA ,  Yasuhiro AOKI

IPC: B23K20/12

CPC classification number: B23K20/1205 ,  B23K2103/12

Abstract: Provided are an easy and efficient linear friction-joining method with which it is possible to form an excellent joined section between materials being joined that are of different sizes and shapes, and a linear friction-joining structure obtained through the aforementioned friction-joining method. The present invention discloses a linear friction-joining method characterized by having a first step for bringing an end surface of one member into contact with an end surface of another member to form a joining interface, a second step for repeatedly causing the one member and the other member to slide on the same trajectory in a state in which pressure is applied roughly perpendicularly to the joining interface and eliminating burrs from the joining interface, and a third step for stopping the sliding and forming a joined surface, the linear friction-joining method also being characterized in that the end surface of the one member and the end surface of the other member have different surface areas, and in that the protrusion length of the member having the lesser surface area is set equal to or greater than the upset distance.

公开(公告)号：US20240153248A1

公开(公告)日：2024-05-09

申请号：US18228679

申请日：2023-08-01

Applicant: Fujitsu Limited ,  OSAKA UNIVERSITY

Inventor： Ryosuke KAWAMURA ,  Noriko IKEMOTO TAKEMURA ,  Hajime NAGAHARA

IPC: G06V10/774 ,  G06V10/10 ,  G06V10/74 ,  G06V10/764 ,  G06V40/16

CPC classification number: G06V10/774 ,  G06V10/16 ,  G06V10/761 ,  G06V10/764 ,  G06V40/176 ,  G06V10/82

Abstract: A storage unit stores therein first inference results respectively corresponding to a plurality of face images, which are output from a first model of outputting a first inference result in response to an input of a face image. A processing unit selects, from the plurality of face images, first and second face images whose distance calculated based their first inference results exceeds a threshold. The processing unit performs machine learning to train a second model of outputting a second inference result in response to an input of a face image, using a third face image obtained by combining the first and second face images.

公开(公告)号：US20240149060A1

公开(公告)日：2024-05-09

申请号：US18280209

申请日：2022-02-08

Applicant: OSAKA UNIVERSITY

Inventor： Kazuhiro MATSUI

IPC: A61N1/36 ,  A61B5/313 ,  A61B5/316 ,  A61N1/04

CPC classification number: A61N1/36031 ,  A61B5/313 ,  A61B5/316 ,  A61N1/0452

Abstract: The electrical stimulation device includes: positive and negative electrodes to be attached to epidermis of agonist-antagonist muscles acting on a target joint; a display unit; an EMG rehabilitation unit that detects an electromyogram of the agonist-antagonist muscles via the electrodes and outputs variation information corresponding to the detected electromyogram to the display unit; a FES rehabilitation unit that instructs motion of the agonist-antagonist muscles via the display unit and outputs a stimulation current signal corresponding to the instructed motion of the agonist-antagonist muscles to the electrodes; a model (inverse model) storage unit that stores models obtained beforehand and relating to target muscle characteristics, the models including: a model for converting the detected electromyogram into the variation information; and a model for converting information on the motion of the agonist-antagonist muscles into the stimulation current signal; and a rehabilitation processing unit that selectively executes the EMG rehabilitation unit and the FES rehabilitation unit.

公开(公告)号：US20240148775A1

公开(公告)日：2024-05-09

申请号：US18547071

申请日：2022-02-25

Applicant: Osaka University

Inventor： Masahito SHIMOJO ,  Satoshi OBIKA ,  Keishiro MISHIMA ,  Misa YOSHIDA

IPC: A61K31/713 ,  A61P35/00 ,  C12N15/113

CPC classification number: A61K31/713 ,  A61P35/00 ,  C12N15/113

Abstract: An oligonucleotide or a pharmacologically acceptable salt thereof according to the present invention contains a nucleotide sequence complementary to a continuous sequence of at least 12 bases in a target region constituted by a base sequence of SEQ ID No. 1, and induces N-exon skipping in human REST pre-mRNA processing. Such oligonucleotides are useful for manufacturing medicines for treatment of cancer, for example.

公开(公告)号：US11976062B2

公开(公告)日：2024-05-07

申请号：US18073180

申请日：2022-12-01

Applicant: OSAKA UNIVERSITY ,  KYOTO UNIVERSITY ,  INTER-UNIVERSITY RESEARCH INSTITUTE CORP NATIONAL INSTITUTES OF NATURAL SCIENCES

Inventor： Ryu Nagata ,  Yasuo Mori ,  Masayuki Mori ,  Motohiro Nishida ,  Takuro Tomita

IPC: C07D413/12 ,  A61P43/00 ,  C07D261/20 ,  C07D413/04 ,  C07D413/14 ,  C07D417/12 ,  C07D487/08

CPC classification number: C07D413/12 ,  A61P43/00 ,  C07D261/20 ,  C07D413/04 ,  C07D413/14 ,  C07D417/12 ,  C07D487/08

Abstract: The present invention provides a compound, a salt thereof, or a prodrug thereof as a compound effective for preventing and/or treating fibrosis, the compound being represented by formula (1)




(wherein A is an optionally substituted benzene ring; B is optionally substituted aryl or optionally substituted heteroaryl; X is an oxygen atom or a sulfur atom; Y is a nitrogen atom or a carbon atom, of Y is a single or double bond when Y is a carbon atom, or of Y is a single bond when Y is a nitrogen atom; each R1 independently represents lower alkyl, or two R1s may be bound to each other to form a spiro ring or a crosslinked structure, or two R1s may be bound to each other to form a saturated fused heterocycle together with nitrogen and carbon atoms constituting a ring containing Y; p is 0, 1, or 2; or (R1)p is oxo).