公开(公告)号：US10048939B2

公开(公告)日：2018-08-14

申请号：US14907423

申请日：2014-08-28

Applicant: STC.UNM

Inventor： James Plusquellic

IPC: G06F7/58 ,  G09C1/00 ,  H04L9/00 ,  H04L9/08

Abstract: This disclosure describes techniques for analyzing statistical quality of bitstrings produced by a physical unclonable function (PUF). The PUF leverages resistance variations in the power grid wires of an integrated circuit. Temperature and voltage stability of the bitstrings are analyzed. The disclosure also describes converting a voltage drop into a digital code, wherein the conversion is resilient to simple and differential side-channel attacks.

公开(公告)号：US10047135B2

公开(公告)日：2018-08-14

申请号：US14622217

申请日：2015-02-13

Applicant: STC.UNM

Inventor： Yubin Miao

IPC: A61K51/00 ,  A61M36/14 ,  C07K14/68 ,  A61K51/08 ,  A61K45/06 ,  C07K7/54 ,  A61K38/00

Abstract: The present invention is directed to novel non-invasive diagnostic tools/compounds to image cancers, especially, melanoma, including metastatic melanoma in vivo. The present compounds exhibit enhanced uptake in cancerous cells and tissue and decreased renal uptake in kidney, evidencing favorable pharmacokinetics of compounds of the present invention. The compounds according to the present invention represent an advance in the diagnosis and treatment of melanoma, including metastatic melanoma using non-invasive molecular imaging techniques. The novel probes of the present invention are also useful for initiating therapy for melanoma as well as monitor patients' response to chemotherapy treatments and other interventions or therapies used in the treatment of melanoma/metastatic melanoma. Compounds according to the present invention may be used as diagnostic tools for a number of conditions and diseases states as well as therapeutic agents for treating such conditions and disease states.

公开(公告)号：US09934469B1

公开(公告)日：2018-04-03

申请号：US15370224

申请日：2016-12-06

Applicant: National Technology & Engineering Solutions of Sandia, LLC ,  STC.UNM

Inventor： Yuan Yu Jau ,  Grant Biedermann ,  Ivan Deutsch

IPC: G06N99/00

CPC classification number: G06N99/002

Abstract: A method for preparing an entangled quantum state of an atomic ensemble is provided. The method includes loading each atom of the atomic ensemble into a respective optical trap; placing each atom of the atomic ensemble into a same first atomic quantum state by impingement of pump radiation; approaching the atoms of the atomic ensemble to within a dipole-dipole interaction length of each other; Rydberg-dressing the atomic ensemble; during the Rydberg-dressing operation, exciting the atomic ensemble with a Raman pulse tuned to stimulate a ground-state hyperfine transition from the first atomic quantum state to a second atomic quantum state; and separating the atoms of the atomic ensemble by more than a dipole-dipole interaction length.

公开(公告)号：US09925153B2

公开(公告)日：2018-03-27

申请号：US15036968

申请日：2014-12-05

Applicant: STC.UNM

Inventor： David L Vander Jagt ,  Lorraine M Deck ,  Robert E Royer ,  John E Heidrich

IPC: A61K31/085 ,  A61K31/12 ,  A61K45/06 ,  A61K31/09 ,  A61K31/121 ,  A61K31/137 ,  A61K31/222 ,  A61K31/4406 ,  A61K31/4409 ,  A61K9/00 ,  A61K31/05 ,  A61K31/136 ,  A61K31/444

CPC classification number: A61K31/12 ,  A61K9/0014 ,  A61K31/05 ,  A61K31/085 ,  A61K31/09 ,  A61K31/121 ,  A61K31/136 ,  A61K31/137 ,  A61K31/222 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/444 ,  A61K45/06

Abstract: The present invention relates to method(s) of treating a subject afflicted with a skin disease or condition, the method comprising administering to the subject or patient in need a composition comprising a therapeutically effective amount of a substituted cis or trans-stilbene or a stilbene hybrid. A method of treating or reducing the likelihood of a skin disease or condition in a patient is an additional embodiment of the present invention. Preferred pharmaceutical compositions of the invention include nanoemulsions comprising a therapeutically effective amount of a substituted cis or trans-stilbene or stilbene hybrid and at least one antibiotic.

公开(公告)号：US09884107B2

公开(公告)日：2018-02-06

申请号：US15331155

申请日：2016-10-21

Applicant: STC.UNM

Inventor： Bryce C. Chackerian ,  David S. Peabody

IPC: A61K39/155 ,  C07K14/005 ,  A61K39/295 ,  A61K39/12 ,  C12N7/00 ,  A61K47/48 ,  A61K39/00

CPC classification number: A61K39/155 ,  A61K39/12 ,  A61K39/295 ,  A61K47/69 ,  A61K47/6901 ,  A61K47/6929 ,  A61K2039/5256 ,  A61K2039/5258 ,  A61K2039/55566 ,  A61K2039/6075 ,  C07K14/005 ,  C07K2319/40 ,  C12N7/00 ,  C12N2760/18523 ,  C12N2760/18534 ,  C12N2795/00023

Abstract: The invention provides immunotherapeutic and prophylactic bacteriophage viral-like particle (VLPs) which are useful in the treatment and prevention of Respiratory Syncytial Virus (RSV) infections and related disorders, including bronchiolitis and viral pneumonia. Related compositions (e.g. vaccines), nucleic acid constructs, and therapeutic methods are also provided. VLPs and related compositions of the invention induce high titer antibody responses against RSV. VLPs, VLP-containing compositions, and therapeutic methods of the invention induce an immunogenic response against RSV infection, confer immunity against RSV infection, protect against RSV infection, and reduce the likelihood of infection by RSV infection.

公开(公告)号：US20180022805A1

公开(公告)日：2018-01-25

申请号：US15548871

申请日：2016-02-05

Applicant: Bridget S. WILSON ,  Stuart S. WINTER ,  Michael Frank ERASMUS ,  Michael HOROWITZ ,  STC.UNM

Inventor： Bridget S. Wilson ,  Stuart S. Winter ,  Michael Frank Erasmus ,  Michael Horowitz

IPC: C07K16/28

CPC classification number: C07K16/2803 ,  A61K39/3955 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/35 ,  C07K2317/52 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/732 ,  C07K2317/76 ,  C07K2317/92 ,  A61K2300/00

Abstract: This disclosure describes the identification of pre-B Cell Receptor (pre-BCR) antagonists and the use of pre-BCR antagonists as a targeted therapy. The compositions and methods generally involve a composition that includes a pre-B cell receptor (pre-BCR) antagonist and is engineered for expression as a T cell chimeric receptor. In some embodiments, the pre-BCR antagonists can include an anti-pre-BCR antibody.

公开(公告)号：US09766123B2

公开(公告)日：2017-09-19

申请号：US15317592

申请日：2015-06-09

Applicant: STC.UNM

Inventor： Steven R. J. Brueck ,  Alexander Neumann ,  Payman Zarkesh-Ha

IPC: G01J5/02 ,  G01J1/06 ,  G01J3/28 ,  G01J3/18 ,  G01J1/44 ,  H01L27/144 ,  H01L31/0232 ,  H01L31/103 ,  H01L31/02 ,  H01L31/0216 ,  G02B6/122 ,  G02B6/12 ,  G02B6/124

CPC classification number: G01J1/06 ,  G01J1/44 ,  G01J3/0218 ,  G01J3/0259 ,  G01J3/18 ,  G01J3/1895 ,  G01J3/2803 ,  G01J2001/448 ,  G02B6/12004 ,  G02B6/122 ,  G02B6/124 ,  G02B2006/12061 ,  G02B2006/12107 ,  G02B2006/12138 ,  H01L27/1446 ,  H01L31/02019 ,  H01L31/02164 ,  H01L31/02327 ,  H01L31/103

Abstract: A 2-D sensor array includes a semiconductor substrate and a plurality of pixels disposed on the semiconductor substrate. Each pixel includes a coupling region and a junction region, and a slab waveguide structure disposed on the semiconductor substrate and extending from the coupling region to the region. The slab waveguide includes a confinement layer disposed between a first cladding layer and a second cladding layer. The first cladding and the second cladding each have a refractive index that is lower than a refractive index of the confinement layer. Each pixel also includes a coupling structure disposed in the coupling region and within the slab waveguide. The coupling structure includes two materials having different indices of refraction arranged as a grating defined by a grating period. The junction region comprises a p-n junction in communication with electrical contacts for biasing and collection of carriers resulting from absorption of incident radiation.

公开(公告)号：US20170189503A1

公开(公告)日：2017-07-06

申请号：US15118143

申请日：2015-02-11

Applicant: THE USA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES ,  STC.UNM

Inventor： Alan Remaley ,  John T. Schillerr ,  Marcelo Amar ,  Bryce Chackerian

IPC: A61K39/00 ,  A61K45/06 ,  C12N9/64

CPC classification number: A61K39/0005 ,  A61K38/10 ,  A61K45/06 ,  A61K47/6901 ,  A61K2039/60 ,  A61K2039/627 ,  A61P9/10 ,  C07K11/00 ,  C07K14/47 ,  C12N9/6454 ,  C12N2795/18123 ,  C12N2795/18134 ,  C12N2795/18141 ,  C12Y304/21061

Abstract: A vaccine construct comprising an antigenic PCSK9 peptide and an immunogenic carrier, and methods of using the same that are effective to lower blood cholesterol levels in a mammal and treat dyslipidemias and related disease states in a mammal without the frequency of administration required by passive immunity strategies.

公开(公告)号：US09692234B2

公开(公告)日：2017-06-27

申请号：US15031125

申请日：2014-10-21

Applicant: STC.UNM

Inventor： Andrea A. Mammoli ,  Olga Lavrova ,  Brian Arellano ,  Feng Cheng ,  Wesley Greenwood ,  Jonathan Hawkins ,  Steve Willard

IPC: H02J3/32 ,  H02S40/38 ,  H02J3/38 ,  H02J3/12 ,  H02J7/00 ,  H02M3/04 ,  H02M7/44

CPC classification number: H02J3/383 ,  H02J3/12 ,  H02J3/32 ,  H02J3/386 ,  H02J7/0068 ,  H02M3/04 ,  H02M7/44 ,  H02S40/38 ,  Y02E10/563 ,  Y02E10/566 ,  Y02E70/30

Abstract: The present invention is an apparatus and method for delivering energy using a renewable resource. The method includes providing a photovoltaic energy source and applying energy storage to the photovoltaic energy source via a battery storage unit. The energy output from the photovoltaic energy source and the battery system is controlled using a battery control system. The battery control system predicts peak load, develops a schedule that includes when to begin discharging power and when to stop discharging power, shifts power to the battery storage unit when excess power is available, and prioritizes the functionality of the battery storage unit and the photovoltaic energy source.

公开(公告)号：US09671297B2

公开(公告)日：2017-06-06

申请号：US14434313

申请日：2013-10-07

Applicant: STC.UNM ,  Scott Sibbett

Inventor： Scott Sibbett

IPC: G01L1/22 ,  B25J19/02 ,  G06F3/041 ,  G01L1/18 ,  G01L1/20 ,  G01L1/04 ,  G06F3/045 ,  B25J13/08 ,  G01L5/16

CPC classification number: G01L1/22 ,  B25J13/084 ,  B25J19/02 ,  G01L1/04 ,  G01L1/18 ,  G01L1/205 ,  G01L5/162 ,  G06F3/041 ,  G06F3/0414 ,  G06F3/045

Abstract: A pliable pressure sensitive sensor device and method of making the same is provided. The sensor includes first and second pliable protective layers, which cover sets of conductive fibers that spatially separated by an electrically conductive pliable layer, which deforms in response to a pressure event. The fiber sets form a grid pattern and are in electrical communication with sets of electrical contacts located in predetermined locations along the fibers. In response to a pressure event in proximity to the contact, the pliable layer deforms and increases the amount of surface area in contact with an electrical contact whereby an electrical resistance at an individual electrical contact decreases in response to the pressure event.