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    HYDROGEL PRECURSORS HAVING NANOPARTICLES
    44.
    发明申请
    HYDROGEL PRECURSORS HAVING NANOPARTICLES 审中-公开
    具有纳米颗粒的HYDROGEL PRECURSORS

    公开(公告)号：US20160038643A1

    公开(公告)日：2016-02-11

    申请号：US14918229

    申请日：2015-10-20

    Applicant: The University of Kansas

    Inventor： Michael Detamore ,  Emily Beck ,  Stevin Gehrke ,  Cory Berkland

    IPC: A61L27/48 ,  A61L27/52 ,  A61L27/54 ,  A61L27/20 ,  A61L27/38

    CPC classification number: A61L27/48 ,  A61L27/20 ,  A61L27/3817 ,  A61L27/383 ,  A61L27/3834 ,  A61L27/50 ,  A61L27/52 ,  A61L27/54 ,  A61L2430/06 ,  A61L2430/32 ,  C08L5/08

    Abstract: An implantable hydrogel precursor composition can include: a cross-linkable polymer matrix that is biocompatible; and a plurality of polymer particles in the cross-linkable polymer matrix. The cross-linkable polymer matrix can include a cross-linkable hyaluronic acid polymer that has cross-linkable functional groups. The hyaluronic acid polymer can be a methacrylated hyaluronic acid polymer. The methacrylated hyaluronic acid polymer can have a molecular weight from about 500 kDa to about 1.8 MDa. The polymer particles can include a cross-linked hyaluronic acid. The cross-linkable polymer matrix having the polymer particles has a yield stress. The cross-linkable polymer matrix having the polymer particles has shape retention at physiological temperatures. The composition can include live cells in the cross-linkable polymer matrix. The composition can include a biologically active agent in the cross-linkable polymer matrix.

    Abstract translation: 可植入水凝胶前体组合物可以包括：可生物相容的可交联聚合物基质; 和可交联聚合物基质中的多个聚合物颗粒。 可交联聚合物基质可以包括具有可交联官能团的可交联的透明质酸聚合物。 透明质酸聚合物可以是甲基丙烯酸酯化的透明质酸聚合物。 甲基丙烯酸酯化的透明质酸聚合物可以具有约500kDa至约1.8MDa的分子量。 聚合物颗粒可以包括交联的透明质酸。 具有聚合物颗粒的可交联聚合物基质具有屈服应力。 具有聚合物颗粒的可交联聚合物基质在生理温度下具有形状保持性。 组合物可以包括可交联聚合物基质中的活细胞。 组合物可以在可交联的聚合物基质中包括生物活性剂。

    Microstrip antenna for RFID device having both far-field and near-field functionality
    45.
    发明授权
    Microstrip antenna for RFID device having both far-field and near-field functionality 有权
    用于RFID设备的微带天线具有远场和近场功能

    公开(公告)号：US08970378B2

    公开(公告)日：2015-03-03

    申请号：US14025188

    申请日：2013-09-12

    Applicant: The University of Kansas

    Inventor： Daniel D. Deavours ,  Mutharasu Sivakumar

    IPC: G08B13/14 ,  G06K19/077 ,  H01Q9/04 ,  H01Q9/06

    CPC classification number: G06K19/07775 ,  G06K19/07773 ,  H01Q9/0407 ,  H01Q9/045 ,  H01Q9/0464 ,  H01Q9/06

    Abstract: Microstrip patch antenna (46), feed structure (48), and matching circuit (50) designs for an RFID tag (10). A balanced feed design using balanced feeds coupled by a shorting stub (56) to create a virtual short between the two feeds so as to eliminate the need for physically connecting the substrate to the ground plane. A dual feed structure design using a four-terminal IC can be connected to two antennas (46a,46b) resonating at different frequencies so as to provide directional and polarization diversity. A combined near-field/far-field design using a microstrip antenna providing electromagnetic coupling for far-field operation, and a looping matching circuit providing inductive coupling for near-field operation. A dual-antenna design using first and second microstrip antennas providing directional diversity when affixed to a cylindrical or conical object, and a protective superstrate (66). An annular antenna (46c) design for application to the top of a metal cylinder around a stem.

    Abstract translation: 用于RFID标签（10）的微带贴片天线（46），馈电结构（48）和匹配电路（50）设计。 平衡进给设计，使用通过短路短线（56）耦合的平衡进给，以在两个进给之间产生虚拟短路，从而不需要将基板物理连接到接地平面。 使用四端子IC的双馈电结构设计可以连接到以不同频率谐振的两个天线（46a，46b），以便提供方向和极化分集。 使用提供用于远场操作的电磁耦合的微带天线的组合近场/远场设计，以及为近场操作提供感应耦合的循环匹配电路。 使用第一和第二微带天线的双天线设计，当固定到圆柱形或圆锥形物体上时提供定向分集，以及保护性覆层（66）。 环形天线（46c）设计用于施加到围绕杆的金属圆筒的顶部。

    Synthesis of epothilones
    46.
    发明申请
    Synthesis of epothilones 失效
    埃坡霉素的合成

    公开(公告)号：US20020156289A1

    公开(公告)日：2002-10-24

    申请号：US10014754

    申请日：2001-12-11

    Applicant: THE UNIVERSITY OF KANSAS

    Inventor： Gunda I. Georg ,  Sajiv K. Nair ,  Emily Reiff ,  Ashok Rao Tunoori

    IPC: C07D277/22 ,  C07D263/30

    CPC classification number: C07D417/06 ,  C07B2200/07 ,  C07C45/29 ,  C07C67/31 ,  C07C67/343 ,  C07D277/24 ,  C07D493/04 ,  C07F7/1892 ,  C07C47/21 ,  C07C69/734 ,  C07C69/675

    Abstract: Commercially feasible methods for synthesizing various epothilones precursors needed for the preparation of final epothilones are provided, including techniques for the synthesis of epothilone segment A and C precursors. Segment C precursors are prepared using starting nitriles, which can alternately be oxidized to ketones and converted, or reacted to form the diol with subsequent conversion to the segment. Segment A precursors are prepared by reacting a starting enone with a chiral catalyst to give an intermediate alcohol in high enantomeric excess, followed by conversion of the alcohol to the desired Segment A precursor.

    Abstract translation: 提供了用于合成制备最终埃坡霉素所需的各种埃坡霉素前体的商业上可行的方法，包括合成埃博霉素片段A和C前体的技术。 使用起始腈制备段C前体，其可以交替地被氧化成酮并转化，或反应形成二醇，随后转化为链段。 通过使起始烯酮与手性催化剂反应制备段A前体，得到高泛醇过量的中间体醇，随后将醇转化为所需的A段前体。

    Renal tube assay device and methods of manufacture and use
    47.
    发明授权
    Renal tube assay device and methods of manufacture and use 有权

    公开(公告)号：US12281333B2

    公开(公告)日：2025-04-22

    申请号：US17518395

    申请日：2021-11-03

    Applicant: The University of Kansas

    Inventor： Andras Czirok ,  Pamela Tran

    IPC: C12N5/071 ,  C12M1/12 ,  C12M1/34 ,  C12M3/06 ,  G01N33/50

    Abstract: A renal tube assay device can include: a container having an inlet port and an outlet port; a matrix material in the container; and a lumen in the matrix material extending from the inlet port to the outlet port. The lumen can include a luminal surface with at least one low density region that has a lower density compared to another adjacent region of the matrix material that is located at least partially around the at least one low density region. The low density region can have a form of a bubble, bulge, capsule, or the like. The low density region can bulge into the lumen. A port can be adapted for receiving a pipette tip. The matrix material can include a hydrogel. The container can be located in a cell culture dish.

    Graphene oxide-based nanolab and methods of detecting of exosomes
    50.
    发明授权
    Graphene oxide-based nanolab and methods of detecting of exosomes 有权

    公开(公告)号：US10788486B2

    公开(公告)日：2020-09-29

    申请号：US15728155

    申请日：2017-10-09

    Applicant: The University of Kansas ,  Kansas State University Research Foundation

    Inventor： Peng Zhang ,  Yong Zeng ,  Mei He

    IPC: G01N33/543 ,  B01L3/00 ,  G01N33/68

    Abstract: A capture device for capturing a biological substance can include: a substrate; a graphene-oxide layer on the substrate; at least one polydopamine polymer coupled with the graphene-oxide; and at least one targeting receptor coupled to the polydopamine(s), wherein the targeting receptor is capable of targeting/binding with a target biological substance. The graphene-oxide may be covalently coupled with the substrate and polydopamine, and the polydopamine may be covalently coupled with the targeting receptor. The targeting receptor can be an antibody or fragment thereof. The target biological substance can be an exosome. The substrate can be a particle (e.g., magnetic, such as magnetically responsive) or a surface in a microfluidic channel. The surface can be a top surface of a post, the post having a Y-shaped cross-sectional profile. In one aspect, the substrate is a particle. The capture device can include the target biological substance bound to the targeting receptor.

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