公开(公告)号：US11766306B2

公开(公告)日：2023-09-26

申请号：US16620678

申请日：2018-06-11

申请人： THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

发明人： Zach Folzenlogen ,  Joshua Seinfeld ,  Joshua Buehler ,  Talia Cioth ,  Joshua Dwernychuk ,  Nico Andresen ,  Adam Jung ,  Gilang Manurung ,  Hao Yuan

IPC分类号： A61B90/10 ,  A61B90/11 ,  A61B17/34 ,  A61B90/00 ,  A61B17/00

CPC分类号： A61B90/10 ,  A61B17/3423 ,  A61B90/11 ,  A61B2017/00526 ,  A61B2017/3458 ,  A61B2090/103 ,  A61B2090/3983

摘要： The present disclosure relates to an intracranial guide for use in a medical procedure, such as to evacuate a subdural hematoma or to relieve an intracerebral hemorrhage. The intracranial guide generally includes a guide cannula to be received within a portion of a cranial port. The cranial port is configured to be anchored in a burr hole to be formed in the patient's cranium. The guide cannula includes at least one channel that may be used to guide a catheter to a targeted portion of the patient's anatomy or to apply a suction force within the patient's cranium.

公开(公告)号：US20230295265A1

公开(公告)日：2023-09-21

申请号：US18156887

申请日：2023-01-19

申请人： The Regents of The University of Colorado, A Body Corporate

发明人： Brian Freed ,  Christina Roark ,  Elizabeth Sunderhaus

IPC分类号： C07K14/74 ,  A61K35/17 ,  A61K35/28 ,  A61P37/06 ,  C12Q1/6881

CPC分类号： C07K14/70539 ,  A61K35/17 ,  A61K35/28 ,  A61P37/06 ,  C12Q1/6881

摘要： Methods of preventing or treating autoimmune disease are disclosed. In some cases, subjects with having or at risk of developing autoimmune disease are identified as possessing one or more autoimmunity-susceptibility HLA alleles at one or more HLA loci. In many cases, the HLA loci are selected from Class I and Class II loci, for example Class I A, B, and C, and Class II DQ, DR, and DP. In many cases, subjects suffering from or at risk of developing an autoimmune disease may be administered a plurality engineered autologous HSCs modified to carry and express a variant susceptibility allele having at least one mutation in the antigen binding cleft that alters antigen binding and/or specificity of that variant HLA molecule. In many embodiments, the engineered HSCs are CD34+ immune cells that express one or more modified HLA proteins.

公开(公告)号：US20230293662A1

公开(公告)日：2023-09-21

申请号：US18069058

申请日：2022-12-20

申请人： THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

发明人： Theodore Randolph ,  Robert Garcea ,  Kimberly J. Hassett

IPC分类号： A61K39/12 ,  A61K39/295 ,  A61K45/06

CPC分类号： A61K39/12 ,  A61K39/295 ,  A61K45/06 ,  A61K2039/5252

摘要： Embodiments of the present invention provide for novel compositions and methods for making and using a thermally stable human papilloma virus (HPV) formulation or other stabilized multimeric virus formulation. Certain embodiments concern lyophilizing HPV formulations in the presence or absence of adjuvants. Other embodiments concern lypophilizing HPV capsomere vaccines in order to increase stability of an immunogenic composition against HPV infection for storage, delivery and use. In yet other embodiments, a single immunogenic composition can include a thermally stable formulation of multiple virus serotypes.

公开(公告)号：US20230281728A1

公开(公告)日：2023-09-07

申请号：US18000314

申请日：2021-06-01

申请人： The Regents of the University of Colorado, a body corporate

发明人： Lise A. St. Denis

IPC分类号： G06Q50/00 ,  G06Q50/26 ,  G06F18/2415

CPC分类号： G06Q50/01 ,  G06F18/2415 ,  G06Q50/265

摘要： Various embodiments of the present disclosure relate to a multimodal data classifier, and a method of training the classifier therein, that identifies social network messages about an event and filters the messages to provide a reduced amount of content to assist emergency authorities. For each message identified, the classification model identifies features of the message including an account identity and content of the message. Further, it generates a feature embedding for the message based at least on the account identity and the content of the message, and it submits the feature embeddings as input to a machine learning model to obtain one or more classifications for the message. As a result, the data classifier filters the messages based on the one or more classifications, which provides a prioritized view of the messages based on training criteria.

公开(公告)号：US20230273474A1

公开(公告)日：2023-08-31

申请号：US18114782

申请日：2023-02-27

申请人： The Regents of the University of Colorado, a body corporate

发明人： Souvik Ghosh ,  Ivan Smalyukh

IPC分类号： G02F1/1334 ,  G08C23/04 ,  C09K19/56

CPC分类号： G02F1/1334 ,  G08C23/04 ,  C09K19/56 ,  B82Y30/00

摘要： Assemblies and methods for modulating (e.g., near) infrared radiation are provided. Exemplary assemblies include a composite material interposed between a first substrate and a second substrate. The composite material includes plasmonic nanoparticles (e.g., nanoplates) dispersed in a nematic liquid crystal.

公开(公告)号：US20230257741A1

公开(公告)日：2023-08-17

申请号：US17759402

申请日：2021-01-29

申请人： The Regents of the University of Colorado, a body corporate

发明人： Gabrijela Dumbovic ,  John Rinn ,  Marvin Caruthers ,  Katarzyna Jastrzebska ,  Heera K. Langner

IPC分类号： C12N15/113 ,  A61K31/7115 ,  A61P35/00

CPC分类号： C12N15/113 ,  A61K31/7115 ,  A61P35/00

摘要： The inventive technology relates to systems and methods for the use of chemically modified antisense oligonucleotides (ASOs) to sterically prevent intron excision thus causing nuclear retention of the RNA and inhibiting nuclear export. In preferred therapeutic embodiments, ASOs may be engineered to quarantine clinically relevant RNAs in the nucleus of the cell.

公开(公告)号：US20230250025A1

公开(公告)日：2023-08-10

申请号：US18127498

申请日：2023-03-28

申请人： The Regents of the University of Colorado, a body corporate

发明人： Christopher Bartel ,  Alan W. Weimer ,  Rebecca Jean O'Toole ,  Maila Kodas

IPC分类号： C04B35/488 ,  C04B35/624 ,  C04B35/628 ,  H01M8/1253

CPC分类号： C04B35/4885 ,  C04B35/624 ,  C04B35/62813 ,  H01M8/1253 ,  C04B2235/3217 ,  C04B2235/3246 ,  C04B2235/6026 ,  H01M2008/1293

摘要： Disclosed herein is a ceramic particle comprising a core substrate chosen from yttria-stabilized zirconia, partially stabilized zirconia, zirconium oxide, aluminum nitride, silicon nitride, silicon carbide, and cerium oxide, and a conformal coating of a sintering aid film having a thickness of less than three nanometers and covering the core substrate, and methods for producing the ceramic particle.

公开(公告)号：US11717140B2

公开(公告)日：2023-08-08

申请号：US16573567

申请日：2019-09-17

申请人： The Regents of the University of Colorado, a Body Corporate

发明人： Joel Friedlander ,  Jeremy Prager ,  Emily Deboer ,  Robin Deterding

IPC分类号： A61B1/00 ,  A61B1/233 ,  A61M21/00 ,  A61B5/0205 ,  A61B90/00 ,  A61B5/06 ,  A61B5/01 ,  A61B3/16 ,  A61B3/11 ,  A61B5/12 ,  A61B5/03 ,  A61B7/00 ,  A61B5/00 ,  A61B5/1455 ,  A61B5/145 ,  G06F3/14 ,  A61B5/08 ,  A61B5/021 ,  A61B5/024

CPC分类号： A61B1/00097 ,  A61B1/233 ,  A61B3/111 ,  A61B3/112 ,  A61B3/16 ,  A61B5/01 ,  A61B5/02055 ,  A61B5/03 ,  A61B5/062 ,  A61B5/064 ,  A61B5/126 ,  A61B5/14517 ,  A61B5/14552 ,  A61B5/442 ,  A61B5/6803 ,  A61B7/003 ,  A61B90/39 ,  G06F3/14 ,  A61B5/021 ,  A61B5/024 ,  A61B5/082 ,  A61B5/0816 ,  A61B2090/3945 ,  A61B2090/3954 ,  A61M2021/005 ,  A61M2021/0027

摘要： A system having a scope with a longitudinal length extending between a proximal end and a distal end includes a plurality of markers spaced along the longitudinal length. The system also includes a disassociation and positioning device that is configured to enhance unsedated transnasal endoscopic procedures by at least partially occluding the vision of a patient while enabling body cavity access, and optionally record and sense body functions such as temperature, heart rate and oxygenation of the blood stream. The system further includes a sensor integrated into the distraction device, wherein the sensor is configured to detect the markers on the longitudinal length of the scope.

公开(公告)号：US20230233517A1

公开(公告)日：2023-07-27

申请号：US17852475

申请日：2022-06-29

申请人： The Regents of the University of Colorado, a body corporate

发明人： Ding Xue ,  Yu Peng ,  Man Zhang ,  Lingjun Zheng ,  Qian Liang ,  Hanzeng Li ,  Jau-Song Yu ,  Jeng-Ting Chen

IPC分类号： A61K31/353 ,  A61K31/336 ,  A61K31/4025 ,  A61K31/7048

CPC分类号： A61K31/353 ,  A61K31/336 ,  A61K31/4025 ,  A61K31/7048

摘要： The invention provides novel compositions and methods for the treatment of Radiation-Induced Bystander Effects (RIBE), resulting from radiation exposure. In one preferred embodiment the inventions includes novel therapeutic agents, including but not limited to quercetin and quercetin analogs, as well as E64, CA074, CA074Me, that interfere with the activity of Cathepsin B.

公开(公告)号：US11709132B2

公开(公告)日：2023-07-25

申请号：US16302911

申请日：2017-05-18

申请人： The Regents of the University of Colorado, a body corporate

发明人： Michael Tanksalvala ,  Daniel E. Adams ,  Dennis Gardner ,  Christina L. Porter ,  Giulia F. Mancini ,  Margaret M. Murnane ,  Henry C. Kapteyn

IPC分类号： G01N21/47 ,  G01N21/956 ,  G01N21/45 ,  G01N21/33 ,  G01N21/17

CPC分类号： G01N21/4788 ,  G01N21/33 ,  G01N21/45 ,  G01N21/4795 ,  G01N21/956 ,  G01N2021/1782 ,  G01N2021/335 ,  G01N2021/4711 ,  G01N2201/061

摘要： Apparatus and methods for forming an image of an object which involves focusing partially to fully spatially-coherent radiation onto a sample and collecting the resulting scattered radiation (the “standard data set”) on an array detector. In addition to the standard dataset, an additional measurement or plurality of measurements is made of a relatively-unscattered beam, using the array detector, which comprises the “modulus enforced probe (MEP) dataset”. This MEP dataset serves as an extra constraint, called the MEP constraint, in the phase retrieval algorithm used to reconstruct the image of the object.