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    Endoprosthesis with Selective Drug Coatings
    44.
    发明申请
    Endoprosthesis with Selective Drug Coatings 审中-公开
    选择性药物涂层内置假体

    公开(公告)号：US20100274352A1

    公开(公告)日：2010-10-28

    申请号：US12429392

    申请日：2009-04-24

    Applicant: Michael Kuehling ,  Torsten Scheuermann ,  Jan Weber ,  Yixin Xu

    Inventor： Michael Kuehling ,  Torsten Scheuermann ,  Jan Weber ,  Yixin Xu

    IPC: A61F2/06

    CPC classification number: A61L31/10 ,  A61L31/088 ,  A61L31/146 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/45 ,  A61L2300/61

    Abstract: An endoprosthesis such as a coronary stent includes a luminal surface, at least a portion of which is covered with a first coating including a first drug, and an abluminal surface, at least a portion of which is covered with a second coating including a second drug. The first drug has a first eluting profile based on the first coating, and the second drug has a second eluting profile based on the second coating, the first eluting profile being different from the second eluting profile. Methods of making the same are also provided.

    Abstract translation: 诸如冠状动脉支架的内用假体包括管腔表面，其至少一部分被第一涂层覆盖，第一涂层包括第一药物和腔内表面，其至少一部分被第二涂层覆盖，所述第二涂层包括第二药物 。 第一种药物基于第一种涂层具有第一洗脱分布，而第二种药物基于第二种涂层具有第二种洗脱分布，第一种洗脱分布与第二种洗脱分布不同。 还提供了制备其的方法。

    MEDICAL DEVICES HAVING METAL COATINGS FOR CONTROLLED DRUG RELEASE
    47.
    发明申请
    MEDICAL DEVICES HAVING METAL COATINGS FOR CONTROLLED DRUG RELEASE 有权
    具有用于控制药物释放的金属涂层的医疗装置

    公开(公告)号：US20100015206A1

    公开(公告)日：2010-01-21

    申请号：US12498829

    申请日：2009-07-07

    Applicant: Aiden FLANAGAN ,  Barry O'Brien ,  Torsten SCHEUERMANN

    Inventor： Aiden FLANAGAN ,  Barry O'Brien ,  Torsten SCHEUERMANN

    IPC: A61F2/82

    CPC classification number: A61L31/088 ,  A61L31/16 ,  A61L2300/604 ,  A61L2300/624

    Abstract: Medical devices having a plurality of nanoparticles disposed over a surface of the medical device. The nanoparticles have a core comprising a therapeutic agent and a shell surrounding the core, wherein the shell comprises a metal. A barrier layer is disposed over the nanoparticles. The barrier layer is water-permeable and comprises a metal that may be different from the metal used in the nanoparticle shells. In certain embodiments, the metal in the barrier layer undergoes galvanic corrosion. Also disclosed are medical device having a reservoir containing a therapeutic agent, with nanoparticles and a barrier layer being disposed over the reservoir; and medical devices having multiple barrier layers and multiple reservoirs containing therapeutic agents.

    Abstract translation: 具有设置在医疗装置的表面上的多个纳米颗粒的医疗装置。 纳米颗粒具有包含治疗剂的核心和围绕核心的壳体，其中壳体包含金属。 阻挡层设置在纳米颗粒上。 阻挡层是透水性的并且包含可以与纳米颗粒壳中使用的金属不同的金属。 在某些实施例中，阻挡层中的金属经历电偶腐蚀。 还公开了具有包含治疗剂的储存器的医疗装置，其中纳米颗粒和阻挡层设置在储存器上方; 以及具有多个阻隔层的医疗装置和含有治疗剂的多个储存器。

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