公开(公告)号：US20180240549A1

公开(公告)日：2018-08-23

申请号：US15753372

申请日：2016-08-18

Applicant: University of Exeter

Inventor： John Terry ,  Marc Goodfellow

IPC: G16H50/20 ,  G16H50/50 ,  G06N3/10

CPC classification number: G16H50/20 ,  A61B5/4094 ,  G06N3/10 ,  G16H20/40 ,  G16H50/50

Abstract: A computer-implemented apparatus for predicting an effect of a proposed surgical strategy for treatment of epilepsy and/or epileptic seizures, configured to generate synthetic brain activity data in at least some of the nodes of a brain network model, and repeatedly: a) simulate or effect a surgical strategy comprising removal of at least one node and/or edge from said brain network and subsequently recalculate said BNI value thereof; and b) calculate a value ΔBNI representative of a magnitude of change in BNI following removal of said at least one node/edge from said brain network, so as to output multiple ΔBNI values, or data representative thereof, corresponding to respective multiple proposed surgical strategies, each comprising removal of respective nodes/edges or sets of nodes/edges from said brain network.

公开(公告)号：US20180170759A1

公开(公告)日：2018-06-21

申请号：US15578953

申请日：2016-06-02

Applicant: University of Exeter

Inventor： Thomas Hardisty Bointon ,  Matthew D. Barnes ,  Saverio Russo ,  Monica Craciun

IPC: C01B32/186 ,  C01B32/194 ,  C30B25/18 ,  C30B29/02 ,  C30B29/64 ,  G06F3/044

CPC classification number: C01B32/186 ,  C01B32/194 ,  C01B2204/02 ,  C30B25/186 ,  C30B29/02 ,  C30B29/64 ,  G06F3/044 ,  G06F2203/04102 ,  G06F2203/04103

Abstract: A method for use in the synthesis of graphene is described that comprises the steps of annealing a substrate in a hydrogen gas atmosphere, subsequently undertaking a deposition and nucleation step in which a relatively thick carbon layer is deposited onto the substrate and subsequently thinned to form small graphene islands or nuclei, undertaking a graphene growth step in which the graphene islands or nuclei expand and coalesce, and subsequently allowing the substrate to cool. A sensor 10 incorporating the graphene sheet is also described.

公开(公告)号：US20160256429A1

公开(公告)日：2016-09-08

申请号：US15028139

申请日：2014-10-08

Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE DE POITIERS ,  UNIVERSITY OF EXETER

Inventor： MIROSLAVA SPANOVA ,  THIERRY FERREIRA ,  ROMAIN CLEMENT ,  SHALINEE DHAYAL ,  NOËL MORGAN

IPC: A61K31/231 ,  A61K31/357 ,  A61K45/06 ,  A61K31/7032 ,  A61K31/661 ,  A61K31/232

CPC classification number: A61K31/7024 ,  A23L33/12 ,  A23V2002/00 ,  A61K31/164 ,  A61K31/201 ,  A61K31/231 ,  A61K31/232 ,  A61K31/357 ,  A61K31/661 ,  A61K31/7032 ,  A61K45/06 ,  A61K2300/00

Abstract: The present invention relates to the field of medicine. It more particularly relates to the use of compounds for preventing and/or treating dyslipidemia in a subject, said dyslipidemia typically being linked to the excess presence in the biological membranes, including in the biological membranes of non-adipocyte cells, of fatty acids, in particular of saturated long-chain fatty acids, and/or of sterols. The invention also relates to compositions, in particular pharmaceutical compositions and food supplements or complements, comprising such compounds, and to the uses thereof for preventing and/or treating dyslipidemia. The compounds and compositions according to the invention can in particular be advantageously used for preventing and/or treating a pathological condition selected from metabolic syndrome and/or a symptom or abnormality characteristic of metabolic syndrome, preferably for preventing or treating type 2 diabetes mellitus or hepatic steatosis.

Abstract translation: 本发明涉及药物领域。 更特别地涉及化合物在受试者中预防和/或治疗血脂异常的用途，所述血脂异常通常与生物膜（包括非脂肪细胞的生物膜）中脂肪酸的过量存在有关， 特别是饱和长链脂肪酸和/或甾醇。 本发明还涉及包含这些化合物的组合物，特别是药物组合物和食品添加剂或补充剂，以及其用于预防和/或治疗血脂异常的用途。 根据本发明的化合物和组合物可特别有利地用于预防和/或治疗选自代谢综合征和/或代谢综合征特征的症状或异常的病理状况，优选用于预防或治疗2型糖尿病或肝 脂肪变性

公开(公告)号：US20160230273A1

公开(公告)日：2016-08-11

申请号：US15026437

申请日：2014-09-26

Applicant: University of Exeter

Inventor： Saverio Russo ,  Monica Craciun ,  Thomas Hardisty Bointon

IPC: C23C16/26 ,  H01B1/04

CPC classification number: C23C16/26 ,  B82Y40/00 ,  C01B32/186 ,  C01B32/188 ,  C01B32/194 ,  H01B1/04

Abstract: Methods of producing a uniformly or substantially uniformly doped relatively large area multi-layered graphene element are described comprising the steps of placing the graphene element and a dopant under low pressure conditions, and holding the graphene element and dopant at an elevated temperature for a period of time whilst under the low pressure conditions. In one arrangement, openings are formed in a multi-layered graphene element of relatively large area prior to doping. In another arrangement, a relatively large area multi-layered graphene element formed by an epitaxial growth technique is used. The invention also relates to an element produced using the aforementioned techniques.

Abstract translation: 描述了生产均匀或基本均匀掺杂的相对较大面积的多层石墨烯元件的方法，包括以下步骤：在低压条件下放置石墨烯元件和掺杂剂，并将石墨烯元素和掺杂剂保持在高温下一段时间 时间在低压条件下。 在一种布置中，在掺杂之前，在相对较大面积的多层石墨烯元件中形成开口。 在另一种布置中，使用通过外延生长技术形成的相对大面积的多层石墨烯元件。 本发明还涉及使用上述技术制造的元件。

公开(公告)号：US09346758B2

公开(公告)日：2016-05-24

申请号：US14425385

申请日：2013-09-02

Applicant: UNIVERSITY OF EXETER

Inventor： Alison Curnow ,  Mark Wood ,  Alexis Perry

IPC: C07D213/69 ,  A61K31/4412 ,  A61K41/00 ,  A61K49/00 ,  A61K8/49 ,  A61Q19/00

CPC classification number: C07D213/69 ,  A61K8/4926 ,  A61K41/0057 ,  A61K49/0021 ,  A61K2800/81 ,  A61Q19/00

Abstract: A compound which is a compound of formula (I) or any salt thereof: wherein R1 is a Ci-C6 alkyl group, R2 is H or a Ci-C6 alkyl group, R3 is H or a Ci-C6 alkyl group, and n is an integer from 0 to 5.

Abstract translation: 化合物，其为式（I）化合物或其盐：其中R 1为C 1 -C 6烷基，R 2为H或C 1 -C 6烷基，R 3为H或C 1 -C 6烷基，n为 是从0到5的整数。

公开(公告)号：US20150377907A1

公开(公告)日：2015-12-31

申请号：US14765863

申请日：2014-02-05

Applicant: QUEEN MARY UNIVERSITY OF LONDON ,  UNIVERSITY OF EXETER ,  KING'S COLEGE LONDON

Inventor： Ahuva Nissim ,  David Perrett ,  Paul G. Winyard ,  Valerie M. Corrigall ,  Gabriel S. Panayi

IPC: G01N33/68 ,  A61K39/395 ,  A61K38/17

CPC classification number: G01N33/6893 ,  A61K38/1793 ,  A61K39/3955 ,  G01N33/564 ,  G01N33/6854 ,  G01N2800/102

Abstract: The present invention provides a method of diagnosing rheumatoid arthritis (RA), comprising: testing a sample from a subject for the presence or absence of antibodies against oxidised collagen II; wherein the presence of antibodies against oxidised collagen II in the sample is indicative of RA in the subject. The present invention also provides a method for identifying whether a subject responds to a disease modifying anti-rheumatic drug (DMARD) and related methods of treating RA, a method for identifying whether a subject responds to an anti-TNF biologic and related methods of treating RA, and a method of diagnosing osteoarthritis (OA).

Abstract translation: 本发明提供了一种诊断类风湿性关节炎（RA）的方法，包括：测试受试者的样品是否存在抗氧化胶原II的抗体; 其中样品中抗氧化胶原II的抗体的存在表明受试者中的RA。 本发明还提供了一种用于鉴定受试者是否响应于疾病修饰抗风湿药物（DMARD）的方法以及治疗RA的相关方法，用于鉴定受试者是否对抗TNF生物学作用的相关方法以及相关的治疗方法 RA和诊断骨关节炎（OA）的方法。

公开(公告)号：US20150362669A1

公开(公告)日：2015-12-17

申请号：US14760306

申请日：2014-01-23

Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE ,  UNIVERSITY OF EXETER

Inventor： Joanna AIZENBERG ,  Mathias KOLLE ,  Peter VUKUSIC ,  Robert D. HOWE

IPC: G02B6/02 ,  G01L1/24 ,  G02B1/00 ,  G02B6/028 ,  G02B6/036

CPC classification number: G02B6/0239 ,  G01L1/242 ,  G01L1/247 ,  G02B1/005 ,  G02B6/02033 ,  G02B6/02038 ,  G02B6/023 ,  G02B6/02304 ,  G02B6/02309 ,  G02B6/0285 ,  G02B6/03611

Abstract: The rolled photonic fibers presents two codependent, technologically exploitable features for light and color manipulation: regularity on the nanoscale that is superposed with microscale cylindrical symmetry, resulting in wavelength selective scattering of light in a wide range of directions. The bio-inspired photonic fibers combine the spectral filtering capabilities and color brilliance of a planar Bragg stack compounded with a large angular scattering range introduced by the microscale curvature, which also decreases the strong directional chromaticity variation usually associated with flat multilayer reflectors. Transparent and elastic synthetic materials equip the multilayer interference fibers with high reflectance that is dynamically tuned by longitudinal mechanical strain. A two-fold elongation of the elastic fibers results in a shift of reflection peak center wavelength of over 200 nm.

Abstract translation: 卷绕的光子纤维呈现出两种相互依赖的，技术上可利用的光和颜色操纵特征：纳米级的规则性与微圆柱对称叠加，导致光在宽范围方向上的波长选择性散射。 生物启发的光子纤维结合了平面布拉格堆叠的光谱滤波能力和色彩亮度，与通过微尺度曲率引入的大角度散射范围相结合，这也降低了通常与平面多层反射器相关的强定向色度变化。 透明和弹性的合成材料为多层干涉纤维提供高反射率，通过纵向机械应变动态调整。 弹性纤维的两倍伸长导致反射峰值中心波长超过200nm的偏移。

公开(公告)号：US20150196034A1

公开(公告)日：2015-07-16

申请号：US14347782

申请日：2012-10-01

Applicant: THE UNIVERSITY OF EXETER

Inventor： Mark Wood ,  Matthew Whiteman ,  Alexis Perry

IPC: A01N57/24 ,  C07F9/54 ,  C07F9/6553

CPC classification number: A01N57/24 ,  A61K31/385 ,  A61K31/662 ,  A61K47/54 ,  C07F9/5442 ,  C07F9/655345

Abstract: The invention relates to a compound comprising a mitochondrial targeting group linked to group capable of releasing hydrogen sulfide, or a pharmaceutically acceptable salt thereof, for use in the treatment of the human or animal body by surgery or therapy. The invention also relates to the use of the compound in the treatment of a plant, and to certain forms of the compound.

Abstract translation: 本发明涉及包含与能够释放硫化氢的基团连接的线粒体靶向基团的化合物或其药学上可接受的盐，用于通过手术或治疗来治疗人或动物体。 本发明还涉及该化合物在处理植物和某些形式的化合物中的用途。

公开(公告)号：US20140302094A1

公开(公告)日：2014-10-09

申请号：US14354117

申请日：2012-10-24

Applicant: university of Exeter

Inventor： Richard W. Titball ,  Sérgio Paulo Fernandes Da Costa ,  Claire Naylor ,  Ajit Basak

IPC: C07K14/33

CPC classification number: C07K14/33 ,  A61K38/00 ,  A61K38/4893 ,  A61K39/00 ,  A61K39/08 ,  A61K2039/552 ,  C07K7/06 ,  C07K14/47

Abstract: There is provided a NetB epitope polypeptide comprising at least 10 contiguous amino acids from SEQ ID NO:1 and comprising a mutation in at least one position between amino acids 130 and 297 as compared with the equivalent position in SEQ ID the mutation preferably being located within a rim domain, the polypeptide being capable of binding an antibody which binds to SEQ ID NO:1 and having reduced toxicity compared with the toxicity of SEQ ID NO:1. The polypeptide is useful to vaccinate a subject against infection by Clostridium perfringens.

Abstract translation: 提供了包含SEQ ID NO：1的至少10个连续氨基酸的NetB表位多肽，并且在SEQ ID NO：1中与SEQ ID中的等同位置相比，其突变位于氨基酸130和297之间的至少一个位置，优选位于 边缘结构域，所述多肽能够结合与SEQ ID NO：1结合的抗体，并且与SEQ ID NO：1的毒性相比具有降低的毒性。 该多肽可用于使受试者免疫产气荚膜梭菌感染。

公开(公告)号：US20240322597A1

公开(公告)日：2024-09-26

申请号：US18262470

申请日：2022-01-21

Applicant: UNIVERSITY OF EXETER

Inventor： Zheng Jun CHEW ,  Yang KUANG ,  Tingwen RUAN ,  Meiling ZHU

IPC: H02J50/00 ,  B61L23/04 ,  H02J50/10

CPC classification number: H02J50/001 ,  B61L23/042 ,  H02J50/10

Abstract: Disclosed is an energy harvesting arrangement for use in the harvesting of magnetic field energy from a source in the form of a rail of a railway network, the energy harvesting arrangement comprising an energy harvester arranged in proximity to the rail or a component electrically connected to the rail, and the energy harvester is electrically connected, via a power management circuit, to an electrical storage device.