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48 条记录 (耗时 0.039 秒)

    Microfluidic device for cell and particle separation
    43.
    发明授权
    Microfluidic device for cell and particle separation 有权
    用于细胞和颗粒分离的微流控装置

    公开(公告)号：US07964078B2

    公开(公告)日：2011-06-21

    申请号：US11670945

    申请日：2007-02-02

    申请人： Abraham P. Lee ,  Lisen Wang ,  Lisa Flanagan Monuki ,  Edwin S. Monuki ,  Svyatoslav A. Marchenko

    发明人： Abraham P. Lee ,  Lisen Wang ,  Lisa Flanagan Monuki ,  Edwin S. Monuki ,  Svyatoslav A. Marchenko

    IPC分类号： B03C5/02

    CPC分类号： B01L3/502761 ,  B01L2200/0647 ,  B01L2300/0829 ,  B01L2300/0864 ,  B01L2400/0424 ,  B03C5/005 ,  B03C5/026 ,  C12M23/16 ,  C12M33/00 ,  G01N15/1056 ,  G01N2015/1081

    摘要： A microfluidic separation device includes a microchannel formed in a substrate and being defined at least by a bottom surface, a first side wall, and second side wall. Fluid containing particles or cells is flowed through the microchannel from an upstream end to a downstream end. The downstream end terminates in a plurality of branch channels. A plurality of vertically-oriented electrodes are disposed on the first wall and on the second wall opposite to the first wall. A voltage source is connected to the plurality of opposing electrodes to drive the electrodes. The opposing, vertically-oriented electrodes may be used to focus a heterogeneous population of particles or cells for subsequent downstream separation via additional electrodes placed on one of the side walls. Alternatively, the opposing, vertically-oriented electrodes may be used to spatially separate a heterogeneous population of particles or cells for later collection in one or more of the branch channels.

    摘要翻译： 微流体分离装置包括形成在基板中并且至少由底面，第一侧壁和第二侧壁限定的微通道。 含有流体的颗粒或细胞通过微通道从上游端流到下游端。 下游端终止于多个分支信道。 多个垂直取向的电极设置在第一壁上和与第一壁相对的第二壁上。 电压源连接到多个相对电极以驱动电极。 相对的垂直取向的电极可以用于通过放置在其中一个侧壁上的附加电极来聚焦异质粒子或细胞群，用于随后的下游分离。 或者，可以使用相对的垂直取向的电极在空间上分离多个粒子或细胞的不同群体，用于以后在一个或多个分支通道中进行收集。

    Amphiphilic mediated sample preparation for micro-flow cytometry
    44.
    发明授权
    Amphiphilic mediated sample preparation for micro-flow cytometry 失效
    两亲介导的微流式细胞术样品制备

    公开(公告)号：US07504265B2

    公开(公告)日：2009-03-17

    申请号：US11447754

    申请日：2006-06-05

    申请人： David S. Clague ,  Elizabeth K. Wheeler ,  Abraham P. Lee

    发明人： David S. Clague ,  Elizabeth K. Wheeler ,  Abraham P. Lee

    IPC分类号： G01N33/543

    CPC分类号： G01N15/1404 ,  G01N15/1484 ,  G01N2015/0065 ,  G01N2015/142 ,  Y10S436/80 ,  Y10S436/805 ,  Y10T436/117497

    摘要： A flow cytometer includes a flow cell for detecting the sample, an oil phase in the flow cell, a water phase in the flow cell, an oil-water interface between the oil phase and the water phase, a detector for detecting the sample at the oil-water interface, and a hydrophobic unit operatively connected to the sample. The hydrophobic unit is attached to the sample. The sample and the hydrophobic unit are placed in an oil and water combination. The sample is detected at the interface between the oil phase and the water phase.

    摘要翻译： 流式细胞仪包括用于检测样品的流动池，流动池中的油相，流动池中的水相，油相和水相之间的油 - 水界面，用于在该油相和水相之间检测样品的检测器 油 - 水界面和可操作地连接到样品的疏水单元。 疏水单元附着在样品上。 将样品和疏水单元置于油水组合中。 在油相和水相之间的界面处检测样品。

    Magnetohydrodynamic fluidic system
    46.
    发明授权
    Magnetohydrodynamic fluidic system 失效
    磁流体动力学流体系统

    公开(公告)号：US06780320B2

    公开(公告)日：2004-08-24

    申请号：US10177332

    申请日：2002-06-20

    申请人： Abraham P. Lee ,  Mark G. Bachman

    发明人： Abraham P. Lee ,  Mark G. Bachman

    IPC分类号： B01D1100

    CPC分类号： F04B19/006 ,  B01F13/0059 ,  B01F13/0077 ,  B01L3/5027 ,  Y10T436/118339 ,  Y10T436/2575

    摘要： A magnetohydrodynamic fluidic system includes a reagent source containing a reagent fluid and a sample source containing a sample fluid that includes a constituent. A reactor is operatively connected to the supply reagent source and the sample source. MHD pumps utilize a magnetohydrodynamic drive to move the reagent fluid and the sample fluid in a flow such that the reagent fluid and the sample fluid form an interface causing the constituent to be separated from the sample fluid.

    摘要翻译： 磁流体动力学流体系统包括含有试剂流体的试剂源和含有包含成分的样品流体的样品源。 反应器可操作地连接到供应试剂源和样品源。 MHD泵利用磁流体动力学驱动器以流动方式移动试剂流体和样品流体，使得试剂流体和样品流体形成使构件与样品流体分离的界面。

    Implantable medical sensor system
    47.
    发明授权
    Implantable medical sensor system 失效
    植入式医疗传感器系统

    公开(公告)号：US06201980B1

    公开(公告)日：2001-03-13

    申请号：US09166236

    申请日：1998-10-05

    申请人： Christopher B. Darrow ,  Joe H. Satcher, Jr. ,  Stephen M. Lane ,  Abraham P. Lee ,  Amy W. Wang

    发明人： Christopher B. Darrow ,  Joe H. Satcher, Jr. ,  Stephen M. Lane ,  Abraham P. Lee ,  Amy W. Wang

    IPC分类号： A61B505

    CPC分类号： A61B5/0031 ,  A61B5/14532 ,  A61B2562/028

    摘要： An implantable chemical sensor system for medical applications is described which permits selective recognition of an analyte using an expandable biocompatible sensor, such as a polymer, that undergoes a dimensional change in the presence of the analyte. The expandable polymer is incorporated into an electronic circuit component that changes its properties (e.g., frequency) when the polymer changes dimension. As the circuit changes its characteristics, an external interrogator transmits a signal transdermally to the transducer, and the concentration of the analyte is determined from the measured changes in the circuit. This invention may be used for minimally invasive monitoring of blood glucose levels in diabetic patients.

    摘要翻译： 描述了用于医疗应用的可植入化学传感器系统，其允许使用在分析物存在下经历尺寸变化的可扩展生物相容性传感器（例如聚合物）来选择性识别分析物。 当聚合物改变尺寸时，可膨胀聚合物结合到电子电路组件中，其改变其性质（例如，频率）。 随着电路改变其特性，外部询问器将信号经皮传递至换能器，并根据测量的电路变化确定分析物的浓度。 本发明可用于糖尿病患者血糖水平的微创监测。

    Micromachined magnetohydrodynamic actuators and sensors
    48.
    发明授权
    Micromachined magnetohydrodynamic actuators and sensors 失效
    微加工磁流体动力执行器和传感器

    公开(公告)号：US6146103A

    公开(公告)日：2000-11-14

    申请号：US170614

    申请日：1998-10-09

    申请人： Abraham P. Lee ,  Asuncion V. Lemoff

    发明人： Abraham P. Lee ,  Asuncion V. Lemoff

    IPC分类号： B01F13/00 ,  B01L3/00 ,  F04B19/00 ,  F15C5/00 ,  F16K99/00 ,  H02K44/04 ,  H02K44/02

    CPC分类号： B01F13/0077 ,  B01L3/50273 ,  B01L3/502738 ,  F04B19/006 ,  F16K99/0001 ,  F16K99/0015 ,  F16K99/0026 ,  F16K99/0046 ,  H02K44/04 ,  B01L2300/0816 ,  B01L2400/0415 ,  B01L2400/043 ,  B01L2400/0655 ,  B01L3/502784 ,  F16K2099/0074

    摘要： A magnetohydrodynamic (MHD) micropump and microsensor which utilizes micromachining to integrate the electrodes with microchannels and includes a magnet for producing magnetic fields perpendicular to both the electrical current direction and the fluid flow direction. The magnet can also be micromachined and integrated with the micropump using existing technology. The MHD micropump, for example, can generate continuous, reversible flow, with readily controllable flow rates. The flow can be reversed by either reversing the electrical current flow or reversing the magnetic field. By mismatching the electrodes, a swirling vortex flow can be generated for potential mixing applications. No moving parts are necessary and the dead volume is minimal. The micropumps can be placed at any position in a fluidic circuit and a combination of micropumps can generate fluidic plugs and valves.

    摘要翻译： 磁流体动力学（MHD）微型泵和微传感器，其利用微机械加工将电极与微通道集成，并且包括用于产生垂直于电流方向和流体流动方向的磁场的磁体。 磁体也可以使用现有技术进行微加工和与微型泵集成。 例如，MHD微型泵可以产生具有容易控制的流速的连续可逆流。 可以通过反转电流或反转磁场来逆流。 通过使电极不匹配，可以产生涡流涡流用于潜在的混合应用。 不需要移动部件，死体积最小。 微型泵可以放置在流体回路中的任何位置，并且微型泵的组合可以产生流体塞和阀。