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    Functionalized substrates with ion-exchange properties
    42.
    发明申请
    Functionalized substrates with ion-exchange properties 有权
    具有离子交换性能的功能化底物

    公开(公告)号：US20090277838A1

    公开(公告)日：2009-11-12

    申请号：US12118447

    申请日：2008-05-09

    Applicant: Xiaodong Liu ,  Christopher A. Pohl ,  Jinhua Chen ,  L. Andy Woodruff

    Inventor： Xiaodong Liu ,  Christopher A. Pohl ,  Jinhua Chen ,  L. Andy Woodruff

    IPC: B01D15/08 ,  B01J39/26

    CPC classification number: B01D15/362 ,  B01D15/325 ,  B01D15/361 ,  B01D15/363 ,  B01D15/3847 ,  B01J20/28097 ,  B01J20/3221 ,  B01J20/3285 ,  B01J20/3295 ,  B01J39/26 ,  B01J43/00 ,  B01J41/20

    Abstract: The current invention provides compositions, which are useful as stationary phases for a variety of chromatographic applications, such as high performance liquid chromatography (HPLC) and solid-phase extraction (SPE). The compositions include a porous solid support (e.g., silica gels, silica monoliths or synthetic organic resins) having an exterior surface and pore openings defined by “interior walls”. To the solid support are covalently bound organic ion-exchange ligands (e.g., silyl ligands), which incorporate at least one ion-exchange group (e.g., ionic or ionizable group). The compositions further include micro-particles (e.g., latex particles) incorporating ion-exchange groups having a charge that is opposite to the charge found on the support. The micro-particles are bound to the exterior surface of the support (e.g., via electrostatic forces). The micro-particles have a size that is sufficient to minimize the number of particles that can enter the pores of the support thereby reducing or essentially preventing binding of the micro-particles to the interior walls of the pores. While the pores are essentially too small for the micro-particles, they can still be accessed by the analytes present in a chromatographic sample. The physical separation of ion-exchange groups located within the pores and the surface of the micro-particles, respectively, prevents reactions (e.g., formation of salt-bridges) between the oppositely charged groups and provides compositions with both anion-exchange and cation-exchange capabilities within the same stationary phase. The ligands bound to the solid support can optionally include additional (e.g., reverse-phase) functionalities creating multi-modal (e.g., trimodal) stationary phases.

    Abstract translation: 本发明提供了用于各种色谱应用的固定相的组合物，例如高效液相色谱（HPLC）和固相萃取（SPE）。 组合物包括具有由“内壁”限定的外表面和孔开口的多孔固体支持物（例如硅胶，二氧化硅整料或合成有机树脂）。 固体支持物是共价结合的有机离子交换配体（例如，甲硅烷基配体），其结合至少一个离子交换基团（例如离子或可离子化基团）。 组合物还包括结合离子交换基团的微粒（例如胶乳颗粒），其具有与载体上发现的电荷相反的电荷。 微粒子结合到支撑体的外表面（例如通过静电力）。 微粒具有足以使能够进入载体的孔的颗粒数量最小化的尺寸，从而减少或基本上防止微粒与孔内壁的结合。 虽然孔对于微粒基本上太小，但是它们仍然可以通过色谱样品中存在的分析物进行访问。 分别位于孔和微粒表面之间的离子交换基团的物理分离防止相反电荷基团之间的反应（例如，形成盐桥），并提供具有阴离子交换和阳离子交换的组合物， 交换能力在同一个固定阶段。 与固体支持物结合的配体可以任选地包括产生多模态（例如，三峰）固定相的另外的（例如反相）官能团。

    Compositions useful as chromatography stationary phases
    44.
    发明授权
    Compositions useful as chromatography stationary phases 有权
    用作色谱固定相的组合物

    公开(公告)号：US07557232B2

    公开(公告)日：2009-07-07

    申请号：US11753934

    申请日：2007-05-25

    Applicant: Xiaodong Liu ,  Christopher A. Pohl ,  Jinhua Chen

    Inventor： Xiaodong Liu ,  Christopher A. Pohl ,  Jinhua Chen

    IPC: C07F7/02 ,  C07F7/08 ,  C07F7/18

    CPC classification number: B01J20/288 ,  B01J20/289 ,  B01J20/3204 ,  B01J20/3208 ,  B01J20/3219 ,  B01J20/3257 ,  B01J20/3259 ,  B01J20/3263 ,  B01J20/3285

    Abstract: The current invention provides compositions, which are useful as stationary phases for a variety of chromatographic applications, such as high performance liquid chromatography (HPLC). The compositions include a substrate (e.g., silica gel), covalently bound to a compound, which includes both a hydrophobic moiety and a hydrophilic moiety, which is preferably a 1,2-diol moiety. The hydrophobic moiety is sufficiently hydrophobic for the compositions to exhibit reversed phase characteristics and typically incorporates at least 5 carbon atoms in sequence. Based on having both hydrophilic and hydrophobic functionalities, the new stationary phases exhibit unique chromatographic properties. For example, these media can be used in either hydrophilic (HILIC) mode, in which the mobile phase includes a high percentage of an organic solvent, or in reversed phase mode, in which the mobile phase contains a higher percentage of an aqueous solvent. The current invention also provides methods of making and using the compounds and compositions of the invention.

    Abstract translation: 本发明提供组合物，其可用作多种色谱应用的固定相，例如高效液相色谱（HPLC）。 组合物包括与包含疏水部分和亲水部分的化合物共价结合的底物（例如硅胶），其优选为1,2-二醇部分。 疏水部分足够疏水以使组合物显示反相特性，并通常依次包含至少5个碳原子。 基于具有亲水和疏水官能度，新的固定相显示出独特的色谱性质。 例如，这些介质可用于亲水（HILIC）模式，其中流动相包含高百分比的有机溶剂，或以相反模式使用，其中流动相含有较高百分比的水性溶剂。 本发明还提供了制备和使用本发明化合物和组合物的方法。

    CHEMICAL SUPPRESSORS AND METHOD OF USE
    45.
    发明申请
    CHEMICAL SUPPRESSORS AND METHOD OF USE 审中-公开
    化学抑制剂及其使用方法

    公开(公告)号：US20090166293A1

    公开(公告)日：2009-07-02

    申请号：US12398095

    申请日：2009-03-04

    Applicant: Kannan Srinivasan ,  Christopher A. Pohl

    Inventor： Kannan Srinivasan ,  Christopher A. Pohl

    IPC: B01D15/08 ,  B01D15/10 ,  G01N30/96

    CPC classification number: G01N30/96 ,  B01D15/367 ,  B01D61/48 ,  Y10T436/25

    Abstract: A non-electrolytic method and apparatus for treating an aqueous sample stream including analyte ions and matrix ions of opposite charge, for pretreatment or suppression. The apparatus includes an ion exchange membrane capable of passing only ions of opposite charge to the analyte ions, a sample stream flow channel, a first aqueous stream ion receiving flow channel adjacent one side of the sample stream flow channel and separated therefrom by the first ion exchange membrane, and stationary flow-through ion exchange packing disposed in the sample stream flow channel. The ion receiving channel has an ion exchange capacity for the matrix ions less than about 25% of the ion exchange capacity for the matrix ions.

    Abstract translation: 一种用于处理包含分析物离子和相反电荷的基质离子的水样品流的非电解方法和装置，用于预处理或抑制。 该装置包括能够仅将相反电荷的离子通过到分析物离子的离子交换膜，样品流流动通道，邻近样品流流动通道的一侧的第一含水流离子接收流动通道，并由第一离子 交换膜和设置在样品流流动通道中的固定流通离子交换填料。 离子接收通道对于基质离子的离子交换容量小于基质离子的离子交换容量的约25％。

    Membrane suppressor with an outlet substantially non-retentive for ionic species
    47.
    发明申请
    Membrane suppressor with an outlet substantially non-retentive for ionic species 有权
    具有离子物质基本上非保持性的出口的膜抑制器

    公开(公告)号：US20080069731A1

    公开(公告)日：2008-03-20

    申请号：US11524513

    申请日：2006-09-19

    Applicant: Yan Liu ,  Victor Barreto ,  Christopher A. Pohl

    Inventor： Yan Liu ,  Victor Barreto ,  Christopher A. Pohl

    IPC: G01N30/02

    CPC classification number: G01N30/96 ,  G01N2030/965

    Abstract: An apparatus for ion chromatography comprising a suppressor comprising a housing and a liquid conduit segment disposed in the housing, the liquid conduit segment including a membrane, the membrane having an inlet section adjacent the inlet of the conduit segment and an outlet section adjacent the outlet of the conduit segment, the inlet section having ion exchange sites capable of transmitting ions of one charge, positive or negative, and the outlet section being substantially non-retentive electrostatically for charged ionic species. Also, the method of using the apparatus.

    Abstract translation: 一种用于离子色谱的装置，其包括抑制器，该抑制器包括壳体和设置在壳体中的液体导管段，液体导管段包括膜，该膜具有邻近导管段入口的入口部分和邻近出口部分的出口部分 导管部分，入口部分具有能够传输一个电荷的离子的正离子或负离子的离子交换位置，并且对于带电离子物质，出口部分静电地基本上是非保持性的。 另外，使用该装置的方法。

    Ion exchange cryptands covalently bound to substrates
    48.
    发明授权
    Ion exchange cryptands covalently bound to substrates 有权
    离子交换穴位共价结合到底物上

    公开(公告)号：US06867295B2

    公开(公告)日：2005-03-15

    申请号：US09949010

    申请日：2001-09-07

    Applicant: L. Andy Woodruff ,  Andrei V. Bordunov ,  Christopher A. Pohl

    Inventor： L. Andy Woodruff ,  Andrei V. Bordunov ,  Christopher A. Pohl

    IPC: G01N30/02 ,  B01D15/08 ,  B01J20/281 ,  B01J20/285 ,  B01J41/14 ,  B01J45/00 ,  C08J5/20 ,  G01N30/26 ,  G01N30/34 ,  G01N30/64 ,  G01N30/88 ,  C08B37/16

    CPC classification number: B01J45/00 ,  B01J41/14

    Abstract: One embodiment of the invention comprises an ion exchange composition formed by reacting unsaturated carbon to carbon moieties pendant from derivatized ion binding cryptands with a support substrate under free radical activation conditions to form a covalent bond therebetween.In another embodiment, a cryptand ion exchange composition is made by covalently bonding unsaturated carbon to carbon moieties pendant from a derivatized ion binding cryptands with unsaturated carbon to carbon moieties pendant from a support substrate under free radical activation conditions to form covalent bond.

    Abstract translation: 本发明的一个实施方案包括通过使自由基活化条件下的不饱和碳与衍生的离子结合穴状物侧基的碳部分与支持底物反应而形成的离子交换组合物，在其间形成共价键。在另一个实施方案中，穴状离子交换组合物是 通过共价键合不饱和碳与从不饱和碳衍生的衍生化离子结合穴状结构的碳部分与自由基激活条件下从载体底物侧基形成共价键的碳部分共价键合。

    Method and apparatus for gas-assisted suppressed chromatography
    49.
    发明授权
    Method and apparatus for gas-assisted suppressed chromatography 有权
    气体辅助抑制色谱法的方法和装置

    公开(公告)号：US06425284B1

    公开(公告)日：2002-07-30

    申请号：US09521626

    申请日：2000-03-08

    Applicant: Kannan Srinivasan ,  Christopher A. Pohl

    Inventor： Kannan Srinivasan ,  Christopher A. Pohl

    IPC: G01N3002

    CPC classification number: G01N30/96 ,  G01N2030/965

    Abstract: Ionic species in an aqueous sample stream are analyzed by (a) chromatographically separating the ionic species in the presence of an aqueous eluent solution comprising electrolyte to form a chromatographic effluent, (b) suppressing the electrolyte in the chromatography effluent by flowing the same through a suppressor (e.g., a membrane suppressor) to form a suppressed effluent, (c) detecting the ionic species in the suppressed effluent, and (d) regenerating the suppressor by flowing a mixture of a gas stream and a regenerant liquid stream through the suppressor. The gas stream may be generated by flowing the detected suppressed effluent through an electrolytic gas generator which electrolyzes water in the effluent to hydrogen and oxygen gas. Also, pressurized gas may be directed into a reservoir of regenerant liquid for flow from said reservoir to said regenerant flow channel.

    Abstract translation: 通过（a）在包含电解质的含水洗脱液存在下色谱分离离子物质以形成色谱流出物来分析水样品流中的离子物质，（b）通过使色谱流出物中的电解液流过 抑制器（例如，膜抑制器）以形成抑制的流出物，（c）检测被抑制的流出物中的离子物质，和（d）通过使气流和再生剂液体的混合物流过抑制器来再生抑制剂。 可以通过将检测到的抑制流出物流过电解气体发生器来产生气流，该电解气体发生器将流出物中的水电解为氢气和氧气。 此外，加压气体可以被引导到再生剂液体的储存器中，用于从所述储存器流到所述再生剂流动通道。

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