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公开(公告)号：US20090004705A1
公开(公告)日：2009-01-01
申请号：US12030575
申请日：2008-02-13
CPC分类号： C12N15/77
摘要： The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered or caused transcription rate and/or expression rate, and methods for preparing biosynthetic products by cultivating the genetically modified microorganisms.
摘要翻译： 本发明涉及核酸序列用于调节基因的转录和表达，新型启动子和表达单元本身的用途，用于改变或引起基因的转录速率和/或表达速率的方法，包含表达单位的表达盒 具有改变或引起的转录速率和/或表达速率的转基因微生物，以及通过培养转基因微生物来制备生物合成产物的方法。
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公开(公告)号：US20080268502A1
公开(公告)日：2008-10-30
申请号：US12048599
申请日：2008-03-14
IPC分类号： C12P21/04 , C12N15/11 , C12N15/00 , C12P19/34 , C12P7/64 , C12N15/74 , C12P13/04 , C12N1/20 , C12P1/00
摘要： The present invention relates to multiple promoters and to expression units comprising them; to the use thereof for regulating transcription and expression of genes; to expression cassettes which comprise multiple promoters or expression units of this kind; to vectors which comprise such expression cassettes; to genetically modified microorganisms which comprise vectors and/or expression units of this kind; and to processes for preparing biosynthetic products by culturing said genetically modified microorganisms.
摘要翻译： 本发明涉及多种启动子和包含它们的表达单元; 用于调节基因的转录和表达; 包括多种启动子或这种表达单位的表达盒; 包含这种表达盒的载体; 涉及包含这种载体和/或表达单元的转基因微生物; 以及通过培养所述转基因微生物来制备生物合成产物的方法。
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公开(公告)号：US20080176295A1
公开(公告)日：2008-07-24
申请号：US12050146
申请日：2008-03-17
摘要： The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered or caused transcription rate and/or expression rate, and methods for preparing biosynthetic products by cultivating the genetically modified microorganisms.
摘要翻译： 本发明涉及核酸序列用于调节基因的转录和表达，新型启动子和表达单元本身的用途，用于改变或引起基因的转录速率和/或表达速率的方法，包含表达单位的表达盒 具有改变或引起的转录速率和/或表达速率的转基因微生物，以及通过培养转基因微生物来制备生物合成产物的方法。
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公开(公告)号：US20080166774A1
公开(公告)日：2008-07-10
申请号：US12021112
申请日：2008-01-28
申请人： Corinna Klopprogge , Oskar Zelder , Burkhard Kroger , Hartwig Schroder , Stefan Hafner , Wolfgang Liebl
发明人： Corinna Klopprogge , Oskar Zelder , Burkhard Kroger , Hartwig Schroder , Stefan Hafner , Wolfgang Liebl
CPC分类号： C12P13/04
摘要： The invention relates to a method for producing an amino acid comprising culturing a microorganism of the genus Corynebacterium or Brevibacterium wherein said microorganism is partially or completely deficient in at least one of the gene loci of the group which is formed by otsAB, treZ and treS, and subsequent isolation of the amino acid from the culture medium.
摘要翻译： 本发明涉及一种生产氨基酸的方法，包括培育棒杆菌属或短杆菌属的微生物，其中所述微生物部分或完全缺乏由otsAB，treZ和treS形成的基团的至少一个基因座， 并随后从培养基中分离氨基酸。
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公开(公告)号：US20080131942A1
公开(公告)日：2008-06-05
申请号：US11055717
申请日：2005-02-11
IPC分类号： C12P13/14 , C12N15/74 , C12P13/08 , C12P13/04 , C12P1/04 , C12P25/00 , C12P13/02 , C12N15/00
CPC分类号： C12N9/1007 , C12N15/77
摘要： The invention relates to a process for producing corynebacteria comprising one or more modified genomic sequences, where a vector is used which does not replicate in corynebacteria and whose nucleic acid is not recognized by corynebacteria as foreign.
摘要翻译： 本发明涉及一种生产棒状杆菌的方法，其包含一个或多个修饰基因组序列，其中使用不在棒状杆菌中复制且其核酸不被外源性棒状杆菌识别的载体。
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46.发明申请Method for the Preparation of Lysine by Fermentation of Corynebacterium Glutamicum 审中-公开通过发酵谷氨酸棒杆菌制备赖氨酸的方法公开(公告)号：US20080032374A1
公开(公告)日：2008-02-07
申请号：US10579690
申请日：2004-12-17
申请人： Oskar Zelder , Corinna Klopprogge , Hartwig Schroder , Stefan Hafner , Burkhard Kroger , Patrick Kiefer , Elmar Heinzle , Christoph Wittmann
发明人： Oskar Zelder , Corinna Klopprogge , Hartwig Schroder , Stefan Hafner , Burkhard Kroger , Patrick Kiefer , Elmar Heinzle , Christoph Wittmann
摘要： The present invention features methods of increasing the production of a fine chemical, e.g., lysine from a microorganism, e.g., Corynebacterium by way of deregulating an enzyme encoding gene, i.e., fructose-1,6-bisphosphatase. In a preferred embodiment, the invention provides methods of increasing the production of lysine in Corynebacterium glutamicum by way of increasing the expression of fructose-1,6-bisphosphatase activity. The invention also provides a novel process for the production of lysine by way of regulating carbon flux towards oxaloacetate (OAA). In a preferred embodiment, the invention provides methods for the production of lysine by way of utilizing fructose or sucrose as a carbon source.
摘要翻译： 本发明的特征在于通过使酶编码基因（即果糖-1,6-二磷酸酶）失调来增加精细化学品例如来自微生物例如棒状杆菌的赖氨酸的生产方法。 在优选的实施方案中，本发明提供了通过增加果糖-1,6-二磷酸酶活性的表达来增加谷氨酸棒杆菌中赖氨酸的产生的方法。 本发明还提供了通过调节向草酰乙酸（OAA）的碳通量来生产赖氨酸的新方法。 在优选的实施方案中，本发明提供了通过使用果糖或蔗糖作为碳源来生产赖氨酸的方法。
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公开(公告)号：US07323559B2
公开(公告)日：2008-01-29
申请号：US11591868
申请日：2006-11-02
申请人： Oskar Zelder , Markus Pompejus , Hartwig Schröder , Burkhard Kröger , Corinna Klopprogge , Gregor Haberhauer
发明人： Oskar Zelder , Markus Pompejus , Hartwig Schröder , Burkhard Kröger , Corinna Klopprogge , Gregor Haberhauer
CPC分类号： C12N9/00 , C07K14/34 , C12N9/0006 , C12P13/08
摘要： The invention relates to novel nucleic acid molecules, to the use thereof for constructing genetically improved microorganisms and to methods for preparing fine chemicals, in particular amino acids, with the aid of said genetically improved microorganisms.
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48.发明申请Corynebacterium glutamicum genes encoding proteins involved in membrane synthesis and membrane transport 审中-公开编码参与膜合成和膜转运的蛋白质的谷氨酸棒杆菌基因公开(公告)号：US20070111230A1
公开(公告)日：2007-05-17
申请号：US11507094
申请日：2006-08-18
IPC分类号： C12Q1/68 , G01N33/554 , C07H21/04 , C12N15/74 , G01N33/569 , C07K14/195
CPC分类号： C12Q1/689 , C07K14/34 , C12N9/00 , C12N9/18 , G01N33/56911
摘要： Isolated nucleic acid molecules, designated MCT nucleic acid molecules, which encode novel MCT proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MCT nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated MCT proteins, mutated MCT proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of MCT genes in this organism.
摘要翻译： 描述了编码来自谷氨酸棒杆菌的新型MCT蛋白质的分离的核酸分子，命名为MCT核酸分子。 本发明还提供反义核酸分子，含有MCT核酸分子的重组表达载体，以及引入了表达载体的宿主细胞。 本发明还进一步提供了分离的MCT蛋白，突变的MCT蛋白，融合蛋白，抗原肽和基于该生物体中MCT基因的遗传工程改进从谷氨酸棒球菌生产所需化合物的方法。
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公开(公告)号：US20070077576A1
公开(公告)日：2007-04-05
申请号：US11508673
申请日：2006-08-22
申请人： Markus Pompejus , Burkhard Kroger , Hartwig Schroder , Oskar Zelder , Gregor Haberhauer , Heung-Shick Lee , Hyung-Joon Kim
发明人： Markus Pompejus , Burkhard Kroger , Hartwig Schroder , Oskar Zelder , Gregor Haberhauer , Heung-Shick Lee , Hyung-Joon Kim
CPC分类号： C12P13/04 , C07K14/34 , C07K2319/00 , C12N9/00 , C12N9/18 , C12P13/06 , C12P13/08 , C12P13/10 , C12P13/12 , C12P13/14 , C12P13/20 , C12P13/222 , C12P13/225 , C12P13/227 , C12P13/24
摘要： Isolated nucleic acid molecules, designated SRT nucleic acid molecules, which encode novel SRT proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing SRT nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated SRT proteins, mutated SRT proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of SRT genes in this organism.
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50.发明申请公开(公告)号：US20070065914A1
公开(公告)日：2007-03-22
申请号：US11505231
申请日：2006-08-15
IPC分类号： C12P21/06 , C12P19/62 , C12P19/34 , C12P19/02 , C12P13/04 , C12P13/24 , C12P13/22 , C12P13/20 , C12P13/14 , C12P13/16 , C12P13/12 , C12P13/10 , C12P13/08 , C12P7/64 , C12P7/40 , C12N9/10 , C07H21/04 , C12N15/74 , C12N1/21
CPC分类号： C12N9/18 , C07K14/34 , C07K2319/00 , C12N9/00 , C12N9/90 , C12P7/18 , C12P7/40 , C12P7/6409 , C12P7/6427 , C12P7/6463 , C12P7/6472 , C12P13/04 , C12P13/06 , C12P13/08 , C12P13/10 , C12P13/12 , C12P13/14 , C12P13/20 , C12P13/222 , C12P13/225 , C12P13/227 , C12P13/24 , C12P19/00 , C12P19/34 , C12Y301/01031
摘要： Isolated nucleic acid molecules, designated SMP nucleic acid molecules, which encode novel SMP proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing SMP nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated SMP proteins, mutated SMP proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of SMP genes in this organism.
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