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公开(公告)号：US20180291372A1
公开(公告)日：2018-10-11
申请号：US15573879
申请日：2016-05-13
Applicant: Massachusetts Institute of Technology
Inventor： Timothy Kuan-Ta Lu , Samuel David Perli , Hao Cui
Abstract: The present disclosure is directed, in some embodiments, to engineered nucleic acids comprising a promoter operably linked to a nucleotide sequence encoding a guide ribonucleic acid (gRNA) that comprises a specificity determining sequence (SDS) and a protospacer adjacent motif (PAM). The present disclosure is directed, in some embodiments, to cells comprising, vectors comprising, and methods of producing the engineered nucleic acids.
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公开(公告)号：US20180127759A1
公开(公告)日：2018-05-10
申请号：US15796551
申请日：2017-10-27
Applicant: Massachusetts Institute of Technology
Inventor： Timothy Kuan-Ta Lu , Fahim Farzadfard
IPC: C12N15/113 , C12N9/22 , C12N15/70 , C12N9/12 , C12Q1/6876 , C12N15/74 , C07K16/00 , C12N15/90
CPC classification number: C12N15/1137 , C07K16/00 , C07K2317/14 , C12N9/1276 , C12N9/22 , C12N15/1024 , C12N15/70 , C12N15/74 , C12N15/902 , C12N2310/20 , C12Q1/6876 , C12Y207/07049
Abstract: Provided herein, in some embodiments, are genomic editing constructs that can achieve nearly 100% recombination efficiency within a select population of bacterial cells.
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公开(公告)号：US20180119141A1
公开(公告)日：2018-05-03
申请号：US15411255
申请日：2017-01-20
Applicant: Massachusetts Institute of Technology
Inventor： Ying-Chou Chen , Fahim Farzadfard , Timothy Kuan-Ta Lu
IPC: C12N15/113 , G01N33/50 , C12N15/85
CPC classification number: C12N15/113 , C07K2319/00 , C12N15/85 , C12N2310/20 , C12N2320/12 , G01N33/5014
Abstract: Provided herein are methods for identifying genetic networks and methods of treating neurodegenerative disorders associated with α-synuclein dysfunction.
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公开(公告)号：US20180111968A1
公开(公告)日：2018-04-26
申请号：US15436259
申请日：2017-02-17
Applicant: Massachusetts Institute of Technology
Inventor： Timothy Kuan-Ta Lu , Allen Yuyin Chen
IPC: C07K14/245 , B82Y40/00 , C07K14/47 , B82Y5/00
CPC classification number: C07K14/245 , B82Y5/00 , B82Y40/00 , C07K14/4711 , C07K2319/00 , C07K2319/20 , C07K2319/21 , C07K2319/24 , C07K2319/43 , C07K2319/60 , C07K2319/735
Abstract: Aspects of the invention relate to the engineering of biological nanostructures and materials.
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公开(公告)号：US20170373700A1
公开(公告)日：2017-12-28
申请号：US15535846
申请日：2015-12-22
Applicant: Massachusetts Institute of Technology
Inventor： Timothy Kuan-Ta Lu , Jacob Rosenblum , Gianluca Selvaggio
Abstract: Aspects of the present disclosure relate to analog signal processing circuits and methods for cellular computation.
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Patent Agency Ranking
公开(公告)号：US20170338943A1
公开(公告)日：2017-11-23
申请号：US15521956
申请日：2015-10-29
Applicant: Massachusetts Institute of Technology
Inventor： Timothy Kuan-Ta Lu , Peter A. Carr , Bijan Zakeri
CPC classification number: H04L9/06 , C12Q1/68 , C12Q1/6869 , G09C1/00 , H04L9/00 , H04L9/0656 , H04L9/0866 , C12Q2563/185
Abstract: In some aspects, the instant disclosure relates to the multiplexed encryption of information on nucleic acid molecules. In some aspects, the instant disclosure relates to a method of secure communication of information disseminated across at least one nucleic acid molecule, the method comprising (a) obtaining a modified keyboard comprising a personalized platform for translating text into a nucleic acid sequence; (b) translating a quantum of information into a nucleic acid message sequence using the modified keyboard of (a); and, (c) obtaining an at least one nucleic acid molecule, each molecule comprising: (i) the complete or a portion of the nucleic acid message sequence, and (ii) at least one contiguous stretch of randomized variable nucleic acid sequence flanking and/or inserted into the message sequence, thereby producing a nucleic acid molecule or a set of nucleic acid molecules containing the entire quantum of information.
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公开(公告)号：US20170335411A1
公开(公告)日：2017-11-23
申请号：US15521917
申请日：2015-10-27
Applicant: Massachusetts Institute of Technology
Inventor： Timothy Kuan-Ta Lu , Isaak Elis Mueller , Jacob Rosenblum Rubens
IPC: C12Q1/68 , C12N15/70 , C12N9/50 , G06N3/00 , C07K14/245
CPC classification number: C12Q1/6897 , C07K14/245 , C07K2319/50 , C12N9/506 , C12N15/70 , C12Y304/22044 , G06N3/002 , G16B50/00
Abstract: Aspects of the present disclosure are directed to biosensing circuits that correct crosstalk.
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公开(公告)号：US09691017B2
公开(公告)日：2017-06-27
申请号：US14105994
申请日：2013-12-13
Applicant: Massachusetts Institute of Technology
Inventor： Timothy Kuan-Ta Lu , Piro Siuti
CPC classification number: G06N3/002
Abstract: The invention provides, inter alia, recombinase-based systems that provide for integrated logic and memory in living cells.
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公开(公告)号：US20170096680A1
公开(公告)日：2017-04-06
申请号：US15283162
申请日：2016-09-30
Applicant: Massachusetts Institute of Technology
Inventor： Timothy Kuan-Ta Lu , Nathaniel B. Roquet
CPC classification number: C12N15/85 , C12N9/16 , C12N2800/107 , C12N2800/30 , G16B30/00
Abstract: Provided herein are recombinase-based frameworks for building state machines in vitro and in vivo by using chemically controlled DNA excision and inversion operations to encode state in DNA sequence.
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公开(公告)号：US20160220727A1
公开(公告)日：2016-08-04
申请号：US14540872
申请日：2014-11-13
Applicant: Massachusetts Institute of Technology
Inventor： Timothy Kuan-Ta Lu , Chao Zhong
IPC: A61L24/10 , C07K14/245 , A61L24/00 , C07K14/435
Abstract: Compositions, methods, and kits are provided which involve novel fusion protein-based adhesives for use in medical and marine applications. In some aspects, the novel fusion proteins comprise an adhesive domain (e.g., derived from an adhesive protein of a marine organism) and an amyloid domain (e.g., derived from a bacterial amyloid protein). Also provided are copolymers and fibers of the fusion proteins.
Abstract translation: 提供了组合物，方法和试剂盒，其包括用于医疗和海洋应用的新的基于融合蛋白的粘合剂。 在一些方面，新型融合蛋白包含粘合剂结构域（例如衍生自海洋生物的粘合蛋白）和淀粉样蛋白结构域（例如衍生自细菌淀粉样蛋白）。 还提供了融合蛋白的共聚物和纤维。
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