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公开(公告)号：US5742049A
公开(公告)日：1998-04-21
申请号：US618843
申请日：1996-03-20
申请人： Armin Holle , Claus Koster , Jochen Franzen
发明人： Armin Holle , Claus Koster , Jochen Franzen
CPC分类号： H01J49/164 , H01J49/067 , H01J49/403
摘要： The invention relates to the use of a time-of-flight mass spectrometer to analyze substance molecules which are ionized by laser desorption, particularly by matrix-assisted laser desorption (MALDI). In detail it relates to the process for improving mass resolution by the known method of delayed acceleration (sometimes called delayed extraction) of the ions, and devices for the performance of this method. The invention consists of using an optical device with gridless apertures for the acceleration of the ions and refocusing the ion beam divergence due to the lens effect of the apertures, by means of a lens arrangement in the drift region of the time-of-flight spectrometer. For laser light pulses, illumination, and observation, there are further lateral holes in the electrodes of the optical device.
摘要翻译： 本发明涉及使用飞行时间质谱仪来分析通过激光解吸电离的物质分子，特别是通过基质辅助激光解吸（MALDI）。 具体而言，涉及通过已知的离子加速（有时称为延迟提取）方法提高质量分辨率的方法以及用于执行该方法的装置。 本发明包括使用具有无栅隙的光学装置用于加速离子，并通过在飞行时间谱仪的漂移区域中的透镜布置来重新聚焦由于孔的透镜效应引起的离子束发散 。 对于激光脉冲，照明和观察，光学装置的电极中存在另外的侧孔。
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公开(公告)号：US5708268A
公开(公告)日：1998-01-13
申请号：US644044
申请日：1996-05-09
申请人： Jochen Franzen
发明人： Jochen Franzen
CPC分类号： H01J49/063
摘要： The invention relates to methods and devices for the efficient and loss-free transfer of ions in moderate vacuum from a first location (a source) to a second location (a user). The invention consists of an arrangement, reaching from the first location to the second, of five pole rods (a pentapole) to which a five-phase radio frequency (RF) voltage is applied.
摘要翻译： 本发明涉及用于在中等真空中从第一位置（源）到第二位置（用户）有效和无损地转移离子的方法和装置。 本发明包括从第一位置到第二位置施加五相射频（RF）电压的五极杆（五极）的布置。
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公开(公告)号：US5521379A
公开(公告)日：1996-05-28
申请号：US277666
申请日：1994-07-20
CPC分类号： H01J49/428 , B01J19/087 , H01J49/145 , H01J49/4295
摘要： A method is disclosed for chemical ionization of the molecules of an analysis gas or analysis gas mixture or for studying ion-molecule reactions in ion traps. Specifically, by superposing a quadrupole field with a dipolar introduced frequency mixture in which there are accurately selected frequency gaps in the ionization phase of the analysis, the only ions which are stored are those which are on the selected reaction path of the reactant gas ions for making the proper reactant ions for the desired ion-molecule reaction. All the other ions are eliminated from storage by excitation of their secular oscillations. In a second phase, by switching off the dipolar introduced frequency mixture, all the ions can be stored in a wide range of mass-to-charge ratios, and therefore also the product ions of the desired ion-molecule reactions of the analysis gas. In a third phase the spectrum of the product ions is scanned.
摘要翻译： 公开了用于分析气体或分析气体混合物的分子的化学电离或用于研究离子阱中的离子 - 分子反应的方法。 具体地说，通过将具有偶极引入频率混合的四极场叠加在分析的电离阶段中存在准确选择的频率间隙的情况下，存储的唯一离子是在反应物气体离子的选定反应路径上 使合适的反应物离子进行所需的离子 - 分子反应。 所有其他离子通过其长期振荡的激发从储存中消除。 在第二阶段，通过关闭偶极引入的频率混合物，所有离子可以以宽范围的质荷比存储，因此也可以分析气体所需的离子 - 分子反应的产物离子。 在第三阶段，扫描产物离子的光谱。
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44.发明授权Method and device for control of the excitation voltage for ion ejection from ion trap mass spectrometers 失效用于控制从离子阱质谱仪离子喷射的激发电压的方法和装置
公开(公告)号：US5298746A
公开(公告)日：1994-03-29
申请号：US997284
申请日：1992-12-23
IPC分类号： H01J49/42
CPC分类号： H01J49/424 , H01J49/429
摘要： An improved scanning method used in an ion trap mass spectrometer comprises controlling the amplitude of the excitation RF during the mass scan to produce a smooth, nonlinear, highly suitable function. A smooth function is a function with a steady derivative. According to one embodiment of the invention, the excitation amplitude is set proportionally to the square root of the storage amplitude, thus making the excitation amplitude proportional to the root of the mass number.
摘要翻译： 在离子阱质谱仪中使用的改进的扫描方法包括在质量扫描期间控制激发RF的振幅以产生平滑，非线性，高度适合的功能。 平滑函数是具有稳定导数的函数。 根据本发明的一个实施例，激励振幅与存储幅度的平方根成比例地设定，从而使激励振幅与质量数的根成正比。
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45.发明授权
公开(公告)号：US4259572A
公开(公告)日：1981-03-31
申请号：US39478
申请日：1979-05-16
申请人： Curt Brunnee , Jochen Franzen , Stefan Meier
发明人： Curt Brunnee , Jochen Franzen , Stefan Meier
IPC分类号： G01N27/68 , G01N30/02 , G01N30/84 , H01J49/04 , H01J49/14 , H05H3/02 , H01J27/00 , B01D59/44
CPC分类号： H01J49/0431 , G01N27/68 , H01J49/049 , H01J49/142 , H05H3/02 , G01N2030/027 , G01N2030/8417 , G01N35/00009
摘要： Organic samples from a liquid chromatograph are deposited on a conveyor belt which transports them into a vacuum chamber at the entry end of a mass spectrometer. The samples are ionized directly on the belt by particle bombardment or by means of a laser beam. Ionization is enhanced by applying an oxide layer to the belt, by neutralizing the image force, and by vaporizing alkali atoms on the belt to reduce the ionization potential.
摘要翻译： 来自液相色谱仪的有机样品沉积在传送带上，将其输送到质谱仪入口端的真空室中。 通过粒子轰击或通过激光束将样品直接电离在带上。 通过将氧化层施加到带上，通过中和图像力以及通过汽化带上的碱原子来降低电离电位来提高电离。
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公开(公告)号：US08410429B2
公开(公告)日：2013-04-02
申请号：US13017803
申请日：2011-01-31
CPC分类号： H01J49/4205 , H01J49/062
摘要： An ion cell having an axis includes a sheath of individual electrodes that extends along the axis and defines an internal volume. Adjacent individual electrodes are electrically insulated from each other. The individual electrodes each receive a DC potential and RF voltage. At least some of the individual electrodes have a width that varies in the axial direction such that an electrical effect on an axis potential varies along the axis of the ion cell.
摘要翻译： 具有轴的离子电池包括沿着轴线延伸并且限定内部体积的各个电极的护套。 相邻的单个电极彼此电绝缘。 各个电极各自接收DC电位和RF电压。 单个电极中的至少一些具有在轴向上变化的宽度，使得轴电位上的电效应沿离子电池的轴线变化。
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公开(公告)号：US08368012B2
公开(公告)日：2013-02-05
申请号：US12699550
申请日：2010-02-03
申请人： Evgenij Nikolaev , Jochen Franzen
发明人： Evgenij Nikolaev , Jochen Franzen
CPC分类号： H01J37/248 , H01J49/062 , H01J49/165 , H01J2237/03
摘要： Charged spray droplets are guided in a pseudopotential distribution generated by audio frequency voltages at electrodes of a guiding device, focusing the spray droplets toward the axis. An axial electric field profile and an axial flow profile of a drying gas in the guiding device allow the drift of different-sized droplets to be controlled in the longitudinal direction of the guiding device, so that the droplets are roughly equal in size when they leave the guiding device and finally dry up shortly after leaving. As a result, the ions are formed in a relatively small spatial region. Electrostatic potentials guide the analyte ions from this small spatial region to the entrance aperture of the inlet capillary; during this process, very light ions, especially protons and water-proton complexes, can be filtered out by a mobility filter.
摘要翻译： 带电喷雾液滴由引导装置的电极处的音频电压产生的赝势分布引导，将喷雾液滴聚焦到轴上。 引导装置中的干燥气体的轴向电场分布和轴向流动分布允许不同尺寸的液滴在引导装置的纵向方向上的漂移被控制，使得当它们离开时液滴大小相当大小 引导装置，最后在离开后立即干燥。 结果，离子形成在较小的空间区域。 静电势将分析离子从该小空间区域引导到入口毛细管的入口孔; 在此过程中，非常轻的离子，特别是质子和水 - 质子复合物可以通过迁移率过滤器过滤掉。
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公开(公告)号：US20120273674A1
公开(公告)日：2012-11-01
申请号：US13094146
申请日：2011-04-26
申请人： Melvin Andrew Park , Jochen Franzen
发明人： Melvin Andrew Park , Jochen Franzen
CPC分类号： G01N27/626
摘要： In an ion mobility spectrometer in which a gas pushes ions along a spectrometer axis against and over an electrical field barrier, the electric field barrier is generated with a plateau of slightly increasing height along the axis of the spectrometer. Alternately, the electric filed barrier may have a plateau with constant height, but the gas flow decreases in velocity along the axis of the spectrometer in the vicinity of the plateau.
摘要翻译： 在离子迁移谱仪中，其中气体沿着光谱仪轴线推动离子抵抗和超过电场屏障，电场屏障是沿着光谱仪轴线的高度稍微增加的高原产生的。 或者，电场屏障可以具有恒定高度的平台，但气流在平台附近沿着光谱仪的轴线的速度减小。
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公开(公告)号：US20110062322A1
公开(公告)日：2011-03-17
申请号：US12883885
申请日：2010-09-16
申请人： Jochen Franzen
发明人： Jochen Franzen
CPC分类号： G01N27/622
摘要： A supersonic gas jet having gas molecules with substantially equal velocities is formed by directing the gas through a Laval nozzle into an evacuated chamber. A field barrier having a substantially constant height across a cross-section of the supersonic gas jet is formed by respectively applying potentials U2, U3 and U4 to an arrangement of three apertured diaphragms R2, R3 and R4, which are respectively separated by distances d2 and d3, where (U4−U3)/(U3−U2)=d3/d2. The ions in the supersonic gas jet are directed against the field barrier, where ions with a mobility below a mobility threshold are pushed over the field barrier, and where ions with a mobility higher than the mobility threshold are held back by the field barrier.
摘要翻译： 具有基本相同速度的气体分子的超音速气体射流通过将气体通过拉瓦尔喷嘴引导到抽空的室中而形成。 通过分别将电位U2，U3和U4施加到三个有孔隔膜R2，R3和R4的排列上，形成跨超声波气体射流横截面具有基本恒定高度的场屏障，它们分别以距离d2和 d3，其中（U4-U3）/（U3-U2）= d3 / d2。 超音速气体射流中的离子被引导到场屏障，其中迁移率低于迁移率阈值的离子被推到场屏障上，并且其中迁移率高于迁移率阈值的离子被场屏障阻挡。
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50.发明申请公开(公告)号：US20110039350A1
公开(公告)日：2011-02-17
申请号：US12853637
申请日：2010-08-10
申请人： Jochen Franzen
发明人： Jochen Franzen
CPC分类号： H01J49/0431 , Y10T436/25
摘要： Gaseous analyte molecules are ionized at atmospheric pressure and provided to an inlet capillary of an ion spectrometer vacuum system by passing the ions through a reaction tube that ends in a conical intermediate piece for a gastight and smooth transition into the inlet capillary. The reaction tube is shaped so that the atmospheric pressure gas stream passing therethrough form the entrance of the tune to the intermediate piece is stably laminar. Analyte molecules from gas chromatographs, spray devices or vaporization devices can be introduced into the entrance of the reaction tube and ionized within the tube by single- or multi-photon ionization, by chemical ionization, by reactant ions or by physical ionization. For single- or multi-photon ionization, a beam from a laser can be passed axially down the reaction tube. Reactant ions can be produced by any means outside of the reaction tube and mixed with the analyte molecules within the tube.
摘要翻译： 气态分析物分子在大气压下离子化，并通过使离子通过端接在锥形中间件中的反应管提供给离子光谱仪真空系统的入口毛细管，以便气密和平滑过渡到入口毛细管中。 反应管成形为使得通过其的大气压力气流形成曲调到中间件的入口是稳定的层流的。 来自气相色谱仪，喷雾装置或蒸发装置的分析物分子可以通过单光子或多光子电离，通过化学电离，反应物离子或物理电离引入反应管的入口并离子化。 对于单光子或多光子电离，来自激光束的光束可以沿着反射管轴向通过。 反应物离子可以通过反应管外的任何方式产生并与管内的分析物分子混合。
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