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41.发明申请公开(公告)号：US20060002968A1
公开(公告)日：2006-01-05
申请号：US10882506
申请日：2004-06-30
申请人： Gordon Stewart , Gina Zhang , Nancy Kristen , Paul Consigny , Stephen Dugan , Gene Park , Christopher Feezor , Wouter Roorda , Syed Hossainy
发明人： Gordon Stewart , Gina Zhang , Nancy Kristen , Paul Consigny , Stephen Dugan , Gene Park , Christopher Feezor , Wouter Roorda , Syed Hossainy
IPC分类号： A61K31/4745 , A61F2/00
CPC分类号： A61K31/4745 , A61F2250/0067 , A61K31/436 , A61K31/573 , A61L31/10 , A61L31/16 , A61L2300/41 , A61L2300/416 , A61L2300/45 , A61K2300/00
摘要： Drug-delivery systems such as drug-delivery stents having an anti-proliferative agent such as everolimus and an anti-flammatory agent such as clobetasol are provided. Also disclosed are methods of treating a vascular impairment such as restenosis or vulnerable plaque.
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公开(公告)号：US20050244363A1
公开(公告)日：2005-11-03
申请号：US10835912
申请日：2004-04-30
申请人： Syed Hossainy , Eugene Michal , Thierry Glauser , Connie Kwok , Stephen Pacetti
发明人： Syed Hossainy , Eugene Michal , Thierry Glauser , Connie Kwok , Stephen Pacetti
IPC分类号： A61K31/727 , A61K31/728 , A61K31/785 , A61L27/00 , A61L31/10 , C08G63/48
CPC分类号： A61L31/10 , A61K31/727 , A61K31/728 , A61K31/785 , A61L31/16 , A61K2300/00 , C08L5/08 , C08L5/10
摘要： Hyaluronic acid (HA) conjugates or crosslinked HAs compositions for coating an implantable device are provided. The implantable device can be used for treating a disorder such as atherosclerosis, thrombosis, restenosis, high cholesterol, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.
摘要翻译： 提供了用于涂覆可植入装置的透明质酸（HA）缀合物或交联的HA组合物。 可植入装置可用于治疗动脉粥样硬化，血栓形成，再狭窄，高胆固醇，出血，血管解剖或穿孔，血管动脉瘤，易损斑块，慢性完全闭塞，跛行，静脉和人造移植物的吻合增殖等障碍，胆管 梗阻，输尿管阻塞，肿瘤阻塞及其组合。
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公开(公告)号：US20050238686A1
公开(公告)日：2005-10-27
申请号：US11089763
申请日：2005-03-25
申请人： Syed Hossainy , Steven Wu , Manish Gada , Anthony Andreacchi
发明人： Syed Hossainy , Steven Wu , Manish Gada , Anthony Andreacchi
CPC分类号： A61F2/82 , A61F2250/0068 , A61L31/10 , A61L31/16 , A61L2300/606
摘要： Coatings for implantable devices or endoluminal prosthesis, such as stents, are provided, including a method of forming the coatings. The coatings can be used for the delivery of an active ingredient or a combination of active ingredients.
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公开(公告)号：US20050169957A1
公开(公告)日：2005-08-04
申请号：US10815421
申请日：2004-03-31
申请人： Syed Hossainy
发明人： Syed Hossainy
IPC分类号： A61K31/445 , A61L31/10 , A61L31/12 , A61L31/16 , A61F2/00
CPC分类号： A61L31/16 , A61K31/445 , A61K31/74 , A61L31/10 , C08L33/06
摘要： A composition is disclosed comprising a structural component comprising linear acrylic homopolymers or linear acrylic copolymers and a biobeneficial component comprising copolymers having an acrylate moiety and a biobeneficial moiety.
摘要翻译： 公开了包含包含线性丙烯酸均聚物或线性丙烯酸共聚物的结构组分和包含具有丙烯酸酯部分和生物有益部分的共聚物的生物有益成分的组合物。
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公开(公告)号：US20050033412A1
公开(公告)日：2005-02-10
申请号：US10912025
申请日：2004-08-04
申请人： Steven Wu , Sameer Harish , Deborra Sanders-Millare , Judy Guruwaiya , Daryush Mirzaee , Syed Hossainy , Charlene Chen
发明人： Steven Wu , Sameer Harish , Deborra Sanders-Millare , Judy Guruwaiya , Daryush Mirzaee , Syed Hossainy , Charlene Chen
CPC分类号： A61F2/0077 , A61F2/848 , A61F2/91 , A61F2/915 , A61F2002/91533 , A61F2230/0013 , A61F2250/0067 , A61F2250/0068 , Y10S623/901
摘要： An implantable medical device, such as a stent or graft, having asperities on a designated region of its outer surface is disclosed. The asperities can serve to improve retention of one or more layers of a coating on the device and to increase the amount of coating that can be carried by the device. The asperities can be formed by using a stream of pressurized grit to roughen the surface. The asperities can also be formed by removing material from the outer surface, for example, by chemical etching with or without a patterned mask. Alternatively, the asperities can be formed by adding material to the outer surface, for example, by welding powder particles to the outer surface or sputtering.
摘要翻译： 公开了一种在其外表面的指定区域上具有凹凸的可植入医疗装置，例如支架或移植物。 粗糙度可用于改善设备上一层或多层涂层的保留性并增加该装置可承载的涂层量。 可以通过使用加压砂粒流粗糙表面来形成凹凸。 也可以通过从外表面去除材料来形成凹凸，例如通过具有或不具有图案化掩模的化学蚀刻来形成。 或者，可以通过向外表面添加材料，例如通过将粉末颗粒焊接到外表面或溅射来形成凹凸。
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46.发明授权Drug delivery system and method of treatment of vascular diseases using photodynamic therapy 有权药物输送系统和使用光动力疗法治疗血管疾病的方法公开(公告)号：US09572795B2
公开(公告)日：2017-02-21
申请号：US13572507
申请日：2012-08-10
申请人： Syed Hossainy , Dariush Davalian , Mikael Trollsas , John Stankus , Jinping Wan
发明人： Syed Hossainy , Dariush Davalian , Mikael Trollsas , John Stankus , Yuet Mei Khong , Jinping Wan
IPC分类号： A61M37/00 , A61K31/409 , A61K9/00 , A61K9/127 , A61K9/51 , A61L29/16 , A61K41/00 , A61M25/00 , A61M25/10
CPC分类号： A61K31/409 , A61K9/0009 , A61K9/0019 , A61K9/1272 , A61K9/5146 , A61K41/0071 , A61L29/16 , A61L2300/224 , A61L2300/626 , A61M25/0045 , A61M25/10 , A61M2025/105 , A61M2025/1086
摘要： This invention relates to photodynamic therapy (PDT) of vulnerable plaque using two pluralities of nanoparticles, one plurality comprising a PDT agent that is sensitive to blue-green light wherein the nanoparticles are capable of penetrating only into the fibrous cap of the vulnerable plaque and one plurality comprising a PDT agent that is sensitive to red light wherein the nanoparticles are capable of penetrating into the core of the vulnerable plaque.
摘要翻译： 本发明涉及使用两种纳米颗粒的易损斑块的光动力疗法（PDT），其一个包括对蓝绿色光敏感的PDT剂，其中纳米颗粒仅能穿透易损斑块的纤维帽和一个 多个包含对红光敏感的PDT剂，其中纳米颗粒能够渗入易损斑块的核心。
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47.发明授权Block copolymer comprising at least one polyester block and a poly (ethylene glycol) block 有权包含至少一个聚酯嵌段和聚（乙二醇）嵌段的嵌段共聚物公开(公告)号：US08916188B2
公开(公告)日：2014-12-23
申请号：US12106212
申请日：2008-04-18
CPC分类号： A61L31/10 , A61L31/047 , A61L31/06 , A61L31/148 , A61L31/16 , A61L2300/416 , A61L2300/606 , C08L71/02 , C08L67/04
摘要： The present invention provides a block copolymer for a coating on an implantable device for controlling release of drug and methods of making and using the same.
摘要翻译： 本发明提供了用于控制药物释放的可植入装置上的涂层的嵌段共聚物及其制备和使用方法。
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公开(公告)号：US08568471B2
公开(公告)日：2013-10-29
申请号：US13015488
申请日：2011-01-27
申请人： Mikael Trollsas , Michael H. Ngo , Boris Anukhin , Alexander Nikanorov , Syed Hossainy , John E. Papp , Dudley Jayasinghe , Zella Solter
发明人： Mikael Trollsas , Michael H. Ngo , Boris Anukhin , Alexander Nikanorov , Syed Hossainy , John E. Papp , Dudley Jayasinghe , Zella Solter
IPC分类号： A61F2/82
CPC分类号： A61F2/958 , A61F2/82 , A61F2/844 , A61F2/86 , A61F2/89 , A61F2/91 , A61F2/915 , A61F2002/825 , A61F2002/91558 , A61F2002/91566 , A61F2002/91575 , A61F2002/9522 , A61F2210/0004 , A61F2210/0014 , A61F2210/0019 , A61F2210/0076 , A61F2230/0006 , A61F2230/0008 , A61F2250/0067 , A61F2250/0096 , A61F2250/0098 , A61L27/00 , A61L31/06 , A61L31/14 , B21D39/046 , B29C35/08 , B29C2035/0838 , B29K2067/046 , B29L2023/00 , B29L2031/7543 , Y10T29/49826 , Y10T29/4987 , Y10T29/49908 , Y10T29/49925 , Y10T29/49927 , C08L67/04 , C08L71/02
摘要： A medical device includes a polymer scaffold crimped to a catheter having an expansion balloon. The scaffold, after being deployed by the balloon, provides a crush recovery of about 90% after the diameter of the scaffold has been pinched or crushed by 50%. The scaffold has a pattern including an asymmetric closed cell connecting links connecting the closed cells.
摘要翻译： 医疗装置包括压接到具有膨胀气囊的导管的聚合物构架。 支架在被气囊部署之后，在支架的直径被挤压或压碎50％后，提供约90％的压碎回收率。 支架具有图案，其包括连接连接封闭单元的链接的非对称封闭单元。
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公开(公告)号：US08465773B2
公开(公告)日：2013-06-18
申请号：US13472328
申请日：2012-05-15
申请人： Syed Hossainy , Michael Ngo , Mikael Trollsas , John Stankus , Gene Michal
发明人： Syed Hossainy , Michael Ngo , Mikael Trollsas , John Stankus , Gene Michal
CPC分类号： A61K47/42 , A61K9/0024 , A61K47/34 , A61L27/3804 , A61L27/3839 , A61L27/3895 , A61L27/48 , A61L27/52 , Y10S530/812 , Y10S530/815 , C08L89/00 , C08L71/02
摘要： Compositions for forming a self-reinforcing composite biomatrix, methods of manufacture and use therefore are herein disclosed. Kits including delivery devices suitable for delivering the compositions are also disclosed. In some embodiments, the composition can include at least three components. In one embodiment, a first component can include a first functionalized polymer, a second component can include a second functionalized polymer and a third component can include silk protein or constituents thereof. In some embodiments, the composition can include at least one cell type and/or at least one growth factor. In some embodiments, the composition can include a biologic encapsulated, suspended, disposed within or loaded into a biodegradable carrier. In some embodiments, the composition(s) of the present invention can be delivered by a dual lumen injection device to a treatment area in situ, in vivo, as well as ex vivo applications.
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公开(公告)号：US20120225040A1
公开(公告)日：2012-09-06
申请号：US13472324
申请日：2012-05-15
申请人： Syed Hossainy , Michael Ngo , Mikael Trollsas , John Stankus , Gene Michal
发明人： Syed Hossainy , Michael Ngo , Mikael Trollsas , John Stankus , Gene Michal
CPC分类号： A61K47/42 , A61K9/0024 , A61K47/34 , A61L27/3804 , A61L27/3839 , A61L27/3895 , A61L27/48 , A61L27/52 , Y10S530/812 , Y10S530/815 , C08L89/00 , C08L71/02
摘要： Compositions for forming a self-reinforcing composite biomatrix, methods of manufacture and use therefore are herein disclosed. Kits including delivery devices suitable for delivering the compositions are also disclosed. In some embodiments, the composition can include at least three components. In one embodiment, a first component can include a first functionalized polymer, a second component can include a second functionalized polymer and a third component can include silk protein or constituents thereof. In some embodiments, the composition can include at least one cell type and/or at least one growth factor. In some embodiments, the composition can include a biologic encapsulated, suspended, disposed within or loaded into a biodegradable carrier. In some embodiments, the composition(s) of the present invention can be delivered by a dual lumen injection device to a treatment area in situ, in vivo, as well as ex vivo applications.
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