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    NATRIURETIC COMPOUNDS, CONJUGATES, AND USES THEREOF
    41.
    发明申请
    NATRIURETIC COMPOUNDS, CONJUGATES, AND USES THEREOF 审中-公开
    NATRIURETIC化合物，结合物及其用途

    公开(公告)号：US20100216714A1

    公开(公告)日：2010-08-26

    申请号：US12689342

    申请日：2010-01-19

    申请人： Kenneth D. James ,  Balasingham Radhakrishnan ,  Navdeep B. Malkar ,  Mark A. Miller ,  Nnochiri N. Ekwuribe

    发明人： Kenneth D. James ,  Balasingham Radhakrishnan ,  Navdeep B. Malkar ,  Mark A. Miller ,  Nnochiri N. Ekwuribe

    IPC分类号： A61K38/17 ,  C07K14/47 ,  C07K14/58 ,  A61P9/00 ,  A61P9/04

    CPC分类号： C07K14/58 ,  A61K38/00 ,  A61K47/60 ,  C07K14/72 ,  C07K16/26

    摘要： Modified natriuretic compounds and conjugates thereof are disclosed in the present invention. In particular, conjugated forms of hBNP are provided that include at least one modifying moiety attached thereto. The modified natriuretic compound conjugates retain activity for stimulating cGMP production, binding to NPR-A receptor, and in some embodiments an improved half-life in circulation as compared to unmodified counterpart natriuretic compounds. Oral, parenteral, enteral, subcutaneous, pulmonary, and intravenous forms of the compounds and conjugates may be prepared as treatments and/or therapies for heart conditions particularly congestive heart failure. Modifying moieties comprising oligomeric structures having a variety of lengths and configurations are also disclosed. Analogs of the natriuretic compound are also disclosed, having an amino acid sequence that is other than the native sequence.

    摘要翻译： 本发明公开了改良的利尿钠化合物及其缀合物。 特别地，提供了缀合形式的hBNP，其包括与其连接的至少一个修饰部分。 修饰的利尿钠化合物缀合物保留刺激cGMP产生，与NPR-A受体结合的活性，并且在一些实施方案中，与未修饰的对应利钠化合物相比，循环中的半衰期改善。 口服，胃肠外，肠内，皮下，肺和静脉内形式的化合物和缀合物可以制备为用于心脏状况的治疗和/或治疗，特别是充血性心力衰竭。 还公开了包含具有各种长度和构型的寡聚结构的修饰部分。 还公开了利尿钠化合物的类似物，其具有不同于天然序列的氨基酸序列。

    HIDING CARD INFORMATION
    43.
    发明申请
    HIDING CARD INFORMATION 有权
    隐藏卡信息

    公开(公告)号：US20100113126A1

    公开(公告)日：2010-05-06

    申请号：US12263779

    申请日：2008-11-03

    申请人： Mark A. Miller

    发明人： Mark A. Miller

    IPC分类号： A63F9/24

    CPC分类号： G07F17/32 ,  G07F17/3227 ,  G07F17/3293 ,  G07F19/207

    摘要： Example methods and devices are set forth for playing a game. In some embodiments, an inventory of game indicia is arranged in a random but established, serial order. In some embodiments, for each hand of play the player makes a wager and game indicia are displayed in order from the inventory to define a winning or losing outcome. In some embodiments, a display, as hands are played, displays the remaining constituency of the inventory and the player, before any game, can order re-shuffling and re-constitute of the inventory. Other embodiments are described.

    摘要翻译： 规定了玩游戏的方法和设备。 在一些实施例中，游戏标记的清单以随机但已建立的串行顺序排列。 在一些实施例中，对于玩家的每一只手，玩家进行下注，并且从库存中顺序显示游戏标记以定义获胜或失败的结果。 在一些实施例中，作为手的播放的显示器在任何游戏之前显示库存的剩余选区，并且玩家可以订购重新洗牌和重新组合库存。 描述其他实施例。

    STATE SAVE IN GAME
    45.
    发明申请
    STATE SAVE IN GAME 有权
    状态保存在游戏中

    公开(公告)号：US20100099479A1

    公开(公告)日：2010-04-22

    申请号：US12255123

    申请日：2008-10-21

    申请人： Mark A. Miller

    发明人： Mark A. Miller

    IPC分类号： A63F9/24

    CPC分类号： G07F17/3239 ,  G07F17/32 ,  G07F17/3227 ,  G07F17/3286 ,  G07F17/3293

    摘要： Embodiments related to conducting a wagering game according to the rules of a base game includes defining a finite set of game indicia. In some embodiments the player plays multiple sequential game hand by placing a wager, receiving game indicia from the finite set cumulatively excluding any game indicia previously dealt, playing the game hand to completion, collecting the game indicia from the player and excluding the dealt game indicia from further play, and displaying at least the excluded game indicia or any winning combinations precluded by the excluded game indicia. In some embodiments the game hands continue in sequence until a restoration event, which may include a manually triggered restoration or an automatic restoration event, that restores the excluded game indicia. Other embodiments are also described.

    摘要翻译： 根据基本游戏的规则进行投注游戏的实施例包括限定游戏标记的有限集合。 在一些实施例中，玩家通过放置下注来播放多个顺序游戏手，从有限集合累积地接收游戏标记，累积地排除先前处理的任何游戏标记，玩游戏手完成，从玩家收集游戏标记并排除所处理的游戏标记 进一步播放，并且至少显示被排除的游戏标记或排除的游戏标记排除的任何获奖组合。 在一些实施例中，游戏手继续依次进行，直到恢复事件（其可以包括手动触发的恢复或自动恢复事件）来恢复排除的游戏标记。 还描述了其它实施例。

    Natriuretic compounds, conjugates, and uses thereof
    46.
    发明授权
    Natriuretic compounds, conjugates, and uses thereof 失效
    利尿钠化合物，缀合物及其用途

    公开(公告)号：US07662773B2

    公开(公告)日：2010-02-16

    申请号：US10723933

    申请日：2003-11-26

    申请人： Kenneth D. James ,  Balasingam Radhakrishnan ,  Navdeep B. Malkar ,  Mark A. Miller ,  Nnochiri N. Ekwuribe

    发明人： Kenneth D. James ,  Balasingam Radhakrishnan ,  Navdeep B. Malkar ,  Mark A. Miller ,  Nnochiri N. Ekwuribe

    IPC分类号： A61K38/03 ,  A61K8/64

    CPC分类号： C08G65/329 ,  A61K47/60 ,  C07K14/58 ,  C07K14/72 ,  C08L2203/02

    摘要： Modified natriuretic compounds and conjugates thereof are disclosed in the present invention. In particular, conjugated forms of hBNP are provided that include at least one modifying moiety attached thereto. The modified natriuretic compound conjugates retain activity for stimulating cGMP production, binding to NPR-A receptor, and in some embodiments an improved half-life in circulation as compared to unmodified counterpart natriuretic compounds. Oral, parenteral, subcutaneous, and intravenous forms of the compounds and conjugates may be prepared as treatments and/or therapies for heart conditions particularly congestive heart failure. Modifying moieties comprising oligomeric structures having a variety of lengths and configurations are also disclosed. Analogs of the natriuretic compound are also disclosed, having an amino acid sequence that is other than the native sequence.

    摘要翻译： 本发明公开了改良的利尿钠化合物及其缀合物。 特别地，提供了缀合形式的hBNP，其包括与其连接的至少一个修饰部分。 修饰的利钠化合物缀合物保留用于刺激cGMP产生，与NPR-A受体结合的活性，并且在一些实施方案中，与未修饰的对应利钠化合物相比，循环中的半衰期改善。 可以将口服，胃肠外，皮下和静脉内形式的化合物和缀合物制备为用于心脏状况的治疗和/或治疗，特别是充血性心力衰竭。 还公开了包含具有各种长度和构型的寡聚结构的修饰部分。 还公开了利尿钠化合物的类似物，其具有不同于天然序列的氨基酸序列。

    UZM-22 ALUMINOSILICATE ZEOLITE, METHOD OF PREPARATION AND PROCESSES USING UZM-22
    49.
    发明申请
    UZM-22 ALUMINOSILICATE ZEOLITE, METHOD OF PREPARATION AND PROCESSES USING UZM-22 有权
    UZM-22铝酸钠沸石，使用UZM-22的制备方法和工艺

    公开(公告)号：US20080031810A1

    公开(公告)日：2008-02-07

    申请号：US11462056

    申请日：2006-08-03

    申请人： Mark A. Miller ,  Jaime G. Moscoso ,  Gregory J. Lewis

    发明人： Mark A. Miller ,  Jaime G. Moscoso ,  Gregory J. Lewis

    IPC分类号： B01J29/04 ,  C01B39/00

    CPC分类号： B01J29/70 ,  C01B39/48 ,  C07C2/58 ,  C07C2/66 ,  C07C2529/70 ,  C10G29/205 ,  C10G45/64 ,  C10G50/00 ,  C07C9/16

    摘要： A new family of crystalline aluminosilicate zeolites has been synthesized. These zeolites are represented by the empirical formula. Mmn+Rr+Al(1-x)ExSiyOz where M is an alkali, alkaline earth, or rare earth metal such as lithium and strontium, R is a singly charged organoammonium cation such as the choline cation and E is a framework element such as gallium. These zeolites are similar to ZSM-18 but are characterized by unique x-ray diffraction patterns and compositions and have catalytic properties for carrying out various hydrocarbon conversion processes.

    摘要翻译： 已经合成了一系列结晶硅铝酸盐沸石。 这些沸石由经验公式表示。 <？in-line-formula description =“In-line Formulas”end =“lead”？> M＆lt; n＆gt;＆lt; n +＆lt; R＆gt;＆lt; （1-x）x 1 x x 1 x 1 x 1 x 1 x 1 x 1 x 1 x 1 x 1 line-formula description =“In-line Formulas”end =“tail”？>其中M是碱金属，碱土金属或稀土金属如锂和锶，R是单电荷的有机铵阳离子，如胆碱阳离子和 E是诸如镓的骨架元素。 这些沸石类似于ZSM-18，但是其特征在于独特的x射线衍射图和组成，并具有用于进行各种烃转化方法的催化性能。

    Leash and collar having quick connect/disconnect connector with disconnect control in handle
    50.
    发明授权
    Leash and collar having quick connect/disconnect connector with disconnect control in handle 失效
    皮带和衣领具有快速连接/断开连接器，带手柄中的断开控制

    公开(公告)号：US06374779B1

    公开(公告)日：2002-04-23

    申请号：US09357517

    申请日：1999-07-19

    申请人： Mark A. Miller

    发明人： Mark A. Miller

    IPC分类号： A01K300

    CPC分类号： A01K27/005

    摘要： The collar is disconnected from the leash by activating the mechanism in the handle assembly of the leash. The collar is fitted with a short cable which extends generally radially from the collar. A small cylinder or sphere is attached to the free end of this cable. There is a flared fitting at the end of the leash opposite to the handle end. The collar and leash are connected by trapping the cylinder or sphere in the flared fitting. The leash is a sheathed cable. The tension loads in the leash are carried by the cable. One end of the cable is anchored in the leash handle. There is a second cylinder or sphere attached to its other end and located in the flared fitting when the leash and collar are connected. The second cylinder or sphere retains the first in the flared fitting which is attached to the sheath. When the mechanism in the handle is activated, the mechanism moves the sheath along the cable so that the flared fitting is moved and no longer surrounds the cylinders (or spheres) and the one can no longer retain the other and disconnection is effected. In one embodiment of the invention the mechanism in the handle is reset by pulling the sheath out of the handle.

    摘要翻译： 通过激活皮带手柄组件中的机构，套环与皮带分离。 套环配有从套环大致径向延伸的短电缆。 一个小圆柱体或球体连接到该电缆的自由端。 皮带末端有一个喇叭形的配件，与手柄端相对。 套环和皮带通过将圆柱体或球体捕获在扩口配件中而连接。 皮带是护套电缆。 皮带中的拉力负载由电缆承载。 电缆的一端固定在皮带手柄中。 当连接皮带和衣领时，有一个连接到另一端的第二个圆柱体或球体，并位于喇叭形配件中。 第二圆柱体或球体将第一圆柱体或球体保持在附接到护套的扩口配件中。 当手柄中的机构被激活时，机构沿着电缆移动护套，使得扩口配件移动并且不再包围气缸（或球体），并且不再保持另一个并且断开连接。 在本发明的一个实施例中，通过将护套从手柄拉出来来复位手柄中的机构。