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192 条记录 (耗时 0.042 秒)

    METHOD AND APPARATUS FOR MANIPULATING CHAIN SEGMENTS
    41.
    发明申请
    METHOD AND APPARATUS FOR MANIPULATING CHAIN SEGMENTS 审中-公开
    用于操纵链条部分的方法和装置

    公开(公告)号：US20130116075A1

    公开(公告)日：2013-05-09

    申请号：US13669310

    申请日：2012-11-05

    申请人： Thomas Miller ,  James Gilpin

    发明人： Thomas Miller ,  James Gilpin

    IPC分类号： F16H55/30

    CPC分类号： F16H55/30 ,  B66D1/72 ,  F16H55/303

    摘要： A chain wheel designed to haul in, pay out and/or guide a mooring chain that includes multiple chain sizes. In one configuration, the chain wheel is a dual chain wheel that includes pockets sized to support a larger chain size and pockets sized to support a smaller chain size. The pockets include flat surfaces that support links of the chain as it passes over the chain wheel. The chain wheel also includes whelps designed to support and guide chain segments into proper alignment with the chain wheel.

    摘要翻译： 设计用于牵引，支付和/或引导包括多个链条尺寸的系泊链的链轮。 在一种配置中，链轮是双链轮，其包括尺寸适于支撑较大链条尺寸的口袋和口袋，其大小以支持较小的链条尺寸。 这些口袋包括平坦的表面，当链条经过链轮时支撑链条的链接。 链轮还包括设计成支撑和引导链条与链轮正确对准的小腿。

    Spirocyclic compounds
    43.
    发明授权
    Spirocyclic compounds 有权

    公开(公告)号：US08349825B2

    公开(公告)日：2013-01-08

    申请号：US12912094

    申请日：2010-10-26

    申请人： Dawn M. Mampreian ,  Joey L. Methot ,  Thomas Miller ,  Paul Tempest ,  Anna A. Zabierek

    发明人： Dawn M. Mampreian ,  Joey L. Methot ,  Thomas Miller ,  Paul Tempest ,  Anna A. Zabierek

    IPC分类号： A61K31/00 ,  A61K31/445 ,  C07D221/00 ,  C07D205/00

    CPC分类号： C07D471/10 ,  C07D487/10 ,  C07D491/10 ,  C07D491/107 ,  C07D498/10

    摘要： The present invention relates to a novel class of substituted spirocyclic compounds. These compounds can inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention may also be useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases. The present invention further provides pharmaceutical compositions comprising the compounds of the instant invention and safe dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of these compounds in vivo.

    NOVEL TRIFLUOROMETHYLSULFONAMIDE GAMMA SECRETASE INHIBITOR
    46.
    发明申请
    NOVEL TRIFLUOROMETHYLSULFONAMIDE GAMMA SECRETASE INHIBITOR 有权
    新型三氟甲磺酰胺游离氨基酸抑制剂

    公开(公告)号：US20110275719A1

    公开(公告)日：2011-11-10

    申请号：US13145190

    申请日：2010-01-29

    申请人： Matthew Daniels ,  Jed Hubbs ,  Thomas Miller

    发明人： Matthew Daniels ,  Jed Hubbs ,  Thomas Miller

    IPC分类号： A61K31/18 ,  A61P25/28 ,  C07C305/18

    CPC分类号： C07D233/42 ,  C07C317/30 ,  C07C2601/14 ,  C07D295/185

    摘要： The present invention is directed to a novel trifluoromethylsulfonamide derivative which inhibits the processing of APP by the putative γ-secretase and thus is useful in the treatment or prevention of Alzheimer's disease. This compound possesses favorable pharmacokinetic properties in higher species (rhesus) and thus can be dosed on an intermittent dosing regiment (e.g., once weekly). When dosed on such a regiment the compound exhibits significant and continuous Aβ lowering without the manifestation of Notch associated gastrointestinal toxicity for extended periods, e.g., 7 days. Pharmaceutical compositions and methods of use are also included.

    摘要翻译： 本发明涉及一种新的三氟甲基磺酰胺衍生物，其抑制通过推定的γ-分泌酶处理APP，因此可用于治疗或预防阿尔茨海默氏病。 该化合物在较高种类（恒河猴）中具有有利的药代动力学性质，因此可以间歇给药剂量（例如每周一次）给药。 当这样一个团体配合时，该化合物显示出显着和连续的A＆Bgr; 降低Notch相关胃肠道毒性长期持续的表现，例如7天。 还包括药物组合物和使用方法。

    Delay locked loop
    48.
    发明授权
    Delay locked loop 失效
    延迟锁定环路

    公开(公告)号：US07457392B2

    公开(公告)日：2008-11-25

    申请号：US10266296

    申请日：2002-10-08

    申请人： Christian Weis ,  Thomas Miller ,  Patrick Heyne

    发明人： Christian Weis ,  Thomas Miller ,  Patrick Heyne

    IPC分类号： H03D3/24

    CPC分类号： G11C7/1066 ,  G11C7/1072 ,  G11C7/22 ,  G11C7/222 ,  G11C11/4076 ,  H03K5/131 ,  H03K2005/00058 ,  H03K2005/00156 ,  H03L7/0814 ,  H03L7/0818

    摘要： A delay locked loop includes a first delay device for obtaining a fine setting and a downstream-connected second delay device for obtaining a coarse setting of the delay time. The control signals for controlling the respective delay devices are provided by synchronization latches, which receive a clock obtained by the output signal of the first delay device for obtaining the fine setting. The delay locked loop enables a linear operating behavior at a high operating frequency and is particularly suitable when a differential embodiment of the two delay devices is used.

    摘要翻译： 延迟锁定环包括用于获得精细设置的第一延迟装置和用于获得延迟时间的粗略设置的下游连接的第二延迟装置。 用于控制各个延迟装置的控制信号由同步锁存器提供，同步锁存器接收由第一延迟装置的输出信号获得的时钟，以获得精细设置。 延迟锁定环使得能够在高工作频率下的线性操作特性，并且当使用两个延迟装置的差分实施例时特别合适。

    Robotic Trajectory Guide
    50.
    发明申请
    Robotic Trajectory Guide 有权
    机器人轨迹指南

    公开(公告)号：US20080039869A1

    公开(公告)日：2008-02-14

    申请号：US11873154

    申请日：2007-10-16

    申请人： Gerald Mills ,  Martin Brady ,  Raghu Raghavan ,  John David ,  Thomas Miller ,  Matthew Solar

    发明人： Gerald Mills ,  Martin Brady ,  Raghu Raghavan ,  John David ,  Thomas Miller ,  Matthew Solar

    IPC分类号： A61B19/00

    CPC分类号： A61B90/11 ,  A61B34/20 ,  A61B34/30 ,  A61B34/70 ,  A61B2034/107 ,  A61B2034/2055 ,  A61B2034/301 ,  A61B2090/374

    摘要： A surgical alignment device is disclosed that is controlled remotely through the use of an actuator, where the actuator in turn controls at least one local adjustment device. The alignment device is suited for neurosurgery, although it is not exclusively limited to neurosurgery. The alignment device includes an insertion guide that is coupled to the local adjustment device, the insertion guide being used to guide a device such as a catheter into a patient. The alignment device may also be coupled to a control module such as a microcomputer that controls the orientation of the insertion guide in response to inputs from the surgeon as to a location of interest within the patient.

    摘要翻译： 公开了通过使用致动器远程控制的外科对准装置，其中致动器依次控制至少一个局部调节装置。 对准装置适用于神经外科手术，但并不限于神经外科手术。 对准装置包括联接到局部调节装置的插入引导件，插入引导件用于将诸如导管的装置引导到患者体内。 对准装置还可以耦合到诸如微型计算机的控制模块，微型计算机响应于来自外科医生的输入以及患者内感兴趣的位置来控制插入引导件的取向。