-
公开(公告)号：US20120177537A1
公开(公告)日：2012-07-12
申请号：US13262057
申请日：2009-12-07
申请人： Arata Aota , Takehiko Kitamori
发明人： Arata Aota , Takehiko Kitamori
CPC分类号： G01N33/491 , G01N1/4005
摘要： An apparatus for separating plasma by which plasma can be separated from a small amount of whole blood cell sample without centrifugation is disclosed. This apparatus includes a blood channel through which blood flows; and a plasma channel through which plasma separated from said blood flows. The plasma channel is arranged at least partially in parallel with said blood channel and the blood channel and the plasma channel are at least partially in contact with each other along the longitudinal direction of the channels. Blood is made to flow at a flow rate at which blood cell components in the blood flowing through the blood channel axially accumulate and at which hemolysis does not occur. The plasma moves to the plasma channel after being separated into a blood cell layer and a plasma layer.
摘要翻译： 公开了一种用于分离等离子体的装置，通过该装置可以将血浆与少量的全血细胞样品分离而不进行离心。 该装置包括血流通过的血液通道; 以及等离子体通道，血浆从血液中分离出来。 等离子体通道至少部分地与所述血液通道平行布置，并且血液通道和等离子体通道沿着通道的纵向方向至少部分地彼此接触。 使血液以流过血液通道的血液中的血细胞成分轴向积聚并且不发生溶血的流速流动。 在分离成血细胞层和等离子体层之后，等离子体移动到等离子体通道。
-
42.发明授权Microchip, nucleic acid extracting kit, and nucleic acid extracting method 有权Microchip，核酸提取试剂盒和核酸提取方法公开(公告)号：US08012680B2
公开(公告)日：2011-09-06
申请号：US10550302
申请日：2004-03-24
CPC分类号： B01L3/502746 , B01J19/0093 , B01J2219/00783 , B01L3/502707 , B01L2200/0668 , B01L2300/0816 , B01L2400/086 , C12N15/1006 , C12Q1/6806
摘要： A new technical means is provided that can be produced and prepared at low cost, and in which the generation of stagnation in the flow of a liquid sample can be suppressed, microbeads can be smoothly and simply injected, filled and transported and the generation of dust can be also suppressed and a new extracting method for nucleic acid using the new technical means is provided. A microchip has a microchannel (3) formed by groove parts (11, 21) provided in connecting surfaces of upper and lower substrates (1, 2). In the microchannel (3), a gap part (31) in which the section of the channel is reduced is provided in a central part upward and downward, rightward and leftward, or upward and downward and rightward and leftward the section thereof, and microbeads are checked.
摘要翻译： 提供了可以以低成本生产和制备的新技术手段，可以抑制液体样品流动停滞的产生，微珠可以平稳简单地注入，填充和运输，并产生粉尘 也可以抑制新的技术手段提供新的核酸提取方法。 微芯片具有由设置在上基板和下基板（1,2）的连接表面中的槽部（11,21）形成的微通道（3）。 在微通道（3）中，通道的上部，下部，左右，中央部分设有间隙部（31），其中，上述部分的上下左右 被检查。
-
公开(公告)号：US20110038758A1
公开(公告)日：2011-02-17
申请号：US11791102
申请日：2005-11-18
申请人： Shuichi Akaba , Yuichi Oku , Manabu Tokeshi , Takehiko Kitamori
发明人： Shuichi Akaba , Yuichi Oku , Manabu Tokeshi , Takehiko Kitamori
IPC分类号： G01N30/00
CPC分类号： B01L3/502761 , B01L2200/0668 , B01L2300/0627 , B01L2300/0825 , B01L2300/0877 , B81B1/002 , B81B2201/058 , G01N33/54366
摘要： A microchip, which is used in a diagnostic system using a microfluid system, has a flow path capable of greatly improving the reaction efficiency and realizing a stable measurement with high reproducibility. The microchip has two substrates with at least a flow path 12 formed at the interface between the two substrates, the flow path 12 having a reaction area 14 and a detection area 15 downstream of the reaction area 14, and the flow path 12 at the detection area 15 having a depth which is deeper than the flow path 12 in the reaction area 14.
摘要翻译： 在使用微流体系统的诊断系统中使用的微芯片具有能够大大提高反应效率并且以高再现性实现稳定测定的流路。 微芯片具有两个基板，至少形成在两个基板之间的界面处的流路12，流路12具有反应区域14和反应区域14下游的检测区域15以及检测流路12 区域15的深度比反应区域14中的流路12深。
-
公开(公告)号：US20090306414A1
公开(公告)日：2009-12-10
申请号：US12281182
申请日：2007-02-27
申请人： Yasuhiro Uozumi , Yoichi Yamada , Naoshi Fukuyama , Tomohiko Beppu , Takehiko Kitamori , Masaharu Ueno
发明人： Yasuhiro Uozumi , Yoichi Yamada , Naoshi Fukuyama , Tomohiko Beppu , Takehiko Kitamori , Masaharu Ueno
IPC分类号： C07D307/12 , B01J35/02
CPC分类号： B01J37/0219 , B01J19/0093 , B01J31/06 , B01J31/165 , B01J31/24 , B01J2219/00835 , B01J2219/0086 , B01J2219/00873 , B01J2219/00891 , B01J2219/00907 , B01J2531/824
摘要： The present invention provides a microchannel reactor that is used as a new reaction device capable of greatly expanding the utilization range of chemical reactions occurring in microspaces. A solution of a soluble linear polymer containing ligands and a solution of a soluble transition metal molecule are individually introduced into a microreactor, the flows are merged inside a microchannel and a metal polymer membrane of a complex formed is generated at the interface of the flows. The membrane is used as a solid catalyst, and various reactions such as carbon-carbon bond formation reactions, oxidation reactions and the like can be conducted at extremely fast reaction rates.
摘要翻译： 本发明提供一种微通道反应器，其用作能够大大扩大在微球中发生的化学反应的利用范围的新的反应装置。 将包含配体的可溶性线性聚合物和可溶性过渡金属分子的溶液的溶液分别引入微反应器中，将该流体在微通道内并入，并且在流动的界面处产生形成的络合物的金属聚合物膜。 该膜用作固体催化剂，并且可以以非常快的反应速率进行各种反应，例如碳 - 碳键形成反应，氧化反应等。
-
45.发明申请Chip element for micro chemical system and micro chemical system using the chip element 审中-公开用于微化学系统的芯片元件和使用芯片元件的微量化学系统公开(公告)号：US20080124247A1
公开(公告)日：2008-05-29
申请号：US11983917
申请日：2007-11-13
CPC分类号： G01N21/0303 , B01L3/5027 , G01N21/171 , G01N21/645
摘要： There are provided a chip for micro chemical systems which can obviate the need of alignment at every measurement and can improve the measurement sensitivity and reduce the variation of measurement, and a micro chemical system using the chip. A thermal lens spectrometry system 10 comprises: a micro chemical chip 2 having a groove 1 into which a sample solution is injected; a rod lens 3 disposed on the micro chemical chip 2 at a predetermined spacing above the groove 1; a lens holder 9 disposed above the micro chemical chip 2; a securing section 4; an optical fiber 5; a ferrule 6 secured by the securing section 4 above the rod lens 3; a light source unit 7 connected to the optical fiber 5, and a detection device 8 disposed below the micro chemical chip 2. The securing section 4 comprises a seating 32 laid on the micro chemical chip 2, and a metal split sleeve 33 for fitting the ferrule 6 and the lens holder 9 at the outside thereof.
摘要翻译： 提供了一种用于微量化学系统的芯片，可以消除每次测量时对准的需要，并且可以提高测量灵敏度并减少测量的变化，以及使用该芯片的微型化学系统。 热透镜分光系统10包括：微化学芯片2，其具有注入样品溶液的槽1; 棒状透镜3，以规定的间隔配置在微细化学品片2上， 设置在微化学芯片2上方的透镜架9; 固定部分4; 光纤5; 由杆状透镜3上方的固定部4固定的套圈6; 连接到光纤5的光源单元7和设置在微化学芯片2下方的检测装置8。 固定部分4包括放置在微化学芯片2上的座32和用于将套圈6和透镜保持器9装配在其外侧的金属分开套筒33。
-
46.发明申请Microchip, nucleic acid extracting kit, and nucleic acid extracting method 有权Microchip，核酸提取试剂盒和核酸提取方法公开(公告)号：US20060234241A1
公开(公告)日：2006-10-19
申请号：US10550302
申请日：2004-03-24
CPC分类号： B01L3/502746 , B01J19/0093 , B01J2219/00783 , B01L3/502707 , B01L2200/0668 , B01L2300/0816 , B01L2400/086 , C12N15/1006 , C12Q1/6806
摘要： A new technical means is provided that can be produced and prepared at low cost, and in which the generation of stagnation in the flow of a liquid sample can be suppressed, microbeads can be smoothly and simply injected, filled and transported and the generation of dust can be also suppressed and a new extracting method for nucleic acid using the new technical means is provided. A microchip has a microchannel (3) formed by groove parts (11, 21) provided in connecting surfaces of upper and lower substrates (1, 2). In the microchannel (3), a gap part (31) in which the section of the channel is reduced is provided in a central part upward and downward, rightward and leftward, or upward and downward and rightward and leftward the section thereof, and microbeads are checked.
摘要翻译： 提供了可以以低成本生产和制备的新技术手段，可以抑制液体样品流动停滞的产生，微珠可以平稳简单地注入，填充和运输，并产生粉尘 也可以抑制新的技术手段提供新的核酸提取方法。 微芯片具有由设置在上基板和下基板（1,2）的连接表面中的槽部（11,21）形成的微通道（3）。 在微通道（3）中，通道的上部，下部，左右，中央部分设有间隙部（31），其中，上述部分的上下左右 被检查。
-
公开(公告)号：US20060060811A1
公开(公告)日：2006-03-23
申请号：US11229695
申请日：2005-09-20
申请人： Masahiro Kuwata , Hajime Sudo , Takehiko Kitamori
发明人： Masahiro Kuwata , Hajime Sudo , Takehiko Kitamori
IPC分类号： F16K3/00
CPC分类号： F16K51/02 , F16K11/0655 , F16K27/044 , F16K99/0001 , F16K99/0011 , F16K2099/0074 , F16K2099/0076 , F16K2099/0078 , F16K2099/0084 , Y10T29/49405 , Y10T137/7036
摘要： A slide valve apparatus includes a first member having a first fluid channel for allowing a fluid to flow therethrough, a second member sliding along the first member and having a second fluid channel formed in a manner to communicate with the first fluid channel, and a first elastic membrane formed in the sliding surface along which the second member and the first member slide relative to each other and having a first communicating hole communicating with the first fluid channel. In manufacturing the slide valve apparatus, a gas is spurted from the open edge of the first fluid channel in at least a stage between the start up of the step of forming the elastic membrane and the end of the step of baking the elastic membrane so as to form in the elastic membrane the communicating hole communicating with the first fluid channel.
摘要翻译： 滑阀装置包括具有用于允许流体流过其中的第一流体通道的第一构件，沿着第一构件滑动并具有以与第一流体通道连通的方式形成的第二流体通道的第二构件，以及第一构件 弹性膜，其形成在所述滑动表面中，所述第二构件和所述第一构件沿着所述滑动表面相对于彼此滑动并具有与所述第一流体通道连通的第一连通孔。 在制造滑阀装置时，在形成弹性膜的步骤的启动与烧结弹性膜的步骤的结束之间的至少一个阶段中，从第一流体通道的开口边缘喷出气体，以便 在弹性膜中形成与第一流体通道连通的连通孔。
-
公开(公告)号：US20050263398A1
公开(公告)日：2005-12-01
申请号：US11138373
申请日：2005-05-27
CPC分类号： G01N35/1097 , G01N2035/00237
摘要： For enlarging the application range of samples capable of being treated, decreasing the amount of samples used, preventing deterioration of samples by a change with the passage of time and preventing mixing of samples by diffusion, a micro fluidics system according to the present invention comprises a sample server which stores plural samples and which has sample efflux portions, a microchip for feeding samples to a treating portion through plural sample introducing portions communicating with the sample efflux portions and further through a microchannel, allowing the samples to be subjected to a predetermined treatment, and a sample feeder for feeding the samples stored in the sample server to the sample introducing portions through the sample efflux portions. The sample feeder comprises valves for opening and closing communication paths between the sample efflux portions of the sample server and the sample introducing portions of the microchip and pressurizing devices for pressurizing the samples stored in the sample server and pushing them out into the sample introducing portions in an open condition of the valves.
摘要翻译： 为了扩大能够处理的样品的应用范围，减少使用的样品量，通过随时间的改变改变样品的劣化并防止样品通过扩散混合，根据本发明的微流体系统包括： 存储多个样品并具有样品外排部分的样品服务器，用于通过与样品排出部分连通的多个样品导入部分进一步将样品供给到处理部分的微芯片，并且进一步通过微通道，允许样品经受预定处理， 以及用于将存储在样品服务器中的样品通过样品排出部分供给到样品引入部分的样品进料器。 样品供给器包括用于打开和关闭样品服务器的样品排出部分和微芯片的样品引入部分之间的连通路径的阀，以及用于对存储在样品服务器中的样品加压并将其推出到样品引入部分中的加压装置 阀的开启状态。
-
公开(公告)号：US06930778B2
公开(公告)日：2005-08-16
申请号：US10733491
申请日：2003-12-10
CPC分类号： G01N21/171
摘要： A microchemical system is provided, which can improve the working efficiency of the user and can be designed compact in size. The microchemical system is provided with an optical fiber 10 with a gradient index rod lens 102 mounted on an end thereof. The lens-possessing optical fiber 10 is comprised of an optical fiber 101 that transmits exciting light and detecting light in the single mode, and a ferrule 103 for expanding the outer diameter of the optical fiber 101 to the same value as that of the gradient index rod lens 102. The gradient index rod lens 102 and the optical fiber 101 are rigidly joined together by means of a sleeve 104.
摘要翻译： 提供了一种微化学系统，可以提高用户的工作效率，设计尺寸紧凑。 微化学系统设置有光纤10，其具有安装在其一端的梯度折射率棒透镜102。 具有透镜的光纤10包括以单模发射激发光并检测光的光纤101，以及用于将光纤101的外径扩大到与梯度指数相同的值的套圈103 棒状透镜102。 梯度分度杆透镜102和光纤101通过套筒104刚性地接合在一起。
-
公开(公告)号：US20050158213A1
公开(公告)日：2005-07-21
申请号：US11028673
申请日：2005-01-05
CPC分类号： B01L3/502715 , B01L3/565 , B01L9/527 , B01L2200/027 , B01L2300/0825 , B01L2300/0887 , B01L2400/0487
摘要： In a microfluid system it is intended to expand the application range of samples capable of being treated, decrease the amount of samples used, and prevent deterioration of samples with the lapse of time. In a microfluid system having a microchip for feeding plural samples to a treating portion and performing predetermined treatments, plural sample servers for storage of the samples therein are provided in the microchip, the sample servers and the treating portion are connected with each other through capillary channels provided respectively on outlet sides of the sample servers, and a pressurizing device for pressurizing the samples stored in the sample servers and feeding them to the treating portion is provided.
摘要翻译： 在微流体系统中，旨在扩大能够处理的样品的应用范围，减少使用的样品量，并防止样品随时间的退化。 在具有用于向处理部供给多个样品并执行预定处理的微芯片的微流体系统中，在微芯片中提供用于存储样品的多个样品服务器，样品服务器和处理部通过毛细通道彼此连接 分别设置在样本服务器的出口侧，并且提供用于对存储在样本服务器中的样本加压并将其馈送到处理部分的加压装置。
-
-
-
-
-
-
-
-
-
搜索结果
52 条记录 (耗时 0.026 秒)