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公开(公告)号：US08034296B2
公开(公告)日：2011-10-11
申请号：US11428289
申请日：2006-06-30
IPC分类号： G01N33/00
CPC分类号： G01N15/1459 , B01L3/502723 , B01L3/502746 , B01L3/502761 , B01L3/502776 , B01L2200/0636 , B01L2200/0684 , B01L2200/10 , B01L2300/0816 , B01L2300/0887 , B01L2400/0406 , B01L2400/0415 , B01L2400/0427 , B01L2400/0487 , B01L2400/086 , G01N15/1404 , G01N15/1484 , G01N2015/0073 , G01N2015/1006 , G01N2015/1486 , G01N2015/149
摘要： A microfluidic circuit cartridge for a complete blood count, including analyses of red blood cells. Various parameters of the red blood cells may be attained. The cartridge may have sphering mechanism which has a channel or loop with a configuration for reducing or eliminating cell settling. The channel or loop may incorporate a combination of straight and curve paths in the context of gravity. The channel may alternatively have a hydrophilic or hydrophobic inside surface. Again alternatively, the channel may have an electro-wettable inside surface. Or, the channel may be subject to an electric or magnetic field. There may also be a mechanism for reducing or eliminating clumping of a sample.
摘要翻译： 用于完整血细胞计数的微流体电路盒，包括红细胞分析。 可以获得红细胞的各种参数。 盒可以具有球形机构，其具有通道或环，其具有用于减少或消除细胞沉降的构造。 通道或环路可以在重力的上下文中包含直线和曲线路径的组合。 通道也可以具有亲水或疏水的内表面。 或者，通道可以具有电润湿的内表面。 或者，通道可能受到电场或磁场的影响。 还可以存在减少或消除样品团块的机理。
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公开(公告)号：US07671987B2
公开(公告)日：2010-03-02
申请号：US11030407
申请日：2005-01-06
IPC分类号： G01B11/00
CPC分类号： G01N15/1404 , A61B5/150022 , A61B5/150213 , A61B5/150221 , A61B5/150274 , A61B5/150343 , A61B5/150351 , A61B5/157 , A61B5/417 , A61B5/7264 , B01L3/5027 , G01B11/272 , G01N15/1434 , G01N15/1459 , G01N15/1484 , G01N33/5094 , G01N33/569 , G01N35/085 , G01N2015/0069 , G01N2015/0073 , G01N2015/008 , G01N2015/0238 , G01N2015/1075 , G01N2015/1486 , Y10T436/24
摘要： An optical detection system for flow cytometry that uses light sources positioned laterally at different distances from the central axis of the flow stream for providing light through different parts of the flow stream. By using two or more light sources, the particle position can be detected, and the alignment and width of the core stream can be monitored and controlled.
摘要翻译： 一种用于流式细胞术的光学检测系统，其使用位于与流动流的中心轴线不同的距离处的光源，用于通过流动流的不同部分提供光。 通过使用两个或更多个光源，可以检测颗粒位置，并且可以监测和控制核心流的对准和宽度。
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公开(公告)号：US07553453B2
公开(公告)日：2009-06-30
申请号：US11618502
申请日：2006-12-29
申请人： Yuandong Gu , Aravind Padmanabhan
发明人： Yuandong Gu , Aravind Padmanabhan
CPC分类号： G01N15/1459 , B01L3/502715 , B01L3/502776 , B01L9/527 , B01L2200/0636 , B01L2200/0647 , B01L2200/0684 , B01L2200/10 , B01L2200/143 , B01L2200/146 , B01L2300/0816 , B01L2300/0867 , B01L2300/087 , B01L2300/0887 , B01L2400/0487 , G01N15/1484 , G01N33/5094 , G01N2015/0073 , G01N2015/008 , G01N2015/0084 , G01N2015/0088 , G01N2015/1486 , G01N2035/00158 , G01N2333/445 , G01N2333/70514 , G01N2333/70589 , G01N2800/26 , Y02A50/58 , Y10T436/2575
摘要： An assay implementation in a microfluidic format in a cartridge relating to a point-of-care instrument platform for monitoring and diagnosing infectious diseases (e.g., AIDS and malaria). The platform may also provide a complete blood count. The instrument platform may hold the cartridge and a portion of an optical system for fluorescent and scattered light related analyses of blood sample in a flow channel of the cartridge.
摘要翻译： 在与用于监测和诊断感染性疾病（例如艾滋病和疟疾）的护理点仪器平台相关的盒中的微流体形式的测定实现。 该平台还可以提供完整的血液计数。 仪器平台可以将墨盒和一部分光学系统用于荧光和散射光相关分析的血液样品在墨盒的流动通道中。
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公开(公告)号：US20080096289A1
公开(公告)日：2008-04-24
申请号：US11552383
申请日：2006-10-24
申请人： Jicang Zhou , Yuandong Gu , Allen A. Cox , Aravind Padmanabhan
发明人： Jicang Zhou , Yuandong Gu , Allen A. Cox , Aravind Padmanabhan
IPC分类号： G01N33/549
CPC分类号： G01N33/587 , G01N33/54346 , G01N33/54373
摘要： A nanoparticle having a self assembly monolayer of molecules as a shell on the nanoparticle. The monolayer may include organic molecules working as surface enhanced Raman spectroscopy (SERS) reporters. Also, the core shell may include at least a receptor, and/or the like, to ensure that a target analyte can be bound for measurement with SERS. The target analyte may be organic, chemical, biological, inorganic, gas, liquid, solid, and so forth.
摘要翻译： 具有在纳米颗粒上作为壳的自组装单分子层的纳米颗粒。 单层可以包括作为表面增强拉曼光谱（SERS）记者工作的有机分子。 此外，核心壳可以包括至少一种受体和/或类似物，以确保靶分析物能够与SERS结合以进行测量。 目标分析物可以是有机的，化学的，生物的，无机的，气体的，液体的，固体的等等。
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公开(公告)号：US07312870B2
公开(公告)日：2007-12-25
申请号：US11263333
申请日：2005-10-31
IPC分类号： G01B11/00
CPC分类号： G01N15/1456 , G01B11/272 , G01N15/1434 , G01N35/085 , G01N2015/0069 , G01N2015/0073 , G01N2015/008 , G01N2015/0238 , G01N2015/1075
摘要： An optical alignment detection system for detecting the alignment of a first object relative to a second object is provided. One or more light sources and one or more light detectors, either or both of which are secured relative to the second object, are used to detect the position of one or more light scattering elements on the first object.
摘要翻译： 提供了一种用于检测第一物体相对于第二物体的对准的光学对准检测系统。 一个或多个光源和一个或多个光检测器用于检测第一物体上的一个或多个光散射元件的位置，其中一个或两个光检测器相对于第二物体固定。
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公开(公告)号：US20070149863A1
公开(公告)日：2007-06-28
申请号：US11306399
申请日：2005-12-27
申请人： Aravind Padmanabhan , Tom Rezachek , Ron Bardell
发明人： Aravind Padmanabhan , Tom Rezachek , Ron Bardell
IPC分类号： A61B5/00
CPC分类号： G01N35/1079 , B01L3/502715 , B01L3/502746 , B01L9/527 , B01L2200/027 , B01L2200/143 , B01L2300/0627 , B01L2300/0672 , B01L2300/0816 , B01L2400/0481 , B01L2400/0487 , G01N35/1095 , G01N2035/00158
摘要： Instrument-cartridge interfaces for fluidic analyzers that have an instrument and a removable cartridge are disclosed. For example, and in one illustrative embodiment, the instrument may include a needle that is adapted to penetrate a septum on a removable cartridge. In another illustrative embodiment, the instrument may include a plunger that is adapted to deform a deformable membrane on a removable cartridge. In yet another illustrative embodiment, the instrument may include a nozzle that is adapted to mate and seal with a flow channel on a removable cartridge. Techniques for detecting the flow rate in a flow channel on a removable cartridge, as well as the position of fluid in a flow channel of a removable cartridge, are also disclosed.
摘要翻译： 公开了具有仪器和可移除盒的流体分析仪的盒式磁带接口。 例如，在一个说明性实施例中，仪器可以包括适于穿透可移除盒的隔膜的针。 在另一说明性实施例中，仪器可以包括适于使可移除盒上的可变形膜变形的柱塞。 在另一个说明性实施例中，仪器可以包括适于与可移除盒上的流动通道配合和密封的喷嘴。 还公开了用于检测可移除盒上的流动通道中的流速以及可移除盒的流动通道中的流体位置的技术。
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47.发明申请Architectures of sensor networks for biological and chemical agent detection and identification 审中-公开用于生物和化学试剂检测和鉴定的传感器网络架构公开(公告)号：US20070093970A1
公开(公告)日：2007-04-26
申请号：US11186263
申请日：2005-07-21
CPC分类号： G08B21/12
摘要： A sensor network provides the ability to detect, classify and identify a diverse range of agents over a large area, such as a geographical region or building. The network possesses speed of detection, sensitivity, and specificity for the diverse range of agents. Different functional level types of sensors are employed in the network to perform early warning, broadband detection and highly specific and sensitive detection. A high probability of detection with low probability of false alarm is provided by the processing of information provided from multiple sensors. A Bayesian net is utilized to combine probabilities from the multiple sensors in the network to reach a decision regarding the presence or absence of a threat. The network is field portable and capable of autonomous operation. It also is capable of providing automated output decisions.
摘要翻译： 传感器网络提供检测，分类和识别大面积（例如地理区域或建筑物）上的各种代理的能力。 网络具有各种代理的检测速度，灵敏度和特异性。 在网络中采用不同功能级别的传感器进行预警，宽带检测和高度特异性和灵敏度的检测。 通过处理从多个传感器提供的信息来提供具有低误报率的检测的高概率。 使用贝叶斯网络来组合来自网络中的多个传感器的概率以达成有关威胁的存在或不存在的决定。 该网络是现场便携式的，能够进行自主操作。 它还能够提供自动输出决定。
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公开(公告)号：US20070009386A1
公开(公告)日：2007-01-11
申请号：US11428370
申请日：2006-06-30
申请人： Aravind Padmanabhan , Ron Bardell
发明人： Aravind Padmanabhan , Ron Bardell
IPC分类号： G01N33/00
CPC分类号： G01N15/1484 , B01L3/502715 , B01L3/502776 , B01L2200/0621 , B01L2200/0636 , B01L2200/12 , B01L2300/087 , B01L2300/0877 , G01N15/1404 , G01N2015/008 , G01N2015/1486 , Y10T436/117497 , Y10T436/2575
摘要： A microfluidic circuit cartridge having 3-D hydrodynamic focusing. The cartridge may be fabricated with injection-molded or other molded layers providing a 3-D structure. A flow channel on the card may have a sample core flowing in a fluid of a flow channel for analysis. The sample core may be adjustable in position within the channel with one or more jets or channels of fluid being injected into the flow channel. The jets may also adjust the size of the sample core. There may be a hemoglobin measurement mechanism or card with a cuvette
摘要翻译： 具有3-D流体动力学聚焦的微流体电路盒。 盒可以用提供3-D结构的注射成型或其它模制层制造。 卡上的流动通道可以具有在流动通道的流体中流动的样本核心用于分析。 样品芯可以在通道内的位置可调节，其中一个或多个喷射流体或通道的流体被注入到流动通道中。 射流也可以调节样品芯的尺寸。 可能有一个血红蛋白测量机制或一个有比色皿的卡
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公开(公告)号：US07016022B2
公开(公告)日：2006-03-21
申请号：US10938245
申请日：2004-09-09
IPC分类号： G01N21/00
CPC分类号： G01B11/272 , G01N15/1434 , G01N15/147 , G01N15/1484 , G01N35/085 , G01N2015/0069 , G01N2015/0073 , G01N2015/008 , G01N2015/0088 , G01N2015/0238 , G01N2015/1075 , G01N2015/1413 , G01N2015/1452 , G01N2015/1497
摘要： An optical alignment system for aligning a light beam with a core flow in a flow stream. The flow stream may have a sheath fluid and a core flow, where the core flow has a current position within the flow stream. A light source may be used to produce a light beam, and an optical element may be used to direct the light beam at the core flow. In some illustrative embodiments, an actuator is provided for moving the optical element, light source and/or flow stream such that the light directed by the optical element is aligned with the current position of the core flow.
摘要翻译： 一种用于将光束与流动流中的核心流对准的光学对准系统。 流动流可以具有护套流体和芯流，其中核心流具有流动流内的当前位置。 可以使用光源来产生光束，并且可以使用光学元件来引导光束在核心流动。 在一些说明性实施例中，提供致动器用于移动光学元件，光源和/或流动流，使得由光学元件引导的光与核心流的当前位置对准。
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公开(公告)号：US20050105077A1
公开(公告)日：2005-05-19
申请号：US10938265
申请日：2004-09-09
申请人： Aravind Padmanabhan , Bernard Fritz
发明人： Aravind Padmanabhan , Bernard Fritz
CPC分类号： G01N15/1404 , A61B5/150022 , A61B5/150213 , A61B5/150221 , A61B5/150274 , A61B5/150343 , A61B5/150351 , A61B5/157 , A61B5/417 , A61B5/7264 , B01L3/5027 , G01B11/272 , G01N15/1434 , G01N15/1459 , G01N15/1484 , G01N33/5094 , G01N33/569 , G01N35/085 , G01N2015/0069 , G01N2015/0073 , G01N2015/008 , G01N2015/0238 , G01N2015/1075 , G01N2015/1486 , Y10T436/24
摘要： A system for scattered light and simultaneous multi-color (e.g., greater than sixteen colors) fluorescence light detecting, and for analyzing, classifying and identifying biological particles and items of interest. A sample to be tested may be entered in a disposable microfluidic cartridge which in turn is insertable in a portable, hand-holdable, or wearable miniaturized cytometer instrument. The present system may be incorporated in the cytometer instrument. It may have significant application relative to biological warfare, environmental substances, the medical field and other fields.
摘要翻译： 用于散射光和同时多色（例如，大于十六种颜色）荧光检测的系统，并用于分析，分类和识别生物颗粒和感兴趣的物品。 待测试的样品可以输入到一次性微流控盒中，该滤芯又可插入便携式，手持式或可穿戴式小型化的细胞仪器中。 本系统可以并入细胞仪器中。 相对于生物战，环境物质，医疗领域等领域可能有重大应用。
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