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公开(公告)号：US08383043B2
公开(公告)日：2013-02-26
申请号：US11615884
申请日：2006-12-22
申请人： Aravind Padmanabhan , James A. Cox , Bernard S. Fritz , Tom M. Rezachek , Peter L. Reutiman , Ron L. Bardell , Cleopatra Cabuz
发明人： Aravind Padmanabhan , James A. Cox , Bernard S. Fritz , Tom M. Rezachek , Peter L. Reutiman , Ron L. Bardell , Cleopatra Cabuz
CPC分类号： G01N35/00603 , B01L3/502715 , B01L3/502723 , B01L3/50273 , B01L3/502746 , B01L9/527 , B01L2200/027 , B01L2200/04 , B01L2200/0636 , B01L2200/0684 , B01L2200/143 , B01L2200/146 , B01L2300/021 , B01L2300/044 , B01L2300/0627 , B01L2300/0672 , B01L2300/0816 , B01L2300/0877 , B01L2300/14 , B01L2400/0406 , B01L2400/0481 , B01L2400/0487 , G01N15/1404 , G01N15/1459 , G01N15/1484 , G01N21/53 , G01N29/032 , G01N33/5094 , G01N35/00663 , G01N2015/0069 , G01N2015/0073 , G01N2015/008 , G01N2015/0084 , G01N2015/1452 , G01N2015/1486 , G01N2035/00148 , G01N2035/00158 , G01N2035/00247 , G01N2035/1034 , G01N2035/1053 , G01N2291/02433 , G01N2291/02836 , G01N2291/02872
摘要： A system relating to sample analyzers, and more particular, to sample analyzers that are simple to operate and have a reduce risk of providing an erroneous result to a user. In some cases, the sample analyzer may be a portable sample analyzer that includes a disposable fluidic cartridge. The operators of the analyzers need not be trained.
摘要翻译： 与样品分析仪相关的系统，更具体地，涉及操作简单且降低向用户提供错误结果的风险的样品分析仪。 在一些情况下，样品分析仪可以是便携式样品分析仪，其包括一次性流体盒。 不需要对分析仪的操作员进行培训。
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公开(公告)号：US07485153B2
公开(公告)日：2009-02-03
申请号：US11306401
申请日：2005-12-27
IPC分类号： G01D21/00
CPC分类号： B01L9/527 , B01L3/502715 , B01L3/502746 , B01L2200/027 , B01L2300/0809 , B01L2300/0877 , B01L2300/123 , B01L2400/0481 , F04C2/18 , F04C13/001 , G01N33/18 , G01N2035/00158
摘要： Instrument-cartridge interfaces for fluidic analyzers that have an instrument and a removable cartridge are disclosed. For example, and in one illustrative embodiment, the instrument may include a needle that is adapted to penetrate a septum on a removable cartridge. In another illustrative embodiment, the instrument may include a plunger that is adapted to deform a deformable membrane on a removable cartridge. In yet another illustrative embodiment, the instrument may include a nozzle that is adapted to mate and seal with a flow channel on a removable cartridge. Techniques for detecting the flow rate in a flow channel on a removable cartridge, as well as the position of fluid in a flow channel of a removable cartridge, are also disclosed.
摘要翻译： 公开了具有仪器和可移除盒的流体分析仪的盒式磁带接口。 例如，在一个说明性实施例中，仪器可以包括适于穿透可移除盒的隔膜的针。 在另一说明性实施例中，仪器可以包括适于使可移除盒上的可变形膜变形的柱塞。 在另一个说明性实施例中，仪器可以包括适于与可移除盒上的流动通道配合和密封的喷嘴。 还公开了用于检测可移除盒上的流动通道中的流速以及可移除盒的流动通道中的流体位置的技术。
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公开(公告)号：US07333197B2
公开(公告)日：2008-02-19
申请号：US10991001
申请日：2004-11-17
IPC分类号： G01N21/00
CPC分类号： G01N21/658 , G01N15/147
摘要： A method and apparatus for enabling chemical identification of individual particles, cells of molecules by obtaining a Raman spectrum of a particle, cell or molecule as it flows past a sensing point in a flow cytometer. The particles, which may be cells or molecules, are associated with a suitable noble metal colloid or colloidal aggregate. Cellular particles may be associated with gold or silver colloidal particles by ultra-sonic sonification while in a sample preparation reservoir containing the gold or silver colloidal suspension. The colloid associated particles are then hydrodynamically focused into a single file by a fluid control module. The surface-enhance Raman Spectrum of individual particles are obtained by illuminating the particle with a laser as the particle flows past a sensing point and gathering the light that is non-elastically scattered (Raman scattered) by the particle. The surface-enhanced Raman spectrum is then analyzed to identify the particle.
摘要翻译： 一种方法和装置，用于通过在流式细胞计数器中流过感测点时获得粒子，细胞或分子的拉曼光谱，从而能够化学鉴定单个颗粒，分子细胞。 可以是细胞或分子的颗粒与合适的贵金属胶体或胶体聚集体相关联。 在含有金或银胶体悬浮液的样品制备储存器中，细胞颗粒可以通过超声波超声处理与金或银胶体颗粒结合。 然后通过流体控制模块将胶体相关颗粒流体动力聚焦成单个文件。 当颗粒流过感测点并通过颗粒收集非弹性散射（拉曼散射）的光时，通过用激光照射颗粒来获得单个颗粒的表面增强拉曼光谱。 然后分析表面增强拉曼光谱以鉴定颗粒。
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公开(公告)号：US08323564B2
公开(公告)日：2012-12-04
申请号：US11615874
申请日：2006-12-22
申请人： Aravind Padmanabhan , James A. Cox , Bernard S. Fritz , Tom M. Rezachek , Peter L. Reutiman , Ron L. Bardell , Cleopatra Cabuz
发明人： Aravind Padmanabhan , James A. Cox , Bernard S. Fritz , Tom M. Rezachek , Peter L. Reutiman , Ron L. Bardell , Cleopatra Cabuz
CPC分类号： G01N35/00603 , B01L3/502715 , B01L3/502723 , B01L3/50273 , B01L3/502746 , B01L9/527 , B01L2200/027 , B01L2200/04 , B01L2200/0636 , B01L2200/0684 , B01L2200/143 , B01L2200/146 , B01L2300/021 , B01L2300/0627 , B01L2300/0672 , B01L2300/0816 , B01L2300/0877 , B01L2300/14 , B01L2400/0487 , G01N15/1404 , G01N15/1459 , G01N15/1484 , G01N21/53 , G01N29/032 , G01N35/00663 , G01N2015/0069 , G01N2015/0073 , G01N2015/008 , G01N2015/0084 , G01N2015/1452 , G01N2015/1486 , G01N2035/00148 , G01N2035/00247 , G01N2035/1034 , G01N2035/1053 , G01N2291/02433 , G01N2291/02836 , G01N2291/02872
摘要： A system relating to sample analyzers, and more particular, to sample analyzers that are simple to operate and have a reduced risk of providing an erroneous result to a user. In some cases, the sample analyzer may be a portable sample analyzer that includes a disposable fluidic cartridge. The operators of the analyzers need not be trained.
摘要翻译： 与样品分析仪有关的系统，更具体地说，涉及操作简单且降低向用户提供错误结果的风险的样品分析仪。 在一些情况下，样品分析仪可以是便携式样品分析仪，其包括一次性流体盒。 不需要对分析仪的操作员进行培训。
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公开(公告)号：US07911617B2
公开(公告)日：2011-03-22
申请号：US12572694
申请日：2009-10-02
CPC分类号： G01N15/1404 , A61B5/150022 , A61B5/150213 , A61B5/150221 , A61B5/150274 , A61B5/150343 , A61B5/150351 , A61B5/157 , A61B5/417 , A61B5/7264 , B01L3/5027 , G01B11/272 , G01N15/1434 , G01N15/1459 , G01N15/1484 , G01N33/5094 , G01N33/569 , G01N35/085 , G01N2015/0069 , G01N2015/0073 , G01N2015/008 , G01N2015/0238 , G01N2015/1075 , G01N2015/1486 , Y10T436/24
摘要： A system for scattered light and simultaneous multi-color (e.g., greater than sixteen colors) fluorescence light detecting, and for analyzing, classifying and identifying biological particles and items of interest. A sample to be tested may be entered in a disposable microfluidic cartridge which in turn is insertable in a portable, hand-holdable, or wearable miniaturized cytometer instrument. The present system may be incorporated in the cytometer instrument. It may have significant application relative to biological warfare, environmental substances, the medical field and other fields.
摘要翻译： 用于散射光和同时多色（例如，大于十六种颜色）荧光检测的系统，并用于分析，分类和识别生物颗粒和感兴趣的物品。 待测试的样品可以输入到一次性微流控盒中，该滤芯又可插入便携式，手持式或可穿戴式小型化的细胞仪器中。 本系统可以并入细胞仪器中。 相对于生物战，环境物质，医疗领域等领域可能有重大应用。
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公开(公告)号：US07630063B2
公开(公告)日：2009-12-08
申请号：US10938265
申请日：2004-09-09
CPC分类号： G01N15/1404 , A61B5/150022 , A61B5/150213 , A61B5/150221 , A61B5/150274 , A61B5/150343 , A61B5/150351 , A61B5/157 , A61B5/417 , A61B5/7264 , B01L3/5027 , G01B11/272 , G01N15/1434 , G01N15/1459 , G01N15/1484 , G01N33/5094 , G01N33/569 , G01N35/085 , G01N2015/0069 , G01N2015/0073 , G01N2015/008 , G01N2015/0238 , G01N2015/1075 , G01N2015/1486 , Y10T436/24
摘要： A system for scattered light and simultaneous multi-color (e.g., greater than sixteen colors) fluorescence light detecting, and for analyzing, classifying and identifying biological particles and items of interest. A sample to be tested may be entered in a disposable microfluidic cartridge which in turn is insertable in a portable, hand-holdable, or wearable miniaturized cytometer instrument. The present system may be incorporated in the cytometer instrument. It may have significant application relative to biological warfare, environmental substances, the medical field and other fields.
摘要翻译： 用于散射光和同时多色（例如，大于十六种颜色）荧光检测的系统，并用于分析，分类和识别生物颗粒和感兴趣的物品。 待测试的样品可以输入到一次性微流控盒中，该滤芯又可插入便携式，手持式或可穿戴式小型化的细胞仪器中。 本系统可以并入细胞仪器中。 相对于生物战，环境物质，医疗领域等领域可能有重大应用。
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公开(公告)号：US06970245B2
公开(公告)日：2005-11-29
申请号：US10225325
申请日：2002-08-21
CPC分类号： G01N15/1456 , G01B11/272 , G01N15/1434 , G01N35/085 , G01N2015/0069 , G01N2015/0073 , G01N2015/008 , G01N2015/0238 , G01N2015/1075
摘要： An optical alignment detection system for detecting the alignment of a first object relative to a second object is provided. One or more light sources and one or more light detectors, either or both of which are secured relative to the second object, are used to detect the position of one or more light scattering elements on the first object.
摘要翻译： 提供了一种用于检测第一物体相对于第二物体的对准的光学对准检测系统。 一个或多个光源和一个或多个光检测器用于检测第一物体上的一个或多个光散射元件的位置，其中一个或两个光检测器相对于第二物体固定。
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公开(公告)号：US07671987B2
公开(公告)日：2010-03-02
申请号：US11030407
申请日：2005-01-06
IPC分类号： G01B11/00
CPC分类号： G01N15/1404 , A61B5/150022 , A61B5/150213 , A61B5/150221 , A61B5/150274 , A61B5/150343 , A61B5/150351 , A61B5/157 , A61B5/417 , A61B5/7264 , B01L3/5027 , G01B11/272 , G01N15/1434 , G01N15/1459 , G01N15/1484 , G01N33/5094 , G01N33/569 , G01N35/085 , G01N2015/0069 , G01N2015/0073 , G01N2015/008 , G01N2015/0238 , G01N2015/1075 , G01N2015/1486 , Y10T436/24
摘要： An optical detection system for flow cytometry that uses light sources positioned laterally at different distances from the central axis of the flow stream for providing light through different parts of the flow stream. By using two or more light sources, the particle position can be detected, and the alignment and width of the core stream can be monitored and controlled.
摘要翻译： 一种用于流式细胞术的光学检测系统，其使用位于与流动流的中心轴线不同的距离处的光源，用于通过流动流的不同部分提供光。 通过使用两个或更多个光源，可以检测颗粒位置，并且可以监测和控制核心流的对准和宽度。
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公开(公告)号：US07312870B2
公开(公告)日：2007-12-25
申请号：US11263333
申请日：2005-10-31
IPC分类号： G01B11/00
CPC分类号： G01N15/1456 , G01B11/272 , G01N15/1434 , G01N35/085 , G01N2015/0069 , G01N2015/0073 , G01N2015/008 , G01N2015/0238 , G01N2015/1075
摘要： An optical alignment detection system for detecting the alignment of a first object relative to a second object is provided. One or more light sources and one or more light detectors, either or both of which are secured relative to the second object, are used to detect the position of one or more light scattering elements on the first object.
摘要翻译： 提供了一种用于检测第一物体相对于第二物体的对准的光学对准检测系统。 一个或多个光源和一个或多个光检测器用于检测第一物体上的一个或多个光散射元件的位置，其中一个或两个光检测器相对于第二物体固定。
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公开(公告)号：US07016022B2
公开(公告)日：2006-03-21
申请号：US10938245
申请日：2004-09-09
IPC分类号： G01N21/00
CPC分类号： G01B11/272 , G01N15/1434 , G01N15/147 , G01N15/1484 , G01N35/085 , G01N2015/0069 , G01N2015/0073 , G01N2015/008 , G01N2015/0088 , G01N2015/0238 , G01N2015/1075 , G01N2015/1413 , G01N2015/1452 , G01N2015/1497
摘要： An optical alignment system for aligning a light beam with a core flow in a flow stream. The flow stream may have a sheath fluid and a core flow, where the core flow has a current position within the flow stream. A light source may be used to produce a light beam, and an optical element may be used to direct the light beam at the core flow. In some illustrative embodiments, an actuator is provided for moving the optical element, light source and/or flow stream such that the light directed by the optical element is aligned with the current position of the core flow.
摘要翻译： 一种用于将光束与流动流中的核心流对准的光学对准系统。 流动流可以具有护套流体和芯流，其中核心流具有流动流内的当前位置。 可以使用光源来产生光束，并且可以使用光学元件来引导光束在核心流动。 在一些说明性实施例中，提供致动器用于移动光学元件，光源和/或流动流，使得由光学元件引导的光与核心流的当前位置对准。
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