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    GASTRIC RETENTIVE DOSAGE FORMS FOR EXTENDED RELEASE OF ACAMPROSATE INTO THE UPPER GASTROINTESTINAL TRACT
    41.
    发明申请
    GASTRIC RETENTIVE DOSAGE FORMS FOR EXTENDED RELEASE OF ACAMPROSATE INTO THE UPPER GASTROINTESTINAL TRACT 有权
    胃肠增强剂用于延长放射治疗剂量的方法

    公开(公告)号：US20150164832A1

    公开(公告)日：2015-06-18

    申请号：US14632959

    申请日：2015-02-26

    申请人： Depomed, Inc.

    发明人： Bret Berner ,  Cuiping Chen

    IPC分类号： A61K31/185

    CPC分类号： A61K9/0065 ,  A61K9/2027 ,  A61K9/2031 ,  A61K9/2054 ,  A61K31/185 ,  A61K47/10

    摘要： Gastric retentive dosage forms for sustained release of acamprosate are described which may allow once- or twice-daily dosing for both acute and long-term treatment of a disorder including alcohol dependence, tinnitus, sleep apnea, Parkinson's disease, levodopa-induced dyskinesias in Parkinson's disease, Alzheimer's disease, Huntington's disease, Amyotrophic lateral sclerosis, Cortical spreading depression, migraine, schizophrenia, anxiety, tardive dyskinesia, spasticity, multiple sclerosis, various types pain, or binge eating. Methods of treatment using the dosage forms and methods of making the dosage forms are also described.

    摘要翻译： 描述了用于持续释放阿坎酸的胃滞留剂型，其可以允许急性和长期治疗包括酒精依赖性，耳鸣，睡眠呼吸暂停，帕金森病，左旋多巴诱导的帕金森氏症运动障碍的疾病的每日一次或两次 疾病，阿尔茨海默病，亨廷顿舞蹈病，肌萎缩性侧索硬化，皮质扩张抑郁症，偏头痛，精神分裂症，焦虑症，迟发性运动障碍，痉挛性，多发性硬化，各种类型的疼痛或暴饮暴食。 还描述了使用剂型和制备剂型的方法的治疗方法。

    Gastric retentive dosage forms for extended release of acamprosate into the upper gastrointestinal tract
    42.
    发明授权
    Gastric retentive dosage forms for extended release of acamprosate into the upper gastrointestinal tract 有权
    胃酸滞留剂用于将阿坎酸延长释放到上消化道

    公开(公告)号：US09000046B2

    公开(公告)日：2015-04-07

    申请号：US13247956

    申请日：2011-09-28

    申请人： Bret Berner ,  Cuiping Chen

    发明人： Bret Berner ,  Cuiping Chen

    IPC分类号： A61K31/16 ,  A61K9/22 ,  A61K9/26 ,  A61K31/185 ,  A61K9/00 ,  A61K9/20

    CPC分类号： A61K9/0065 ,  A61K9/2027 ,  A61K9/2031 ,  A61K9/2054 ,  A61K31/185 ,  A61K47/10

    摘要： Gastric retentive dosage forms for sustained release of acamprosate are described which may allow once- or twice-daily dosing for both acute and long-term treatment of a disorder including alcohol dependence, tinnitus, sleep apnea, Parkinson's disease, levodopa-induced dyskinesias in Parkinson's disease, Alzheimer's disease, Huntington's disease, Amyotrophic lateral sclerosis, Cortical spreading depression, migraine, schizophrenia, anxiety, tardive dyskinesia, spasticity, multiple sclerosis, various types pain, or binge eating. Methods of treatment using the dosage forms and methods of making the dosage forms are also described.

    摘要翻译： 描述了用于持续释放阿坎酸的胃滞留剂型，其可以允许急性和长期治疗包括酒精依赖性，耳鸣，睡眠呼吸暂停，帕金森病，左旋多巴诱导的帕金森氏症运动障碍的疾病的每日一次或两次 疾病，阿尔茨海默病，亨廷顿舞蹈病，肌萎缩性侧索硬化，皮质扩张抑郁症，偏头痛，精神分裂症，焦虑症，迟发性运动障碍，痉挛性，多发性硬化，各种类型的疼痛或暴饮暴食。 还描述了使用剂型和制备剂型的方法的治疗方法。

    Vinyl alcohol co-polymer cryogels, vinyl alcohol co-polymers, and methods and products thereof
    43.
    发明授权
    Vinyl alcohol co-polymer cryogels, vinyl alcohol co-polymers, and methods and products thereof 有权
    乙烯醇共聚物冷冻凝胶，乙烯醇共聚物及其方法和产品

    公开(公告)号：US08975309B2

    公开(公告)日：2015-03-10

    申请号：US12998077

    申请日：2009-09-14

    申请人： Maria Stromme ,  Albert Mihranyan

    发明人： Maria Stromme ,  Albert Mihranyan

    IPC分类号： A61F2/00 ,  C08F220/12 ,  C08F220/18 ,  C08F16/06 ,  A61K9/00 ,  C08F218/08 ,  A61K47/34 ,  A61L27/52 ,  A61K9/06 ,  A61L27/16 ,  A61K9/19 ,  A61K9/70 ,  C08J5/18 ,  C08F220/06 ,  C08F220/56

    CPC分类号： A61L27/16 ,  A61K9/0014 ,  A61K9/0024 ,  A61K9/0031 ,  A61K9/006 ,  A61K9/0065 ,  A61K9/06 ,  A61K9/19 ,  A61K9/7007 ,  A61K47/34 ,  A61L27/52 ,  C08F8/12 ,  C08F218/08 ,  C08F220/06 ,  C08F220/56 ,  C08J5/18 ,  C08L29/04

    摘要： A cryogel-forming vinyl alcohol co-polymer is operable to form a cryogel, i.e., a hydrogel formed by crytropic gelation, in an aqueous solution at a concentration of less than about 10% by weight, in the absence of a chemical cross-linking agent and in the absence of an emulsifier. In one embodiment, a vinyl alcohol co-polymer cryogel comprises at least about 75% by weight water and a vinyl alcohol co-polymer, wherein the vinyl alcohol co-polymer is operable to form a cryogel in an aqueous solution at a concentration of less than about 10% by weight, in the absence of a chemical cross-linking agent and in the absence of an emulsifier. In another embodiment, a vinyl alcohol co-polymer cryogel comprises at least about 75% by weight water and a vinyl alcohol co-polymer comprising a saponified product of a vinyl acetate co-polymer formed from at least about 80% by weight of vinyl acetate monomer, and (i) at least about 3% by weight of acrylamide monomer or a mixture of acrylamide monomer and acrylic acid monomer, or (ii) at least about 5% by weight acrylic acid monomer. The vinyl acetate co-polymer, vinyl alcohol co-polymer and vinyl alcohol co-polymer cryogel may be formed according to particular methods, and the vinyl alcohol co-polymer cryogels may be used in various applications including biomedical implants and thin films and for delivery of therapeutic or cosmetic agents.

    摘要翻译： 低温凝胶形成乙烯醇共聚物可操作以在不存在化学交联的情况下，以小于约10重量％的浓度在水溶液中形成冷冻凝胶，即通过热溶胶凝胶形成的水凝胶 并且在不存在乳化剂的情况下。 在一个实施方案中，乙烯醇共聚物冷冻凝胶包含至少约75重量％的水和乙烯醇共聚物，其中乙烯醇共聚物可操作以在浓度较低的水溶液中形成冷冻凝胶 在不存在化学交联剂的条件下和在不存在乳化剂的条件下进行。 在另一个实施方案中，乙烯醇共聚物冷冻凝胶包含至少约75重量％的水和包含由至少约80重量％的乙酸乙烯酯形成的乙酸乙烯酯共聚物的皂化产物的乙烯醇共聚物 单体，和（i）至少约3重量％的丙烯酰胺单体或丙烯酰胺单体和丙烯酸单体的混合物，或（ii）至少约5重量％的丙烯酸单体。 可以根据具体方法形成乙酸乙烯酯共聚物，乙烯醇共聚物和乙烯醇共聚物冷冻凝胶，并且乙烯醇共聚物冷冻凝胶可用于各种应用，包括生物医学植入物和薄膜并用于递送 的治疗或化妆品。

    Device for delivery of a substance
    48.
    发明授权
    Device for delivery of a substance 有权
    物质运送装置

    公开(公告)号：US08795721B2

    公开(公告)日：2014-08-05

    申请号：US12517752

    申请日：2007-12-18

    申请人： Martin Pavlov Mintchev ,  Orly Yadid-Pecht ,  Michel Fattouche

    发明人： Martin Pavlov Mintchev ,  Orly Yadid-Pecht ,  Michel Fattouche

    IPC分类号： A61K9/54 ,  A61M29/00 ,  A61K9/22 ,  A61M31/00 ,  A61K9/00

    CPC分类号： A61K9/0065 ,  A61K9/009 ,  A61L31/146 ,  A61M29/02 ,  A61M31/00 ,  A61M31/002

    摘要： A device for delivering a substance in situ in a body comprising at least one permeable expandable container having a first dimension and a second dimension and having contained therein the substance to be delivered; and at least one expandable particle comprising a swellable material contained within the container and capable of expanding when contacted with a fluid; whereby when the device is positioned in situ, bodily fluid permeates the container causing the at least one expandable particle contained therein to swell and the container to expand from the first dimension to the second dimension so that the device remains in situ for a period of time sufficient to achieve the desired delivery of the substance is provided.

    摘要翻译： 一种用于在物体中原位输送物质的装置，包括至少一个具有第一尺寸和第二尺寸的渗透性可扩张容器，并且其中容纳有待输送物质; 以及至少一个可膨胀颗粒，其包含容纳在容器内的可膨胀材料，并且当与流体接触时能够膨胀; 由此当装置位于原位时，体液渗透容器，导致容纳在其中的至少一个可膨胀颗粒膨胀，并且容器从第一维度膨胀到第二维度，使得装置保持原位一段时间 提供了足以实现物质所需的输送。