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409 条记录 (耗时 0.024 秒)

    Therapeutic compositions
    41.
    发明授权
    Therapeutic compositions 有权
    治疗组合物

    公开(公告)号：US06207856B1

    公开(公告)日：2001-03-27

    申请号：US09630007

    申请日：2000-07-31

    申请人： Richard L. Veech

    发明人： Richard L. Veech

    IPC分类号： A61K31275

    CPC分类号： C07C69/72 ,  A23L27/66 ,  A23L33/10 ,  A23L33/105 ,  A23L33/30 ,  A23V2002/00 ,  A61K31/19 ,  A61K31/22 ,  A61K31/365 ,  A61K31/765 ,  C07B2200/07 ,  C07C67/14 ,  C07C67/46 ,  C07C67/465 ,  C07C69/675 ,  C07D323/00 ,  A23V2250/30

    摘要： Compositions comprising ketone bodies and/or their metabolic precursors are provided that are suitable for administration to humans and animals and which have the properties of, inter alia, (i) increasing cardiac efficiency, particularly efficiency in use of glucose, (ii) for providing energy source, particularly in diabetes and insulin resistant states and (iii) treating disorders caused by damage to brain cells, particularly by retarding or preventing brain damage in memory associated brain areas such as found in Alzheimer's and similar conditions. These compositions may be taken as nutritional aids, for example for athletes, or for the treatment of medical conditions, particularly those associated with poor cardiac efficiency, insulin resistance and neuronal damage. The invention further provides methods of treatment and novel esters and polymers for inclusion in the compositions of the invention.

    摘要翻译： 提供了包含酮体和/或其代谢前体的组合物，其适用于给予人和动物，并且其特性包括（i）提高心脏效率，特别是使用葡萄糖的效率，（ii）提供 能源，特别是在糖尿病和胰岛素抵抗状态下，以及（iii）治疗由脑细胞损伤引起的疾病，特别是通过延缓或预防记忆相关脑区域的脑损伤，例如在阿尔茨海默病和类似病症中发现的这些组合物可以被认为是 营养辅助剂，例如用于运动员，或用于治疗医疗状况，特别是与心脏功能低下，胰岛素抵抗和神经元损伤相关的那些。 本发明还提供了用于包含在本发明的组合物中的治疗方法和新的酯和聚合物。

    Template-directed ring-closing metathesis and ring-opening metathesis polymerization of functionalized dienes
    43.
    发明授权
    Template-directed ring-closing metathesis and ring-opening metathesis polymerization of functionalized dienes 失效
    功能化二烯的模板定向闭合复分解和开环易位聚合

    公开(公告)号：US6080826A

    公开(公告)日：2000-06-27

    申请号：US993757

    申请日：1997-12-18

    申请人： Robert H. Grubbs ,  Michael J. Marsella ,  Heather D. Maynard

    发明人： Robert H. Grubbs ,  Michael J. Marsella ,  Heather D. Maynard

    IPC分类号： C07D323/00 ,  C08F2/00 ,  C08G65/329 ,  C07C2/02

    CPC分类号： C07D323/00 ,  C08G65/329

    摘要： Functionalized cyclic olefins and methods for making the same are disclosed. Methods include template-directed ring-closing metathesis ("RCM") of functionalized acyclic dienes and template-directed depolymerization of functionalized polymers possessing regularly spaced sites of unsaturation. Although the template species may be any anion, cation, or dipolar compound, cationic species, especially alkali metals, are preferred. Functionalized polymers with regularly spaced sites of unsaturation and methods for making the same are also disclosed. One method for synthesizing these polymers is by ring-opening metathesis polymerization ("ROMP") of functionalized cyclic olefins. The metathesis catalysts for both RCM and ROMP reaction are ruthenium or osmium carbene complex catalysts of the formula ##STR1## where M is Os or Ru; R and R.sup.1 each may be hydrogen, C.sub.2 -C.sub.20 alkenyl, C.sub.2 -C.sub.20 alkynyl, C.sub.1 -C.sub.20 alkyl, aryl, C.sub.1 -C.sub.20 carboxylate, C.sub.1 -C.sub.20 alkoxy, C.sub.2 -C.sub.20 alkenyloxy, C.sub.2 -C.sub.20 alkynyloxy, aryloxy, C.sub.2 -C.sub.20 alkoxycarbonyl, C.sub.1 -C.sub.20 alkylthio, C.sub.1 -C.sub.20 alkylsulfonyl or C.sub.1 -C.sub.20 alkylsulfinyl; X and X.sup.1 may be any anionic ligand; and L and L.sup.1 may be any neutral electron donor.

    摘要翻译： 公开了官能化环烯烃及其制备方法。 方法包括官能化无环二烯的模板导向闭合复分解（“RCM”）和具有规则间隔的不饱和位置的官能化聚合物的模板定向解聚。 尽管模板物质可以是任何阴离子，阳离子或偶极化合物，但优选阳离子物质，特别是碱金属。 还公开了具有规则间隔的不饱和位置的官能化聚合物及其制备方法。 合成这些聚合物的一种方法是通过官能化环烯烃的开环易位聚合（“ROMP”）。 用于RCM和ROMP反应的复分解催化剂是下式的钌或锇卡宾络合物催化剂，其中M是Os或Ru; R和R 1各自可以是氢，C 2 -C 20烯基，C 2 -C 20炔基，C 1 -C 20烷基，芳基，C 1 -C 20羧酸酯，C 1 -C 20烷氧基，C 2 -C 20链烯氧基，C 2 -C 20炔氧基，芳氧基， 烷氧基羰基，C 1 -C 20烷硫基，C 1 -C 20烷基磺酰基或C 1 -C 20烷基亚磺酰基; X和X 1可以是任何阴离子配体; L和L1可以是任何中性电子给体。

    Cyclic oligomers for production of linear polyketones, polyphthalazines and polyisoquinolines
    46.
    发明授权
    Cyclic oligomers for production of linear polyketones, polyphthalazines and polyisoquinolines 失效
    用于生产线性聚酮，多酞嗪和聚异喹啉的环状低聚物

    公开(公告)号：US5516566A

    公开(公告)日：1996-05-14

    申请号：US367584

    申请日：1995-01-03

    申请人： Allan S. Hay ,  Kwok P. Chan

    发明人： Allan S. Hay ,  Kwok P. Chan

    IPC分类号： C07D321/00 ,  C07D323/00 ,  C07D327/00 ,  C07D327/10 ,  C07D498/08 ,  B29D23/00 ,  C07D498/00 ,  C08G10/00

    CPC分类号： C07D321/00 ,  C07D323/00 ,  C07D327/00 ,  C07D327/10 ,  Y10T428/1352 ,  Y10T428/1362 ,  Y10T428/1369 ,  Y10T428/1372 ,  Y10T428/139

    摘要： Low molecular weight cyclic oligomers of formula (I) ##STR1## in which n is an integer of 2 to 20, and each C in the oligomer is a radical of formula (II): ##STR2## and each X in the oligomer is --O--R--O-- or --S--R--S--, B and D are both carbonyl groups CO, or together represent a divalent radical of formula ##STR3## in which A.sub.1, A.sub.2, A.sub.3 A.sub.4, Ar.sub.1, Ar.sub.2 and Ar.sub.3 are selected from a variety of aromatic radicals, A.sub.1, A.sub.2, Ar.sub.3 and Ar.sub.4 also possibly being hydrogen, are useful in the production of high molecular weight, linear, polyketones, polyphthalazines and polyisoquinolines; the cyclic oligomers have low melt viscosities when heated above their softening temperatures and can be readily molded, whereafter they can be ring-open polymerized to form molded high molecular weight polymer products with excellent properties.

    摘要翻译： （I）的低分子量环状低聚物，其中n为2至20的整数，低聚物中的每个C为式（II）的基团：每个 低聚物中的X是-ORO-或-SRS-，B和D都是羰基CO，或者一起代表式为“IMAGE”的二价基团，其中A1，A2，A3A4，Ar1，Ar2和Ar3选自 各种芳基，A1，A2，Ar3和Ar4也可能是氢，可用于生产高分子量，线性，聚酮，多酞嗪和聚异喹啉; 环状低聚物在其软化温度以上加热时具有低熔融粘度，并且可以容易地模塑，然后它们可以开环聚合以形成具有优异性能的模制高分子量聚合物产品。