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41.发明授权公开(公告)号：US08962332B2
公开(公告)日：2015-02-24
申请号：US14025951
申请日：2013-09-13
Inventor： Guangping Gao , James M. Wilson , Mauricio R. Alvira
IPC: C12N15/63 , C12N15/85 , A61K35/76 , C07K14/005 , C07K14/755 , C12N7/00 , C12N15/86 , A61K48/00
CPC classification number: C12N15/86 , A61K9/0019 , A61K35/761 , A61K38/177 , A61K38/45 , A61K38/4846 , A61K48/00 , C07K14/005 , C07K14/705 , C07K14/755 , C12N7/00 , C12N9/1018 , C12N9/644 , C12N2750/14122 , C12N2750/14143 , C12N2750/14152 , C12N2830/008 , C12N2830/48 , C12N2830/85 , C12Y201/03003 , C12Y304/21021 , C12Y304/21022
Abstract: Sequences of a serotype 8 adeno-associated virus and vectors and host cells containing these sequences are provided. Also described are methods of using such host cells and vectors in production of rAAV particles.
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42.发明申请MICROORGANISMS FOR PRODUCING PUTRESCINE AND METHOD FOR PRODUCING PUTRESCINE USING SAME 有权用于生产聚氨酯的微生物和使用它们生产聚氨酯的方法公开(公告)号：US20140004577A1
公开(公告)日：2014-01-02
申请号：US13992242
申请日：2011-12-08
Applicant: Hyang Choi , Kyoung Min Lee , Min Sun Kang , Sung Hoo Jhon , Hye Won Um , Su Jin Choi , Han Won Lee , Soo An Shin
Inventor： Hyang Choi , Kyoung Min Lee , Min Sun Kang , Sung Hoo Jhon , Hye Won Um , Su Jin Choi , Han Won Lee , Soo An Shin
IPC: C12P13/00
CPC classification number: C12P13/001 , C07K14/34 , C12N9/0008 , C12N9/1018 , C12N9/1029 , C12N9/1096 , C12N9/1217 , C12N9/88 , C12R1/15 , C12Y102/01038 , C12Y201/03003 , C12Y203/01035 , C12Y206/01013 , C12Y207/02008 , C12Y401/01017
Abstract: The present invention relates to a putrescine-producing microorganism and a method for producing putrescine using the same. To be more specific, the present invention is directed to a microorganism given the ability to produce putrescine which is generated by blocking a biosynthetic pathway from ornithine to arginine, increasing the intracellular level of glutamate, enhancing the biosynthetic pathway of ornithine from glutamate, and introducing extracellular ornithine decarboxylase; and a method for producing putrescine by using the microorganism.
Abstract translation: 本发明涉及产生腐胺的微生物和使用其的腐胺的制造方法。 更具体地，本发明涉及一种微生物，其赋予通过阻断从鸟氨酸到精氨酸的生物合成途径产生腐胺的能力，增加谷氨酸的细胞内水平，增强鸟氨酸从谷氨酸的生物合成途径，并引入 细胞外鸟氨酸脱羧酶; 以及使用微生物制造腐胺的方法。
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43.发明授权Adeno-associated virus (AAV) serotype 8 sequences, vectors containing same, and uses therefor 有权腺相关病毒（AAV）血清型8序列，含有其的载体及其用途公开(公告)号：US08318480B2
公开(公告)日：2012-11-27
申请号：US11981191
申请日：2007-10-31
Applicant: Guangping Gao , James M. Wilson , Mauricio R. Alvira
Inventor： Guangping Gao , James M. Wilson , Mauricio R. Alvira
CPC classification number: C12N15/86 , A61K9/0019 , A61K35/761 , A61K38/177 , A61K38/45 , A61K38/4846 , A61K48/00 , C07K14/005 , C07K14/705 , C07K14/755 , C12N7/00 , C12N9/1018 , C12N9/644 , C12N2750/14122 , C12N2750/14143 , C12N2750/14152 , C12N2830/008 , C12N2830/48 , C12N2830/85 , C12Y201/03003 , C12Y304/21021 , C12Y304/21022
Abstract: Sequences of a serotype 8 adeno-associated virus and vectors and host cells containing these sequences are provided. Also described are methods of using such host cells and vectors in production of rAAV particles.
Abstract translation: 提供血清型8腺相关病毒和含有这些序列的载体和宿主细胞的序列。 还描述了在生产rAAV颗粒中使用这种宿主细胞和载体的方法。
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公开(公告)号：US20120142756A1
公开(公告)日：2012-06-07
申请号：US13306781
申请日：2011-11-29
Applicant: Braydon Charles Guild , Michael Heartlein
Inventor： Braydon Charles Guild , Michael Heartlein
CPC classification number: A61K38/47 , A61K38/1816 , A61K38/27 , A61K38/45 , A61K48/005 , C07K14/505 , C07K14/61 , C12N9/1018 , C12N9/2465 , C12N15/67 , C12Y201/03003 , C12Y302/01022
Abstract: Compositions for modulating the expression of a protein in a target cell comprising at least one RNA molecule which comprises at least one modification conferring stability to the RNA, as well as related methods, are disclosed.
Abstract translation: 用于调节包含至少一个RNA分子的靶细胞中蛋白质表达的组合物，其包含至少一个赋予RNA稳定性的修饰以及相关方法。
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45.发明授权Adeno-associated virus (AAV) serotype 8 sequences, vectors containing same, and uses therefor 有权腺相关病毒（AAV）血清型8序列，含有其的载体及其用途公开(公告)号：US07282199B2
公开(公告)日：2007-10-16
申请号：US10423704
申请日：2003-04-25
Applicant: Guangping Gao , James M. Wilson , Mauricio R. Alvira
Inventor： Guangping Gao , James M. Wilson , Mauricio R. Alvira
IPC: C12N15/864 , C12N15/35 , C12N15/63 , C12N15/64 , C12N7/01 , C12P21/00 , C07K14/015 , C12Q1/70 , C12Q1/68
CPC classification number: C12N15/86 , A61K9/0019 , A61K35/761 , A61K38/177 , A61K38/45 , A61K38/4846 , A61K48/00 , C07K14/005 , C07K14/705 , C07K14/755 , C12N7/00 , C12N9/1018 , C12N9/644 , C12N2750/14122 , C12N2750/14143 , C12N2750/14152 , C12N2830/008 , C12N2830/48 , C12N2830/85 , C12Y201/03003 , C12Y304/21021 , C12Y304/21022
Abstract: Sequences of a serotype 8 adeno-associated virus and vectors and host cells containing these sequences are provided. Also described are methods of using such host cells and vectors in production of rAAV particles. rAAV8-mediated delivery of therapeutic and immunogenic genes, including Factor VIII, is also provided.
Abstract translation: 提供血清型8腺相关病毒和含有这些序列的载体和宿主细胞的序列。 还描述了在生产rAAV颗粒中使用这种宿主细胞和载体的方法。 还提供rAAV8介导的治疗和免疫原性基因的递送，包括因子VIII。
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Patent Agency Ranking
46.发明公开公开(公告)号：US20240189449A1
公开(公告)日：2024-06-13
申请号：US18282647
申请日：2022-03-24
Applicant: ModernaTX, Inc.
Inventor： Kerry Benenato , Alicia Anne Bicknell , Mark Cornebise , Athanasios Dousis , Andrew Jacob Giessel , Edward Hennessy , Ruchi Jain , Caroline Köhrer , Stuart Spencer Licht , Kanchana Ravichandran , David Reid
CPC classification number: A61K48/005 , A61K9/1271 , A61K9/5123 , A61K31/7105 , A61K48/0041 , A61P7/00 , C12N9/1018 , C12N15/67 , C12Y201/03003
Abstract: This disclosure relates to mRNA therapy for the treatment of ornithine transcarbamylase deficiency (OTCD). mRNAs for use in the invention, when administered in vivo, encode human ornithine transcarbamylase (OTC). mRNA therapies of the disclosure increase and/or restore deficient levels of OTC expression and/or activity in subjects. mRNA therapies of the disclosure further decrease levels of toxic ammonia associated with deficient OTC activity in subjects.
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公开(公告)号：US11965201B2
公开(公告)日：2024-04-23
申请号：US17203617
申请日：2021-03-16
Applicant: LanzaTech NZ, Inc.
Inventor： Kaspar Valgepea , Michael Koepke , James Bruce Yarnton Haycock Behrendorff , Esteban Marcellin , Lars K. Nielsen , Renato de S. P. Lemgruber
IPC: C12P7/56 , C12N1/20 , C12N1/38 , C12N9/06 , C12N9/10 , C12N9/12 , C12N9/78 , C12N9/90 , C12N15/52 , C12P7/04 , C12P7/06 , C12P7/18 , C12P7/40 , C12P7/54
CPC classification number: C12P7/56 , C12N1/20 , C12N1/38 , C12N9/0016 , C12N9/1018 , C12N9/1029 , C12N9/1217 , C12N9/78 , C12N9/90 , C12N15/52 , C12P7/04 , C12P7/065 , C12P7/18 , C12P7/40 , C12P7/54 , C12Y104/01012 , C12Y201/03003 , C12Y207/02002 , C12Y305/03006 , C12Y501/01012 , C12Y504/03005 , Y02E50/10
Abstract: The invention provides methods for improving efficiency of fermentation by arginine supplementation, and genetically modified bacterium for use therefor. More particularly the invention provides methods for (i) increasing the production ATP intensive products with arginine supplementation, (ii) increasing utilization of arginine by a C1-fixing bacterium; and (iii) providing C1-fixing bacterium with optimized arginine de-aminase pathways.
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公开(公告)号：US11938197B2
公开(公告)日：2024-03-26
申请号：US16477168
申请日：2018-01-10
Applicant: Children's Medical Research Institute , The Sydney Children's Hospitals Network (Randwick and Westmead) (incorporating The Royal Alexandra Hospital for Children)
Inventor： Ian Alexander , Sharon Cunningham
CPC classification number: A61K48/0058 , C12N9/1018 , C12N15/67 , C12N15/86 , C12N2750/14143 , C12N2840/007 , C12Y201/03003
Abstract: Polynucleotides and vectors can be used for the expression of a transgene in cells, such as liver cells. The expression of the transgene from the polynucleotides and vectors can be useful in gene therapy. Various methods can be used for expressing the transgene from the polynucleotides and vectors in liver cells.
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公开(公告)号：US20240002815A1
公开(公告)日：2024-01-04
申请号：US18319977
申请日：2023-05-18
Applicant: ARCTURUS THERAPEUTICS, INC.
Inventor： Carlos G. PEREZ-GARCIA , Kiyoshi TACHIKAWA , Daiki MATSUDA , Padmanabh CHIVUKULA
CPC classification number: C12N9/1018 , A61P9/00 , C12Y201/03003 , A61K48/00
Abstract: The present disclosure provides a modified human OTC protein having improved properties for the treatment of OTC deficiency in a patient. Preferably, the protein of the disclosure is produced from a codon optimized mRNA suitable for administration to a patient suffering from OTC deficiency wherein upon administration of the mRNA to the patient, the protein of the disclosure is expressed in the patient in therapeutically effective amounts to treat OTC deficiency. The present disclosure also provides codon optimized mRNA sequences encoding wild type human OTC comprising a 5′ UTR derived from a gene expressed by Arabidopsis thaliana for use in treating OTC deficiency in a patient.
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公开(公告)号：US11685906B2
公开(公告)日：2023-06-27
申请号：US16705102
申请日：2019-12-05
Applicant: Arcturus Therapeutics, Inc.
Inventor： Carlos G. Perez-Garcia , Kiyoshi Tachikawa , Daiki Matsuda , Padmanabh Chivukula
CPC classification number: C12N9/1018 , A61P9/00 , C12Y201/03003 , A61K48/00
Abstract: The present disclosure provides a modified human OTC protein having improved properties for the treatment of OTC deficiency in a patient. Preferably, the protein of the disclosure is produced from a codon optimized mRNA suitable for administration to a patient suffering from OTC deficiency wherein upon administration of the mRNA to the patient, the protein of the disclosure is expressed in the patient in therapeutically effective amounts to treat OTC deficiency. The present disclosure also provides codon optimized mRNA sequences encoding wild type human OTC comprising a 5′ UTR derived from a gene expressed by Arabidopsis thaliana for use in treating OTC deficiency in a patient.
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