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公开(公告)号：US20050069942A1
公开(公告)日：2005-03-31
申请号：US10976917
申请日：2004-11-01
申请人： Andrew Murdin , Raymond Oomen , Joe Wang , Pamela Dunn
发明人： Andrew Murdin , Raymond Oomen , Joe Wang , Pamela Dunn
IPC分类号： G01N33/569 , A61K31/711 , A61K38/00 , A61K39/118 , A61K39/395 , A61K48/00 , A61P11/00 , A61P31/04 , C07K14/295 , C07K16/12 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/31 , C12P21/02 , C12Q1/68 , C07H21/04 , C12N15/74
CPC分类号： A61K31/711 , A61K39/118 , A61K2039/53 , C07K14/295 , Y10S435/975
摘要： The present invention provides a method of nucleic acid, including DNA, immunization of a host, including humans, against disease caused by infection by a strain of Chlamydia, specifically C. pneumoniae, employing a vector containing a nucleotide sequence encoding a 60 kDa cysteine-rich membrane protein of a strain of Chlamydia pneumoniae and a promoter to effect expression of the 60 kDa cysteine-rich membrane protein gene in the host. Modifications are possible within the scope of this invention.
摘要翻译： 本发明提供了包含DNA，宿主（包括人）在内的免疫针对由衣原体特异性肺炎衣原体感染引起的疾病的核酸的方法，其使用含有编码60kDa半胱氨酸 - 肺炎衣原体菌株的富含膜蛋白和在宿主中有效表达60kDa富含半胱氨酸的膜蛋白基因的启动子。 在本发明的范围内可以进行修改。
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公开(公告)号：US20050002944A1
公开(公告)日：2005-01-06
申请号：US10746251
申请日：2003-12-29
申请人： Andrew Murdin , Raymond Oomen , Joe Wang , Pamela Dunn
发明人： Andrew Murdin , Raymond Oomen , Joe Wang , Pamela Dunn
IPC分类号： G01N33/50 , A61K9/127 , A61K35/76 , A61K38/00 , A61K39/00 , A61K39/02 , A61K39/118 , A61K39/395 , A61K48/00 , A61P11/00 , A61P31/00 , C07K14/295 , C07K16/12 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/31 , C12P21/02 , C12Q1/68 , C12R1/01 , G01N33/15 , G01N33/53 , G01N33/566 , G01N33/569 , A61K39/38
CPC分类号： A61K9/127 , A61K39/00 , A61K39/118 , A61K2039/53 , C07K14/295 , C07K2319/00 , Y02A50/396 , Y02A50/472 , Y02A50/476 , Y10S435/975
摘要： The present invention provides a method of nucleic acid, including DNA, immunization of a host, including humans, against disease caused by infection by a strain of Chlamydia, specifically C. pneumoniae, employing a vector containing a nucleotide sequence encoding OMP (outer membrane protein) of a strain of Chlamydia pneumoniae and a promoter to effect expression of the OMP (outer membrane protein) gene in the host. Modifications are possible within the scope of this invention.
摘要翻译： 本发明提供了一种核酸的方法，包括DNA，宿主（包括人）免疫针对由衣原体特异性肺炎衣原体感染引起的疾病，使用含有编码OMP的核苷酸序列的载体（外膜蛋白 ）肺炎衣原体的菌株和在宿主中影响OMP（外膜蛋白）基因表达的启动子。 在本发明的范围内可以进行修改。
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公开(公告)号：US6096519A
公开(公告)日：2000-08-01
申请号：US969644
申请日：1997-11-13
IPC分类号： A61K38/00 , A61K39/00 , C07K14/295 , C07K16/12 , C12N15/30 , C12N15/74 , C12P21/02 , C07K1/00 , G01N33/543 , G01N33/554
CPC分类号： C07K14/295 , C07K16/125 , C12N15/74 , A61K38/00 , A61K39/00 , C07K2319/00 , C07K2319/75
摘要： A plasmid isolated from Clamydia trachomatis is described, which comprises 8 genes encoding proteins useful in the formulation of vaccines or diagnostic test for determining the bacterium or specific antibodies generated during C. trachomatis infections; in particular the recombinant fusion MS2-pgp3D protein is described comprising polypeptidic sequences encoded by pCT and immunogenic in the course of infections in man. A method for preparing said protein in E. coli further described.
摘要翻译： 描述了从沙眼衣原体分离的质粒，其包含编码用于疫苗制剂的蛋白质的8种基因或用于确定沙眼衣原体感染期间产生的细菌或特异性抗体的诊断试验; 特别地描述了重组融合物MS2-pgp3D蛋白质，其包括由pCT编码的多肽序列和在人类感染过程中具有免疫原性。 进一步描述在大肠杆菌中制备所述蛋白质的方法。
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44.发明授权Immunoassays for detecting chlamydial antigens or antibodies thereto using recombinant or synthetic major outer membrane protein polypeptides as substitute antigens 失效使用重组或合成的主要外膜蛋白多肽作为替代抗原来检测衣原体抗原或其抗体的免疫测定
公开(公告)号：US6030799A
公开(公告)日：2000-02-29
申请号：US466152
申请日：1995-06-06
申请人： Nina Agabian , Richard Stephens , Cho-Chou Kuo , Guy Mullenbach
发明人： Nina Agabian , Richard Stephens , Cho-Chou Kuo , Guy Mullenbach
IPC分类号： C07K14/295 , C12Q1/68 , G01N33/569 , G01N33/571 , A61K38/00 , C12N15/00 , C12P21/04
CPC分类号： C07K14/295 , C12Q1/689 , G01N33/56927 , C07K2319/00 , C07K2319/035 , C07K2319/40 , C07K2319/61 , G01N2333/295 , G01N2469/20
摘要： Methods and compositions are provided for the production of a polypeptide which is immunologically cross-reactive with a naturally-occurring major outer membrane protein (MOMP) of Chlamydia trachomatis. A DNA construct including a replication system recognized by E. coli, and an MOMP gene under the transcriptional control of a .beta.-glactosidase promoter and terminator is provided. Recombinant phage .lambda.gtll/L2/33 was deposited at the American Type Culture Collection, 12301 Parklawn Drive, Rockville, Md. 20852, on Jan. 10, 1985 and granted accession no. 40157. L2 B9-F DNA was deposited at the American Type Culture Collection on Dec. 31, 1985, and granted accession No. 40217.
摘要翻译： 提供了用于产生与沙眼衣原体的天然存在的主要外膜蛋白（MOMP）具有免疫交叉反应性的多肽的方法和组合物。 提供了包含由大肠杆菌识别的复制系统的DNA构建体和在β-谷氨酸酶启动子和终止子的转录控制下的MOMP基因。 1985年1月10日，重组噬菌体λgtll/ L2 / 33保藏于美国典型培养物保藏中心（American Type Culture Collection），12301 Parklawn Drive，Rockville，Md。20852，并授予登录号。 L15B9-F DNA于1985年12月31日在美国典型培养物保藏中心保藏，授予第40217号。
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公开(公告)号：US5858720A
公开(公告)日：1999-01-12
申请号：US899028
申请日：1997-07-23
IPC分类号： G01N33/50 , A61K38/00 , A61K39/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P31/04 , C07K14/295 , C07K16/12 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/00 , C12N15/00 , C12N15/09 , C12P21/02 , C12P21/08 , C12Q1/02 , C12R1/01 , C12N1/20 , C12N15/11
摘要： The invention provides hisS polypeptides and DNA (RNA) encoding hisS polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing hisS polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了hisS多肽和编码hisS多肽的DNA（RNA），以及通过重组技术产生此类多肽的方法。 还提供了利用hisS多肽筛选抗菌化合物的方法。
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46.发明授权Immunogenic LHRH peptide constructs and synthetic universal immune stimulators for vaccines 失效免疫原性LHRH肽构建体和疫苗的合成通用免疫刺激剂
公开(公告)号：US5843446A
公开(公告)日：1998-12-01
申请号：US488351
申请日：1995-06-07
IPC分类号： A61K39/00 , C07K7/23 , C07K14/02 , C07K14/12 , C07K14/16 , C07K14/235 , C07K14/24 , C07K14/245 , C07K14/295 , C07K14/33 , C07K14/34 , C07K14/445 , C07K14/575 , C07K14/595 , C07K16/00 , C07K19/00 , A61K39/38 , A61K39/385 , A61K39/395
CPC分类号： C07K14/005 , A61K39/0006 , C07K14/235 , C07K14/24 , C07K14/245 , C07K14/295 , C07K14/33 , C07K14/34 , C07K14/445 , C07K14/575 , C07K14/57572 , C07K14/595 , C07K16/00 , C07K19/00 , C07K7/23 , A61K2039/6031 , C12N2730/10122 , C12N2740/16222 , C12N2760/18422 , Y10S424/811 , Y10S514/841 , Y10S514/843
摘要： This invention relates to immunogenic luteinizing hormone releasing hormone (LHRH) peptides that lead to suppression of LHRH activity in males or females. These peptides are useful for inducing infertility and for treating prostatic hyperplasia, androgen-dependent carcinoma, prostatic carcinoma and testicular carcinoma in males. In females, the peptides are useful for treating endometriosis, benign uterine tumors, recurrent functional ovarian cysts and (severe) premenstrual syndrome as well as prevention or treatment of estrogen-dependent breast cancer. The subject peptides contain a helper T cell epitope and have LHRH at the C terminus. The helper T cell epitope aids in stimulating the immune response against LHRH. The peptides, optionally contain an invasin domain which acts as a general immune stimulator. In another aspect this invention relates to immunogenic synthetic peptides having an invasin domain, a helper T cell epitope and a peptide hapten and methods of using these peptides to treat disease or provide protective immunity. The peptide haptens of the invention include LHRH, amylin, gastrin, gastrin releasing peptide, IgE CH4 peptide, Chlamydia MOMP peptides, HIV V3 peptides and Plasmodium berghei.
摘要翻译： 本发明涉及导致男性或女性LHRH活性抑制的免疫原性促黄体激素释放激素（LHRH）肽。 这些肽可用于诱导不育症和用于治疗男性前列腺增生，雄激素依赖性癌，前列腺癌和睾丸癌。 在女性中，肽可用于治疗子宫内膜异位症，良性子宫肿瘤，复发性功能性卵巢囊肿和（严重）经前期综合征以及预防或治疗雌激素依赖性乳腺癌。 主题肽含有辅助T细胞表位，并在C末端具有LHRH。 辅助T细胞表位有助于刺激对LHRH的免疫应答。 肽可任选地含有作为一般免疫刺激剂的侵袭素结构域。 在另一方面，本发明涉及具有侵入蛋白结构域，辅助T细胞表位和肽半抗原的免疫原性合成肽以及使用这些肽治疗疾病或提供保护性免疫的方法。 本发明的肽半抗原包括LHRH，胰岛淀粉样多肽，胃泌素，胃泌素释放肽，IgE CH4肽，衣原体MOMP肽，HIV V3肽和疟原虫。
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公开(公告)号：US5716793A
公开(公告)日：1998-02-10
申请号：US406113
申请日：1995-03-17
IPC分类号： G01N33/53 , A61K31/00 , A61K39/00 , A61K39/395 , A61P31/00 , A61P31/04 , C07K14/295 , C07K16/12 , C07K16/42 , C12N5/10 , C12N15/02 , C12P21/08 , C12R1/91 , G01N33/569 , G01N33/571 , G01N33/577
CPC分类号： C07K16/4233 , C07K16/125 , G01N33/56927 , A61K39/00 , Y10S435/965 , Y10S436/811
摘要： A method of detecting chlamydia in a extracellular sample is provided which comprises contacting the sample with an idiotypic antibody to GLXA to form an immunocomplex and detecting the immunocomplex.
摘要翻译： 提供了检测细胞外样品中衣原体的方法，其包括使样品与GLXA的独特型抗体接触以形成免疫复合物并检测免疫复合物。
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48.发明授权Detection of antibodies against Chlamydia trachomatis pgp3 antigen in patient sera by enzyme-linked immunosorbent assay 失效通过酶联免疫吸附试验检测患者血清中沙眼衣原体pgp3抗原的抗体
公开(公告)号：US5629167A
公开(公告)日：1997-05-13
申请号：US229980
申请日：1994-04-19
申请人： Giulio Ratti
发明人： Giulio Ratti
IPC分类号： G01N33/531 , A61K38/00 , A61K39/00 , A61K39/118 , A61P31/04 , C07K14/195 , C07K14/295 , C12N1/21 , C12N15/00 , C12N15/09 , C12N15/31 , C12P21/02 , C12R1/01 , C12R1/19 , G01N33/569 , G01N38/53
CPC分类号： C07K14/295 , C07K14/195 , A61K39/00 , C07K2319/00 , Y10S435/975
摘要： A new recombinant form of the plasmid-encoded protein pgp3 from C. trachomatis, serotype D, was purified by ion exchange column chromatography and shown to be suitable for quantitative immunoassy on clinical samples in an ELISA format.
摘要翻译： 通过离子交换柱色谱法纯化来自沙眼衣原体（Seracacacia）的质粒编码蛋白质pgp3的新型重组形式，并且显示适用于ELISA样品中临床样品的定量免疫。
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公开(公告)号：US5387511A
公开(公告)日：1995-02-07
申请号：US911378
申请日：1992-07-13
申请人： Ian W. Davidson , Paul Sheard
发明人： Ian W. Davidson , Paul Sheard
IPC分类号： A61K39/118 , C07K14/195 , C07K14/21 , C07K14/295 , G01N33/569 , G01N33/571 , C12P19/04 , C12P21/04
CPC分类号： G01N33/56927 , A61K39/118 , C07K14/195 , C07K14/21 , C07K14/295 , Y10S435/871
摘要： Enhanced extraction of solubilized antigens is obtained from bacteria such as Chlamydia and Neisseri by the use of a buffer containing a zwitterionic surface active agent, especially CHAPS or CHAPSO, in the absence of divalent cations. The extraction is conducted at elevated temperature, and provides a sample useful in assays for the presence of the bacteria.
摘要翻译： 通过在不存在二价阳离子的情况下，使用含有两性离子表面活性剂，特别是CHAPS或CHAPSO的缓冲液，从细菌如衣原体和奈瑟氏菌获得增溶的抗原的增强。 提取在升高的温度下进行，并提供可用于测定细菌存在的样品。
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50.发明授权High pH extraction composition and its use to determine a chlamydial, gonococcal or herpes antigen 失效高PH提取物组合物及其用于测定氯胺酮，甘露醇或其他抗生素
公开(公告)号：US5132205A
公开(公告)日：1992-07-21
申请号：US255928
申请日：1988-10-07
申请人： Allan D. Pronovost , John C. Mauck , Sheryl S. Sullivan , Catherine E. Greer , James H. Gilbert
发明人： Allan D. Pronovost , John C. Mauck , Sheryl S. Sullivan , Catherine E. Greer , James H. Gilbert
IPC分类号： G01N33/569 , A61K39/00 , A61K39/095 , A61K39/118 , A61K39/245 , C07K2/00 , C07K14/005 , C07K14/03 , C07K14/035 , C07K14/195 , C07K14/22 , C07K14/295 , C07K14/41 , C07K16/08 , C07K16/12 , C12P21/00 , C12R1/01 , C12R1/92 , G01N33/571
CPC分类号： C07K16/1203 , A61K39/095 , A61K39/118 , C07K14/005 , C07K14/22 , C07K14/295 , C07K16/085 , A61K39/00 , C12N2710/16622 , Y10S435/871 , Y10S436/825
摘要： An extraction composition is useful for lysing chlamydial, gonococcal or herpes organisms and extracting detectable antigen from the organisms. In particular, this composition has a high pH (at least about 8) and comprises an alcoholamine which is effective in extracting antigen. It is particularly useful for extracting either or both of the lipopolysaccharide and major outer membrane protein chlamydial antigens.
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