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51.发明申请METHODS OF AND COMPOSITIONS FOR STIMULATION OF GLUCOSE UPTAKE INTO MUSCLE CELLS AND TREATMENT OF DISEASES 审中-公开用于刺激葡萄糖摄入到肌肉细胞和治疗疾病的方法和组合物公开(公告)号：US20110319324A1
公开(公告)日：2011-12-29
申请号：US12955779
申请日：2010-11-29
申请人： Junyu Lin , Srinivas Kothakota , Ge Wu , Stephen Doberstein , Thomas Brennan , Lorianne Masuoka , Minmin Qin , Shannon Marshall , Yan Wang , Diane Hollenbaugh , Lewis T. Williams
发明人： Junyu Lin , Srinivas Kothakota , Ge Wu , Stephen Doberstein , Thomas Brennan , Lorianne Masuoka , Minmin Qin , Shannon Marshall , Yan Wang , Diane Hollenbaugh , Lewis T. Williams
CPC分类号： A61K38/28 , A61K31/155 , A61K38/1808 , A61K38/26 , A61K38/00
摘要： The present invention relates to therapeutic uses of ErbB ligands, including betacellulin. The therapeutic uses include methods of using ErbB ligand family compounds alone, or in conjunction with other agents, for reducing blood glucose levels, treating Type I and Type II diabetes, obesity, muscle wasting diseases, and cardiotoxicity.
摘要翻译： 本发明涉及ErbB配体（包括β细胞素）的治疗用途。 治疗用途包括单独使用ErbB配体家族化合物或与其它药物联合用于降低血糖水平，治疗I型和II型糖尿病，肥胖症，肌肉消瘦疾病和心脏毒性的方法。
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52.发明申请公开(公告)号：US20110281302A1
公开(公告)日：2011-11-17
申请号：US13157712
申请日：2011-06-10
申请人： Lewis T. WILLIAMS , Elizabeth Bosch , Stephen Doberstein , Kevin Hestir , Diane Hollenbaugh , Ernestine Lee , Minmin Qin , Ali Sadra , Justin Wong , Ge Wu , Hongbing Zhang
发明人： Lewis T. WILLIAMS , Elizabeth Bosch , Stephen Doberstein , Kevin Hestir , Diane Hollenbaugh , Ernestine Lee , Minmin Qin , Ali Sadra , Justin Wong , Ge Wu , Hongbing Zhang
CPC分类号： C07K14/71 , A61K45/06 , C07K14/765 , C07K16/2863 , C07K17/08 , C07K2319/30 , C07K2319/32
摘要： The invention provides FGFR fusion proteins, methods of making them, and methods of using them to treat proliferative disorders, including cancers and disorders of angiogenesis. The FGFR fusion molecules can be made in CHO cells and may comprise deletion mutations in the extracellular domains of the FGFRs which improve their stability. These fusion proteins inhibit the growth and viability of cancer cells in vitro and in vivo. The combination of the relatively high affinity of these receptors for their ligand FGFs and the demonstrated ability of these decoy receptors to inhibit tumor growth is an indication of the clinical value of the compositions and methods provided herein.
摘要翻译： 本发明提供了FGFR融合蛋白，其制备方法以及使用它们来治疗增殖性疾病（包括癌症和血管生成障碍）的方法。 FGFR融合分子可以在CHO细胞中制备，并且可以包含改善其稳定性的FGFRs的细胞外结构域中的缺失突变。 这些融合蛋白体外和体内抑制癌细胞的生长和活力。 这些受体对其配体FGF的相对高亲和力的组合以及这些诱饵受体抑制肿瘤生长的证明的能力是本文提供的组合物和方法的临床价值的指示。
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53.发明申请STROMAL CELL-DERIVED FACTOR-1 POLYPEPTIDES, POLYNUCLEOTIDES, MODULATORS THEREOF AND METHODS OF USE 有权结晶细胞衍生因子-1多肽，多核苷酸，调节剂及其使用方法公开(公告)号：US20110020375A1
公开(公告)日：2011-01-27
申请号：US12752936
申请日：2010-04-01
申请人： Keting Chu , Lewis T. Williams , Justin G. P. Wong , Kevin Hestir , Amy L. Tsui Collins , Ernestine Lee
发明人： Keting Chu , Lewis T. Williams , Justin G. P. Wong , Kevin Hestir , Amy L. Tsui Collins , Ernestine Lee
IPC分类号： A61K38/17 , C12N15/12 , C07K14/435 , C12N15/00 , C07K1/00 , C07K16/18 , G01N33/48 , G01N33/53 , A61K35/12 , A61K39/00 , C12N5/00 , A61P7/02 , A61P3/10 , A61P9/00 , A61P37/00 , A61P31/00 , A61P9/10 , A61P35/00 , A61P37/08 , A61P17/00 , A61P11/00
CPC分类号： C07K14/522 , Y10T436/143333
摘要： Disclosed herein is a newly identified SDF-1 splice variant molecule, its polypeptide sequence, and the polynucleotides encoding the polypeptide sequence, and active fragments thereof. Also provided is a procedure for producing such polypeptides by recombinant techniques employing, for example, vectors and host cells. Also disclosed are methods for utilizing such polypeptides and modulators thereof for the treatment of diseases, including cancer, immune diseases, infectious diseases, and ischemic diseases.
摘要翻译： 本文公开了新鉴定的SDF-1剪接变体分子，其多肽序列和编码多肽序列的多核苷酸及其活性片段。 还提供了通过使用例如载体和宿主细胞的重组技术产生此类多肽的方法。 还公开了利用这些多肽及其调节剂治疗疾病的方法，包括癌症，免疫疾病，感染性疾病和缺血性疾病。
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公开(公告)号：US20110020352A1
公开(公告)日：2011-01-27
申请号：US12819648
申请日：2010-06-21
IPC分类号： A61K39/42 , C07H21/02 , A61K31/7084 , C07K16/10 , C12Q1/70 , C07K14/15 , A61K39/21 , A61K35/12 , A61P35/00 , A61P37/04 , A61P31/14
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/505 , A61K2039/53 , C12N7/00 , C12N2740/10021 , C12N2740/10022 , C12Q1/6886 , C12Q1/702 , C12Q2600/158 , G01N33/57434 , G01N2333/15
摘要： Human endogenous retroviruses of the HML-2 family show up-regulated expression in prostate tumors. This finding can be used in prostate cancer screening, diagnosis and therapy.
摘要翻译： HML-2家族的人内源性逆转录病毒在前列腺肿瘤中显示出上调的表达。 这一发现可用于前列腺癌筛查，诊断和治疗。
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公开(公告)号：US07776523B2
公开(公告)日：2010-08-17
申请号：US10016604
申请日：2001-12-07
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/505 , A61K2039/53 , C12N7/00 , C12N2740/10021 , C12N2740/10022 , C12Q1/6886 , C12Q1/702 , C12Q2600/158 , G01N33/57434 , G01N2333/15
摘要： Human endogenous retroviruses of the HML-2 family show up-regulated expression in prostate tumors. This finding can be used in prostate cancer screening, diagnosis and therapy.
摘要翻译： HML-2家族的人内源性逆转录病毒在前列腺肿瘤中显示出上调的表达。 这一发现可用于前列腺癌筛查，诊断和治疗。
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公开(公告)号：US20100136522A1
公开(公告)日：2010-06-03
申请号：US10016604
申请日：2001-12-07
IPC分类号： C12Q1/68
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/505 , A61K2039/53 , C12N7/00 , C12N2740/10021 , C12N2740/10022 , C12Q1/6886 , C12Q1/702 , C12Q2600/158 , G01N33/57434 , G01N2333/15
摘要： Human endogenous retroviruses of the HML-2 family show up-regulated expression in prostate tumors. This finding can be used in prostate cancer screening, diagnosis and therapy.
摘要翻译： HML-2家族的人内源性逆转录病毒在前列腺肿瘤中显示出上调的表达。 这一发现可用于前列腺癌筛查，诊断和治疗。
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57.发明申请Human cDNA clones comprising polynucleotides encoding polypeptides and methods of their use 审中-公开包含编码多肽的多核苷酸的人cDNA克隆及其使用方法公开(公告)号：US20080182974A1
公开(公告)日：2008-07-31
申请号：US11983397
申请日：2007-11-07
申请人： Lewis T. Williams , Keting Chu , Ernestine Lee , Kevin Hestir , Justin Wong , Stephen K. Doberstein
发明人： Lewis T. Williams , Keting Chu , Ernestine Lee , Kevin Hestir , Justin Wong , Stephen K. Doberstein
IPC分类号： C07K14/00
CPC分类号： C07K14/47 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A61K38/00 , A61K39/00 , A61K48/00 , C07K14/705
摘要： The invention provides novel human full-length cDNA clones, novel polynucleotides, related polypeptides, related nucleic acid and polypeptide compositions, and related modulators, such as antibodies and small molecule modulators. The invention also provides methods to make and use these cDNA clones, polynucleotides, polypeptides, related compositions, and modulators. These methods include diagnostic, prophylactic and therapeutic applications. The compositions and methods of the invention are useful in treating proliferative disorders, e.g., cancers, and inflammatory, immune, bacterial, and viral disorders.
摘要翻译： 本发明提供新型人全长cDNA克隆，新型多核苷酸，相关多肽，相关核酸和多肽组合物以及相关调节剂，例如抗体和小分子调节剂。 本发明还提供了制备和使用这些cDNA克隆，多核苷酸，多肽，相关组合物和调节剂的方法。 这些方法包括诊断，预防和治疗应用。 本发明的组合物和方法可用于治疗增殖性疾病，例如癌症，炎症，免疫，细菌和病毒性疾病。
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公开(公告)号：US07279554B2
公开(公告)日：2007-10-09
申请号：US10644548
申请日：2003-08-20
申请人： Vivien Chan , Michael Rohan , Lewis T. Williams
发明人： Vivien Chan , Michael Rohan , Lewis T. Williams
IPC分类号： C07K14/435 , C07K14/475 , C07K14/515
CPC分类号： C07K14/47 , C07K14/705
摘要： The invention provides polynucleotides encoding Notch receptor ligands, encoded polypeptides, and antibodies specific to the polypeptides. Also provided are methods and compositions for enhancing or inhibiting angiogenesis as well as modulating immune responses.
摘要翻译： 本发明提供编码Notch受体配体的多核苷酸，编码的多肽和对多肽特异性的抗体。 还提供了用于增强或抑制血管发生以及调节免疫应答的方法和组合物。
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公开(公告)号：US07122373B1
公开(公告)日：2006-10-17
申请号：US09313292
申请日：1999-05-13
申请人： Lewis T. Williams , Jaime Escobedo , Michael A. Innis , Pablo Dominguez Garcia , Julie Sudduth-Klinger , Christoph Reinhard , Klaus Giese , Filippo Randazzo , Giulia C. Kennedy , David Pot , Altaf Kassam , George Lamson , Radoje Drmanac , Radomir Crkvenjakov , Mark Dickson , Snezana Drmanac , Ivan Labat , Dena Leshkowitz , David Kita , Veronica Garcia , Lee William Jones , Birgit Stache-Crain
发明人： Lewis T. Williams , Jaime Escobedo , Michael A. Innis , Pablo Dominguez Garcia , Julie Sudduth-Klinger , Christoph Reinhard , Klaus Giese , Filippo Randazzo , Giulia C. Kennedy , David Pot , Altaf Kassam , George Lamson , Radoje Drmanac , Radomir Crkvenjakov , Mark Dickson , Snezana Drmanac , Ivan Labat , Dena Leshkowitz , David Kita , Veronica Garcia , Lee William Jones , Birgit Stache-Crain
CPC分类号： C07K14/47 , C12Q1/6886 , C12Q2600/106
摘要： This invention relates to novel human polynucleotides and variants thereof, their encoded polypeptides and variants thereof, to genes corresponding to these polynucleotides and to proteins expressed by the genes. The invention also relates to diagnostic and therapeutic agents employing such novel human polynucleotides, their corresponding genes or gene products, e.g., these genes and proteins, including probes, antisense constructs, and antibodies.
摘要翻译： 本发明涉及对应于这些多核苷酸的基因和由该基因表达的蛋白质的新型人多核苷酸及其变体，其编码的多肽及其变体。 本发明还涉及使用这种新型人多核苷酸的诊断和治疗剂，其相应的基因或基因产物，例如这些基因和蛋白质，包括探针，反义构建体和抗体。
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60.发明授权Isolated dishevelled associated kinases, polynucleotides encoding the kinases, and methods of use thereof 失效分离的蓬乱相关激酶，编码激酶的多核苷酸及其使用方法公开(公告)号：US06958238B2
公开(公告)日：2005-10-25
申请号：US10464939
申请日：2003-06-18
申请人： Tian-Qiang Sun , Lewis T. Williams
发明人： Tian-Qiang Sun , Lewis T. Williams
IPC分类号： G01N33/50 , A61K31/7088 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P35/00 , C12N9/12 , C12N15/09 , C12N15/54 , G01N33/15
CPC分类号： C12N9/12
摘要： The invention provides Dishevelled Associated Kinase polypeptides, which phosphorylate Dsh proteins involved in the Wnt/Wg signalling pathway. Isolated polynucleotides encoding DAK polypeptides are further provided, as are recombinant vectors, and host cells comprising the polynucleotides. Methods of using the polynucleotides and polypeptides of the invention are further aspects of the invention, including assays to detect agents which modulate DAK kinase activity. Further provided are methods of modulating pathways involved in control of cell proliferation.
摘要翻译： 本发明提供了Dishevelled Associated Kinase多肽，其使参与Wnt / Wg信号通路的Dsh蛋白质磷酸化。 还提供编码DAK多肽的分离的多核苷酸，重组载体以及包含多核苷酸的宿主细胞也是如此。 使用本发明的多核苷酸和多肽的方法是本发明的另外的方面，包括检测调节DAK激酶活性的试剂的测定法。 进一步提供调节参与控制细胞增殖的途径的方法。
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