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    Unsymmetrical cyanine dimer compounds and their application
    52.
    发明申请
    Unsymmetrical cyanine dimer compounds and their application 审中-公开
    不对称花青二聚体化合物及其应用

    公开(公告)号：US20050074796A1

    公开(公告)日：2005-04-07

    申请号：US10911423

    申请日：2004-08-02

    Applicant: Stephen Yue ,  Ching-Ying Cheung

    Inventor： Stephen Yue ,  Ching-Ying Cheung

    IPC: C07D215/18 ,  C07H21/02 ,  C09B23/02 ,  C12Q1/68

    CPC classification number: C12Q1/6816 ,  C09B23/0016 ,  C09B23/0066 ,  C09B23/04 ,  C09B23/06 ,  C09B55/006 ,  Y10S436/80 ,  C12Q2563/173

    Abstract: Embodiments of the present invention provide methods and nucleic acid reporter molecules for the detection of nucleic acid in a sample. The nucleic acid reporter molecule comprises two unsymmetrical cyanine monomer moieties, which may be the same or different, that are covalently attached by a linker comprising at least one aromatic, heteroaromatic, cyclic or heterocyclic moiety comprising 3-20 non-hydrogen atoms selected from the group consisting of O, N, S, P and C. The linker may be rigid, relatively flexible or some degree thereof. The unsymmetrical cyanine monomer moieties comprise a substituted or unsubstituted benzazolium moiety and a substituted or unsubstituted pyridinium or quinolinium moiety that is connected by a methine bridge that is monomethine, trimethine or pentamethine. The linkers form the cyanine dimer compounds by attaching to the pyridinium or quinolinium moiety of the monomer moieties. The present nucleic acid reporter molecules find utility in forming a nucleic acid-reporter molecule complex and detecting the nucleic acid. In particular, present nucleic acid reporter molecules with a rigid linker and monomer moieties with a monomethine bridge find utility in detecting RNA in the presence of DNA.

    Abstract translation: 本发明的实施方案提供了用于检测样品中核酸的方法和核酸报告分子。 核酸报告分子包含两个不对称的花青单体部分，其可以相同或不同，其通过包含至少一个芳族，杂芳族，环状或杂环部分的连接体共价连接，该部分包含3-20个非氢原子，所述非氢原子选自 由O，N，S，P和C组成的组。接头可以是刚性的，相对柔性的或其某种程度的。 不对称花青单体部分包含取代或未取代的苯并唑鎓部分和通过单甲基，三甲基或五甲氧基的次甲基桥连接的取代或未取代的吡啶鎓或喹啉鎓部分。 连接体通过连接到单体部分的吡啶鎓或喹啉鎓部分而形成花青二聚体化合物。 本发明的核酸报告分子可用于形成核酸 - 报道分子复合物并检测核酸。 特别地，具有刚性连接体和具有单甲基桥的单体部分的本发明的核酸报告分子在DNA存在下可用于检测RNA。

    Interstitial free steels and method thereof
    53.
    发明授权
    Interstitial free steels and method thereof 失效
    无间隙钢及其方法

    公开(公告)号：US5200005A

    公开(公告)日：1993-04-06

    申请号：US652872

    申请日：1991-02-08

    Applicant: Abbas Najah-Zadeh ,  John J. Jonas ,  Stephen Yue

    Inventor： Abbas Najah-Zadeh ,  John J. Jonas ,  Stephen Yue

    IPC: C21D8/00 ,  C21D8/02

    CPC classification number: C21D8/0231 ,  C21D8/00 ,  B21B2201/04 ,  C21D2211/005 ,  C21D8/0226

    Abstract: The strength of interstitial free steels is increased by up to 100% and the ductile to brittle transition temperature is decreased by up to 100.degree. C. by warm finish rolling in the single phase ferrite region below A.sub.rl to effect ferrite dynamic recrystallization of the steel microstructure to a ferrite structure of grain size having a grain size of up to 5 .mu.m, and especially an ultra fine grain size of 1 to 2 .mu.m; the method may be employed in various hot working methods including strip and rod mills, planetary hot rolling and extrusion.

    Abstract translation: 无间隙钢的强度提高高达100％，延性至脆性转变温度通过在Arl以下的单相铁素体区域中的热精轧降低高达100℃，以实现钢微观结构的铁素体动态再结晶 涉及粒径高达5μm的粒径的铁素体结构，特别是1〜2μm的超细晶粒度; 该方法可以用于各种热加工方法，包括带钢和棒磨机，行星式热轧和挤压。

    Steel rolling using optimized rolling schedule
    54.
    发明授权
    Steel rolling using optimized rolling schedule 失效
    采用优化轧制计划进行轧钢

    公开(公告)号：US4840051A

    公开(公告)日：1989-06-20

    申请号：US55945

    申请日：1987-06-01

    Applicant: Francisco Boratto ,  Stephen Yue ,  John J. Jonas

    Inventor： Francisco Boratto ,  Stephen Yue ,  John J. Jonas

    IPC: B21B1/26 ,  B21B1/32

    CPC classification number: B21B1/32 ,  B21B1/26 ,  B21B2201/04 ,  B21B2265/22 ,  Y10T70/375

    Abstract: A series of thermomechanical workings such as temperature-controlled torsional strains are applied to a specimen of steel at strain and temperature levels and interpass times selected to simulate rolling mill conditions. The measured stress values are compared with the temperatures of the steel during the working periods during which the respective values were obtained. Thermomechanical working schedules are repeated at selected varying starting and terminating temperatures thereby to obtain a series of possible rolling schedules. These simulations are selected so that a varying number of reduction passes in the sequence occur at steel temperatures below temperature A.sub.r3. The value of a selected parameter of the worked steel, e.g. yield strength, is measured at ambient temperature. From the rolling mill analogue of possible rolling schedule simulations, an optimized rolling schedule is selected which will predictably impart to the steel a value of the selected parameter falling within a predetermined range. Linear regression analysis is applied to empirically obtained rolling mill data to derive one or more linear relationships between a selected property (e.g. yield strength) of the steel and rolling mill parameters thereby to permit selection of an optimum rolling schedule suitable to obtain a preselected value of the selected property of the steel.

    Abstract translation: 将温度控制的扭转应变的一系列热机械工作应用于钢的样品的应变和温度水平以及所选择的插层时间以模拟轧机条件。 将测量的应力值与获得各个值的工作期间的钢的温度进行比较。 在选择的变化的起始和终止温度下重复热机械工作时间表，从而获得一系列可能的轧制时间表。 选择这些模拟，使得在低于温度Ar 3的钢温度下，顺序发生不同数量的还原。 加工钢的选定参数的值，例如 屈服强度，在环境温度下测量。 从可能的轧制计划模拟的轧机模拟中，选择优化的轧制计划，其可预测地赋予钢所选参数的值落在预定范围内。 线性回归分析被应用于经验获得的轧机数据以导出钢的选定性质（例如屈服强度）与轧机参数之间的一个或多个线性关系，从而允许选择适于获得预定值 钢的选定属性。

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