公开(公告)号：US07393935B1

公开(公告)日：2008-07-01

申请号：US11385006

申请日：2006-03-21

申请人： Hiroya Kirimura ,  Ichiro Yamashita

发明人： Hiroya Kirimura ,  Ichiro Yamashita

IPC分类号： C07K14/00 ,  H01L21/00 ,  H01L21/314 ,  H01L21/471

CPC分类号： C07K14/47 ,  C07K2319/00

摘要： A method for selectively arranging ferritin in a specified inorganic material part formed on a substrate is provided. The method for arranging ferritin of the present invention is characterized in that ferritin is selectively arranged on a part including titanium or silicon nitride (SiN) in an efficient manner by adding a nonionic surface active agent. Also, selective arrangement capability of ferritin can be markedly improved by modifying the N-terminus of ferritin with a certain peptide.

摘要翻译： 提供了一种在基板上形成的规定的无机材料部分中选择性地配置铁蛋白的方法。 本发明的铁蛋白的配置方法的特征在于，通过添加非离子表面活性剂，有效地将铁蛋白选择性地配置在包含钛或氮化硅（SiN）的部分上。 此外，通过用某种肽修饰铁蛋白的N末端，可以显着改善铁蛋白的选择性排列能力。

公开(公告)号：US07204999B2

公开(公告)日：2007-04-17

申请号：US10702459

申请日：2003-11-07

申请人： Mitsuhiro Okuda ,  Hideyuki Yoshimura ,  Ichiro Yamashita

发明人： Mitsuhiro Okuda ,  Hideyuki Yoshimura ,  Ichiro Yamashita

IPC分类号： A61K9/50

CPC分类号： B82Y30/00 ,  B82Y10/00 ,  C01G3/02 ,  C01G37/02 ,  C01G53/04 ,  C01P2004/04 ,  C01P2004/64 ,  H01L21/28273

摘要： The method of the production of a nanoparticle of the present invention includes a step of forming a nanoparticle including a compound of ametal ion in a cavity part of aprotein, in a solution containing the protein having the cavity part therein, the metal ion, and a carbonate ion and/or a hydrogen carbonate ion. Examples of the aforementioned compound include e.g., a hydroxide. The aforementioned metal ion is preferably any one of a nickel ion (Ni2+), a chromium ion (Cr2+) or a copper ion (Cu2+). According to the aforementioned method, nanoparticles having a uniform particle diameter can be produced.

摘要翻译： 本发明的纳米粒子的制造方法包括在含有蛋白质的溶液中形成含有离子的化合物的纳米粒子的步骤，所述纳米粒子在空泡部分的蛋白质中，含有其中具有空腔部分的蛋白质，金属离子和 碳酸根离子和/或碳酸氢根离子。 上述化合物的实例包括例如氢氧化物。 上述金属离子优选为镍离子（Ni 2+ +），铬离子（Cr 2+ +）或铜离子（Cu 2 O 3）中的任一种 + ）。 根据上述方法，可以制造具有均匀粒径的纳米粒子。

公开(公告)号：US07129047B2

公开(公告)日：2006-10-31

申请号：US10628840

申请日：2003-07-28

申请人： Ichiro Yamashita

发明人： Ichiro Yamashita

IPC分类号： C12Q1/68 ,  C12M1/36 ,  C07H21/04 ,  G01N15/06

CPC分类号： C12Q1/6825 ,  B01J2219/00648 ,  B01J2219/00722 ,  C12Q1/6837 ,  C40B40/06 ,  C12Q2565/507

摘要： A nucleotide detector 10 includes: metal particles 12 having a size of the order of nanometers (diameter: about 6 nm) placed on a surface of a substrate 11 at high density with high precision (with spaces of about 12 nm between adjacent particles); and single-stranded DNAs (thiol DNAs) 13 having sulfur atoms at ends bonded to the gold particles 12. The thiol DNAs 13 are placed uniformly over the entire substrate 11 at high density with high precision. Therefore, once a fluorescence-labeled single-stranded DNA is hybridized with any of the thiol DNAs 13, high fluorescence intensity is stably obtained. This detector is therefore usable as a high-performance DNA sensor with a high SN ratio.

摘要翻译： 核苷酸检测器10包括：以高精度（相邻颗粒之间约12nm的间隔）以高密度放置在基板11的表面上的尺寸为纳米（直径：约6nm）的金属颗粒12; 和在金粒子12上结合的具有硫原子的单链DNA（硫醇DNA）13。硫醇DNA 13以高精度以高密度均匀地放置在整个基板11上。 因此，一旦荧光标记的单链DNA与任何硫醇DNAs 13杂交，就可以稳定地获得高荧光强度。 因此，该检测器可用作具有高SN比的高性能DNA传感器。

公开(公告)号：US07085347B2

公开(公告)日：2006-08-01

申请号：US10416016

申请日：2002-08-23

申请人： Kazumasa Mihara ,  Kenji Hara ,  Ichiro Yamashita ,  Ikuo Wakamoto ,  Yuichiro Kamino

发明人： Kazumasa Mihara ,  Kenji Hara ,  Ichiro Yamashita ,  Ikuo Wakamoto ,  Yuichiro Kamino

IPC分类号： A61N5/10 ,  H05G1/02

CPC分类号： A61N5/1049 ,  A61B2090/101 ,  A61N5/10 ,  A61N5/1037 ,  A61N5/1082 ,  A61N2005/1061

摘要： The radiotherapy apparatus in the present invention includes a bed, a radiation irradiating head, head swing mechanisms, a precise inspection unit and a control unit. The bed carries a subject. The radiation irradiating head irradiates a treatment radiation to a treatment field of the subject. The head swing mechanisms, which are coupled to the radiation irradiating head, swings the head of the radiation irradiating head so that the treatment radiation emitted from the radiation irradiating head pursues the motion of the treatment field. The precise inspection unit obtains a diagnosis image containing the treatment field. The control unit controls the positions of the head swing mechanisms so that an irradiation field of the radiation irradiating head pursues the treatment field, based on the diagnosis image, the position of the radiation irradiating head and the state of the swung head. Then, the control unit controls the radiation irradiating head so that the treatment radiation is irradiated from the radiation irradiating head, after the positional control of the head swing mechanisms.

摘要翻译： 本发明的放射线治疗装置包括床，放射线照射头，头摆动机构，精密检查单元和控制单元。 床上有一个主题。 辐射照射头将治疗辐射照射到受试者的治疗区域。 耦合到辐射照射头的头部摆动机构摆动辐射照射头的头部，使得从辐射照射头发射的治疗辐射追求治疗场的运动。 精确检查单元获得包含治疗区域的诊断图像。 控制单元基于诊断图像，放射线照射头的位置和摆动头的状态来控制头摆动机构的位置，使得放射线照射头的照射场追求治疗场。 然后，在头摆动机构的位置控制之后，控制单元控制辐射照射头，使得从辐射照射头照射治疗辐射。

公开(公告)号：US07041530B2

公开(公告)日：2006-05-09

申请号：US10864881

申请日：2004-06-10

申请人： Masahiro Nunoshita ,  Ichiro Yamashita ,  Shigeo Yoshii

发明人： Masahiro Nunoshita ,  Ichiro Yamashita ,  Shigeo Yoshii

IPC分类号： H01L51/40

CPC分类号： H01L29/127 ,  B82Y10/00 ,  B82Y30/00 ,  C01P2004/64 ,  H01L21/266 ,  H01L29/158 ,  Y10S438/917 ,  Y10S438/918 ,  Y10S438/962

摘要： A method of the production of a nanoparticle dispersed composite material capable of controlling a particle size and a three dimensional arrangement of the nanoparticles is provided. The method of the production of a nanoparticle dispersed composite material of the present invention includes a step (a) of arranging a plurality of core fine particle-protein complexes having a core fine particle, which comprises an inorganic material, internally included within a protein on the top surface of a substrate, a step (b) of removing the protein, a step (c) of conducting ion implantation from the top surface of the substrate, and a step (d) of forming nanoparticles including the ion implanted by the ion implantation as a raw material, inside of the substrate.

摘要翻译： 提供了能够控制纳米颗粒的粒度和三维排列的纳米颗粒分散复合材料的制造方法。 制备本发明的纳米颗粒分散复合材料的方法包括：将包含内部包含在蛋白质内的无机材料的多个具有核心细颗粒的核心细颗粒 - 蛋白复合物排列在 衬底的顶表面，去除蛋白质的步骤（b），从衬底的顶表面进行离子注入的步骤（c）和形成纳米颗粒的步骤（d），其包括由离子注入的离子 作为原料植入，在基板的内部。

公开(公告)号：US07033613B2

公开(公告)日：2006-04-25

申请号：US10142838

申请日：2002-05-13

申请人： Ichiro Yamashita

发明人： Ichiro Yamashita

IPC分类号： A61K33/24 ,  A01N59/16

CPC分类号： H01L29/42332 ,  A61K38/00 ,  C07K14/47 ,  Y10T428/12868 ,  Y10T428/253

摘要： Using a gene recombination technique, a glutamic acid and an aspartic acid positioned in a channel of apoferritin are substituted with serine having a small size and no charges. Then, a glutamic acid positioned in a holding portion is substituted with a basic amino acid such as lysine or a neutral amino acid. Furthermore, at least one cysteine is introduced into the holding portion. This prevents a repulsive force due to electrostatic interaction between (AuCl4)− having a negative charge and a negative amino acid from occurring, which facilitates the capture of (AuCl4)− into the channel and the holding portion. The (AuCl4)− captured into the holding portion is subsequently reduced to Au, and thus apoferritin including gold particles can be produced.

摘要翻译： 使用基因重组技术，位于脱铁铁蛋白通道中的谷氨酸和天冬氨酸被具有小尺寸和无电荷的丝氨酸取代。 然后，将置于保持部分中的谷氨酸用碱性氨基酸如赖氨酸或中性氨基酸取代。 此外，至少一个半胱氨酸被引入保持部分。 这防止由于发生具有负电荷的负电荷和负氨基酸之间的静电相互作用引起的排斥力，这有助于捕获（AuCl _{4 ） ^{- 进入通道和保持部分。 捕获到保持部分中的（AuCl 4+） - 随后被还原成Au，因此可以制备包含金颗粒的脱铁铁蛋白。}}

公开(公告)号：US20060070494A1

公开(公告)日：2006-04-06

申请号：US11284910

申请日：2005-11-23

申请人： Shigeo Yoshii ,  Michihito Ueda ,  Nozomu Matsukawa ,  Ichiro Yamashita

发明人： Shigeo Yoshii ,  Michihito Ueda ,  Nozomu Matsukawa ,  Ichiro Yamashita

IPC分类号： B22F9/20

CPC分类号： B82Y10/00 ,  H01L21/28273 ,  H01L21/28282 ,  H01L29/42332

摘要： An object of the present invention is to provide a method of forming fine particles on a substrate in which reoxidization of reduced fine particles is suppressed. Reduced fine particles (FeO fine particles) are formed by embedding metal oxide fine particles (Fe2O3 fine particles) fixed on a p type silicon semiconductor substrate into a silicon oxidized film, and carrying out a heat treatment in a reducing gas atmosphere. Presence of the silicon oxidized film enables suppression of reoxidization of the reduced fine particles (FeO fine particles) due to exposure to the ambient air.

摘要翻译： 本发明的目的是提供一种在抑制还原的微粒的再氧化的基板上形成微粒的方法。 通过将固定在p型硅半导体衬底上的金属氧化物微粒（Fe 2 O 3 O 3微粒）嵌入到硅氧化膜中而形成还原的微粒（FeO微粒） ，并在还原气体气氛中进行热处理。 硅氧化膜的存在能够抑制由于暴露于环境空气而导致的还原的微粒（FeO微粒）的再氧化。

公开(公告)号：US06977987B2

公开(公告)日：2005-12-20

申请号：US10762358

申请日：2004-01-23

申请人： Ichiro Yamashita ,  Yuichiro Kamino ,  Ikuo Wakamoto ,  Kazumasa Mihara

发明人： Ichiro Yamashita ,  Yuichiro Kamino ,  Ikuo Wakamoto ,  Kazumasa Mihara

IPC分类号： A61B19/00 ,  A61N5/02 ,  A61N5/10

CPC分类号： A61N5/1049 ,  A61B2090/101 ,  A61N5/10 ,  A61N5/1037 ,  A61N5/1082 ,  A61N2005/1061

摘要： A radiotherapy apparatus comprising an irradiation head having a linear accelerator and an intra-head waveguide unit whose one end portion is electromagnetically connected to the linear accelerator, a supporting moving mechanism which supports and moves the irradiation head on predetermined first spherical coordinates, a microwave oscillator which generates microwaves to be supplied to the irradiation head, and which is placed in a stationary position, a fixed waveguide unit having one end portion electromagnetically connected to the microwave oscillator, and the other end portion positioned on the supporting moving mechanism, and a moving waveguide unit having one end portion electromagnetically connected to the other end portion of the fixed waveguide unit positioned on the supporting moving mechanism.

摘要翻译： 一种放射治疗装置，包括具有线性加速器的照射头和一端部与线性加速器电磁连接的头内波导单元，支撑移动机构，其以预定的第一球坐标支撑并移动照射头，微波振荡器 其产生要供给到照射头的微波，并且被放置在静止位置，具有与微波振荡器电磁连接的一个端部的固定波导单元和位于支撑移动机构上的另一端部，以及移动 波导单元，其一端部与位于支撑移动机构上的固定波导单元的另一端电磁连接。

公开(公告)号：US06342716B1

公开(公告)日：2002-01-29

申请号：US09320695

申请日：1999-05-27

申请人： Kiyoyuki Morita ,  Kiyoshi Morimoto ,  Kiyoshi Araki ,  Koichiro Yuki ,  Kazuyasu Adachi ,  Masayuki Endo ,  Ichiro Yamashita

发明人： Kiyoyuki Morita ,  Kiyoshi Morimoto ,  Kiyoshi Araki ,  Koichiro Yuki ,  Kazuyasu Adachi ,  Masayuki Endo ,  Ichiro Yamashita

IPC分类号： H01L29788

CPC分类号： G11C13/0014 ,  B82Y10/00 ,  G11C11/5664 ,  G11C11/5671 ,  G11C13/0019 ,  G11C2216/08 ,  H01L21/28273 ,  H01L21/288 ,  H01L21/768 ,  H01L29/7883 ,  Y10S438/962

摘要： A semiconductor device as a nonvolatile memory comprises dot elements which are formed out of the semiconductor or conductor fine particles and function as a floating gate. The dot elements are asymmetrically formed to a control gate and may be formed in a sidewall insulating film formed over the side face of the control gate or a select gate. When inclined or stepped portions having level differences are formed in a semiconductor substrate, the dot elements are formed on a specified portion of the inclined or stepped portions.

摘要翻译： 作为非易失性存储器的半导体器件包括由半导体或导体细颗粒形成并作为浮栅的功能的点元件。 点元件与控制栅极不对称地形成，并且可以形成在形成在控制栅极或选择栅极的侧面上的侧壁绝缘膜中。 当在半导体衬底中形成具有电平差的倾斜或阶梯部分时，点元素形成在倾斜或阶梯部分的特定部分上。

公开(公告)号：US6121075A

公开(公告)日：2000-09-19

申请号：US228276

申请日：1999-01-11

申请人： Ichiro Yamashita

发明人： Ichiro Yamashita

IPC分类号： B05D1/20 ,  H01L21/225 ,  H01L21/308 ,  H01L21/329 ,  H01L21/768 ,  H01L21/8222 ,  H01L27/15 ,  H01L29/76 ,  H01L33/06 ,  H01L33/18 ,  H01L49/00 ,  H01L21/00

CPC分类号： H01L49/006 ,  B05D1/202 ,  B82Y10/00 ,  B82Y30/00 ,  B82Y40/00 ,  H01L21/2254 ,  H01L21/3081 ,  H01L21/3086 ,  H01L21/76838 ,  H01L21/8222 ,  H01L27/156 ,  H01L29/66136 ,  H01L29/7613 ,  G11C2216/08 ,  H01L2924/0002 ,  H01L33/06 ,  H01L33/18 ,  Y10S438/939 ,  Y10S438/945 ,  Y10S438/947 ,  Y10S438/962

摘要： A quantum device is constituted from a two-dimensional array of quantum dots formed from metal atom aggregates contained in metalloprotein complex. The metalloprotein is arranged on the surface of a substrate having an insulation layer with a pitch of the size of the metalloprotein complex. The diameter of the metal atom aggregates used in the quantum device is 7 nm or smaller, and the pitch of the metalloprotein complex is preferably from 11 to 14 nm.

摘要翻译： 量子器件由金属蛋白复合物中包含的金属原子聚集体形成的量子点的二维阵列构成。 金属蛋白被布置在具有金属蛋白复合物尺寸的间距的绝缘层的基底的表面上。 在量子器件中使用的金属原子聚集体的直径为7nm以下，金属蛋白复合体的间距优选为11〜14nm。