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公开(公告)号：US08920369B2
公开(公告)日：2014-12-30
申请号：US13463537
申请日：2012-05-03
申请人： Amr Salahieh , Jonah Lepak , Emma Leung , Tom Saul , Jean-Pierre Dueri , Brice Arnault De La Menardiere , Clayton Baldwin
发明人： Amr Salahieh , Jonah Lepak , Emma Leung , Tom Saul , Jean-Pierre Dueri , Brice Arnault De La Menardiere , Clayton Baldwin
CPC分类号： A61M25/0144 , A61B1/00135 , A61B17/00234 , A61B90/10 , A61B2017/00309 , A61B2017/00314 , A61M25/0013 , A61M25/0045 , A61M25/0053 , A61M25/0136 , A61M25/0138 , A61M25/0147 , A61M2025/0161
摘要： Steerable medical delivery devices and their methods of use.
摘要翻译： 可导向的医疗输送装置及其使用方法。
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公开(公告)号：US08858620B2
公开(公告)日：2014-10-14
申请号：US13157733
申请日：2011-06-10
申请人： Amr Salahieh , Jean-Pierre Dueri , Hans F. Valencia , Daniel Hildebrand , Brian D. Brandt , Dwight P. Morejohn , Claudio Argento , Tom Saul , Ulrich R. Haug
发明人： Amr Salahieh , Jean-Pierre Dueri , Hans F. Valencia , Daniel Hildebrand , Brian D. Brandt , Dwight P. Morejohn , Claudio Argento , Tom Saul , Ulrich R. Haug
CPC分类号： A61F2/2439 , A61F2/24 , A61F2/2409 , A61F2/2412 , A61F2/2418 , A61F2/243 , A61F2/2433 , A61F2/2436 , A61F2/90 , A61F2002/9528 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2230/005 , A61F2230/0054 , A61F2230/0078 , A61F2230/008 , A61F2250/006
摘要： The invention includes methods of and apparatus for endovascularly replacing a heart valve of a patient. One aspect of the invention provides a method including the steps of endovascularly delivering a replacement valve and an expandable anchor to a vicinity of the heart valve in an unexpanded configuration; and applying an external non-hydraulically expanding or non-pneumatically expanding actuation force on the anchor to change the shape of the anchor, such as by applying proximally and/or distally directed force on the anchor using a releasable deployment tool to expand and contract the anchor or parts of the anchor. Another aspect of the invention provides an apparatus including a replacement valve; an anchor; and a deployment tool comprising a plurality of anchor actuation elements adapted to apply a non-hydraulically expanding or non-pneumatically expanding actuation force on the anchor to reshape the anchor.
摘要翻译： 本发明包括用于血管内置换患者心脏瓣膜的方法和装置。 本发明的一个方面提供了一种方法，包括以未膨胀的构造将置换瓣膜和可扩张锚固件血管内输送到心脏瓣膜附近的步骤; 以及在所述锚上施加外部非液压膨胀或非气动扩张的致动力以改变所述锚的形状，例如通过使用可释放的展开工具向所述锚上施加近端和/或远端定向的力， 锚或锚的部分。 本发明的另一方面提供了一种包括置换阀的装置; 锚点 以及展开工具，其包括适于在锚上施加非液压膨胀或非气动膨胀的致动力的多个锚致动元件，以重构锚固件。
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公开(公告)号：US20140058197A1
公开(公告)日：2014-02-27
申请号：US13943633
申请日：2013-07-16
申请人： Amr Salahieh , Jonah Lepak , Emma Leung , Brian D. Brandt , John P. Claude , Tom Saul
发明人： Amr Salahieh , Jonah Lepak , Emma Leung , Brian D. Brandt , John P. Claude , Tom Saul
CPC分类号： A61B1/05 , A61B1/06 , A61B5/01 , A61B5/0422 , A61B5/6853 , A61B5/6855 , A61B5/6858 , A61B18/1206 , A61B18/1492 , A61B18/1815 , A61B2017/003 , A61B2017/00867 , A61B2017/22038 , A61B2018/00011 , A61B2018/00023 , A61B2018/00029 , A61B2018/00083 , A61B2018/0016 , A61B2018/00214 , A61B2018/0022 , A61B2018/00232 , A61B2018/00238 , A61B2018/00267 , A61B2018/00285 , A61B2018/00291 , A61B2018/00357 , A61B2018/00375 , A61B2018/00613 , A61B2018/00642 , A61B2018/00702 , A61B2018/00744 , A61B2018/00791 , A61B2018/00797 , A61B2018/00839 , A61B2018/00898 , A61B2018/0212 , A61B2018/0262 , A61B2018/124 , A61B2018/1465 , A61B2090/065 , A61B2090/3966 , A61B2217/007 , A61B2562/125 , A61B2562/164 , A61M25/0108 , A61M25/0133 , A61M25/0147 , A61M25/04 , A61M25/10 , A61M25/1011 , A61M2025/0681 , A61N1/05 , A61N5/02 , C08L2201/12
摘要： A tissue electrode assembly includes a membrane configured to form an expandable, conformable body that is deployable in a patient. The assembly further includes a flexible circuit positioned on a surface of the membrane and comprising at least one base substrate layer, at least one insulating layer and at least one planar conducting layer. An electrically-conductive electrode covers at least a portion of the flexible circuit and a portion of the surface of the membrane not covered by the flexible circuit, wherein the electrically-conductive electrode is foldable upon itself with the membrane to a delivery conformation having a diameter suitable for minimally-invasive delivery of the assembly to the patient.
摘要翻译： 组织电极组件包括被配置成形成可展开在患者体内的可扩张的适形身体的膜。 组件还包括位于膜的表面上的柔性电路，并且包括至少一个基底衬底层，至少一个绝缘层和至少一个平面导电层。 导电电极覆盖柔性电路的至少一部分和未被柔性电路覆盖的膜的表面的一部分，其中导电电极可以自身与膜折叠成具有直径的输送构型 适合于将组件的微创传送给患者。
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公开(公告)号：US08617236B2
公开(公告)日：2013-12-31
申请号：US13287420
申请日：2011-11-02
申请人： David Paul , Benjamin Sutton , Brian McCollum , Brian D. Brandt , Emma Leung , Kenneth M. Martin , Amr Salahieh , Daniel Hildebrand
发明人： David Paul , Benjamin Sutton , Brian McCollum , Brian D. Brandt , Emma Leung , Kenneth M. Martin , Amr Salahieh , Daniel Hildebrand
CPC分类号： A61F2/2427 , A61F2/24 , A61F2/2412 , A61F2/2418 , A61F2/243 , A61F2/2433 , A61F2/2436 , A61F2/2439 , A61F2/90 , A61F2/95 , A61F2/954 , A61F2/962 , A61F2/966 , A61F2/97 , A61F2002/9517 , A61F2002/9528 , A61F2002/9534 , A61F2220/0041 , A61F2220/0075 , A61F2230/0067 , A61F2250/006
摘要： Medical devices and delivery systems for delivering medical devices to a target location within a subject. In some embodiments the medical devices can be locked in a fully deployed and locked configuration. In some embodiments the delivery systems are configured with a single actuator to control the movement of multiple components of the delivery system. In some embodiments the actuator controls the independent and dependent movement of multiple components of the delivery system.
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55.发明申请VASCULAR DEVICE FOR EMBOLI, THROMBUS AND FOREIGN BODY REMOVAL AND METHODS OF USE 审中-公开用于EMBOLI，THROMBUS和外来身体移除的血管装置和使用方法公开(公告)号：US20130238009A9
公开(公告)日：2013-09-12
申请号：US12190319
申请日：2008-08-12
申请人： Leo N. Hopkins , Farhad Khosravi , Amr Salahieh , Jackson F. Demond , Jonah Lepak , Stephen Ramee , Jeff A. Krolik , Richard Renati
发明人： Leo N. Hopkins , Farhad Khosravi , Amr Salahieh , Jackson F. Demond , Jonah Lepak , Stephen Ramee , Jeff A. Krolik , Richard Renati
IPC分类号： A61M29/02
CPC分类号： A61F2/01 , A61B2017/00287 , A61B2017/2212 , A61F2/013 , A61F2002/011 , A61F2002/018 , A61F2230/0008 , A61F2230/008 , A61M25/0069 , A61M2025/09183 , A61M2025/1052 , A61M2025/109
摘要： Apparatus and methods are provided for use in filtering emboli from a vessel and/or performing thrombectomy and embolectomy, wherein a vascular device comprises one or more support hoops connected near a distal end of a guide wire, each support hoop having an articulation region, and a blood permeable sac affixed to the support hoop or hoops to form a mouth of the blood permeable sac. The mouth of the sac closes when the apparatus is collapsed for removal to prevent material from escaping from the sac.
摘要翻译： 提供了用于从血管过滤栓塞和/或进行血栓切除术和止血切除术的装置和方法，其中血管装置包括连接在导丝的远端附近的一个或多个支撑箍，每个支撑箍具有铰接区域，以及 固定在支撑环上的血液渗透性囊或箍形成透血囊的口。 当装置塌陷以移除时，囊的口闭合，以防止材料从囊中逸出。
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公开(公告)号：US08343213B2
公开(公告)日：2013-01-01
申请号：US10971535
申请日：2004-10-21
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2433 , A61F2/2436 , A61F2/2439 , A61F2002/9528 , A61F2230/0054 , A61F2230/0078 , A61F2250/006
摘要： The present invention relates to apparatus for methods for endovascularly replacing a patient's heart valve. The apparatus includes an expandable anchor with leaflet engagement elements on the proximal end of the anchor and a replacement valve. The leaflet engagement elements can be used to prevent distal migration and insure proper positioning of the apparatus.
摘要翻译： 本发明涉及用于血管内置换患者心脏瓣膜的方法的装置。 该装置包括在锚固件的近端上具有小叶接合元件的可扩张锚和更换阀。 传单接合元件可用于防止远端迁移并确保设备的正确定位。
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57.再颁专利Vascular device for emboli, thrombus and foreign body removal and methods of use 有权用于栓塞，血栓和异物去除的血管装置及其使用方法公开(公告)号：USRE43882E1
公开(公告)日：2012-12-25
申请号：US13162769
申请日：2011-06-17
申请人： Leo N. Hopkins , Farhad Khosravi , Amr Salahieh , Jackson F. Demond , Jonah Lepak , Stephen Ramee , Jeff A. Krolik , Richard Renati
发明人： Leo N. Hopkins , Farhad Khosravi , Amr Salahieh , Jackson F. Demond , Jonah Lepak , Stephen Ramee , Jeff A. Krolik , Richard Renati
IPC分类号： A61M29/00
CPC分类号： A61F2/01 , A61B2017/2212 , A61F2/013 , A61F2002/011 , A61F2002/018 , A61M2025/09183 , A61M2025/1052 , A61M2025/109
摘要： Apparatus and methods are provided for use in filtering emboli from a vessel and/or performing thrombectomy and embolectomy, wherein a vascular device comprises one or more support hoops connected near a distal end of a guide wire, each support hoop having an articulation region, and a blood permeable sac affixed to the support hoop or hoops to form a mouth of the blood permeable sac. The mouth of the sac closes when the apparatus is collapsed for removal to prevent material from escaping from the sac.
摘要翻译： 提供了用于从血管过滤栓塞和/或进行血栓切除术和止血切除术的装置和方法，其中血管装置包括连接在导丝的远端附近的一个或多个支撑箍，每个支撑箍具有铰接区域，以及 固定在支撑环上的血液渗透性囊或箍形成透血囊的口。 当装置塌陷以移除时，囊的口闭合，以防止材料从囊中逸出。
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公开(公告)号：US08295902B2
公开(公告)日：2012-10-23
申请号：US12616758
申请日：2009-11-11
申请人： Amr Salahieh , Jonah Lepak , Emma Leung , Brian Brandt , John P. Claude
发明人： Amr Salahieh , Jonah Lepak , Emma Leung , Brian Brandt , John P. Claude
CPC分类号： A61N1/05 , A61B5/01 , A61B5/0422 , A61B5/6846 , A61B18/1206 , A61B18/1492 , A61B2017/003 , A61B2017/00867 , A61B2017/22038 , A61B2018/00011 , A61B2018/00023 , A61B2018/00029 , A61B2018/00083 , A61B2018/0016 , A61B2018/00214 , A61B2018/0022 , A61B2018/00232 , A61B2018/00267 , A61B2018/00285 , A61B2018/00291 , A61B2018/00357 , A61B2018/00375 , A61B2018/00613 , A61B2018/00642 , A61B2018/00702 , A61B2018/00744 , A61B2018/00791 , A61B2018/00797 , A61B2018/00839 , A61B2018/00898 , A61B2018/124 , A61B2018/1465 , A61B2090/3966 , A61B2562/125 , C08L2201/12
摘要： A tissue electrode assembly includes a membrane configured to form an expandable, conformable body that is deployable in a patient. The assembly further includes a flexible circuit positioned on a surface of the membrane and comprising at least one base substrate layer, at least one insulating layer and at least one planar conducting layer. An electrically-conductive electrode covers at least a portion of the flexible circuit and a portion of the surface of the membrane not covered by the flexible circuit, wherein the electrically-conductive electrode is foldable upon itself with the membrane to a delivery conformation having a diameter suitable for minimally-invasive delivery of the assembly to the patient.
摘要翻译： 组织电极组件包括被配置成形成可展开在患者体内的可扩张的适形身体的膜。 组件还包括位于膜的表面上的柔性电路，并且包括至少一个基底衬底层，至少一个绝缘层和至少一个平面导电层。 导电电极覆盖柔性电路的至少一部分和未被柔性电路覆盖的膜的表面的一部分，其中导电电极可以自身与膜折叠成具有直径的输送构型 适合于将组件的微创传送给患者。
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59.发明授权Surgical instruments and procedures for stabilizing the beating heart during coronary artery bypass graft 失效用于在冠状动脉旁路移植术期间稳定跳动心脏的手术器械和程序公开(公告)号：US08277476B2
公开(公告)日：2012-10-02
申请号：US10684557
申请日：2003-10-14
申请人： Charles S. Taylor , William N. Aldrich , Thomas L. Baughman , Federico J. Benetti , Brian J. Bennett , Michael J. Billig , Thomas J. Fogarty , John J. Frantzen , Richard S. Ginn , Robert C. Glines , Harry L. Green , Dwight P. Morejohn , Brent Regan , Eugene E. Reis , Amr Salahieh , Ivan Sepetka , Benjamin Sherman , Christian Skieller , Valavanur A. Subramanian , Gary B. Weller , William F. Witt
发明人： Charles S. Taylor , William N. Aldrich , Thomas L. Baughman , Federico J. Benetti , Brian J. Bennett , Michael J. Billig , Thomas J. Fogarty , John J. Frantzen , Richard S. Ginn , Robert C. Glines , Harry L. Green , Dwight P. Morejohn , Brent Regan , Eugene E. Reis , Amr Salahieh , Ivan Sepetka , Benjamin Sherman , Christian Skieller , Valavanur A. Subramanian , Gary B. Weller , William F. Witt
IPC分类号： A61M29/00
CPC分类号： A61B17/3421 , A61B17/00234 , A61B17/02 , A61B17/0206 , A61B17/0218 , A61B17/0642 , A61B17/12 , A61B17/3423 , A61B17/8076 , A61B90/00 , A61B2017/00243 , A61B2017/00539 , A61B2017/00703 , A61B2017/00858 , A61B2017/00991 , A61B2017/0243 , A61B2017/0648 , A61B2017/1139 , A61B2017/2825 , A61B2017/2913 , A61B2017/2929 , A61B2017/306 , A61B2017/349
摘要： The invention is methods and devices which a surgeon may use to stabilize the beating heart during a surgical procedure on the heart. Pursuant to the invention, a stabilizing device is introduced through an opening in the chest and brought into contact with the beating heart. By contacting the heart with the device and by exerting a stabilizing force on the device, the motion of the heart caused by the contraction of the heart muscles is effectively eliminated such that the heart is stabilized and the site of the surgery moves only minimally if at all. Typically, in separate steps, the surgeon contacts the heart with the stabilizing means, assesses the degree of movement of the anastomosis site, and exerts a force on the stabilizing means such that the contraction of the beating heart causes orgy minimal excess motion at the surgery site. By fixing the position of the stabilizing means in a configuration where the motion of the beating heart is effectively eliminated, the surgeon is able to stabilize the beating heart for the duration of the procedure. The stabilizing means may be attached to a rigid support or may be attached to a semi-rigid support which is rendered motionless mechanically, chemically, or by human intervention. In certain preferred embodiments, the stabilizing means is affixed to a semi-rigid support which is caused to become rigid, by any of a variety of techniques, such that the position of the stabilizing means becomes fixed by the support, and the heart remains substantially motionless for the duration of the procedure.
摘要翻译： 本发明是外科医生可以在心脏手术过程中稳定跳动心脏的方法和装置。 根据本发明，稳定装置通过胸部的开口引入并与打浆心接触。 通过将心脏与装置接触并且通过在装置上施加稳定力，由心脏肌肉收缩引起的心脏的运动被有效地消除，使得心脏稳定，并且手术部位仅在最小程度上移动，如果在 所有。 通常，在单独的步骤中，外科医生将心脏与稳定装置接触，评估吻合部位的移动程度，并对稳定装置施加力，使得跳动心脏的收缩导致手术时的最小过度运动 现场。 通过将稳定装置的位置固定在跳动心脏的运动被有效地消除的构造中，外科医生能够在手术期间稳定跳动的心脏。 稳定装置可以附接到刚性支撑件，或者可以附接到半刚性支撑件，其通过机械，化学方式或通过人为干预使其不动。 在某些优选实施例中，稳定装置通过各种技术中的任一种被固定到半刚性支撑件上，使其变得刚性，使得稳定装置的位置由支撑件固定，并且心脏基本保持 在程序期间不动。
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60.发明申请公开(公告)号：US20120089224A1
公开(公告)日：2012-04-12
申请号：US13324519
申请日：2011-12-13
申请人： Ulrich R. Haug , Hans F. Valencia , Robert A. Geshlider , Tom Saul , Amr Salahieh , Dwight P. Morejohn
发明人： Ulrich R. Haug , Hans F. Valencia , Robert A. Geshlider , Tom Saul , Amr Salahieh , Dwight P. Morejohn
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/24 , A61F2/2415 , A61F2/2436 , A61F2/2439 , A61F2220/0075 , A61F2230/0054 , A61F2230/0078 , A61F2250/0039
摘要： The present invention provides methods and apparatus for endovascularly replacing a patient's heart valve. The apparatus includes a replacement valve and an anchor having an expandable braid. In some embodiments, the expandable braid is fabricated from a single strand of wire. In some embodiments, the expandable braid comprises at least one turn feature. The anchor and the valve preferably are configured for endovascular delivery and deployment.
摘要翻译： 本发明提供了用于血管内替代患者心脏瓣膜的方法和装置。 该装置包括更换阀和具有可膨胀编织物的锚固件。 在一些实施例中，可膨胀编织物由单根线材制成。 在一些实施例中，可膨胀编织物包括至少一个匝特征。 锚和阀优选地构造成用于血管内递送和展开。
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