-
公开(公告)号：US08362032B2
公开(公告)日：2013-01-29
申请号：US12830743
申请日：2010-07-06
申请人： Aarti Sameer Kawatkar , Tara Whitney , Timothy D. Neubert , Nicole Hilgraf , Andreas P. Termin , Esther Martinborough
发明人： Aarti Sameer Kawatkar , Tara Whitney , Timothy D. Neubert , Nicole Hilgraf , Andreas P. Termin , Esther Martinborough
IPC分类号： C07D417/12 , A61K31/47
CPC分类号： C07D417/14 , C07D403/12 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/12
摘要： Bicyclic derivatives having formula (I) and a composition thereof are useful as ion channel antagonists:
-
公开(公告)号：US08314125B2
公开(公告)日：2012-11-20
申请号：US12761502
申请日：2010-04-16
申请人： Andreas P. Termin , Nicole Hilgraf , Tara Leanne Hampton , Gabriel Martinez-Botella , Esther Martinborough
发明人： Andreas P. Termin , Nicole Hilgraf , Tara Leanne Hampton , Gabriel Martinez-Botella , Esther Martinborough
IPC分类号： A61K31/04
CPC分类号： C07D417/12 , C07D401/12
摘要： The present invention relates to bicyclic compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用作离子通道抑制剂的双环化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
-
公开(公告)号：US08163720B2
公开(公告)日：2012-04-24
申请号：US12844047
申请日：2010-07-27
申请人： Esther Martinborough , Lev T. D. Fanning , Urvi Sheth , Dean Wilson , Andreas P. Termin , Timothy D. Neubert , Nicole Hilgraf , Tara Leanne Hampton , Tara Whitney , Aarti Sameer Kawatkar , Danielle Lehsten , Dean Stamos , Jinglan Zhou , Vijayalaksmi Arumugam , Corey Anderson
发明人： Esther Martinborough , Lev T. D. Fanning , Urvi Sheth , Dean Wilson , Andreas P. Termin , Timothy D. Neubert , Nicole Hilgraf , Tara Leanne Hampton , Tara Whitney , Aarti Sameer Kawatkar , Danielle Lehsten , Dean Stamos , Jinglan Zhou , Vijayalaksmi Arumugam , Corey Anderson
IPC分类号： A01N51/00 , A61N31/655
CPC分类号： C07D417/12 , C07D239/42 , C07D401/12 , C07D405/12 , C07D417/14 , C07D471/10 , C07D491/10
摘要： The present invention relates to phenyl sulfonamides useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including for example the treatment of pain.
摘要翻译： 本发明涉及可用作离子通道抑制剂的苯基磺酰胺。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病（包括例如治疗疼痛）的方法。
-
公开(公告)号：US08129546B2
公开(公告)日：2012-03-06
申请号：US12879237
申请日：2010-09-10
申请人： Esther Martinborough , Andreas P. Termin , Timothy D. Neubert , Nicole Hilgraf , Corey Anderson
发明人： Esther Martinborough , Andreas P. Termin , Timothy D. Neubert , Nicole Hilgraf , Corey Anderson
IPC分类号： C07D209/04 , A61K31/405
CPC分类号： C07D401/08 , C07D207/10 , C07D207/12 , C07D211/54 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/08
摘要： Sulfonamide derivatives act as ion channel antagonists. The compositions are useful for treating or relieving pain-related conditions.
摘要翻译： 磺酰胺衍生物作为离子通道拮抗剂。 该组合物可用于治疗或缓解疼痛相关病症。
-
公开(公告)号：US08097636B2
公开(公告)日：2012-01-17
申请号：US12269109
申请日：2008-11-12
申请人： Dean Stamos , Esther Martinborough , Nicole Zimmermann , Timothy Neubert , Mehdi Michel Djamel Numa , Tara Whitney , Tara Leanne Hampton
发明人： Dean Stamos , Esther Martinborough , Nicole Zimmermann , Timothy Neubert , Mehdi Michel Djamel Numa , Tara Whitney , Tara Leanne Hampton
IPC分类号： A61K31/47 , C07D217/00
CPC分类号： C07D417/14
摘要： The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
-
公开(公告)号：US20110306542A1
公开(公告)日：2011-12-15
申请号：US13157264
申请日：2011-06-09
申请人： Marcus F. Boehm , Esther Martinborough , Manisha Moorjani , Liming Huang , Junko Tamiya , Mark T. Griffith , Thomas Fowler , Andrew Novak , Michael Knaggs , Premji Meghani
发明人： Marcus F. Boehm , Esther Martinborough , Manisha Moorjani , Liming Huang , Junko Tamiya , Mark T. Griffith , Thomas Fowler , Andrew Novak , Michael Knaggs , Premji Meghani
IPC分类号： A61K38/16 , A61K31/495 , A61K31/498 , A61K31/437 , A61K31/47 , A61K31/445 , A61K31/4406 , A61K31/433 , A61K31/428 , A61K31/421 , A61K31/423 , A61K31/41 , A61K31/415 , A61K31/40 , A61K31/381 , A61K31/351 , A61K31/343 , A61K31/341 , A61K31/24 , C07D265/30 , C07D241/44 , C07D471/04 , C07D215/38 , C07D211/62 , C07D213/56 , C07D285/14 , C07D277/82 , C07D263/48 , C07D261/20 , C07D261/18 , C07D257/06 , C07D231/38 , C07D207/44 , C07D333/70 , C07D333/22 , C07D309/14 , C07D307/85 , C07D307/66 , C07C69/76 , A61P3/04 , A61P3/00 , A61P3/10 , A61K31/5375
CPC分类号： A61K38/02 , A61K31/24 , A61K31/34 , A61K31/343 , A61K31/381 , A61K31/42 , A61K31/428 , A61K31/455 , A61K31/498 , A61K31/5375 , A61K45/06 , C07C233/87 , C07C235/52 , C07C235/84 , C07C237/36 , C07C237/42 , C07C255/57 , C07C275/42 , C07C317/44 , C07D207/44 , C07D211/62 , C07D213/56 , C07D213/82 , C07D215/48 , C07D231/14 , C07D233/90 , C07D241/44 , C07D257/06 , C07D261/18 , C07D261/20 , C07D263/48 , C07D265/30 , C07D277/62 , C07D277/82 , C07D285/14 , C07D295/15 , C07D295/155 , C07D307/66 , C07D307/68 , C07D307/85 , C07D309/08 , C07D317/60 , C07D333/38 , C07D333/70 , C07D471/04
摘要： Compounds that bind the glucagon-like peptide 1 receptor (GLP-1) receptor are provided including compounds which are modulators of the GLP-1 receptors and compounds which are capable of inducing a stabilizing effect on the receptor for use in structural analyses of the GLP-1 receptor. Methods of synthesis, methods of therapeutic and/or prophylactic use, and methods of use in stabilizing GLP-1 receptor in vitro for crystallization of the GLP-1 receptor of such compounds are provided.
摘要翻译： 提供了结合胰高血糖素样肽1受体（GLP-1）受体的化合物，包括作为GLP-1受体的调节剂的化合物和能够诱导对受体的稳定作用的化合物，用于GLP的结构分析 -1受体。 提供了合成方法，治疗和/或预防用途的方法，以及用于稳定GLP-1受体体外用于结合这些化合物的GLP-1受体的方法。
-
57.发明申请SELECTIVE SPHINGOSINE 1 PHOSPHATE RECEPTOR MODULATORS AND METHODS OF CHIRAL SYNTHESIS 有权选择性SPHINGOSINE 1磷酸酯受体调节剂和方法合成公开(公告)号：US20110172202A1
公开(公告)日：2011-07-14
申请号：US12946819
申请日：2010-11-15
申请人： Esther Martinborough , Marcus F. Boehm , Adam Richard Yeager , Junko Tamiya , Liming Huang , Enugurthi Brahmachary , Manisha Moorjani , Gregg Alan Timony , Jennifer L. Brooks , Robert Peach , Fiona Lorraine Scott , Michael Allen Hanson
发明人： Esther Martinborough , Marcus F. Boehm , Adam Richard Yeager , Junko Tamiya , Liming Huang , Enugurthi Brahmachary , Manisha Moorjani , Gregg Alan Timony , Jennifer L. Brooks , Robert Peach , Fiona Lorraine Scott , Michael Allen Hanson
IPC分类号： A61K31/4245 , C07D271/06 , A61P25/00 , A61P37/06 , A61P11/00 , A61P1/00 , A61P31/16 , C07C255/53 , C07C257/18 , C07D413/10 , A61K31/454 , C07C255/52 , C07C255/58 , A61K31/5377 , C07D413/12
CPC分类号： C07D271/06 , A61K31/4245 , A61K31/427 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K45/06 , C07C245/14 , C07C255/58 , C07C311/13 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/12
摘要： Compounds that selectively modulate the sphingosine 1 phosphate receptor are provided including compounds which modulate subtype 1 of the S1P receptor. Methods of chiral synthesis of such compounds is provided. Uses, methods of treatment or prevention and methods of preparing inventive compositions including inventive compounds are provided in connection with the treatment or prevention of diseases, malconditions, and disorders for which modulation of the sphingosine 1 phosphate receptor is medically indicated.
摘要翻译： 提供了选择性调节鞘氨醇1磷酸受体的化合物，包括调节S1P受体亚型1的化合物。 提供了这种化合物的手性合成方法。 本发明化合物的用途，治疗或预防方法以及制备本发明组合物的方法与治疗或预防医学上指示鞘氨醇1磷酸受体调节的疾病，病症和病症有关。
-
公开(公告)号：US07888384B2
公开(公告)日：2011-02-15
申请号：US12424883
申请日：2009-04-16
IPC分类号： A61K31/496 , A61K31/55 , C07D403/14 , C07D401/12 , C07D401/14 , C07D209/42
CPC分类号： A61K31/405 , A61K31/343 , A61K31/381 , A61K31/404 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/55
摘要： Heterocyclic derivatives act as Ca channel antagonists. The compositions are useful for treating or relieving Ca channel mediated conditions.
摘要翻译： 杂环衍生物作为Ca通道拮抗剂。 该组合物可用于治疗或缓解Ca通道介导的病症。
-
公开(公告)号：US07855220B2
公开(公告)日：2010-12-21
申请号：US11517754
申请日：2006-09-08
IPC分类号： A61K31/426 , A61K31/4245 , A61K31/425 , C07D277/52 , C07D271/07 , C07D271/113 , C07D275/03
CPC分类号： C07D417/12 , C07D277/52
摘要： Bicyclic derivatives useful as ion channel antagonists are disclosed herein. The compositions thereof are useful for treating or relieving pain-related conditions.
摘要翻译： 本文公开了用作离子通道拮抗剂的双环衍生物。 其组合物可用于治疗或缓解疼痛相关病症。
-
公开(公告)号：US07842819B2
公开(公告)日：2010-11-30
申请号：US11584961
申请日：2006-10-23
申请人： Esther Martinborough , Andreas P. Termin , Timothy D. Neubert , Nicole Zimmermann , Corey Don Gutierrez
发明人： Esther Martinborough , Andreas P. Termin , Timothy D. Neubert , Nicole Zimmermann , Corey Don Gutierrez
IPC分类号： C07D209/02 , A61K31/40
CPC分类号： C07D401/08 , C07D207/10 , C07D207/12 , C07D211/54 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/08
摘要： Sulfonamide derivatives act as ion channel antagonists. The compositions are useful for treating or relieving pain-related conditions.
摘要翻译： 磺酰胺衍生物作为离子通道拮抗剂。 该组合物可用于治疗或缓解疼痛相关病症。
-
-
-
-
-
-
-
-
-
搜索结果
86 条记录 (耗时 0.081 秒)
