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317 条记录 (耗时 0.136 秒)

    Human ependymin
    53.
    发明授权
    Human ependymin 失效
    人类室灵

    公开(公告)号：US06489138B1

    公开(公告)日：2002-12-03

    申请号：US09229583

    申请日：1999-01-13

    申请人： Reinhard Ebner ,  Steven M. Ruben

    发明人： Reinhard Ebner ,  Steven M. Ruben

    IPC分类号： C12N1512

    CPC分类号： G01N33/6893 ,  A61K38/00 ,  C07K14/475 ,  G01N2500/00 ,  G01N2800/28 ,  Y10S530/857

    摘要： The present invention relates to a novel human Ependymin protein which is a member of the ependymin family. In particular, isolated nucleic acid molecules are provided encoding the human Ependymin protein. Ependymin polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of Ependymin activity. Also provided are diagnostic methods for detecting nervous system-related disorders and therapeutic methods for treating nervous system-related disorders.

    摘要翻译： 本发明涉及一种新型人类ependymin蛋白，其是室温室家族的成员。 特别地，提供编码人类ependymin蛋白的分离的核酸分子。 也可以提供ependymin多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定Ependymin活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测神经系统相关疾病的诊断方法和用于治疗神经系统相关疾病的治疗方法。

    Interleukin-20
    54.
    发明授权
    Interleukin-20 失效
    白细胞介素20

    公开(公告)号：US06486301B1

    公开(公告)日：2002-11-26

    申请号：US09231788

    申请日：1999-01-15

    申请人： Reinhard Ebner ,  Marianne Murphy ,  Steven M. Ruben ,  Jing-Shan Hu ,  D. Roxanne Duan ,  Kimberly A. Florence ,  Craig A. Rosen

    发明人： Reinhard Ebner ,  Marianne Murphy ,  Steven M. Ruben ,  Jing-Shan Hu ,  D. Roxanne Duan ,  Kimberly A. Florence ,  Craig A. Rosen

    IPC分类号： C07K14475

    CPC分类号： C07K14/47 ,  A61K38/00 ,  C07K14/54 ,  C07K2319/00 ,  C12N2799/026

    摘要： The present invention relates to a novel IL-20 protein which is a member of the cytokine polypeptide family. In particular, isolated nucleic acid molecules are provided encoding the human IL-20 protein. IL-20 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of IL-20 activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.

    摘要翻译： 本发明涉及作为细胞因子多肽家族成员的新型IL-20蛋白。 特别地，提供编码人IL-20蛋白的分离的核酸分子。 还提供了IL-20多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定IL-20活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。

    Human G-Protein Chemokine Receptor (CCR5) HDGNR10
    57.
    发明申请
    Human G-Protein Chemokine Receptor (CCR5) HDGNR10 审中-公开
    人类G蛋白趋化因子受体（CCR5）HDGNR10

    公开(公告)号：US20110081360A1

    公开(公告)日：2011-04-07

    申请号：US12943722

    申请日：2010-11-10

    申请人： Viktor Roschke ,  Craig A. Rosen ,  Steven M. Ruben

    发明人： Viktor Roschke ,  Craig A. Rosen ,  Steven M. Ruben

    IPC分类号： A61K39/395 ,  C07H21/04 ,  C07K16/00 ,  A61P37/04 ,  A61P9/00 ,  A61P17/06 ,  A61P17/00 ,  A61P11/00

    CPC分类号： C07K14/7158 ,  A01K2217/05 ,  A01K2217/075 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/505 ,  C07K16/24 ,  C07K16/2866 ,  C07K2319/00 ,  C12N2799/026

    摘要： The present invention relates to a novel human protein called Human G-protein Chemokine Receptor (CCR5) HDGNR10, and isolated polynucleotides encoding this protein. The invention is also directed to human antibodies that bind Human G-protein Chemokine Receptor (CCR5) HDGNR10 and to polynucleotides encoding those antibodies. Also provided are vectors, host cells, antibodies, and recombinant methods for producing Human G-protein Chemokine Receptor (CCR5) HDGNR10 and human anti-Human G-protein Chemokine Receptor (CCR5) HDGNR10 antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to this novel human protein and these novel human antibodies.

    摘要翻译： 本发明涉及一种称为人G蛋白趋化因子受体（CCR5）HDGNR10的新型人类蛋白质，以及编码该蛋白质的分离的多核苷酸。 本发明还涉及结合人G蛋白趋化因子受体（CCR5）HDGNR10的人抗体和编码那些抗体的多核苷酸。 还提供了用于产生人G蛋白趋化因子受体（CCR5）HDGNR10和人抗人G蛋白趋化因子受体（CCR5）HDGNR10抗体的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与该新型人蛋白质和这些新型人抗体相关的疾病，病症和/或病症的诊断和治疗方法。

    HEMCM42 nucleic acids
    58.
    发明授权
    HEMCM42 nucleic acids 有权
    HEMCM42核酸

    公开(公告)号：US07906634B2

    公开(公告)日：2011-03-15

    申请号：US12324825

    申请日：2008-11-26

    申请人： Steven M. Ruben ,  Craig A. Rosen ,  Gregory A. Endress

    发明人： Steven M. Ruben ,  Craig A. Rosen ,  Gregory A. Endress

    IPC分类号： C07H21/04

    CPC分类号： C07K14/47 ,  A61K38/00 ,  C07K16/00

    摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.

    摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。

    Antibodies that immunospecifically bind to B lymphocyte stimulator
    59.
    发明授权
    Antibodies that immunospecifically bind to B lymphocyte stimulator 有权
    免疫特异性结合B淋巴细胞刺激物的抗体

    公开(公告)号：US07879328B2

    公开(公告)日：2011-02-01

    申请号：US11054515

    申请日：2005-02-10

    申请人： Steven M. Ruben ,  Gil H. Choi ,  Tristan Vaughan ,  David Hilbert

    发明人： Steven M. Ruben ,  Gil H. Choi ,  Tristan Vaughan ,  David Hilbert

    IPC分类号： C07K16/00 ,  C12P21/08 ,  A61K39/395

    CPC分类号： C07K16/2875 ,  A61K35/12 ,  A61K47/6849 ,  A61K49/0004 ,  A61K2039/505 ,  C07K14/52 ,  C07K14/70575 ,  C07K2317/21 ,  C07K2317/622 ,  G01N33/5008 ,  G01N33/5011 ,  G01N33/5052 ,  G01N33/5091 ,  G01N33/564 ,  G01N33/574 ,  G01N33/68

    摘要： The present invention relates to antibodies and related molecules that immunospecifically bind to B Lymphocyte Stimulator. The present invention also relates to methods and compositions for detecting or diagnosing a disease or disorder associated with aberrant B Lymphocyte Stimulator expression or inappropriate function of B Lymphocyte Stimulator comprising antibodies or fragments or variants thereof or related molecules that immunospecifically bind to B Lymphocyte Stimulator. The present invention further relates to methods and compositions for preventing, treating or ameliorating a disease or disorder associated with aberrant B Lymphocyte Stimulator expression or inappropriate B Lymphocyte Stimulator function comprising administering to an animal an effective amount of one or more antibodies or fragments or variants thereof or related molecules that immunospecifically bind to B Lymphocyte Stimulator.

    摘要翻译： 本发明涉及免疫特异性结合B淋巴细胞刺激物的抗体和相关分子。 本发明还涉及用于检测或诊断与异常B淋巴细胞刺激物表达或B淋巴细胞刺激因子不适当功能相关的疾病或病症的方法和组合物，其包含免疫特异性结合B淋巴细胞刺激物的抗体或其片段或变体或相关分子。 本发明还涉及用于预防，治疗或改善与异常B淋巴细胞刺激物表达或不适当B淋巴细胞刺激因子功能相关的疾病或病症的方法和组合物，包括向动物施用有效量的一种或多种抗体或其片段或变体 或免疫特异性结合B淋巴细胞刺激物的相关分子。

    Antibodies to HWHGU54 polypeptides
    60.
    发明授权
    Antibodies to HWHGU54 polypeptides 有权
    HWHGU54多肽的抗体

    公开(公告)号：US07838636B1

    公开(公告)日：2010-11-23

    申请号：US11760578

    申请日：2007-06-08

    申请人： Steven M. Ruben ,  Craig A. Rosen ,  Ying-Fei Wei

    发明人： Steven M. Ruben ,  Craig A. Rosen ,  Ying-Fei Wei

    IPC分类号： C07K16/40 ,  C12P21/08 ,  C12P21/06 ,  C12N15/09

    CPC分类号： C07K14/47

    摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

    摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。