公开(公告)号：US20110182782A1

公开(公告)日：2011-07-28

申请号：US12985119

申请日：2011-01-05

Applicant: JIMMY DZUONG

Inventor： JIMMY DZUONG

IPC: B01L3/00

CPC classification number: B01L3/0217 ,  B01L3/0275 ,  B01L2200/025 ,  B01L2200/14 ,  B01L2300/0627 ,  B01L2300/0832 ,  B01L2300/0858 ,  B01L2300/14 ,  B01L2400/0478

Abstract: A positive displacement pump (1) is equipped with a pump cylinder (2), a pump piston (7), a cylinder space (9), a pressure sensor (10), and a pressure channel (12). A main portion (13) of the pressure channel (12) extends parallel to a longitudinal axis (3) of the pump cylinder (2), for providing fluidic connection between the cylinder space (9) and the pressure sensor (10). In the improved alternative positive displacement pump (1), the cylinder wall (4) comprises a piston sleeve (14) that is located on the inner side of the cylinder wall (4) and that extends over essentially the entire length of the pump cylinder (2) to the cylinder bottom (5). The improved alternative positive displacement pump (1) is further characterized in that, the main portion (13) of the pressure channel (12) is located in the cylinder wall (4) comprising the piston sleeve (14), which is thus preventing the pump piston (7) from touching or compromising the pressure sensor (10) or an inner surface (30) of the cylinder wall (4) when moving past the position of the pressure sensor (10). Also disclosed are a liquid handling robot that comprises a single or multiple arrangement of the positive displacement pump (1) and liquid handling workstation that comprises such a liquid handling robot.

Abstract translation: 正排量泵（1）配备有泵缸（2），泵活塞（7），气缸空间（9），压力传感器（10）和压力通道（12）。 压力通道（12）的主要部分（13）平行于泵缸（2）的纵向轴线（3）延伸，用于在气缸空间（9）和压力传感器（10）之间提供流体连接。 在改进的替代性容积式泵（1）中，气缸壁（4）包括位于气缸壁（4）的内侧上的活塞套筒（14），其基本上在泵缸体的整个长度上延伸 （2）连接到气缸底部（5）。 改进的替代正排量泵（1）的特征还在于，压力通道（12）的主要部分（13）位于包括活塞套筒（14）的气缸壁（4）中，从而防止 泵活塞（7）在移动经过压力传感器（10）的位置时不接触或损害压力传感器（10）或气缸壁（4）的内表面（30）。 还公开了一种液体处理机器人，其包括容积式泵（1）的单个或多个排列以及包括这种液体处理机器人的液体处理工作站。

公开(公告)号：US20110114854A1

公开(公告)日：2011-05-19

申请号：US13012476

申请日：2011-01-24

Applicant: Frank FISCHER ,  Harald GEBETSROITHER ,  Andreas GFRORER

Inventor： Frank FISCHER ,  Harald GEBETSROITHER ,  Andreas GFRORER

IPC: G01N21/64 ,  G01J1/58

CPC classification number: G01N35/00029 ,  G01N15/1475 ,  G01N21/6458 ,  G02B21/0076 ,  G02B21/26 ,  G02B21/34 ,  Y10T436/112499

Abstract: A slide transfer mechanism for a laser scanner device (1) is proposed. The laser scanner device (1) is configured for imaging and/or measuring fluorescent samples which are located in a sample plane (49) on sample slides (8). The laser scanner device (1) comprises a motor-drivable sample table (2) for holding a sample slide (8); a first optical system (53) for providing at least one laser beam (54); a scanner apparatus (72) for deflecting the laser beam (54) toward the sample, wherein the scanner head (50) is configured to be moveable back and forth in a direction of a scanning axis or X axis of a coordinate system. The laser scanner device (1) also comprises at least one detector (61) for detecting an emission beam bundle (59) coming from the sample and a second optical system (58) for forwarding the emission beam bundle (59) to the at least one detector (61). The slide transfer mechanism of the laser scanner device (1) is characterized in that it comprises a motorized transport device (3) that is configured for transferring a sample slide (8) from a storage unit (4) of the laser scanner device (1) to the sample table (2) and back, and in that the sample table (2), for the purpose of transferring sample slides (8), is configured so as to be able to move to immediately before the storage unit (4) for the sample slides (8) or before a loading opening (100) of an additional housing (29).

Abstract translation: 提出了一种用于激光扫描仪装置（1）的滑块传送机构。 激光扫描仪装置（1）被配置用于对位于样品载玻片（8）上的样品平面（49）中的荧光样品进行成像和/或测量。 激光扫描仪装置（1）包括用于保持样品载玻片（8）的电动机驱动样品台（2）。 用于提供至少一个激光束（54）的第一光学系统（53）; 用于将激光束（54）朝向样品偏转的扫描仪装置（72），其中扫描仪头部（50）构造成可以在坐标系的扫描轴线或X轴的方向上前后移动。 激光扫描仪装置（1）还包括用于检测来自样品的发射束束（59）的至少一个检测器（61）和用于将发射束束（59）转发至少至少 一个检测器（61）。 激光扫描器装置（1）的滑块传送机构的特征在于，其包括电动传送装置（3），其被配置用于从激光扫描装置（1）的存储单元（4）传送样品载玻片（8） ）到样品台（2）并返回，并且为了转移样品载玻片（8）的目的，样品台（2）被配置为能够在存储单元（4）之前立即移动， 用于样品载片（8）或在附加壳体（29）的装载开口（100）之前。

公开(公告)号：US07746229B2

公开(公告)日：2010-06-29

申请号：US11547597

申请日：2005-03-30

Applicant: Matthias Gräter ,  Nikolaus Ingenhoven

Inventor： Matthias Gräter ,  Nikolaus Ingenhoven

IPC: G08B13/14

CPC classification number: G01N35/04 ,  G01N35/00732 ,  G01N2035/00772 ,  G01N2035/00782 ,  G01N2035/0491

Abstract: The invention concerns a system (1) to locate or track objects (2) that can be positioned on the work table (3) of a laboratory apparatus (4). To do this, the system (1) comprises at least: a) a central transmitter (5) with the capability to transmit and receive radio frequency (RF) signals, convert RF signals received and transfer the converted signals to a computer (7); b) a local unit (6) mounted on a surface (8) of the work table (3) with the capability to receive and transmit RF signals; c) radio frequency identification (RFID) tags (10) to be affixed to the local unit (6) and to articles of laboratory ware (15) that are to be identified and/or located or tracked; d) a work table (3) of a laboratory apparatus (4) and a computer (7) that can be connected to the laboratory apparatus (4) and is linked to the central transmitter (5) via an interface, the computer (7) having the capability to communicate with the central transmitter (5), to process signals received from the latter and to address selected RFID tags (10) through the central transmitter (5). The system (1) according to the invention can be integrated in a higher-ranking logistical system (31) for the processing and analysis of samples of any desired kind.

Abstract translation: 本发明涉及一种定位或跟踪可位于实验室设备（4）的工作台（3）上的物体（2）的系统（1）。 为此，系统（1）至少包括：a）具有发送和接收射频（RF）信号的能力的中央发射机（5），转换所接收的RF信号并将转换的信号传送到计算机（7） ; b）安装在工作台（3）的表面（8）上的本地单元（6），具有接收和发送RF信号的能力; c）要被标识和/或定位或跟踪的要附加到本地单元（6）和实验室仪器（15）的物品的射频识别（RFID）标签（10）; d）实验室设备（4）的工作台（3）和可以连接到实验室设备（4）并通过接口连接到中央发射机（5）的计算机（7），计算机（7） ）具有与中央发射机（5）进行通信的能力，以处理从后者接收到的信号并通过中央发射机（5）寻址选定的RFID标签（10）。 根据本发明的系统（1）可以集成在更高级的物流系统（31）中，用于处理和分析任何所需类型的样品。

公开(公告)号：US07577064B2

公开(公告)日：2009-08-18

申请号：US11456610

申请日：2006-07-11

Applicant: Robert Marsche ,  Wolfgang Fuchs ,  Harald Gebetsroither

Inventor： Robert Marsche ,  Wolfgang Fuchs ,  Harald Gebetsroither

IPC: G11B7/00 ,  G01J1/10

CPC classification number: G01J3/12 ,  G01J3/02 ,  G01J3/027 ,  G01J3/0275 ,  G01J2003/1217 ,  G01N2021/317

Abstract: Microplate reader (21) with a computer for controlling the components of said microplate reader (21), comprising a light source (15) for emitting light for irradiating samples (22) or transmitting light through samples (22), and a filter slide (1) situated in the excitation or detection beam path. The microplate reader (21) in accordance with the invention is characterized in that said filter slide (1) comprises an electronic memory (4) for recording and/or retrieving filter-specific data, with said filter-specific data comprising the number and intensity of the light flashes impinging upon a certain filter (2) of said filter slide (1) and/or the intensity and duration of all exposures performed, and that said filter slide (1) comprises a contact point (5,7) jointly with the microplate reader (21) for transmitting such filter-specific data from the computer to the electronic memory (4) of the filter slide (1) and for retrieving such filter-specific data with the computer. According to the method in accordance with the invention for acquiring filter-specific data in a filter slide (1) of such a microplate reader (21), filter-specific data which comprise the number and intensity of the light flashes impinging upon a specific filter (2) of said filter slide (1) and/or the intensity and duration of all exposures performed are transmitted by the computer via a contact point common to said filter slide (1) and the microplate reader (21) to an electronic memory (4) of said filter slide (1) and/or are retrieved with the computer from said electronic memory (4).

Abstract translation: 一种用于控制所述微板读数器（21）的组件的计算机的微孔板读数器（21），包括用于发射用于照射样品（22）的光或者通过样品（22）透射光的光源（15） 1）位于激励或检测光束路径中。 根据本发明的酶标仪（21）的特征在于，所述过滤器滑块（1）包括用于记录和/或检索过滤器特定数据的电子存储器（4），所述过滤器特定数据包括数量和强度 撞击在所述过滤器滑块（1）的某个过滤器（2）上的闪光和/或所执行的所有曝光的强度和持续时间，并且所述过滤器滑块（1）包括与 所述微板读数器（21）用于将所述过滤器特定数据从所述计算机发送到所述过滤器滑板（1）的所述电子存储器（4）并且用所述计算机检索所述过滤器特定数据。 根据本发明的用于在这种酶标板读数器（21）的滤光片（1）中获得滤光器特定数据的方法，滤光器专用数据包括闪光的数量和强度，其冲击特定滤光片 （1）和/或所执行的所有曝光的强度和持续时间由计算机通过所述过滤板（1）和微板读数器（21）共同的接触点传送到电子存储器（ 4）和/或从所述电子存储器（4）用计算机检索。

公开(公告)号：US07479391B2

公开(公告)日：2009-01-20

申请号：US11009247

申请日：2004-12-10

Applicant: Torleif Ove Bjornson ,  Robert Liebhard ,  Adi Zuppiger ,  Dirk Heerklotz

Inventor： Torleif Ove Bjornson ,  Robert Liebhard ,  Adi Zuppiger ,  Dirk Heerklotz

IPC: B01L3/02

CPC classification number: G01N35/1009 ,  G01F23/185 ,  Y10T436/119163 ,  Y10T436/2575

Abstract: A pipetting apparatus (1) comprises a fluidic space (7), to which a pressure transducer (11) with a pressure sensor (12) is attached with a gas filled space (15). The fluidic space (7) is defined by a pipette tip (2), a first tubing (5) that connects the pipette tip (2) to a pump (4), and an active part (6) of the pump (4). The pipetting apparatus (1) according to the present invention is characterized in that the pipetting apparatus (1) further comprises an impulse generating means (16, 18, 19) that is in operative contact with a column (10) of system liquid (8) inside the fluidic space (7). The impulse generating means (16, 18, 19) is designed to induce a vertical movement in this system liquid column (10), which results in a pressure variation in the gas filled space (15) that is pneumatically connected with the fluidic space (7). This pressure variation—as recorded with the pressure transducer (11) and as processed by a first data processing unit (13) during utilization of this pipetting apparatus—is taken as an indicator for the detection of penetration or of quitting of a surface (17) of a liquid, with an orifice (3) of the pipette tip (2), of which liquid an amount is to be aspirated and dispensed. This pressure variation is also taken as an indicator for the detection of the presence or the absence of gas bubbles in the system liquid (8) contained in the fluidic space (7) of this pipetting apparatus.

Abstract translation: 移液装置（1）包括流体空间（7），具有压力传感器（12）的压力传感器（11）与气体填充空间（15）连接在该流体空间上。 流体空间（7）由移液管吸头（2），将移液管吸头（2）连接到泵（4）的第一管（5）和泵（4）的有源部分（6） 。 根据本发明的移液装置（1）的特征在于，移液装置（1）还包括与系统液体（8）的柱（10）有效接触的脉冲发生装置（16,18,19） ）在流体空间（7）内。 脉冲发生装置（16,18,19）被设计成在该系统液柱（10）中引起垂直运动，这导致与流体空间气动连接的气体填充空间（15）中的压力变化（ 7）。 该压力变化（如压力传感器11记录的）并且在利用该移液装置期间由第一数据处理单元（13）处理）被作为用于检测表面的穿透或退出的指示器（17 ），其具有移液器吸头（2）的孔口（3），其中液体的量将被吸入和分配。 该压力变化也被用作检测包含在该移液装置的流体空间（7）中的系统液体（8）中是否存在气泡的指示器。

公开(公告)号：US07158226B2

公开(公告)日：2007-01-02

申请号：US10470154

申请日：2002-01-10

Applicant: Andreas Gfrörer ,  Josef Atzler

Inventor： Andreas Gfrörer ,  Josef Atzler

IPC: G01J3/30

CPC classification number: B01L3/50855 ,  B01L9/06 ,  G01N21/64 ,  G02B21/16

Abstract: An optical system and method of exciting and measuring fluorescence on or in samples treated using fluorescent pigments using such an optical system having at least one first laser (1); a mirror (4); a deflection element (7); an optic (8); and a unit (10), which includes mirror (4) and optic (8) mounted fixed in relation to one another. The unit (10) is positioned so it is linearly movable back and forth along the optical axis (5) and is mechanically connected to an oscillating linear drive (11). The optic (8) additionally acts as a collimator and the mirror (4) additionally acts to deflect the collimated light (12) parallel to the optical axis (5).

Abstract translation: 使用具有至少一个第一激光器（1）的光学系统激发和测量使用荧光颜料处理的样品中的荧光的光学系统和方法; 镜子（4）; 偏转元件（7）; 光学（8）; 以及包括相对于彼此固定的镜子（4）和光学装置（8）的单元（10）。 单元（10）被定位成使其能够沿光轴（5）前后移动并机械连接到振荡线性驱动器（11）。 光学元件（8）另外用作准直器，反射镜（4）还用于使准直光（12）平行于光轴（5）偏转。

公开(公告)号：US20040203136A1

公开(公告)日：2004-10-14

申请号：US10746821

申请日：2003-12-24

Applicant: Tecan Trading AG

Inventor： Gregory Kellogg ,  Timothy Johnson ,  Eric Schilling

IPC: C12M001/34

CPC classification number: G01N21/07 ,  B01F5/0646 ,  B01F5/0647 ,  B01F13/0059 ,  B01F15/0201 ,  B01F15/0233 ,  B01F2215/0431 ,  B01L3/5025 ,  B01L3/5027 ,  B01L3/50273 ,  B01L2200/0605 ,  B01L2200/0621 ,  B01L2200/10 ,  B01L2300/0806 ,  B01L2400/0406 ,  B01L2400/0409 ,  Y10T436/111666 ,  Y10T436/25625 ,  Y10T436/2575

Abstract: This invention relates to methods and apparatus for performing microanalytic and microsynthetic analyses and procedures. The invention provides a microsystem platform and a micromanipulation device for manipulating the platform that utilizes the centripetal force resulting from rotation of the platform to motivate fluid movement through microchannels. These assays may be performed for a variety of purposes, including but not limited to screening of drug candidate compounds, life sciences research, and clinical and molecular diagnostics. Methods specific for the apparatus of the invention for performing any of a wide variety of microanalytical or microsynthetic processes are provided.

Abstract translation: 本发明涉及用于进行微量分析和微合成分析和方法的方法和装置。 本发明提供一种用于操纵平台的微系统平台和显微操纵装置，所述平台利用由平台旋转产生的向心力，以激励通过微通道的流体运动。 这些测定可以用于多种目的，包括但不限于候选化合物的筛选，生命科学研究以及临床和分子诊断。 提供了用于执行各种微分析或微合成方法中的任何一种的本发明装置的特异性方法。

公开(公告)号：US12290804B2

公开(公告)日：2025-05-06

申请号：US17294853

申请日：2018-12-20

Applicant: TECAN TRADING AG

Inventor： Patrick Kinney ,  Sujata Iyer ,  Philipp Ott ,  Adrian Sager

IPC: B01L3/02 ,  C12Q1/6806 ,  G01N1/28 ,  G01N1/30 ,  G01N35/10 ,  G01N1/31

Abstract: A method of treating an isolated area of a sample with a liquid is disclosed. The method has the steps of generating an isolated area of a sample by a first fluid reservoir where the first fluid reservoir enclosing a distal end of a second fluid reservoir and the isolated area of the sample being sealed towards the remaining area of the sample, bringing the isolated area of the sample into fluid connection with the second fluid reservoir, dispensing a fluid from the second fluid reservoir into the first fluid reservoir thereby generating a fluid flow on the sample at the isolated area in a first direction, and aspirating the fluid from the first fluid reservoir into the second fluid reservoir thereby generating a fluid flow on the sample at the isolated area in a second direction.

公开(公告)号：US20250093376A1

公开(公告)日：2025-03-20

申请号：US18888828

申请日：2024-09-18

Applicant: Tecan Trading AG

Inventor： Luca Frei ,  Fred Schinzel ,  Dominic Erb ,  Philipp Ott

IPC: G01N35/10 ,  G01N35/04

Abstract: A guiding frame for a laboratory automation device comprises: a bottom side for placing the guiding frame on a component of the laboratory automation device; a top side with a position detection area; and an opening for accessing a port of the component, which opening is arranged besides the position detection area. The position detection area has two recesses, each recess having two straight edges, which from a view direction onto the top side are arranged inclined with respect to each other. The bottom side comprises alignment means for aligning the guiding frame with respect to the component, the alignment means comprising a base surface for contacting a top surface of the component and/or guiding surfaces for contacting walls of the component.

公开(公告)号：USD1038431S1

公开(公告)日：2024-08-06

申请号：US29861332

申请日：2022-11-29

Applicant: Tecan Trading AG

Designer： Adrian Sager

Abstract: FIG. 1 is a side perspective view of a pipetting tip according to a first embodiment of my new design;
FIG. 2 is a top and side perspective view thereof;
FIG. 3 is a bottom plan view thereof;
FIG. 4 is a top plan view thereof;
FIG. 5 is front elevation view thereof;
FIG. 6 is a rear elevation view thereof;
FIG. 7 is a left side elevation view thereof;
FIG. 8 is a right side elevation view thereof;
FIG. 9 is a side perspective view of a pipetting tip according to a second embodiment my new design;
FIG. 10 is a top and side perspective view thereof;
FIG. 11 is a bottom plan view thereof;
FIG. 12 is a top plan view thereof;
FIG. 13 is front elevation view thereof;
FIG. 14 is a rear elevation view thereof;
FIG. 15 is a left side elevation view thereof; and,
FIG. 16 is a right side elevation view thereof.