公开(公告)号：US20090191233A1

公开(公告)日：2009-07-30

申请号：US12201894

申请日：2008-08-29

申请人： Dominique Bonnet ,  Carlton B. Brown ,  Bertrand Georges ,  Philip J. Sizer

发明人： Dominique Bonnet ,  Carlton B. Brown ,  Bertrand Georges ,  Philip J. Sizer

IPC分类号： A61K39/12 ,  C07K14/00 ,  A61K39/00

CPC分类号： A61K47/4833 ,  A61K39/12 ,  A61K39/145 ,  A61K39/21 ,  A61K39/385 ,  A61K47/54 ,  A61K47/58 ,  A61K47/646 ,  A61K2039/54 ,  A61K2039/55511 ,  A61K2039/60 ,  A61K2039/6018 ,  A61K2039/6031 ,  C07K14/005 ,  C12N2740/16122 ,  C12N2740/16134 ,  C12N2760/16034 ,  C12N2760/16122 ,  C12N2760/16222 ,  C12N2760/16322

摘要： The present invention relates to fluorocarbon vectors for the delivery of influenza antigens to immunoresponsive target cells. It further relates to fluorocarbon vector-influenza antigen constructs and the use of such vectors associated with antigens as vaccines and immunotherapeutics in animals, including humans.

摘要翻译： 本发明涉及用于将流感抗原递送至免疫反应性靶细胞的碳氟载体。 它进一步涉及氟碳载体 - 流感抗原构建体，以及在动物（包括人）中使用与抗原相关的载体作为疫苗和免疫治疗剂。

公开(公告)号：US07534441B2

公开(公告)日：2009-05-19

申请号：US11027683

申请日：2005-01-03

申请人： Michael Kerin McNamara

发明人： Michael Kerin McNamara

IPC分类号： A61K39/385 ,  A61K38/09 ,  A61K31/721 ,  C07K14/59 ,  C07K7/06

CPC分类号： A61K47/4833 ,  A61K38/09 ,  A61K39/0006 ,  A61K47/646 ,  A61K2039/55583 ,  A61K2039/6037

摘要： The present invention relates generally to an immunogenic LHRH composition and more particularly to an immunogenic LHRH composition comprising a LHRH C-terminal fragment of at least five amino acids. The present invention is useful, inter alia, as a prophylactic and/or therapeutic agent for the modification of fertility and behaviour patterns of animals, the achievement of livestock production gains such as increasing growth, decreasing feed conversion ratios or the control of unwanted organoleptic characteristics or the treatment of disorders of the reproductive organs.

摘要翻译： 本发明一般涉及免疫原性LHRH组合物，更具体地涉及包含至少五个氨基酸的LHRH C-末端片段的免疫原性LHRH组合物。 本发明尤其可用作改变动物的生育力和行为模式的预防和/或治疗剂，实现家畜生产增益如增加生长，降低饲料转化率或控制不想要的感官特征 或治疗生殖器官疾病。

公开(公告)号：US20080026012A1

公开(公告)日：2008-01-31

申请号：US11878460

申请日：2007-07-24

申请人： Eckhard Podack ,  Julie Spielman ,  Koichi Yamazaki

发明人： Eckhard Podack ,  Julie Spielman ,  Koichi Yamazaki

IPC分类号： A61K39/00 ,  A61K35/12 ,  A61P35/00 ,  A61P37/04

CPC分类号： A61K47/4833 ,  A61K38/00 ,  A61K39/385 ,  A61K47/646 ,  A61K47/68 ,  A61K2039/6043 ,  A61K2039/622 ,  C07K14/47 ,  C07K2319/00 ,  C07K2319/30 ,  Y02A50/403 ,  Y02A50/41 ,  Y02A50/466

摘要： The present invention relates to methods for purifying immunogenic, prophylactically and therapeutically effective complexes of modified heat shock proteins noncovalently associated with antigenic peptides of cancer or infected cells. The claimed methods comprise the constructing of a nucleotide sequence encoding a secretable modified heat shock protein, expressing the sequence in an appropriate host cell, recovering the immunogenic complexes from the cell culture and the cells, and purifying the immunogenic complexes by affinity chromatography. Large amounts of such immunogenic complexes can be obtained by large-scale culturing of host cells containing the genetic sequence. The complexes can be used as a vaccine to elicit specific immune responses against cancer or infected cells, and to treat or prevent cancer or infectious diseases.

摘要翻译： 本发明涉及纯化与癌症或感染细胞的抗原肽非共价结合的修饰的热休克蛋白的免疫原性，预防和治疗有效复合物的方法。 要求保护的方法包括构建编码可分泌修饰的热休克蛋白的核苷酸序列，在合适的宿主细胞中表达该序列，从细胞培养物和细胞中回收免疫原性复合物，并通过亲和层析纯化免疫原性复合物。 通过大规模培养含有遗传序列的宿主细胞可以获得大量的这样的免疫原性复合物。 该复合物可用作疫苗以引发针对癌症或感染细胞的特异性免疫应答，以及治疗或预防癌症或感染性疾病。

公开(公告)号：US20050095257A1

公开(公告)日：2005-05-05

申请号：US10380926

申请日：2001-09-17

申请人： Larry Kwak ,  Arya Biragyn

发明人： Larry Kwak ,  Arya Biragyn

IPC分类号： A61K38/00 ,  A61P31/12 ,  A61P35/00 ,  C07K14/47 ,  C12N1/21 ,  A61K39/00 ,  C07H21/04 ,  C07K14/195 ,  C12N15/74

CPC分类号： A61K47/4833 ,  A61K31/7088 ,  A61K38/00 ,  A61K38/19 ,  A61K39/0011 ,  A61K39/39558 ,  C07K14/005 ,  C07K14/4723 ,  C07K2319/00

摘要： The present invention relates to a vaccine for increasing the immunogenicity of a tumor antigen thus allowing treatment of cancer, as well as a vaccine that increases the immunogenicity of a viral antigen, thus allowing treatment of viral infection, including immunodeficiency virus (HIV) infection. In particular, the present invention provides a fusion protein comprising a defensin fused to either a tumor antigen or viral antigen which is administered as either a protein or nucleic acid vaccine to elicit an immune response effective in treating cancer or effective in treating or preventing viral infection.

摘要翻译： 本发明涉及用于增加肿瘤抗原的免疫原性的疫苗，从而允许治疗癌症，以及增加病毒抗原的免疫原性的疫苗，从而允许治疗包括免疫缺陷病毒（HIV）感染在内的病毒感染。 特别地，本发明提供一种融合蛋白，其包含与肿瘤抗原或病毒抗原融合的防御素，其作为蛋白质或核酸疫苗施用以引发有效治疗癌症或有效治疗或预防病毒感染的免疫应答 。

公开(公告)号：US5917017A

公开(公告)日：1999-06-29

申请号：US257781

申请日：1994-06-08

申请人： R. John Collier ,  Wei Hai Shen ,  David Eisenberg ,  Seunghyon Choe

发明人： R. John Collier ,  Wei Hai Shen ,  David Eisenberg ,  Seunghyon Choe

IPC分类号： C12N15/09 ,  A61K39/00 ,  A61K39/05 ,  A61K47/48 ,  A61P31/04 ,  C07H21/04 ,  C07K14/255 ,  C07K14/34 ,  C07K16/12 ,  C07K19/00 ,  C12N1/21 ,  C12P21/02 ,  C12P21/04 ,  C12P21/08 ,  C12R1/01 ,  C12R1/07 ,  C12R1/16 ,  C12R1/19 ,  C12R1/42 ,  C12R1/63 ,  C07K1/00 ,  A61K39/08

CPC分类号： C07K14/34 ,  A61K47/4833 ,  C07K16/12 ,  A61K39/00 ,  C07K2319/00

摘要： Diphtheria toxin polypeptides comprising a mutant R binding domain exhibit reduced target cell binding and may be used as vaccines to immunize a mammal against infection by Corynebacterium diphtheria.

摘要翻译： 包含突变体R结合结构域的白喉毒素多肽表现出降低的靶细胞结合，并且可以用作免疫哺乳动物免受白喉棒状杆菌感染的疫苗。

公开(公告)号：US5858362A

公开(公告)日：1999-01-12

申请号：US466210

申请日：1995-06-06

申请人： James L. Michel ,  Dennis L. Kasper ,  Frederick M. Ausubel ,  Lawrence C. Madoff

发明人： James L. Michel ,  Dennis L. Kasper ,  Frederick M. Ausubel ,  Lawrence C. Madoff

IPC分类号： A61K47/48 ,  A61P31/04 ,  C07K14/315 ,  C12N15/70 ,  A61K39/40 ,  A61K39/385 ,  C07K1/04

CPC分类号： A61K39/092 ,  A61K47/4833 ,  C07K14/315 ,  C12N15/70 ,  A61K2039/6068

摘要： A vaccine capable of protecting a recipient from infection caused by group B Streptococcus. The vaccine provides polysaccharide-protein moieties and contain (a) a group B Streptococcus polysaccharide conjugated to (b) a functional derivative of a group B Streptococcus C protein alpha antigen that retains the ability to elicit protective antibodies against group B Streptococcus. The vaccine may contain only one type of such polysaccharide-protein unit or may contain a mixture of more than one type of unit.

公开(公告)号：US5843461A

公开(公告)日：1998-12-01

申请号：US924401

申请日：1997-08-22

申请人： Harold J. Jennings ,  Dennis L. Kasper

发明人： Harold J. Jennings ,  Dennis L. Kasper

IPC分类号： A61K39/116 ,  A61K47/48 ,  A61K39/09

CPC分类号： A61K47/4833 ,  A61K39/092 ,  A61K2039/55 ,  A61K2039/6037 ,  Y10S530/813 ,  Y10S530/825

摘要： This invention relates to antigenic conjugate molecules comprising the capsular polysaccharide of Group B streptococcus type II which are covalently linked to protein. This invention also relates to vaccines and methods of immunizing mammals, including humans against infection by Group B streptococcus type II (GBS II). Multivalent vaccines comprising the conjugate molecules of this invention and antigens to other pathogenic bacteria are also claimed.

摘要翻译： 本发明涉及包含与蛋白质共价连接的B型链球菌II型荚膜多糖的抗原性缀合物分子。 本发明还涉及免疫哺乳动物的疫苗和方法，包括人类免受B组链球菌II型（GBS II）感染。 还要求保护包含本发明缀合物分子的多价疫苗和其它病原菌的抗原。

公开(公告)号：US5840588A

公开(公告)日：1998-11-24

申请号：US469084

申请日：1995-06-05

申请人： Meir Strahilevitz

发明人： Meir Strahilevitz

IPC分类号： A61K38/43 ,  A61K39/00 ,  A61K39/385 ,  A61K47/48 ,  A61M1/16 ,  A61M1/34 ,  B01D15/08 ,  C12N9/00 ,  G01N33/531 ,  G01N33/543 ,  G01N33/94 ,  G01N33/546 ,  G01N33/555

CPC分类号： B01D69/02 ,  A61K47/4833 ,  A61M1/1696 ,  A61M1/3482 ,  A61M1/3493 ,  B01D15/08 ,  B01D61/243 ,  C12N9/00 ,  G01N33/54313 ,  G01N33/94 ,  B01D2311/06 ,  Y10S435/975 ,  Y10S436/805 ,  Y10S436/809 ,  Y10S436/815 ,  Y10S436/816 ,  Y10S436/822

摘要： Immunoassays of psychoactive drugs including psychotomimetic drugs, narcotic drugs, and tetrahydrocannabinols and treatment methods based on the antigenic properties of protein conjugates of these drugs. These methods are based upon treating the psychoactive substances as haptens and utilizing their protein conjugates to produce antibodies to the psychoactive materials themselves. The immunoassay methods include both agglutination and agglutination-inhibition reactions. The treatment methods include treatment or both exogenous, administered drugs (such as cannabinols, LSD, heroin and morphine) and endogenous substances (such as N,N-Dimethyltryptamine and 5-Methoxy-N,N-Dimethyltryptamine, by active immunization and also passive immunization.

摘要翻译： 包括精神药物，麻醉药物和四氢大麻酚的精神药物的免疫测定和基于这些药物的蛋白质缀合物的抗原性质的治疗方法。 这些方法基于将精神活性物质作为半抗原并利用其蛋白质缀合物来产生对精神活性物质本身的抗体。 免疫测定方法包括凝集和凝集抑制反应。 治疗方法包括治疗或外源性施用药物（例如大麻素，LSD，海洛因和吗啡）和内源性物质（如N，N-二甲基色胺和5-甲氧基-N，N-二甲基色胺，通过主动免疫，也被动 免疫接种。

公开(公告)号：US5773003A

公开(公告)日：1998-06-30

申请号：US456444

申请日：1995-06-01

申请人： Philip A. Swain ,  Victoria Carol Schad ,  Julia Lea Greenstein ,  Mark Adrian Exley ,  Barbara Saxton Fox ,  Stephen P. Powers ,  Malcolm L. Gefter

发明人： Philip A. Swain ,  Victoria Carol Schad ,  Julia Lea Greenstein ,  Mark Adrian Exley ,  Barbara Saxton Fox ,  Stephen P. Powers ,  Malcolm L. Gefter

IPC分类号： A61K47/48 ,  A61P25/30 ,  A61K39/385 ,  A61K39/12

CPC分类号： C07K16/44 ,  A61K39/0013 ,  A61K47/4833 ,  A61K2039/6037

摘要： Hapten-carrier conjugates capable of eliciting anti hapten antibodies in vivo by administering, in a therapeutic composition, are disclosed. Anti-hapten antibodies elicited compete with free hapten upon subsequent challenge of a vaccinated individual. Methods of preparing the conjugates and therapeutic compositions are also disclosed. Where the hapten is a drug of abuse, a therapeutic composition containing the hapten-carrier conjugate is particularly useful in the treatment of drug addiction, more particularly, cocaine addiction. Passive immunization using antibodies raised against conjugates of the instant invention is also disclosed. The therapeutic composition is suitable for co-therapy with other conventional drugs.

摘要翻译： 公开了通过在治疗组合物中施用能够在体内引发抗半抗原抗体的穿孔载体缀合物。 抗半抗原抗体引起与免疫半抗原的竞争，随后对接种疫苗的个体进行攻击。 还公开了制备缀合物和治疗组合物的方法。 当半抗原是滥用药物时，含有半抗原 - 载体结合物的治疗组合物特别可用于治疗药物成瘾，特别是可卡因成瘾。 还公开了使用针对本发明的缀合物产生的抗体的被动免疫。 该治疗组合物适用于与其它常规药物共同治疗。

公开(公告)号：US5760184A

公开(公告)日：1998-06-02

申请号：US563673

申请日：1995-11-28

申请人： Philip A. Swain ,  Victoria C. Schad ,  Julia L. Greenstein ,  Mark A. Exley ,  Barbara S. Fox ,  Stephen P. Powers ,  Malcolm L. Gefter ,  Thomas J. Briner

发明人： Philip A. Swain ,  Victoria C. Schad ,  Julia L. Greenstein ,  Mark A. Exley ,  Barbara S. Fox ,  Stephen P. Powers ,  Malcolm L. Gefter ,  Thomas J. Briner

IPC分类号： A61K47/48 ,  A61P25/30 ,  C07K16/00 ,  A61K39/385 ,  A61K39/395

CPC分类号： C07K16/44 ,  A61K39/0013 ,  A61K47/4833 ,  A61K2039/6037

摘要： Hapten-carrier conjugates capable of eliciting anti-hapten antibodies in vivo are disclosed. Methods of preparing the hapten-carrier conjugates and therapeutic compositions are also disclosed. Where the hapten is a drug of abuse, a therapeutic composition containing the hapten-carrier conjugate is particularly useful in the treatment of drug addiction, more particularly, cocaine addiction. Passive immunization using antibodies raised against conjugates of the instant invention is also disclosed. The therapeutic composition is suitable for co-therapy with other conventional drugs.