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    Medical devices having porous polymeric regions for controlled drug delivery and regulated biocompatibility
    51.
    发明申请
    Medical devices having porous polymeric regions for controlled drug delivery and regulated biocompatibility 有权

    公开(公告)号：US20060171985A1

    公开(公告)日：2006-08-03

    申请号：US11048616

    申请日：2005-02-01

    申请人： Robert Richard ,  Frederick Strickler ,  Marlene Schwarz ,  Rudolf Faust ,  Shrirang Ranade ,  Michael Helmus

    发明人： Robert Richard ,  Frederick Strickler ,  Marlene Schwarz ,  Rudolf Faust ,  Shrirang Ranade ,  Michael Helmus

    IPC分类号： A61F2/00

    CPC分类号： A61L31/129 ,  A61L27/48 ,  A61N1/05

    摘要： The present invention relates to phase separated polymeric regions and to their use in conjunction with implantable or insertable medical devices. In some aspects of the invention, phase separated polymeric regions are provided that include (a) at least one biostable polymeric phase and (b) at least one biodisintegrable polymeric phase, which is of nanoscale dimensions and which undergoes biodisintegration such that the phase separated polymeric region becomes a nanoporous polymeric region in vivo. Other aspects of the invention are directed to methods of making implantable or insertable medical devices having at least one nanoporous polymeric region. These methods include (a) providing a phase separated polymeric region comprising a stable polymeric phase and a disintegrable polymeric phase of nanoscale dimensions, (b) selectively removing the disintegrable polymeric phase thereby producing the nanoporous polymeric region. In still other aspects, implantable or insertable medical devices are provided which have phase separated polymeric regions that include (a) at least one block copolymer having at least one biostable polymer block and at least one biodisintegrable polymer block and (b) at least one therapeutic agent which is released in vivo upon implantation or insertion of the medical device.

    Mesh implant for use in reconstruction of soft tissue defects
    52.
    发明申请
    Mesh implant for use in reconstruction of soft tissue defects 有权
    网状植入物用于重建软组织缺损

    公开(公告)号：US20060142786A1

    公开(公告)日：2006-06-29

    申请号：US11019534

    申请日：2004-12-23

    申请人： Torbjorn Mathisen ,  Henrik Magnusson

    发明人： Torbjorn Mathisen ,  Henrik Magnusson

    IPC分类号： A61B17/08

    CPC分类号： A61L27/58 ,  A61F2/0063 ,  A61F2210/0004 ,  A61F2240/001 ,  A61F2250/0018 ,  A61F2250/003 ,  A61L27/48 ,  A61L27/56 ,  A61L31/125 ,  A61L31/129 ,  A61L31/148

    摘要： The present invention relates to a resorbable polymeric mesh implant, that is intended to be used in the reconstruction of soft tissue defects. The mesh implant comprises at least a first and a second material, wherein the second material is substantially degraded at a later point in time than the first material following the time of implantation. The mesh implant is adapted to have a predetermined modulus of elasticity that gradually is decreased until the mesh implant is completely degraded and subsequently resorbed. Due to the gradual decrease in the modulus of elasticity of the inventive mesh implant, the regenerating tissue may gradually take over the load applied to the tissue defect area.

    摘要翻译： 本发明涉及可再吸收的聚合物网状植入物，其旨在用于重建软组织缺陷。 网状植入物包括至少第一和第二材料，其中在植入时间之后，第二材料在稍后的时间点比第一材料基本上劣化。 网状植入物适于具有逐渐降低的预定的弹性模量，直到网状植入完全降解并随后再吸收。 由于本发明的网状植入物的弹性模量的逐渐降低，再生组织可逐渐地承受施加于组织缺损区域的负荷。

    Composite absorbable/biodegradable rings for controlled drug delivery
    55.
    发明申请
    Composite absorbable/biodegradable rings for controlled drug delivery 有权
    用于受控药物递送的复合吸收/可生物降解环

    公开(公告)号：US20040265355A1

    公开(公告)日：2004-12-30

    申请号：US10860677

    申请日：2004-06-03

    发明人： Shalaby W. Shalaby

    IPC分类号： A61F002/00

    CPC分类号： A61K47/34 ,  A61K47/10 ,  A61K47/32 ,  A61L31/129 ,  A61L31/16 ,  A61L2300/602

    摘要： A fiber-reinforced composite ring for the controlled release of at least one bioactive agent includes a biocompatible matrix reinforced with absorbable/biodegradable fibers capable of providing the mechanical properties needed for inserting and maintaining the ring in a body cavity for a desired period of time. Such ring system as can be used for the intravaginal, intraperitoneal, and subcutaneous delivery of at least one bioactive agent, including those used as contraceptives, antimicrobial agents, and/or antiviral agents, as well as those for the treatment of cancer.

    摘要翻译： 用于控制释放至少一种生物活性剂的纤维增强复合环包括用可吸收/可生物降解的纤维增强的生物相容性基质，其能够提供将环在体腔中插入和保持所需时间所需的机械性能。 可用于阴道内，腹膜内和皮下递送至少一种生物活性剂（包括用作避孕药，抗微生物剂和/或抗病毒剂）以及用于治疗癌症的生物活性剂的环状体系。

    Drug-free biodegradable 3D porous collagen-glycosaminoglycan scaffold
    57.
    发明申请
    Drug-free biodegradable 3D porous collagen-glycosaminoglycan scaffold 审中-公开
    无毒素生物降解3D多孔胶原 - 糖胺聚糖支架

    公开(公告)号：US20040121943A1

    公开(公告)日：2004-06-24

    申请号：US10327528

    申请日：2002-12-20

    发明人： Wei-Cherng Hsu ,  Jo-Yi Hsiao ,  Hsiao-Cheng Yen

    IPC分类号： A61K038/38

    CPC分类号： A61L31/146 ,  A61L31/129 ,  C08L5/00 ,  C08L89/06

    摘要： A drug-free biodegradable 3D porous collagen-glycosaminoglycan scaffold is designed for preventing scar formation and creating a physiological aqua buffer environment around the conjuctival space for glaucoma. The scaffold improves the re-modeling of the regenerating tissue and prevents scar formation and further infection. It is prepared without further chemical linkage, and consequently becomes softer and without the uncertainty of chemical remnants after implantation. In addition, the scaffold can be cut preferably in a form upon request before being saturated by a physiological buffer for implantation.

    摘要翻译： 无毒素生物降解3D多孔胶原 - 糖胺聚糖支架设计用于防止瘢痕形成并在青光眼结膜间隙周围产生生理性的水中缓冲环境。 支架改善了再生组织的再建模，并防止瘢痕形成和进一步的感染。 其制备没有进一步的化学键合，因此变得更柔软，并且在植入后没有化学残留物的不确定性。 此外，可以根据要求优选以支架形式切割支架，然后用用于植入的生理缓冲液饱和。

    Bioabsorbable composites of derivatized hyaluronic acid and other biodegradable, biocompatible polymers
    59.
    发明授权
    Bioabsorbable composites of derivatized hyaluronic acid and other biodegradable, biocompatible polymers 有权

    公开(公告)号：US06548081B2

    公开(公告)日：2003-04-15

    申请号：US09863029

    申请日：2001-05-22

    申请人： Khalid K. Sadozai ,  Jing-wen Kuo ,  Charles H. Sherwood

    发明人： Khalid K. Sadozai ,  Jing-wen Kuo ,  Charles H. Sherwood

    IPC分类号： A61F202

    CPC分类号： C08B37/0072 ,  A61K47/61 ,  A61L31/10 ,  A61L31/129 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/00 ,  C08L5/08

    摘要： The present invention relates to a composite and a method for reducing post-operative adhesion of tissues. The composite includes a biocompatible, biodegradable support, and a water-insoluble hyaluronic acid derivative at the support. The hyaluronic acid derivative includes an N-acylurea that results from cross-linking by the reaction of hyaluronic acid with a multifunctional carbodiimide. Optionally, a monocarbodiimide also may be employed. A pharmaceutically-active molecule may be added to the N-acylurea derivative of hyaluronic acid. Although the composite includes material that prevents adhesion between tissues, in order to reduce the need for suturing when the composite is being used during a surgical procedure, a material that enhances adhesion of the composite to tissues may be applied to a surface of the composite. A method of forming the composite for reducing post-operative adhesion of tissues, including the step of applying an N-acylurea derivative of hyaluronic acid resulting from cross-linking with a multifunctional carbodiimide, to a biocompatible, biodegradable support; a method of preparing a drug delivery vehicle that includes a pharmaceutically-active molecule with the N-acylurea derivative of hyaluronic acid resulting from cross-linking with a multifunctional carbodiimide; and a method of reducing post-operative adhesion of tissues are disclosed.