公开(公告)号：US20240279743A1

公开(公告)日：2024-08-22

申请号：US18412413

申请日：2024-01-12

申请人： The Chinese University of Hong Kong

发明人： Yuk-Ming Dennis LO ,  Kwan Chee Allen CHAN ,  Chunming DING

IPC分类号： C12Q1/6886

CPC分类号： C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/154

摘要： The present invention concerns a method for the detection or monitoring of cancer using a biological sample selected from blood, plasma, serum, saliva, urine from an individual, said method comprising:



(a) obtaining DNA from the said biological sample;
(b) digesting the DNA sample with one or more methylation-sensitive restriction enzymes;
(c) quantifying or detecting a DNA sequence of interest after step (b), wherein the target sequence of interest contains at least two methylation-sensitive restriction enzyme recognition sites; and
(d) comparing the level of the DNA sequence from the individual to a normal standard, to detect, prognosticate or monitor cancer.

公开(公告)号：US12065471B2

公开(公告)日：2024-08-20

申请号：US17478041

申请日：2021-09-17

申请人： Immatics Biotechnologies GmbH

发明人： Colette Song ,  Heiko Schuster ,  Daniel Johannes Kowalewski ,  Oliver Schoor ,  Jens Fritsche ,  Toni Weinschenk ,  Harpreet Singh

IPC分类号： C07K14/47 ,  A61K35/17 ,  A61K38/08 ,  A61K39/00 ,  C07K7/04 ,  C07K7/06 ,  C07K14/725 ,  C07K14/74 ,  C07K16/18 ,  C12N5/0783 ,  C12Q1/6886 ,  G16B25/10

CPC分类号： C07K14/4748 ,  A61K35/17 ,  A61K39/0011 ,  C07K14/7051 ,  C07K14/70539 ,  C07K16/18 ,  C12N5/0636 ,  C12Q1/6886 ,  A61K38/08 ,  C07K7/04 ,  C07K7/06 ,  C07K2319/00 ,  C07K2319/55 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/158 ,  G16B25/10

摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.

公开(公告)号：US20240271223A1

公开(公告)日：2024-08-15

申请号：US18569317

申请日：2022-04-07

申请人： Eisai R&D Management Co., Ltd.

发明人： Megumi KURONISHI ,  Yu Kato

IPC分类号： C12Q1/6886 ,  A61K31/47 ,  A61P35/00

CPC分类号： C12Q1/6886 ,  A61K31/47 ,  A61P35/00 ,  G01N2800/52

摘要： Biomarkers are provided that predict whether a human subject having a tumor is in need of a therapy comprising an angiogenesis inhibitor (e.g. lenvatinib or a pharmaceutically acceptable salt thereof, such as lenvatinib mesylate). The biomarkers, compositions, and methods described herein are useful in selecting appropriate treatment modalities for and treating a subject having a tumor.

公开(公告)号：US12060614B2

公开(公告)日：2024-08-13

申请号：US13417119

申请日：2012-03-09

申请人： Yuk-Ming Dennis Lo ,  Rossa Wai Kun Chiu ,  Kwan Chee Chan

发明人： Yuk-Ming Dennis Lo ,  Rossa Wai Kun Chiu ,  Kwan Chee Chan

IPC分类号： G01N33/50 ,  C12Q1/6809 ,  C12Q1/6827 ,  C12Q1/6874 ,  C12Q1/6883 ,  C12Q1/6886 ,  G16B20/00 ,  G16B20/10 ,  G16B20/20 ,  G16B30/00 ,  G16B30/10

CPC分类号： C12Q1/6886 ,  C12Q1/6809 ,  C12Q1/6827 ,  C12Q1/6874 ,  C12Q1/6883 ,  G16B20/00 ,  G16B20/10 ,  G16B20/20 ,  G16B30/00 ,  G16B30/10 ,  C12Q2600/156 ,  C12Q1/6827 ,  C12Q2537/16

摘要： Embodiments of this invention provide methods, systems, and apparatus for determining whether a fetal chromosomal aneuploidy exists from a biological sample obtained from a pregnant female. Nucleic acid molecules of the biological sample are sequenced, such that a fraction of the genome is sequenced. Respective amounts of a clinically-relevant chromosome and of background chromosomes are determined from results of the sequencing. The determination of the relative amounts may count sequences of only certain length. A parameter derived from these amounts (e.g. a ratio) is compared to one or more cutoff values, thereby determining a classification of whether a fetal chromosomal aneuploidy exists. Prior to sequencing, the biological sample may be enriched for DNA fragments of a particular sizes.

公开(公告)号：US20240263246A1

公开(公告)日：2024-08-08

申请号：US18620056

申请日：2024-03-28

申请人： GUARDANT HEALTH, INC.

发明人： Stefanie Ann Ward MORTIMER ,  AmirAli TALASAZ ,  Darya CHUDOVA ,  Helmy ELTOUKHY

IPC分类号： C12Q1/6886 ,  C12M1/00 ,  C12M1/34 ,  C12Q1/6806 ,  C12Q1/6855 ,  C12Q1/6869 ,  G01N33/574 ,  G16B20/20 ,  G16B30/10 ,  G16H50/20 ,  G16H50/30

CPC分类号： C12Q1/6886 ,  C12M1/00 ,  C12M1/34 ,  C12Q1/6806 ,  C12Q1/6855 ,  C12Q1/6869 ,  G01N33/57407 ,  G16B20/20 ,  G16B30/10 ,  G16H50/20 ,  G16H50/30 ,  C12Q2600/118 ,  C12Q2600/154 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/166

摘要： Disclosed herein are methods, compositions, and devices for use in the early detection of cancer. The methods include preparing cell-free nucleic acid molecules from a subject for sequencing, sequencing a panel of regions in the cell-free nucleic acid molecules, and detecting one or more markers that are indicative of a cancer.

公开(公告)号：US20240263243A1

公开(公告)日：2024-08-08

申请号：US18565594

申请日：2022-06-03

申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  Centre national de la recherche scientifique ,  Université d'Aix-Marseille ,  INSTITUT JEAN PAOLI & IRENE CALMETTES CENTRE REGIONAL DE LUTTE CONTRE LE CANCER

发明人： Juan IOVANNA ,  Nelson DUSETTI ,  Nicolas FRAUNHOFFER

IPC分类号： C12Q1/6886 ,  A61K31/282 ,  A61K31/337 ,  A61K31/4745 ,  A61K31/513 ,  A61K31/7068 ,  A61P35/00

CPC分类号： C12Q1/6886 ,  A61K31/282 ,  A61K31/337 ,  A61K31/4745 ,  A61K31/513 ,  A61K31/7068 ,  A61P35/00 ,  C12Q2600/106

摘要： The present invention relates to a method and a kit for determining if a patient having pancreatic ductal adenocarcinoma (PDAC) is sensitive to a treatment. It further relates to a method for determining a suitable treatment for a patient having PDAC.

公开(公告)号：US20240263242A1

公开(公告)日：2024-08-08

申请号：US18557660

申请日：2022-04-29

申请人： INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY

发明人： Jae-Ho Cheong ,  Jae-woo Kim ,  Bo Kyung YOON

IPC分类号： C12Q1/6886 ,  G01N33/574

CPC分类号： C12Q1/6886 ,  G01N33/57484 ,  C12Q2600/118 ,  C12Q2600/158

摘要： A composition and method according to the present invention may be very effectively used to diagnose malignant gastric cancer and predict the prognosis of gastric cancer.

公开(公告)号：US20240263240A1

公开(公告)日：2024-08-08

申请号：US18290138

申请日：2022-05-13

申请人： Foundation Medicine, Inc.

发明人： Richard Sheng Poe HUANG ,  Brennan DECKER ,  Jeffrey ROSS

IPC分类号： C12Q1/6886 ,  A61K45/06

CPC分类号： C12Q1/6886 ,  A61K45/06 ,  C12Q2600/106 ,  C12Q2600/156

摘要： Provided herein are methods related to detecting CD274 gene mutations, as well as methods of treatment, uses, and kits related thereto. Detection of CD274 gene mutations can be used to identify individuals that may or may not benefit from an anti-cancer therapy.

公开(公告)号：US20240254560A1

公开(公告)日：2024-08-01

申请号：US18429449

申请日：2024-02-01

申请人： Cancer Institute and Hospital

发明人： Yan WANG ,  Baowen YUAN ,  Wei HUANG ,  Hefen YU ,  Jingyao ZHANG ,  Yunkai YANG

IPC分类号： C12Q1/6886 ,  C12Q1/6851

CPC分类号： C12Q1/6886 ,  C12Q1/6851 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/158

摘要： An application of feature gene TRIM22 in preparing reagent for regulating expression of breast cancer-related genes is provided. The feature gene TRIM22 disclosed in the present disclosure upregulates the expression of breast cancer-related genes SIX3, GATA6, PTX3, MMP1 and DMBT1 through overexpression, and downregulates the expression of the breast cancer-related genes SOX4, CXCL10, TNF, TP63 and CXCL16 through overexpression. Therefore, the feature gene TRIM22 provided in the present disclosure can be used as a reagent product to regulate the expression of breast cancer-related genes GATA6, SIX3, SOX4, CXCL10, PTX3, TNF, TP63, MMP1, CXCL16 and DMBT1 through overexpression.

公开(公告)号：US20240253038A1

公开(公告)日：2024-08-01

申请号：US18233819

申请日：2023-08-14

申请人： Bio-Rad Laboratories, Inc.

发明人： Kalyan Handique ,  Vishal Sharma ,  Priyadarshini Gogoi ,  William Chow ,  Austin Payne ,  Kyle Gleason ,  Brian Boniface ,  John Connolly ,  Sam Tuck

IPC分类号： B01L3/00 ,  C12M1/00 ,  C12Q1/6816 ,  C12Q1/6886 ,  G01N15/10 ,  G01N15/14 ,  G01N15/1434 ,  G01N15/149 ,  G01N33/543 ,  G01N33/569 ,  G01N33/574

CPC分类号： B01L3/502761 ,  C12M47/04 ,  C12Q1/6816 ,  G01N15/1434 ,  G01N15/1484 ,  G01N33/543 ,  G01N33/569 ,  G01N33/574 ,  B01L3/502715 ,  B01L3/527 ,  B01L2200/0668 ,  B01L2300/0636 ,  B01L2300/0819 ,  B01L2300/0829 ,  B01L2300/0851 ,  B01L2400/0406 ,  C12Q1/6886 ,  G01N2015/1006 ,  G01N15/149

摘要： A system and method, wherein the method includes: (a) receiving a fluid comprising a process reagent for an assay and nucleic acid material from a sample into a fluid pathway coupled to an array of wells, wherein the array of wells is defined within a substrate and each well in the array of wells extends vertically into a planar surface of the substrate; (b) distributing the fluid along the fluid pathway and into wells of the array of wells; and (c) distributing a liquid immiscible with the fluid comprising the process reagent and nucleic acid material along the fluid pathway upon positive pressure generation by a pump of a flow control system in communication with an inlet to the fluid pathway, thereby displacing said fluid along the fluid pathway and into wells of the array of wells and preventing contents of each well from transferring to adjacent wells.