公开(公告)号：US09115116B2

公开(公告)日：2015-08-25

申请号：US14160515

申请日：2014-01-21

Applicant: Academia Sinica ,  National Taiwan University

Inventor： Jung-Hsin Lin ,  Ching-Chow Chen ,  Jim-Min Fang ,  Jhih-Bin Chen ,  Ting-Rong Chern ,  Tzu-Tang Wei

IPC: C07D207/32 ,  C07D309/10 ,  A61K31/4192 ,  A61K31/351 ,  C07D405/12 ,  C07D309/30 ,  C07F7/18

CPC classification number: C07D405/12 ,  C07D309/30 ,  C07F7/1804

Abstract: Disclosed herein are novel compounds of formula (I), and uses thereof. The compounds of Formula (I) are inhibitors of histone deacetylases (HDACs) and 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (HMGR). Also provided are methods of using the compounds of Formula (I) for inhibiting the activity of HDACs and HMGR, treating diseases associated with HDACs or HMGR (e.g., cancer, hypercholesterolemia, an acute or chronic inflammatory disease, autoimmune disease, allergic disease, pathogen infection, neurodegenerative disease, or a disease associated with oxidative stress,

Abstract translation: 本文公开了新的式（I）化合物及其用途。 式（I）的化合物是组蛋白脱乙酰酶（HDAC）和3-羟基-3-甲基戊二酰辅酶A（HMG-CoA）还原酶（HMGR）的抑制剂。 还提供了使用式（I）化合物抑制HDAC和HMGR活性的方法，治疗与HDAC或HMGR相关的疾病（例如，癌症，高胆固醇血症，急性或慢性炎性疾病，自身免疫性疾病，过敏性疾病，病原体 感染，神经变性疾病或与氧化应激相关的疾病，

公开(公告)号：US20150197480A9

公开(公告)日：2015-07-16

申请号：US14287833

申请日：2014-05-27

Applicant: Chi-Ming Liang ,  Academia Sinica

Inventor： Klim King ,  Rong-Jie Chein

IPC: C07C69/96 ,  C07C69/757 ,  C07C69/007 ,  C07C49/757 ,  C07C62/32 ,  C07C47/36 ,  C07C35/37

CPC classification number: C07C69/96 ,  C07C22/02 ,  C07C29/15 ,  C07C33/16 ,  C07C33/44 ,  C07C35/37 ,  C07C45/00 ,  C07C45/41 ,  C07C47/36 ,  C07C47/46 ,  C07C49/757 ,  C07C62/32 ,  C07C67/30 ,  C07C69/007 ,  C07C69/24 ,  C07C69/33 ,  C07C69/587 ,  C07C69/757 ,  C07C211/31 ,  C07C215/42 ,  C07C225/14 ,  C07C253/00 ,  C07C253/30 ,  C07C259/06 ,  C07C271/24 ,  C07C275/28 ,  C07C321/20 ,  C07C323/15 ,  C07C323/22 ,  C07C323/28 ,  C07C327/06 ,  C07C327/16 ,  C07C2603/30 ,  C07D303/46 ,  C07F9/117

Abstract: The present disclosure provides novel glucagon-like peptide-1 (GLP-1) receptor modulators such as compounds of Formula (I) or (II), and pharmaceutically acceptable salts thereof. The present disclosure also provides pharmaceutical compositions, kits, and uses that involve the GLP-1 receptor modulators for regulating blood glucose levels and/or treating diabetes via, e.g., modulating the endogenous signaling pathways mediated by the GLP-1 receptor.

Abstract translation: 本公开提供了新型胰高血糖素样肽-1（GLP-1）受体调节剂，例如式（I）或（II）的化合物及其药学上可接受的盐。 本公开还提供了涉及用于调节血糖水平和/或通过例如调节由GLP-1受体介导的内源性信号传导途径治疗糖尿病的GLP-1受体调节剂的药物组合物，试剂盒和用途。

公开(公告)号：US09072312B2

公开(公告)日：2015-07-07

申请号：US14354995

申请日：2012-10-27

Applicant: ACADEMIA SINICA

Inventor： Wen-Chin Yang ,  Lee-Tian Chang

IPC: A01N65/00 ,  A23K1/17 ,  A61K36/00 ,  A61K36/28 ,  A23K1/14 ,  A23K1/16 ,  A23K1/18 ,  A61K31/7028

CPC classification number: A61K31/7028 ,  A23K10/30 ,  A23K20/00 ,  A23K20/10 ,  A23K20/163 ,  A23K20/195 ,  A23K50/70 ,  A23K50/75 ,  A23K50/80 ,  A23V2002/00 ,  A23V2200/32 ,  A61K36/00 ,  A61K36/28

Abstract: A composition for use in prevention, inhibition and/or treatment of coccidiosis in an animal is disclosed. The composition comprises an effective amount of Bidens pilosa, an active constituent thereof, or an active compound isolated therefrom. In another aspect, a composition for use in preventing and/or treating coccidiosis, and/or enhancing growth in an animal is disclosed, the composition comprising an animal feed and an effective amount of Bidens pilosa, or an isolated active constituent comprising a polyacetylenic compound.

Abstract translation: 公开了用于预防，抑制和/或治疗动物的球虫病的组合物。 该组合物包含有效量的Bidens pilosa，其活性组分或与其分离的活性化合物。 在另一方面，公开了一种用于预防和/或治疗球虫病和/或增强动物生长的组合物，所述组合物包含动物饲料和有效量的Bidens pilosa或包含聚乙炔化合物的分离的活性成分 。

公开(公告)号：US20150114456A1

公开(公告)日：2015-04-30

申请号：US14269640

申请日：2014-05-05

Applicant: Academia Sinica

Inventor： Chih Wei CHU ,  Mohammed Aziz IBRAHEM

IPC: C09D5/24 ,  B02C17/18 ,  H01L31/032 ,  C01G41/00 ,  C01B19/04 ,  C01G39/02 ,  C01G39/06 ,  B02C23/06 ,  C01B31/04

CPC classification number: C01G41/00 ,  C01B19/007 ,  C01B32/19 ,  C01B2204/32 ,  C01G39/02 ,  C01G39/06 ,  C01P2002/72 ,  C01P2002/82 ,  C01P2004/03 ,  C01P2004/16 ,  C01P2004/24 ,  C01P2004/61 ,  C01P2004/62 ,  C01P2004/64 ,  H01L51/42 ,  H01L51/4273 ,  H01L2251/308 ,  Y02E10/549

Abstract: The present invention provides a method for the preparation of low-dimensional materials, comprising mixing a pristine material to be abraded with an organic solvent to form a mixture, abrading the material to be abraded by bead-milling, obtaining a suspension comprising the material of low dimension and the organic solvent, and removing the organic solvent from the suspension to obtain the low-dimensional material.

Abstract translation: 本发明提供了一种制备低维材料的方法，包括将待研磨的原始材料与有机溶剂混合以形成混合物，研磨通过珠磨研磨的材料，得到包含以下物质的悬浮液： 低维和有机溶剂，并从悬浮液中除去有机溶剂，得到低维材料。

公开(公告)号：US08974794B2

公开(公告)日：2015-03-10

申请号：US14254453

申请日：2014-04-16

Applicant: Academia Sinica

Inventor： Tse Wen Chang ,  Jiun-Bo Chen ,  Pheidias C. Wu ,  Alfur F. Hung

IPC: A61K39/00 ,  C07K16/28 ,  C07K16/42 ,  A61K39/395

CPC classification number: C07K16/2803 ,  A61K39/39566 ,  C07K16/4291 ,  C07K2317/24 ,  C07K2317/30 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732 ,  Y10S424/805 ,  Y10S424/81 ,  Y10S530/862 ,  Y10S530/868

Abstract: The invention pertains to methods of using CεmX peptides (e.g., GLAGGSAQSQRAPDRVL; SEQ ID NO:2) that can bind effectively induce immune responses to membrane-bound IgE (mIgE) expressed on the surface of human B lymphocytes.

Abstract translation: 本发明涉及使用可以有效诱导在人B淋巴细胞表面上表达的膜结合IgE（mIgE）的免疫应答的C＆amp; MX肽（例如GLAGGSAQSQRAPDRVL; SEQ ID NO：2）的方法。

公开(公告)号：US08966661B2

公开(公告)日：2015-02-24

申请号：US13948991

申请日：2013-07-23

Applicant: Academia Sinica

Inventor： Wei-Tse Chang ,  Ing-Shouh Hwang

IPC: G01Q70/10 ,  G01Q70/16 ,  B82Y35/00

CPC classification number: G01Q70/10 ,  B82Y35/00 ,  G01Q70/16

Abstract: Disclosed is a method for fabricating a nanoscale probe. A first conductor and a second conductor are immersed into an electrolyte contained in an electrolytic tank. The first conductor and the second conductor are connected to a power source respectively. An electrolytic reaction is established when an electrical circuit is established between the first conductor and the second conductor. The second conductor is configured to output electrons. The first conductor is configured to receive electrons. Therefore, the first conductor is etched when the electrical circuit is established between the first conductor and the second conductor. A necking portion is created at the first conductor approximately near the surface of the electrolyte. A nanoscale probe is fabricated when first conductor breaks at the necking portion.

Abstract translation: 公开了一种制造纳米级探针的方法。 将第一导体和第二导体浸入包含在电解槽中的电解质中。 第一导体和第二导体分别连接到电源。 当在第一导体和第二导体之间建立电路时，建立电解反应。 第二导体被配置为输出电子。 第一导体被配置为接收电子。 因此，当在第一导体和第二导体之间建立电路时，第一导体被蚀刻。 在第一导体处产生大致接近电解质表面的颈缩部分。 当第一导体在颈缩部分断裂时，制造纳米级探针。

公开(公告)号：US08963075B2

公开(公告)日：2015-02-24

申请号：US12314520

申请日：2008-12-11

Applicant: Chung Hsuan Chen ,  Wen-Ping Peng ,  Ming Lee Chu ,  Huan Cheng Chang ,  Huan-Chang Lin

Inventor： Chung Hsuan Chen ,  Wen-Ping Peng ,  Ming Lee Chu ,  Huan Cheng Chang ,  Huan-Chang Lin

IPC: H01J49/00 ,  H01J49/42

CPC classification number: H01J49/4265 ,  H01J49/0077 ,  H01J49/025

Abstract: A novel system and method for charge-monitoring mass spectrometry is provided. The mass spectrometer can be used to measure the mass of one or more analytes having masses in the range of about a few Daltons to more than about 1015 Daltons. The invention can be used for rapid mass distribution measurements. For example, the system and method can be used to distinguish cancer cells from normal cells when their mass distributions are different.

Abstract translation: 提供了一种电荷监测质谱的新型系统和方法。 质谱仪可用于测量质量在约几道尔顿至大于约1015道尔顿范围内的一种或多种分析物的质量。 本发明可用于快速质量分布测量。 例如，当它们的质量分布不同时，系统和方法可以用于区分癌细胞与正常细胞。

公开(公告)号：US08937767B2

公开(公告)日：2015-01-20

申请号：US13468602

申请日：2012-05-10

Applicant: Yia-Chung Chang ,  Li-Chuan Tang

Inventor： Yia-Chung Chang ,  Li-Chuan Tang

IPC: G02B27/22 ,  G02B27/24 ,  H04N13/04

CPC classification number: G02B27/2214 ,  H04N13/302

Abstract: An auto-stereoscopic display and three-dimensional imaging double-sided mirror array being low-loss and nearly dispersion-less. The double-sided mirror array for auto-stereoscopic display and three-dimensional (3D) imaging comprises a display panel, a slab and an array. The display panel comprises multiple display pixels. The slab is in close contact with the display panel. The array comprises at least two vertical mirror strips, at least one vertical blinds and a spacing. Each vertical mirror strip is inserted into the slab. Each vertical blind is shorter than the vertical mirror strip and is inserted into the slab between two vertical mirror strips. The spacing is between the vertical mirror strip and the vertical blind and is chosen to match the width of the display pixels exactly.

Abstract translation: 自动立体显示和三维成像双面镜阵列是低损耗和几乎不分散的。 用于自动立体显示和三维（3D）成像的双面镜阵列包括显示面板，平板和阵列。 显示面板包括多个显示像素。 平板与显示面板紧密接触。 该阵列包括至少两个垂直镜条，至少一个垂直百叶窗和间隔。 每个垂直镜条被插入板中。 每个垂直盲板比垂直镜片条短，并且在两个垂直镜带之间插入板坯。 间隔在垂直镜片条和垂直百叶窗之间，并被选择为精确地匹配显示像素的宽度。

公开(公告)号：US08927462B2

公开(公告)日：2015-01-06

申请号：US13083866

申请日：2011-04-11

Applicant: Yuan-Tsong Chen ,  Shuen-Iu Hung ,  Chun-Yu Wei

Inventor： Yuan-Tsong Chen ,  Shuen-Iu Hung ,  Chun-Yu Wei

IPC: C40B30/04 ,  G01N33/569

CPC classification number: G01N33/56977

Abstract: A method for identifying from an HLA library an HLA complex that specifically binds to a compound. This method can be relied on to assess whether a compound is likely to induce an adverse drug reaction and, if so, in which human population.

Abstract translation: 从HLA文库鉴定特异性结合化合物的HLA复合物的方法。 可以依靠这种方法来评估化合物是否有可能引起不良药物反应，如果是这样，则可以在哪一种人群中。

公开(公告)号：US20140356301A1

公开(公告)日：2014-12-04

申请号：US14295173

申请日：2014-06-03

Applicant: Academia Sinica

Inventor： Lie-Fen SHYUR ,  Jia-Hua FENG ,  Maria Karmella APAYA

IPC: A61K31/7032 ,  A61K36/88 ,  A23L1/30 ,  A61Q19/02 ,  A61K8/60 ,  A61K36/28 ,  A61K8/97

CPC classification number: A61K31/7032 ,  A23L33/105 ,  A61K8/602 ,  A61K8/97 ,  A61K36/28 ,  A61K36/88 ,  A61K2236/00 ,  A61Q19/02

Abstract: The present invention is related to a galactolipids-enriched plant extract, prepared by extracting a plant sample selected from a group consisting of: Gynura divaricata subsp. formosana (Asteraceae) (GD), Murdannia bracteata (C. B. Clarke) J. K. Morton ex D. Y. Hong (Commelinaceae) (MB), and Crassocephalum rabens S. Moore (Asteraceae) (CR) with a series of solvents. A pharmaceutical, nutritional, or healthcare composition for protecting or treating acute fulminant hepatitis, for protecting or treating sepsis or related indication thereof, and a composition for skin whitening are also provided herein. These compositions all comprise effective amounts of the galactolipids-enriched plant extracts or purified compounds thereof as bioactive ingredients.

Abstract translation: 本发明涉及通过提取选自以下的植物样品制备的富含半乳糖脂的植物提取物：Gynura divaricata subsp。 菊科（菊科）（GD），小麦（Murdannia bracteata）（C.B.Clarke）J.K.Morton ex D.Y.Hong（Commelinaceae）（MB）和Crassocephalum rabens S.Moore（菊科）（CR）与一系列溶剂。 还提供了用于保护或治疗急性暴发性肝炎，用于保护或治疗败血症或其相关指征的药物，营养或保健组合物和用于皮肤美白的组合物。 这些组合物都包含有效量的富含脂肪体的植物提取物或其纯化的化合物作为生物活性成分。