中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

714 records (took 0.026 seconds)

    C-reactive protein and its use to treat systemic lupus erythematosus and related conditions
    681.
    发明授权
    C-reactive protein and its use to treat systemic lupus erythematosus and related conditions 失效
    C-反应蛋白及其用于治疗系统性红斑狼疮及相关病症的用途

    公开(公告)号：US08013120B2

    公开(公告)日：2011-09-06

    申请号：US12083055

    申请日：2006-10-26

    Applicant: Terry W. Du Clos ,  Carolyn Mold

    Inventor： Terry W. Du Clos ,  Carolyn Mold

    IPC: C07K14/00

    CPC classification number: A61K38/1709

    Abstract: The present invention relates to the use of C-reactive protein, its mutants, metabolites and polypeptides and related compounds thereof for the treatment of various disease states and conditions associated with systemic lupus erythematosus (SLE), including lupus of the skin (discoid), systemic lupus of the joints, lungs and kidneys, hematological conditions including hemolytic anemia and low lymphocyte counts, lymphadenopathy and CNS effects including memory loss, seizures and psychosis, among numerous others as otherwise disclosed herein, hi another aspect of the invention, the reduction in the likelihood that a patient who is at risk for an outbreak of a disease state or condition with systemic lupus erythematosus will have an outbreak is an additional aspect of the present invention.

    Abstract translation: 本发明涉及C-反应蛋白，其突变体，代谢物和多肽及其相关化合物用于治疗与系统性红斑狼疮（SLE）相关的各种疾病状态和病症（包括皮肤的狼疮）（discoid））的用途， 关节，肺和肾的系统性红斑狼疮，血液病症包括溶血性贫血和低淋巴细胞计数，淋巴结病和CNS作用，包括记忆丧失，癫痫发作和精神病，其他众所周知。另外在本发明的另一方面， 患有疾病状态或患有系统性红斑狼疮的疾病的风险的患者可能发生爆发是本发明的另外一个方面。

    METHOD OF MAKING DENSE, CONFORMAL, ULTRA-THIN CAP LAYERS FOR NANOPOROUS LOW-K ILD BY PLASMA ASSISTED ATOMIC LAYER DEPOSITION
    685.
    发明申请
    METHOD OF MAKING DENSE, CONFORMAL, ULTRA-THIN CAP LAYERS FOR NANOPOROUS LOW-K ILD BY PLASMA ASSISTED ATOMIC LAYER DEPOSITION 审中-公开
    通过等离子体辅助原子层沉积制备纳米级低K薄膜的DENSE，一致，超薄膜层的方法

    公开(公告)号：US20110186971A1

    公开(公告)日：2011-08-04

    申请号：US13083790

    申请日：2011-04-11

    Applicant: Ying-Bing Jiang ,  Joseph L. Cecchi ,  C. Jeffrey Brinker

    Inventor： Ying-Bing Jiang ,  Joseph L. Cecchi ,  C. Jeffrey Brinker

    IPC: H01L29/02 ,  H01L21/02

    CPC classification number: A61K45/06 ,  A61K31/167 ,  A61K31/7048 ,  H01L21/76814 ,  H01L21/76826 ,  H01L21/76831 ,  Y10S977/89 ,  A61K2300/00

    Abstract: Barrier layers and methods for forming barrier layers on a porous layer are provided. The methods can include chemically adsorbing a plurality of first molecules on a surface of the porous layer in a chamber and forming a first layer of the first molecules on the surface of the porous layer. A plasma can then be used to react a plurality of second molecules with the first layer of first molecules to form a first layer of a barrier layer. The barrier layers can seal the pores of the porous material, function as a diffusion barrier, be conformal, and/or have a negligible impact on the overall ILD k value of the porous material.

    Abstract translation: 提供了阻挡层和在多孔层上形成阻挡层的方法。 所述方法可以包括在多孔层的多孔层的表面上化学吸附多个第一分子并在多孔层的表面上形成第一分子的第一层。 然后可以使用等离子体来使多个第二分子与第一分子的第一层反应以形成阻挡层的第一层。 阻挡层可以密封多孔材料的孔，用作扩散阻挡层，保形，和/或对多孔材料的整体ILD k值具有可忽略的影响。

    Ultra-thin high-quality germanium on silicon by low-temperature epitaxy and insulator-capped annealing
    686.
    发明授权
    Ultra-thin high-quality germanium on silicon by low-temperature epitaxy and insulator-capped annealing 有权
    通过低温外延和绝缘体封端退火在硅上超薄的高品质锗

    公开(公告)号：US07968438B2

    公开(公告)日：2011-06-28

    申请号：US11835855

    申请日：2007-08-08

    Applicant: Sang M. Han ,  Qiming Li

    Inventor： Sang M. Han ,  Qiming Li

    IPC: H01L21/20 ,  H01L21/36

    CPC classification number: H01L21/02664 ,  H01L21/02381 ,  H01L21/0245 ,  H01L21/02532 ,  H01L21/02546 ,  H01L21/02667

    Abstract: Exemplary embodiments provide semiconductor devices with a high-quality semiconductor material on a lattice mismatched substrate and methods for their manufacturing using low temperature growth techniques followed by an insulator-capped annealing process. The semiconductor material can have high-quality with a sufficiently low threading dislocation (TD) density, and can be effectively used for integrated circuit applications such as an integration of optically-active materials (e.g., Group III-V materials) with silicon circuitry. In an exemplary embodiment, the high-quality semiconductor material can include one or more ultra-thin high-quality semiconductor epitaxial layers/films/materials having a desired thickness on the lattice mismatched substrate. Each ultra-thin high-quality semiconductor epitaxial layer can be formed by capping a low-temperature grown initial ultra-thin semiconductor material, annealing the capped initial ultra-thin semiconductor material, and removing the capping layer.

    Abstract translation: 示例性实施例在晶格不匹配的衬底上提供具有高质量半导体材料的半导体器件，以及使用低温生长技术接着进行绝缘体封端退火工艺的制造方法。 半导体材料可以具有足够低的穿透位错（TD）密度的高质量，并且可以有效地用于集成电路应用，例如光学活性材料（例如III-V族材料）与硅电路的集成。 在示例性实施例中，高质量半导体材料可以包括在晶格失配衬底上具有期望厚度的一个或多个超薄高品质半导体外延层/薄膜/材料。 每个超薄的高质量半导体外延层可以通过封装低温生长的初始超薄半导体材料，退火封装的初始超薄半导体材料和去除覆盖层来形成。

    Nanostructured separation and analysis devices for biological membranes
    688.
    再颁专利
    Nanostructured separation and analysis devices for biological membranes 有权
    用于生物膜的纳米结构分离和分析装置

    公开(公告)号：USRE42315E1

    公开(公告)日：2011-05-03

    申请号：US11825298

    申请日：2007-07-05

    Applicant: Gabriel P. Lopez ,  Steven R. J. Brueck ,  Linnea K. Ista

    Inventor： Gabriel P. Lopez ,  Steven R. J. Brueck ,  Linnea K. Ista

    IPC: B01D15/34

    CPC classification number: G01N27/44773 ,  B82Y30/00 ,  G01N30/00 ,  G01N30/88 ,  G01N2030/8813 ,  Y10S977/717 ,  Y10S977/845 ,  Y10T436/25375 ,  Y10T436/255

    Abstract: The present invention provides a nanostructured device comprising a substrate including nanotroughs therein; and a lipid bilayer suspended on or supported in the substrate. A separation method is also provided comprising the steps of supporting or suspending a lipid bilayer on a substrate; wherein the substrate comprises nanostructures and wherein the lipid bilayer comprises at least one membrane associated biomolecule; and applying a driving force to the lipid bilayer to separate the membrane associated biomolecule from the lipid bilayer and to drive the membrane associated biomolecule into the nanostructures.

    Abstract translation: 本发明提供一种纳米结构装置，其包括其中包括纳沟的基板; 和悬浮在或支撑在基底中的脂质双层。 还提供了一种分离方法，包括以下步骤：在基质上支持或悬浮脂质双层; 其中所述底物包含纳米结构，并且其中所述脂质双层包含至少一个膜缔合的生物分子; 并将驱动力施加到脂质双层以将膜相关生物分子与脂质双层分离并将膜相关联的生物分子驱动到纳米结构中。

    THERAPEUTIC ULTRASOUND TRANSDUCER CHIP WITH INTEGRATED ULTRASOUND IMAGER AND METHODS OF MAKING AND USING THE SAME
    689.
    发明申请
    THERAPEUTIC ULTRASOUND TRANSDUCER CHIP WITH INTEGRATED ULTRASOUND IMAGER AND METHODS OF MAKING AND USING THE SAME 有权
    具有集成超声波成像器的治疗超声波传感器芯片及其制造和使用方法

    公开(公告)号：US20110060255A1

    公开(公告)日：2011-03-10

    申请号：US12920271

    申请日：2009-02-27

    Applicant: Jingkuang Chen

    Inventor： Jingkuang Chen

    IPC: A61N7/00

    CPC classification number: B06B1/0292

    Abstract: A therapeutic ultrasound device may include a substrate, at least one high power capacitive micromachined ultrasonic transducer, and at least one imager transducer comprising a capacitive micromachined ultrasonic transducer. The at least one high power capacitive micromachined ultrasonic transducer and the imager transducer may be monolithically integrated on the substrate.

    Abstract translation: 治疗性超声装置可以包括衬底，至少一个高功率电容微加工超声换能器，以及包括电容微加工超声换能器的至少一个成像器换能器。 至少一个高功率电容微加工超声换能器和成像器换能器可以单片地集成在基底上。

    Non-invasive rapid diagnostic test for M. tuberculosis infection
    690.
    发明授权
    Non-invasive rapid diagnostic test for M. tuberculosis infection 有权
    结核分枝杆菌感染的非侵入性快速诊断试验

    公开(公告)号：US07897400B2

    公开(公告)日：2011-03-01

    申请号：US11955773

    申请日：2007-12-13

    Applicant: Graham Timmins ,  Vojo P. Deretic

    Inventor： Graham Timmins ,  Vojo P. Deretic

    IPC: G01N33/00 ,  A61K31/44

    CPC classification number: A61B5/0002 ,  A61B5/082 ,  A61B5/411 ,  A61B5/415 ,  A61B5/416 ,  A61B5/418 ,  A61K49/0004 ,  G01N33/5695

    Abstract: This invention relates to a test for detecting a Mycobacterium tuberculosis (tuberculosis or TB) infection in a patient or subject, specifically a diagnostic test, including a breath test, whereby patients are provided a small dose of an isotopically labeled TB drug, Isoniazid (INH) orally or directly to the lungs of the patient or subject. If TB is present, a TB enzyme mycobacterial peroxidase KatG oxidizes the INH; and KatG specific metabolites, in particular, isotopically labeled nitric oxide (NO), nitrites, nitrates, carbon monoxide (CO) or carbon dioxide converted from carbon monoxide of INH cleavage are measured. Other embodiments relate to a diagnostic breath test for detecting TB utilizing isotopically labeled urea (preferably, carbon-13 labeled urea), alone or in combination with isotopically labeled isoniazid (preferably, nitrogen-15 labeled isoniazid), wherein M. tuberculosis organism, if present in the patient or subject's lungs (or other tissues), will metabolize the isotopically labeled urea to isotopically labeled carbon dioxide (CO2) such that a determination of the residence of M. tuberculosis, including residence of an isoniazid resistant strain of M. tuberculosis, may be made.

    Abstract translation: 本发明涉及一种用于检测患者或受试者中结核分枝杆菌（结核病或结核病）感染的试验，特别是包括呼吸试验的诊断试验，其中向患者提供小剂量的同位素标记的结核病药物异烟肼（INH ）口服或直接给予患者或受试者的肺。 如果TB存在，TB酶分枝杆菌过氧化物酶KatG氧化INH; 并测定KatG特异性代谢物，特别是同位素标记的一氧化氮（NO），亚硝酸盐，硝酸盐，一氧化碳（CO）或由INH切割的一氧化碳转化的二氧化碳。 其他实施方案涉及用于使用同位素标记的尿素（优选碳-13标记的尿素）单独或与同位素标记的异烟肼（优选氮-15标记的异烟肼）组合来检测结核病的诊断性呼吸试验，其中结核分枝杆菌生物体如果 存在于患者或受试者的肺部（或其他组织）中，将同位素标记的尿素代谢为同位素标记的二氧化碳（CO 2），从而确定结核分枝杆菌的住所，包括结核分枝杆菌的异烟肼抗性菌株的停留 ，可以做。

Patent Agency Ranking