公开(公告)号：US07776705B2

公开(公告)日：2010-08-17

申请号：US11470552

申请日：2006-09-06

Applicant: Isaiah O. Oladeji ,  Alan Cuthbertson

Inventor： Isaiah O. Oladeji ,  Alan Cuthbertson

IPC: H01L21/20

CPC classification number: H01L21/76885 ,  H01L21/76834 ,  H01L23/5227 ,  H01L23/53238 ,  H01L28/10 ,  H01L2924/0002 ,  H01L2924/00

Abstract: A method of forming one or more inductors on a substrate is disclosed. The method includes forming a first dielectric material over the substrate, forming a trench in the first dielectric material, and substantially filling the trench with copper to form the one or more inductors. The first dielectric material is removed and a second dielectric material is formed over the copper. The second dielectric material is removed from an uppermost portion of the copper, thus leaving a portion of the second dielectric material on the sidewalls of the copper.

Abstract translation: 公开了一种在衬底上形成一个或多个电感器的方法。 该方法包括在衬底上形成第一介电材料，在第一介电材料中形成沟槽，并用铜基本上填充沟槽以形成一个或多个电感器。 去除第一电介质材料，并在铜上形成第二电介质材料。 第二电介质材料从铜的最上部去除，因此在铜的侧壁上留下一部分第二电介质材料。

公开(公告)号：US20100150843A1

公开(公告)日：2010-06-17

申请号：US12600265

申请日：2008-05-16

Applicant: Edvin Wilhelm Johannesen ,  Alan Cuthbertson

Inventor： Edvin Wilhelm Johannesen ,  Alan Cuthbertson

IPC: A61K49/00 ,  C07K7/08

CPC classification number: A61K49/0056 ,  A61B5/0071 ,  A61B5/4842 ,  A61K49/0032

Abstract: The present invention relates to labelled cMet binding peptides suitable for optical imaging in vivo. The peptides are labelled with an optical reporter group suitable for imaging in the red to near-infrared region. Also disclosed are pharmaceutical compositions and kits, as well as in vivo imaging methods, especially of use in the detection, staging, diagnosis, monitoring of disease progression or monitoring of treatment of colorectal cancer (CRC).

Abstract translation: 本发明涉及适用于体内光学成像的标记的cMet结合肽。 肽用适于在红色至近红外区域成像的光学报告基团标记。 还公开了药物组合物和试剂盒，以及体内成像方法，特别是用于检测，分期，诊断，监测疾病进展或监测结肠直肠癌（CRC）的治疗。

公开(公告)号：US20090263320A1

公开(公告)日：2009-10-22

申请号：US11570090

申请日：2005-06-15

Applicant: Alan Cuthbertson

Inventor： Alan Cuthbertson

IPC: A61K47/48 ,  A61K51/08 ,  A61K31/675 ,  A61K31/519 ,  A61K31/7068 ,  A61K31/505 ,  A61K31/337 ,  A61K31/704 ,  A61K31/7048 ,  A61K33/24 ,  A61P35/00

CPC classification number: A61K51/088 ,  A61K47/60 ,  A61K47/62 ,  A61K47/64 ,  A61K51/082 ,  C07K7/02 ,  C07K7/06 ,  C07K14/70546 ,  C07K14/78

Abstract: The invention relates to new peptide-based compounds for use as diagnostic imaging agents or as therapeutic agents wherein the agents comprise targeting vectors which bind to integrin receptors.

Abstract translation: 本发明涉及用作诊断显像剂或作为治疗剂的新的基于肽的化合物，其中所述试剂包含与整联蛋白受体结合的靶向载体。

公开(公告)号：US07521419B2

公开(公告)日：2009-04-21

申请号：US10753729

申请日：2004-01-08

Applicant: Alan Cuthbertson ,  Bard Indrevoll ,  Magne Solbakken ,  Torgrim Engell ,  Colin Mill Archer ,  Harry John Wadsworth

Inventor： Alan Cuthbertson ,  Bard Indrevoll ,  Magne Solbakken ,  Torgrim Engell ,  Colin Mill Archer ,  Harry John Wadsworth

IPC: A61K38/00 ,  A61K38/12 ,  C07K5/00 ,  C07K7/00 ,  C07K16/00 ,  C07K17/00

CPC classification number: C07K7/06 ,  A61K38/00 ,  A61K47/60 ,  A61K47/6425 ,  A61K49/0002 ,  A61K51/082 ,  A61K51/088 ,  C07K14/745

Abstract: The invention relates to new peptide-based compounds for use as diagnostic imaging agents or as therapeutic agents wherein the agents comprise targeting vectors which bind to integrin receptors.

Abstract translation: 本发明涉及用作诊断显像剂或作为治疗剂的新的基于肽的化合物，其中所述试剂包含与整联蛋白受体结合的靶向载体。

公开(公告)号：US20080095704A1

公开(公告)日：2008-04-24

申请号：US11571313

申请日：2005-07-01

Applicant: Alan Cuthbertson ,  Magne Solbakken

Inventor： Alan Cuthbertson ,  Magne Solbakken

IPC: A61K49/00 ,  C07C233/24 ,  C07C233/57 ,  C07C271/22

CPC classification number: A61K49/0004 ,  A61K49/0002 ,  A61K49/0013 ,  A61K49/0438 ,  A61K51/0497 ,  C07C317/32

Abstract: The invention relates to compounds suitable for use in an imaging agent said imaging agent showing an improved pharmacokinetic profile.

Abstract translation: 本发明涉及适用于成像剂的化合物，所述显像剂显示出改善的药代动力学特征。

公开(公告)号：US20080041813A1

公开(公告)日：2008-02-21

申请号：US11618240

申请日：2006-12-29

Applicant: Isaiah Olatunde Oladeji ,  Alan Cuthbertson

Inventor： Isaiah Olatunde Oladeji ,  Alan Cuthbertson

IPC: H01B13/00 ,  C09K13/00

CPC classification number: C09K13/06 ,  C23F1/18 ,  C23F3/06 ,  H01L21/32134 ,  H01L21/76865 ,  H01L21/76885

Abstract: A composition comprising an aqueous solution of: a wet-etch formulation that is proven to etch copper; and a wetting agent. Exemplary wet-etch formulations include a mixture of a strong inorganic acid, such as sulfuric acid or hydrofluoric acid, and an oxidizing agent such as hydrogen peroxide, and further include ammonium persulfate. Exemplary wetting agents include organic acids such as citric acid, acetic acid, oxalic acid, or formic acid. Processes of using the compositions for wet-etching, or chemical mechanical polishing, or fabricating thick copper inductors, are further provided.

Abstract translation: 一种组合物，其包含以下溶液：水蚀刻制剂，被证明可蚀刻铜; 和润湿剂。 示例性的湿蚀刻制剂包括强无机酸（例如硫酸或氢氟酸）和氧化剂如过氧化氢的混合物，并且还包括过硫酸铵。 示例性的润湿剂包括有机酸如柠檬酸，乙酸，草酸或甲酸。 还提供了使用组合物进行湿蚀刻或化学机械抛光或制造厚铜电感器的方法。

公开(公告)号：US07182934B2

公开(公告)日：2007-02-27

申请号：US11108598

申请日：2005-04-18

Applicant: Jo Klaveness ,  Anne Naevestad ,  Alan Cuthbertson

Inventor： Jo Klaveness ,  Anne Naevestad ,  Alan Cuthbertson

IPC: A61K49/00

CPC classification number: A61K49/0056 ,  A61K49/0021 ,  A61K49/0043 ,  A61K49/0052 ,  A61K49/0091 ,  A61K49/10 ,  A61K49/103 ,  A61K49/223 ,  A61K51/04 ,  A61K51/0453 ,  A61K51/0478 ,  A61K51/0497 ,  A61K51/1255

Abstract: The invention provides a composition of matter of formula I V-L-R   (I) where V is an organic group having binding affinity for an angiotensin II receptor site, L is a linker moiety or a bond, and R is a moiety detectable in in vivo imaging of a human or animal body, with the provisos that where V is angiotensin or a peptidic angiotensin derivative or analog then V-L-R is other than a non-metal radionuclide substituted peptide (eg 125I substituted angiotensin II) and L-V is other than simply a peptide with a chelating agent amide bonded to a side chain thereof. This composition of matter may be used to image cardiovascular diseases and disorders.

Abstract translation: 本发明提供式I的物质的组成<？in-line-formula description =“In-line Formulas”end =“lead”？> VLR（I）<？in-line-formula description =“In-Line Formulas “end =”tail“？>其中V是对血管紧张素II受体位点具有结合亲和力的有机基团，L是连接体部分或键，R是在体内成像人或动物体中可检测的部分， 条件是其中V是血管紧张素或肽血管紧张素衍生物或类似物，则VLR不是非金属放射性核素取代肽（例如，125 I取代的血管紧张素II），而LV不仅仅是一种肽 与其侧链结合的螯合剂酰胺。 这种物质的组成可以用于影像心血管疾病和病症。

公开(公告)号：US20060222593A1

公开(公告)日：2006-10-05

申请号：US10469801

申请日：2002-03-01

Applicant: Alan Cuthbertson ,  Marivi Mendizabal ,  Mark Dixon ,  Anthony Storey ,  Edward Bacon ,  Vinay Desai ,  Sudahkar Kasina ,  Henry Wolfe

Inventor： Alan Cuthbertson ,  Marivi Mendizabal ,  Mark Dixon ,  Anthony Storey ,  Edward Bacon ,  Vinay Desai ,  Sudahkar Kasina ,  Henry Wolfe

IPC: A61K49/00 ,  C07K14/47

CPC classification number: C07K7/06 ,  A61K51/088 ,  C07K14/245 ,  G01N33/57419

Abstract: A peptide-chelate with affinity for the ST receptor is disclosed, wherein the chelate is tetradentate. The peptide-chelate conjugate of the invention may be labelled with a radiometal to provide a metal complex. A radiopharmaccutical composition comprising the metal complex is provided, which is suitable for the diagnostic imaging of colorectal cancer. Also provided for in the invention is a kit for the preparation of the radiopharmaceutical preparation.

Abstract translation: 公开了对ST受体具有亲和力的肽螯合物，其中螯合物是四齿酸盐。 本发明的肽 - 螯合物缀合物可用放射性金属标记以提供金属络合物。 提供了包含金属络合物的放射性药物组合物，其适用于结肠直肠癌的诊断成像。 本发明还提供了用于制备放射性药物制剂的试剂盒。

公开(公告)号：US06998335B2

公开(公告)日：2006-02-14

申请号：US10735117

申请日：2003-12-13

Applicant: Zhang Fan ,  Zhang Bei Chao ,  Liu Wuping ,  Chok Kho Liep ,  Hsia Liang Choo ,  Lim Yeow Kheng ,  Alan Cuthbertson ,  Tan Juan Boon

Inventor： Zhang Fan ,  Zhang Bei Chao ,  Liu Wuping ,  Chok Kho Liep ,  Hsia Liang Choo ,  Lim Yeow Kheng ,  Alan Cuthbertson ,  Tan Juan Boon

IPC: H01L21/44

CPC classification number: H01L24/06 ,  H01L23/53223 ,  H01L24/03 ,  H01L24/05 ,  H01L24/11 ,  H01L2224/0401 ,  H01L2224/04042 ,  H01L2224/05559 ,  H01L2224/05572 ,  H01L2224/05624 ,  H01L2224/05647 ,  H01L2224/13099 ,  H01L2924/0002 ,  H01L2924/01005 ,  H01L2924/01006 ,  H01L2924/01013 ,  H01L2924/01014 ,  H01L2924/01019 ,  H01L2924/01022 ,  H01L2924/01024 ,  H01L2924/01029 ,  H01L2924/01033 ,  H01L2924/01073 ,  H01L2924/01074 ,  H01L2924/01082 ,  H01L2924/05042 ,  H01L2924/14 ,  H01L2224/05552

Abstract: A structure and method for an improved a bond pad structure. We provide a top wiring layer and a top dielectric (IMD) layer over a semiconductor structure. The buffer dielectric layer is formed over the top wiring layer and the top dielectric (IMD) layer. We form a buffer opening in the buffer dielectric layer exposing at least of portion of the top wiring layer. We form a barrier layer over the buffer dielectric layer, and the top wiring layer in the buffer opening. A conductive buffer layer is formed over the barrier layer. We planarize the conductive buffer layer to form a buffer pad in the buffer opening. We form a passivation layer over the buffer pad and the buffer dielectric layer. We form a bond pad opening in the passivation layer over at least a portion of the buffer pad. We form a bond pad support layer over the buffer pad and the buffer dielectric layer. We form a bond pad layer over the a bond pad support layer. The bond pad layer and the bond pad support layer are patterned to form a bond pad and bond pad support.

Abstract translation: 一种改进接合焊盘结构的结构和方法。 我们在半导体结构上提供顶部布线层和顶部电介质（IMD）层。 缓冲电介质层形成在顶部布线层和顶部电介质（IMD）层上。 我们在缓冲介电层中形成缓冲开口，露出至少部分顶部布线层。 我们在缓冲介质层上形成阻挡层，缓冲开口中形成顶部布线层。 导电缓冲层形成在阻挡层上。 我们平面化导电缓冲层以在缓冲开口中形成缓冲垫。 我们在缓冲垫和缓冲电介质层上形成钝化层。 我们在缓冲垫的至少一部分上在钝化层中形成接合焊盘开口。 我们在缓冲垫和缓冲电介质层上形成接合焊盘支撑层。 我们在接合垫支撑层上形成接合垫层。 将接合焊盘层和接合焊盘支撑层图案化以形成接合焊盘和接合焊盘支撑。

公开(公告)号：US06921525B2

公开(公告)日：2005-07-26

申请号：US10370092

申请日：2003-02-21

Applicant: Jo Klaveness ,  Anne Naevestad ,  Alan Cuthbertson

Inventor： Jo Klaveness ,  Anne Naevestad ,  Alan Cuthbertson

IPC: A61K47/48 ,  A61K49/00 ,  A61K49/18 ,  A61K49/22 ,  A61K51/04 ,  A61K51/08 ,  A61K51/12 ,  A61M36/14 ,  A61K51/00

CPC classification number: A61K49/0056 ,  A61K49/0021 ,  A61K49/0043 ,  A61K49/0052 ,  A61K49/0091 ,  A61K49/10 ,  A61K49/103 ,  A61K49/223 ,  A61K51/04 ,  A61K51/0453 ,  A61K51/0478 ,  A61K51/0497 ,  A61K51/1255

Abstract: The invention provides a composition of matter of the formula (I): V-L-R where V is an organic group having binding affinity for an angiotensin II receptor site, L is a linker moiety or a bond, and R is a moiety detectable in in vivo imaging of a human or animal body, with the provisos that where V is angiotensin or a peptidic angiotensin derivative or analog then V-L-R is other than a non-metal radionuclide substituted peptide (e.g. 125I substituted angiotensin II) and L-V is other than simply a peptide with a chelating agent amide bonded to a side chain thereof. This composition of matter may be used to image cardiovascular diseases and disorders.

Abstract translation: 本发明提供了式（I）的物质组合物：VLR，其中V是对血管紧张素II受体位点具有结合亲和力的有机基团，L是连接体部分或键，R是在体内成像中可检测的部分 的条件是V是血管紧张素或肽血管紧张素衍生物或类似物时，VLR不是非金属放射性核素取代肽（例如，125 I取代的血管紧张素II）和 LV不仅仅是具有与其侧链结合的螯合剂酰胺的肽。 这种物质的组成可用于影像心血管疾病和病症。