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公开(公告)号：US20170283436A1
公开(公告)日：2017-10-05
申请号：US15507208
申请日：2015-08-28
Applicant: Celia DOMINGUEZ , John WITYAK , Jonathan BARD , Alex KISELYOV , Christopher John BROWN , Sebastien Rene Gabriel GALAN , Michael Edward PRIME , Paul Richard GILES , Elise Luciennen Paulette GADOULEAU , Thomas Martin KRÜLLE , Daniel CLARKFREW , Peter David JOHNSON , Sabinc SCHAERTI , Steffen Kaspar GRIMM , Jan Dirk KAHMANN , Christoph SCHEICH , Samuel COE , Sarah HAYES , CHDI Foundation, Inc.
Inventor： Celia Dominguez , John Wityak , Jonathan Bard , Alex Kiselyov , Christopher John Brown , Sébastien René Gabriel Galan , Michael Edward Prime , Paul Richard Giles , Elise Luciennen Paulette Gadouleau , Thomas Martin Krülle , Daniel Clark-Frew , Peter David Johnson , Samuel Coe , Sarah Hayes
IPC: C07D513/04 , C07D413/04 , C07D413/14 , A61K51/04 , C07D498/04 , C07D405/14 , C07D471/04 , C07D263/57 , C07D413/12
CPC classification number: C07D513/04 , A61K51/0455 , A61K51/0459 , A61K51/0463 , C07D263/57 , C07D405/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D471/04 , C07D498/04
Abstract: Provided are imaging agents comprising a compound of Formula (I), or a pharmaceutically acceptable salt thereof, and methods of their use.
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62.发明申请HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF 审中-公开组织脱乙酰酶抑制剂及其组合物及其使用方法公开(公告)号：US20160326124A1
公开(公告)日：2016-11-10
申请号：US15148907
申请日：2016-05-06
Applicant: CHDI Foundation, Inc.
Inventor： Celia Dominguez , Michel C. Maillard , Alan F. Haughan , Amanda Van de Poël , Andrew J. Stott , Christopher A. Luckhurst , Elizabeth A. Saville-Stones , Grant Wishart , Michael Wall , Perla Breccia , Rebecca E. Jarvis
IPC: C07D271/06 , C07D471/04 , C07D413/12
CPC classification number: C07D271/06 , C07D413/12 , C07D471/04
Abstract: Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use.
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公开(公告)号：US20160053256A1
公开(公告)日：2016-02-25
申请号：US14708511
申请日：2015-05-11
Applicant: ISIS PHARMACEUTICALS, INC. , CHDI FOUNDATION INC.
Inventor： Gene Hung , C. Frank Bennett , Janet M. Leeds , Susan M. Freier
IPC: C12N15/113
CPC classification number: C12N15/113 , C12N2310/11 , C12N2310/111 , C12N2310/31 , C12N2310/315 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/323 , C12N2310/3231 , C12N2310/33 , C12N2310/3341 , C12N2310/335 , C12N2310/341 , C12N2310/346 , C12N2320/30 , C12N2310/3525
Abstract: Disclosed herein are compounds, compositions and methods for modulating the expression of huntingtin in a cell, tissue or animal. Further provided are methods of slowing or preventing Huntington's disease progression using an antisense compound targeted to huntingtin. Additionally provided are methods of delaying or preventing the onset of Huntingtin's disease in an individual susceptible to Huntingtin's Disease. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders.
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公开(公告)号：US20160039745A1
公开(公告)日：2016-02-11
申请号：US14776280
申请日：2014-03-10
Applicant: CHDI FOUNDATION, INC.
Inventor： Celia Dominguez , Ignacio Muñoz-San Juan , Michel Maillard , Gilles Raphy , Alan F. Haughan , Christopher A. Luckhurst , Rebecca E. Jarvis , Roland W. Burli , Grant Wishart , Samantha J. Hughes , Daniel R. Allen , Stephen D. Penrose , Perla Breccia
IPC: C07C233/60 , C07D413/06 , C07D239/26 , C07D471/04 , C07D401/12 , C07D213/58 , C07D231/12 , C07D209/46 , C07D307/81 , C07D235/06 , C07D277/66 , C07D215/06 , C07D311/96 , C07D263/57 , C07D231/56 , C07D265/30 , C07D265/36
CPC classification number: C07C233/60 , C07C259/08 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07D209/46 , C07D213/54 , C07D213/56 , C07D213/58 , C07D215/06 , C07D215/14 , C07D231/12 , C07D231/56 , C07D235/06 , C07D235/08 , C07D239/26 , C07D263/56 , C07D263/57 , C07D265/30 , C07D265/36 , C07D277/64 , C07D277/66 , C07D295/073 , C07D307/79 , C07D307/81 , C07D311/96 , C07D333/54 , C07D401/12 , C07D413/06 , C07D471/04
Abstract: Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use.
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公开(公告)号：US20160031863A1
公开(公告)日：2016-02-04
申请号：US14776058
申请日：2014-03-10
Applicant: CHDI FOUNDATION, INC.
Inventor： Celia Dominguez , Ignacio Muñoz-Sanjuán , Michel Maillard , Huw D. Vater , Rebecca E. Jarvis , Christopher A. Luckhurst , Roland W. Bürli , Grant Wishart , Andrew J. Stott
IPC: C07D409/04 , C07D207/34 , C07D231/14 , C07D401/04 , C07D403/04
CPC classification number: C07D409/04 , C07D207/34 , C07D231/14 , C07D231/22 , C07D401/04 , C07D403/04
Abstract: Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use.
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Patent Agency Ranking
66.发明申请公开(公告)号：US20150203468A1
公开(公告)日：2015-07-23
申请号：US14414149
申请日：2013-07-16
Applicant: CHDI FOUNDATION, INC.
Inventor： Celia Dominguez , Christopher A. Luckhurst , Roland W. Bürli , Andrew J. Stott , Perla Breccia
IPC: C07D319/18 , C07D277/30 , C07D263/32 , C07D239/26 , C07D213/56
CPC classification number: A61K31/505 , A61K31/165 , A61K31/357 , A61K31/421 , A61K31/426 , A61K31/4418 , C07B2200/07 , C07C259/08 , C07C2601/02 , C07D213/56 , C07D213/61 , C07D213/74 , C07D215/18 , C07D237/08 , C07D239/26 , C07D239/30 , C07D239/34 , C07D241/12 , C07D263/32 , C07D263/56 , C07D277/30 , C07D277/64 , C07D295/155 , C07D311/58 , C07D319/18 , C07D401/04 , C07D417/04
Abstract: Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use.
Abstract translation: 提供式I的组蛋白脱乙酰酶（HDAC）抑制剂，其组合物及其使用方法。
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公开(公告)号：US20130189782A1
公开(公告)日：2013-07-25
申请号：US13708839
申请日：2012-12-07
Applicant: Isis Pharmaceuticals, Inc. , CHDI Foundation Inc.
Inventor： Gene Hung , Janet M. Leeds , C. Frank Bennett , Susan M. Freier
IPC: C12N15/113
CPC classification number: C12N15/113 , C12N2310/11 , C12N2310/111 , C12N2310/31 , C12N2310/315 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/323 , C12N2310/3231 , C12N2310/33 , C12N2310/3341 , C12N2310/335 , C12N2310/341 , C12N2310/346 , C12N2320/30 , C12N2310/3525
Abstract: Disclosed herein are compounds, compositions and methods for modulating the expression of huntingtin in a cell, tissue or animal. Further provided are methods of slowing or preventing Huntington's disease progression using an antisense compound targeted to huntingtin. Additionally provided are methods of delaying or preventing the onset of Huntingtin's disease in an individual susceptible to Huntingtin's Disease. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders.
Abstract translation: 本文公开了用于调节细胞，组织或动物中亨廷丁氏蛋白的表达的化合物，组合物和方法。 还提供了使用靶向亨廷顿汀的反义化合物减慢或预防亨廷顿病进展的方法。 另外提供的方法是延缓或预防在亨廷顿病易感的个体中亨廷顿病发病的方法。 还提供了所公开的化合物和组合物在制备用于治疗疾病和病症的药物中的用途。
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公开(公告)号：US12281116B2
公开(公告)日：2025-04-22
申请号：US17988340
申请日：2022-11-16
Applicant: CHDI Foundation, Inc.
Inventor： Longbin Liu , Celia Dominguez , Nikolay V. Plotnikov , Alan Haughan , Andrew Stott , Brett Cosgrove , Cole Clissold , Huw Vater , Jonathan Spencer , William Esmieu , Karine Malagu , Mark Chambers
IPC: C07D471/10 , A61K45/06 , C07D403/14 , C07D405/14 , C07D413/14 , C07D471/04
Abstract: Provided herein are certain compounds useful as HTT modulators. Such compound are useful in the treatment of Huntington's disease.
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公开(公告)号：US12036291B2
公开(公告)日：2024-07-16
申请号：US17353611
申请日：2021-06-21
Applicant: CHDI Foundation, Inc.
Inventor： Celia Dominguez , John Wityak , Jonathan Bard , Christopher John Brown , Thomas Martin Krülle , Daniel Clark-Frew , Sarah Hayes
IPC: A61K51/04 , C07D401/04 , C07D401/14 , C07D403/04 , C07D487/04 , C07D513/04 , C07D513/14
CPC classification number: A61K51/0455 , C07D401/04 , C07D401/14 , C07D403/04 , C07D487/04 , C07D513/04 , C07D513/14 , C07B2200/05
Abstract: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.
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公开(公告)号：US11992535B2
公开(公告)日：2024-05-28
申请号：US17125905
申请日：2020-12-17
Applicant: CHDI Foundation, Inc.
Inventor： Longbin Liu , Matthew Lee , Celia Dominguez , Peter David Johnson , Christopher John Brown , Sarah Hayes , Adrian Kotey , Matthew Robert Mills , Michael Edward Prime
IPC: A61K51/04 , C07B59/00 , C07D401/06 , C07D401/12 , C07D401/14 , C07D413/14 , C07D471/04 , C07D487/04 , C07D491/107
CPC classification number: A61K51/0455 , A61K51/0459 , A61K51/0468 , C07B59/00 , C07D401/06 , C07D401/12 , C07D401/14 , C07D413/14 , C07D471/04 , C07D487/04 , C07D491/107 , C07B2200/05
Abstract: Provided herein are certain compounds and imaging agents useful for detecting a condition or disorder associated with protein aggregation, compositions thereof, and methods of their use.
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